PSYCHOLOGICAL IMPACT OF COVID-19 Introduction As an international public health emergency, the coronavirus disease 2019 (COVID-19) has gained widespread attention from the public. Owing to COVID-19’s high infectivity and mortality rate (3–4%), China initiated its first-level public health emergency response on January 25, 2020.The Chinese government and health authorities strived to slow the virus’ spread by adopting a series of preventive measures, such as strict quarantining, contact tracing, and social distancing. In addition to the health-related and socio-economic concerns associated with COVID-19, the psychological impact of the disease has also attracted considerable attention. In March, the World Health Organization released mental health guidelines to support the psychosocial and mental well-being of the general population. Background With the virus’ exponential diffusion and the related large-scale quarantine policies enacted by most governments, a wide range of psychological disorders, including panic, fear, anxiety, depression, and frustration, gradually emerged. To date, various studies have reported the psychological impact of the COVID-19 pandemic on different populations. For example, patients with COVID-19 have been reported to not only experience several physical symptoms but also diverse psychological effects. Similarly, healthcare providers, especially nurses and physicians caring for COVID-19 patients, experience considerable psychological distress associated with fear of infection. The general population is simultaneously affected by COVID-19 infection as well as social distancing measures. Chinese online study by Wang et al showed that 16.5% of the general population had moderate to severe depressive symptoms and 28.8% suffered from moderate to severe anxiety symptoms. As the virus spreads globally, studies on the psychological impact of the COVID-19 pandemic have proliferated among different nations. For instance, an Australian nationwide survey found that the mental problems of residents during the pandemic were at least twice as high as those prior to the pandemic. Italian series of studies have reported that the COVID-19 pandemic was an important stressor comparable to a traumatic event. Stress Stress is a physiological, psychological, and behavioral process that occurs in individuals as a response to environmental stimuli. Previous studies have demonstrated that stress causes various mental health problems. Although moderate pressure is beneficial to stimulate individual protective behaviors and improve environmental adaptability by developing a warning system, long-term or intense stress causes psychological impairment and physical disease. This phenomenon has been explained through a stress system model, which suggests that adverse life events (stressors) can directly lead to individual stress responses or indirectly affect an individual’s physical and mental health through their coping style, social support, personality traits, and awareness. COPING STYLE Coping style refers to individuals’ cognitive and behavioral efforts to maintain mental balance in stressful situations. Previous studies demonstrated that coping style functions as a mediator between stress and psychological health. Adopting appropriate coping strategies against stressful situations is positively linked to quality of life. Additionally, the role of coping strategies in medical settings has been well-documented. For example, task-based coping strategies appear to prevent the onset of depressive symptoms and help reduce the severity of hypertension. Disease awareness (which refers to the self-evaluation of knowledge about disease transmission, common symptoms, potential treatment, and risk factors associated with the disease) is critical to control and prevent COVID-19. Further, having knowledge about a specific disease can influence individuals’ perception and behavior towards it. Earlier studies have shown that a higher level of COVID-19 knowledge is beneficial for the public to maintain an optimistic attitude and maintain appropriate preventive measures and care-seeking behaviors. In addition, research during the SARS outbreak suggests that the public’s knowledge was associated with a reduction in symptoms of anxiety, fear and panic. Limited disease knowledge may aggravate psychological distress and emotional responses. Therefore, coping styles and disease awareness play a significant role in handling the psychological stress associated with the COVID-19 pandemic. n 30 January 30, 2020, the WHO director-general declared COVID-19 a public health emergency of international concern. To prevent the spread of the virus, individuals testing positive for the disease should be placed in isolation, (“separation of ill or infected persons from others”). Discharge required clinical recovery with two negative sequential RT-PCR results within 24 hours, which was later updated to 10 days after symptom onset plus a minimum of 3 days without symptoms for symptomatic patients and 10 days after a positive test for asymptomatic patients. In addition to isolation, quarantine (“separation of persons who are not ill, but who may have been exposed to an infectious agent or disease”), measures were introduced. Individuals identified as contacts (e.g., providing direct care without the use of personal protective equipment, having face-to face-contact within 1 m >15 minutes) of laboratory-confirmed cases required 14 days of quarantine from the last time they were exposed to the patient. IMPACT OF ISOLATION AND QUARANTINE Although isolation and quarantine have distinct meanings in practice, they both involve the separation of an individual from their loved ones, normal activities, and routines for the purpose of infection prevention. The psychological impact of quarantine and isolation was exacerbated by the harmful effect of limited physical activity and changes in dietary practices. Such changes may result in dramatic and long-lasting psychological impact. A study on quarantined and isolated individuals with severe acute respiratory syndrome (SARS) and H1N1 reported posttraumatic stress symptoms, confusion, and anger. Stressors included longer quarantine, infection fears, frustration, boredom, inadequate supplies, inadequate information, financial loss, and stigma. In a study on health-care workers who had survived the Middle East respiratory syndrome coronavirus (MERS-CoV) epidemic in Saudi Arabia in 2015, participants explained a variety of painful experiences of rejection and avoidance by their colleagues and neighbors post recovery. Similar avoidance was reported by SARS survivors, along with perceived barriers to service access and employment and well beyond the initial outbreak. Stigma, including being shunned, insulted, marginalized, and rejected in the domains of work, interpersonal relationships, use of services, and schooling was also reported. In the context of the current pandemic, reports from China have showed rates of up to 30% for anxiety, 17% depression, and 35% trauma-related distress symptoms. Similar rates have also been reported in Italy following implementation of lockdown measures. Furthermore, reports from India and Bangladesh have described suicidal behaviors (e.g., suicidal ideation, suicide attempts, and actual suicide) for various reasons. It is not to say that quarantine or lockdown strategy should not be used; it may be worse for the psychological consequences of not taking timely measures and allowing the disease to spread (Hawryluck et al., 2004). Government should proceed by informing people with the facts that what is happening and why, explaining how long it will last and ensuring essential supplies (such as food, etc.) and reinforcing the sense of altruism that people should, rightly, be feeling. If this extended lockdown or quarantine experience is negative, there could be long-term effects that impact not just the quarantined individuals, but also the health care system, policymakers and the public. College students were the most affected among occupational categories in this study. Although the number of college students that participated in this study was low, this result is consistent with other studies reporting that the mental health of college students has been significantly affected during the COVID-19 pandemic. Concerns of personal health, health of family members, and finance, particularly for those impacted by prolonged closure of employers, have been reported. The added impact of quarantine has led to high occurrence of distress, depression, anxiety, stress, and even self-reported suicidal thoughts. Loss of income, poor-quality housing, history of psychiatric follow-up, symptoms compatible with COVID-19, low levels of physical activity, not living with family, weak sense of integration, low quality of social relations, and receiving low-quality information were associated with all mental health issues. Consistently with a recent systematic review, our findings suggested that people with preexisting mental conditions are at highest risk of psychological distress and should be targeted for psychological assessment and appropriate intervention. Based on the results of this study and others, female college students with mental health conditions may be particularly vulnerable to psychological impact due to isolation and quarantine. Given the immediate and long-lasting effects, such groups must be the focus of psychological screening, intervention, and future research. Not surprisingly, hospital isolation was more depressing than home isolation. The opposite, however, was true for stigmatization. It is evident from the literature that those with infectious disease have fears of infecting others during quarantine. Fear of infecting others or becoming infected, potentially exacerbated by ignorance of infection transmission, may have resulted in avoidance within the home beyond required social distancing measures. Such experiences of avoidance from family members, as opposed to trained health-care professionals, may have led to feelings of great hurt and shame, increasing the burden of stigma. Other contributing factors were losing one’s job, experiencing social conflict or breakup, transmitting the infection to others, or knowing someone who had died due to the disease. Duration between isolation/quarantine and interview did not have a significant effect on psychological outcomes, which could reflect the long-lasting effect of segregation. In one study, alcohol abuse and dependence symptoms were reported among quarantined individuals 3 years after the SARS outbreak. RATIO OF PSYCHOLOGICAL IMPACT OF COVID-19 IN MEN AND WOMEN Although most reports have indicated that men with COVID-19 have a poorer prognosis, there is an increasing body of evidence to confirm that the psychological impact is more profound in women. This agrees with our results, which showed that females exhibited more psychological depression and distress. CHILDREN AND TEENS AT RISK Children, away from their school, friends, and colleagues, staying at home can have many questions about the outbreak and they look toward their parents or caregivers to get the answer. Not all children and parents respond to stress in the same way. Kids can experience anxiety, distress, social isolation, and an abusive environment that can have short‐ or long‐term effects on their mental health. Some common changes in children's behavior can be: Excessive crying and annoying behavior Increased sadness, depression, or worry Difficulties with concentration and attention Changes in, or avoiding, activities that they enjoyed in the past Unexpected headaches and pain throughout their bodies Changes in eating habits to help offset negative behaviors, requires parents to remain calm, deal with the situation wisely, and answer all of the child's questions to the best of their abilities. Parents can take some time to talk to their children about the COVID‐19 outbreak and share some positive facts, figures, and information. Parents can help to reassure them that they are safe at home and encourage them to engage in some healthy activities including indoor sports and some physical and mental exercises. Parents can also develop a home schedule that can help their children to keep up with their studies. Parents should show less stress or anxiety at their home as children perceive and feel negative energy from their parents. The involvement of parents in healthy activities with their children can help to reduce stress and anxiety and bring relief to the overall situation. ELDERS AND PEOPLE WITH DISABILITIES AT RISK Elderly people are more prone to the COVID‐19 outbreak due to both clinical and social reasons such as having a weaker immune system or other underlying health conditions and distancing from their families and friends due to their busy schedules. According to medical experts, people aged 60 or above are more likely to get the SARS‐CoV‐2 and can develop a serious and life‐ threatening condition even if they are in good health. 10 Physical distancing due to the COVID‐19 outbreak can have drastic negative effects on the mental health of the elderly and disabled individuals. Physical isolation at home among family members can put the elderly and disabled person at serious mental health risk. It can cause anxiety, distress, and induce a traumatic situation for them. Elderly people depend on young ones for their daily needs, and self‐isolation can critically damage a family system. The elderly and disabled people living in nursing homes can face extreme mental health issues. However, something as simple as a phone call during the pandemic outbreak can help to console elderly people. COVID‐19 can also result in increased stress, anxiety, and depression among elderly people already dealing with mental health issues. Family members may witness any of the following changes to the behavior of older relatives Irritating and shouting behavior Change in their sleeping and eating habits Emotional outbursts The World Health Organization suggests that family members should regularly check on older people living within their homes and at nursing facilities. Younger family members should take some time to talk to older members of the family and become involved in some of their daily routines if possible. HEALTH WORKERS AT RISK Doctors, nurses, and paramedics working as a front‐line force to fight the COVID‐19 outbreak may be more susceptible to develop mental health symptoms. Fear of catching a disease, long working hours, unavailability of protective gear and supplies, patient load, unavailability of effective COVID‐19 medication, death of their colleagues after exposure to COVID‐19, social distancing and isolation from their family and friends, and the dire situation of their patients may take a negative toll of the mental health of health workers. The working efficiency of health professionals may decrease gradually as the pandemic prevails. Health workers should take short breaks between their working hours and deal with the situation calmly and in a relaxed manner. STIGMATIZATION Generally, people recently released from quarantine can experience stigmatization and develop a mix of emotions. Everyone may feel differently and have a different welcome by society when they come out of quarantine. People who recently recovered may have to exercise social distancing from their family members, friends, and relatives to ensure their family's safety because of unprecedented viral nature. Different age groups respond to this social behavior differently, which can have both short‐ and long‐term effects. Health workers trying to save lives and protect society may also experience social distancing, changes in the behavior of family members, and stigmatization for being suspected of carrying COVID‐19. Previously infected individuals and health professionals (dealing pandemic) may develop sadness, anger, or frustration because friends or loved ones may have unfounded fears of contracting the disease from contact with them, even though they have been determined not to be contagious. However, the current situation requires a clear understanding of the effects of the recent outbreak on the mental health of people of different age groups to prevent and avoid the COVID‐ 19 pandemic. PSYCHOLOGICAL IMPACT OF COVID-19 IN PAKISTAN The pandemic of coronavirus disease 2019 (COVID-19) has created a public health crisis that has had a drastic effect on the way we understand our world and our everyday lives. Since the emergence of this outbreak on February 26, 2020 in Pakistan, the country is on high alert and has implemented stringent containment measures including closing schools, restricting public gatherings, and reinforcing smart lockdown. Pakistan, being a collectivistic society heavily dependent on socialization (social reinforcement and social connectivity), has been critical toward self-isolation, social distancing, and quarantine and is reluctant to deal with the mental, psychological, behavioral, and social impacts of the instability and unpredictability of this crisis. Besides the general public being affected, medical workers were subjected to physical and psychological pressure including high risk of infection, insufficient protective gear from contagion, isolation, exhaustion, and lack of family contact. The intensity causes more mental health issues which not only impair the decision-making capacity of medical workers but may also have a negative impact on their overall well-being in the long term. Healthcare conditions in Pakistan are worsening on daily basis and therefore controlling the disease would require holistic thorough management on both physical and mental healthcare situations. CONCLUSIONS Although participants experienced inevitable psychological distress during the COVID-19 pandemic, with fear being the most common, most were in a positive psychological state. We observed that the higher the participants’ avoidant coping style scores, the more severe their public emergency psychological state, and that the higher the participants’ level of disease awareness, the milder their stress response. In Hunan Province, the COVID-19 pandemic appears to have a greater psychological impact on employees (such as company employees, migrant workers, and businessmen), individuals with COVID-19-like symptoms, as well as on individuals with limited discernment competence and unconcerned attitudes. With the continuous spread of the COVID-19 epidemic, efforts to develop actionable policies and massive healthcare education campaigns are necessary. Multi-departmental, multi-resource, and multi-component psychological guidelines and interventions still need further development, especially for vulnerable individuals at greater risk of psychological distress. References https://www.bbc.com/worklife/article/20201021-coronavirus-the-possible-long-term-men https://oatext.com/the-psychological-impact-of-covid-19-pandemic-on-pakistani-populat https://onlinelibrary.wiley.com/doi/10.1111/appy.12409 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361582/ https://www.jmir.org/2020/9/e21279/ https://www.dovepress.com/psychological-impact-of-covid-19-isolation-and-quarantine https://www.dovepress.com/the-psychological-impact-and-associated-factors-of-covid-