o ANXIETY DISORDERS Treatment of Anxiety Disorders Generalized Anxiety Disorder - Benzodiazepines o Give short term relief o Carry risks – impair both cognitive and motor functioning o Associated with falls in older adults, resulting in hip fractures o Produce both psychological and physical dependence - Antidepressants (SSRI) o Paroxetine (aka Paxil) o Escitalopram (aka Lexapro) o Duloxetine (aka Cymbalta) o Venlafaxine (aka Effexor) - Psychological treatments o Using images to feel (rather than avoid feeling) anxious o Relaxing deeply to combat tension Panic Disorder and Agoraphobia - Gradual exposure exercises, combined with anxiety-reducing coping mechanisms such as relaxation or breathing retraining - Panic Control Treatment (PCT) o Exposing patients to the cluster of interoceptive (physical) sensations that remind them of their panic attack - Cognitive-behavioral program o Calm Tools for Living Clinician and patient sit side-by-side as they both view the program on screen Helps patient establish a fear hierarchy, demonstrate breathing skills, or design exposure assignments Specific Phobia - Structured and consistent exposure-based exercises Social Anxiety Disorder (Social Phobia) - Cognitive therapy program o Emphasizes real-life experiences to disprove automatic perceptions of danger - Interpersonal Psychotherapy (IPT) - Family-based treatment o Better than individual treatment if parents also have an anxiety disorder - Drugs o Paxil (SSRI) o Zoloft (SSRI) o Effexor (SSRI) o D-cycloserine (DCS) + CBT treatments = enhanced effect of treatment TRAUMA AND STRESSOR-RELATED DISORDERS Treatment of Trauma and Stressor-Related Disorders Posttraumatic Stress Disorder - Psychoanalytic therapy - - Catharsis Reliving emotional trauma o Imaginal exposure Content of the trauma and emotions associated with it are worked through systematically Cognitive therapy o To correct negative assumptions about the trauma e.g., blaming oneself, feeling guilty Drugs o Prozac (SSRI) o Paxil (SSRI) OBSESSIVE-COMPULSIVE AND RELATED DISORDERS Treatment of Obsessive-Compulsive and Related Disorders Obsessive-Compulsive Disorder - Drugs (SSRI) o Clomipramine (aka Anafranil) Relapse occurs when discontinued - Exposure and Ritual Prevention (ERP) o Most effective approach o Rituals are actively prevented and patient is systematically and gradually exposed to the feared thoughts or situations - Cognitive treatments o Focus: overestimation of threat, importance and control of intrusive thoughts, sense of inflated responsibility, need for perfectionism and certainty - Psychosurgery o A misnomer that refers to neurosurgery for a psychological disorder Body Dysmorphic Disorder - Drugs (SSRI) o Clomipramine (aka Anafranil) o Fluvoxamine - Cognitive-Behavioral Therapy (CBT) o Exposure and response prevention o Produce better and longer lasting outcomes than medication alone - Dermatology (skin) treatment o Most often received - Plastic surgery o Most common procedures: rhinoplasties (nose jobs), facelifts, eyeshadow elevations, liposuction, breast augmentation, surgery to alter the jawline Hoarding Disorder - Teaching people to assign different values to objects - Reducing anxiety about throwing away items that are somewhat less valued Trichotillomania and Excoriation - Habit Reversal Training o Patients are carefully taught to be more aware of their repetitive behavior, particularly - as it is just about to begin, and to then substitute a different behavior SSRIs (for Trichotillomania) - Antidepressants o SSRIs Fluoxetine (Prozac) – best known o Mixed reuptake inhibitors Venlafaxine (Effexor) – best known o Tricyclic antidepressants Most widely used treatment before SSRI Imipramine (Tofranil) and amitriptyline (Elavil) – best known Side effects: blurred vision, dry mouth, constipation, difficulty urinating, drowsiness, weight gain, sexual dysfunction Lethal if taken in excessive doses o Monoamine oxidase (MOA) inhibitors Block the enzyme MAO that breaks down such neurotransmitters as norepinephrine and serotonin Used far less often because of two potentially serious consequences: hypertensive episodes or death, when eating and drinking foods and beverages containing tyramine o Lithium carbonate (Lithium) Found in our drinking water Side effects: toxicity (poisoning), lowered thyroid functioning, substantial weight gain Major advantage: effective in preventing and treating manic episodes Most often referred to as a ‘moodstabilizing drug’ - Biological treatments o Electroconvulsive Therapy (ECT) Most controversial treatment for psychological disorders after psychosurgery Electric shock is administered directly through the brain for less than 1 second, producing a seizure and a series of brief convulsions that usually lasts for several minutes o Transcranial Magnetic Stimulation Another method for altering electrical activity in the brain Psychological treatments o Cognitive-Behavioral Therapy (CBT) SOMATIC SYMPTOM AND RELATED DISORDERS Treatment of Somatic Symptom and Related Disorders Somatic Symptom Disorder and Illness Anxiety Disorder - Reassurance and education - Reducing the frequency of help-seeking behaviors (e.g., assigning a gatekeeper physician to each patient to screen all physical complaints) - Cognitive-Behavioral Therapy (CBT) - Antidepressant (SSRI) o Paroxetine (aka Paxil) Conversion Disorder (Functional Neurological Symptom Disorder) - Identify and attend to the traumatic or stressful life event, if it is still present (either in real life or memory) - Reduce any reinforcing or supportive consequences of the conversion symptoms (secondary gain) DISSOCIATIVE DISORDERS Treatment of Dissociative Disorders Depersonalization-Derealization Disorder - Psychological treatments similar to those for panic disorder may be helpful - Stresses associated with onset of disorder should be addressed Dissociative Fugue - Recalling what happened during the amnesic or fugue state, often with the help of friends and family who know what happened, so the patient can confront the information and integrate it into their conscious experience - Hypnosis - Benzodiazepines (minor tranquilizers) Dissociative Identity Disorder - Patient must identify cues or triggers that provoke memories of trauma, dissociation, or both, and to neutralize them - Patient must confront and relive the early trauma and gain control over the horrible events - Therapist must help the patient visualize and relive aspects of the trauma until it is simply a terrible memory - Hypnosis – to access unconscious memories and bring various alters into awareness MOOD DISORDERS AND SUICIDE Treatment of Mood Disorders Depression - Learn to replace negative depressive thoughts and attributions with more positive ones Develop more effective coping behaviors and skills o Interpersonal Psychotherapy (IPT) Focus on the social and interpersonal triggers for their depression (such as the loss of a loved one) Develop skills to resolve interpersonal conflicts and build new relationships Bipolar Disorder - Lithium - Psychological treatments o Increasing compliance with drug treatments, as the “pleasures” of a manic state make refusal to take lithium a major therapeutic obstacle o Interpersonal and Social Rhythm Therapy (IPSRT) Regulates circadian rhythm by helping patients regulate their eating and sleep cycles Seasonal Affective Disorder - Light therapy Prevention of Suicide - Implicit (unconscious) cognition o To assess implicit suicidal ideation; Stroop test - Agreeing to or signing a no-suicide contract - Limiting access to lethal weapons for anyone at risk for suicide - Cognitive-behavioral interventions EATING DISORDERS Treatment of Eating Disorders Bulimia nervosa - Drugs o Fluoxetine (Prozac) Effective particularly during the bingeing and purging cycle - Psychological treatments o Short-term cognitive-behavioral treatments o Cognitive-Behavioral Therapy-Enhanced (CBT-E) Focus is on the distorted evaluation of body shape and weight, and maladaptive attempts to control weight o Interpersonal Psychotherapy (IPT) Binge-Eating Disorder - Cognitive-Behavioral Therapy (CBT) - Interpersonal Psychotherapy (IPT) Anorexia Nervosa - Most important initial goal: restore the patient’s weight to a point that is at least within the low normal range - Cognitive-Behavioral Therapy (CBT) - Cognitive-Behavioral Therapy-Enhanced (CBTE) - Family-based Treatment (FBT) Obesity - Not formally considered an eating disorder in the DSM - Self-directed weight-loss program (e.g., by buying a popular diet book) - Diet programs o Atkins (carbohydrate restriction) diet o Ornish (fat restriction) diet o Zone (micronutrients balance) diet o Weight Watchers (calorie restriction) diet - Commercial self-help programs o Weight Watchers o Jenny Craig - Bariatric surgery o A surgical approach to extreme obesity SLEEP-WAKE DISORDERS Treatment of Sleep Disorders Insomnia - Medical treatments o Benzodiazepine o Triazolam (Halcion) o Zaleplon (Sonata) o Zolpidem (Ambien) o Flurazepam (Dalmane) Circadian Rhythm Sleep Disorder - Environmental treatments o Phase delays (moving bedtime later) Going to bed several hours later each night until bedtime is at the desired hour o Phototherapy Using bright light to trick the brain into readjusting the biological clock - Psychological treatments o Stimulus control Using the bed only for sleeping and for sex, not for work or other anxietyprovoking activities o Progressive relaxation or sleep hygiene Changing daily habits that may interfere with sleep o Sleep restriction o Confronting unrealistic expectations about how much sleep is enough for a person o Cognitive-Behavioral Therapy (CBT) Treatment of Parasomnias Nightmares (or Nightmare Disorder) - Cognitive-Behavioral Therapy (CBT) - Pharmacological treatment o Prazosin Sleep Terrors - Scheduled awakenings PHYSICAL DISORDERS Treatment of Physical Disorders - Psychosocial treatment o Biofeedback Making patients aware of specific physiological functions that, ordinarily, thy would not notice consciously o Relaxation and Meditation Progressive muscle relaxation Transcendental meditation – attention is focused solely on a repeated syllable, or mantra Relaxation response o A Comprehensive Stress-and-PainReduction Program Time-management training Assertiveness training o Drugs and Stress-Reduction Programs o Denial as a Means of Coping Shelley Taylor points out that most individuals who are functioning well deny the implications of a potentially serious condition, at least initially o Modifying Behaviors to Promote Health Injury Prevention AIDS Prevention SEXUAL DYSFUNCTION Treatment of Sexual Dysfunction - Providing basic education about sexual functioning, altering deep-seated myths, and increasing communication - Psychosocial treatment o Sensate focus o Nondemand pleasuring - Medical treatments o Sildenafil (Viagra) o Levitra o Cialis o Injection of vasodilating drugs such as papaverine or prostaglandin directly into the penis o Surgery o Vacuum Device Therapy Works by creating a vacuum in a cylinder placed over the penis Premature Ejaculation - Squeeze technique PARAPHILIC DISORDERS Treatment of Paraphilic Disorders - Psychological treatment o Covert sensitization Carried out entirely in the imagination of the patient Patients associate sexually arousing images in their imagination with some reasons why the behavior is harmful or dangerous o Orgasmic reconditioning Patients are instructed to masturbate to their usual fantasies but to substitute more desirable ones just before ejaculation o Relapse prevention - Drugs o Cyproterone acetate An antiandrogen “chemical castration” drug Eliminates sexual desire and fantasy by reducing testosterone levels dramatically o Medroxyprogesterone (Depo-Provera is the injectable form) A hormonal agent that reduces testosterone GENDER DYSPHORIA Treatment of Gender Dysphoria - Psychological evaluation and education - Administration of gonadal hormones to bring about desired secondary sex characteristics o Partially reversible - Sex Reassignment Surgery o Non-reversible o o o o Alter anatomy physically to be consistent with gender identity Must live in the desired gender for 1-2 years Must be stable psychologically, financially, and socially Gynecomastia The growth of breasts (for transwomen) - Biological treatments o Clonidine Given to people withdrawing from opiates o Sedative drugs (benzodiazepines) Help minimize discomfort for people withdrawing from other drugs, such as alcohol - Agonist substitution o Providing the person with a safe drug that has a chemical makeup similar to the addictive drug (therefore the name agonist) Methadone – an opiate agonist often given as a heroine substitute; originally called “adolphine” Buprenorphine – blocks the effects of opiate and encourage better compliance Nicotine – a cigarette substitute; provided to smokers in the form of gum, patch, inhaler, or nasal spray, which lack the carcinogens included in cigarette smoke Bupropion (Zyban) – medical treatment for smoking; also serves as an antidepressant under the trade name Wellbutrin Antagonist treatments o Antagonist drugs block or counteract the effects of psychoactive drugs Naltrexone – has limited success with individuals who are not simultaneously participating in a structured treatment program Acomprosate – decrease cravings in people dependent on alcohol Treatment of Gender Nonconformity in Children - Work with the child and caregivers to lessen gender dysphoria and decrease cross-gender behaviors on the assumption that these behaviors are unlikely to persist anyway and the negative consequences of social rejection could be avoided, and that avoiding later intrusive surgery would be desirable - “watchful waiting” o Letting expressed gender unfold naturally - Actively affirming and encouraging cross-gender identification, but critics point out that gender nonconformity usually does not persist Treatment of Disorders of Sex Development (Intersexuality) - Surgery - Hormonal Replacement Therapy (HRT) - Psychological treatments to help individuals adapt to their particular sexual anatomy or their emerging gender experience SUBSTANCE-RELATED DISORDERS Treatment of Substance-Related Disorders - First step: help someone through the withdrawal process - Ultimate goal: abstinence - - - Aversive treatments o Disulfiram (Antabuse) For people who are alcohol-dependent Prevents the breakdown of acetaldehyde, a by-product of alcohol, and the resulting build-up of acetaldehyde causes feelings of illness Causes nausea, vomiting, elevated heart rate, and respiration o Use of silver nitrate in lozenges or gum Combines with saliva to produce a bad taste in the mouth Psychosocial treatments o Inpatient facilities Designed to help people get through the initial withdrawal period and to provide supportive therapy so they can go back to their communities Can be extremely expensive o Alcoholics Anonymous (AA) and its variations Twelve Steps program – developed by AA; the basis of its philosophy Foundation of AA is the notion that alcoholism is a disease and alcoholics must acknowledge their addiction to alcohol and its destructive power over them - o Women for Sobriety o SMART Recovery Component treatment o Contingency Management Clinician and client together select the behaviors that the client needs to change and decide on the reinforcers that will reward reaching certain goals o Community Reinforcement Approach Several facets of the drug problem are addressed to help identify and correct aspects of the person’s life that might contribute to substance use or interfere with efforts to abstain o Motivational Enhancement Therapy (MET) Intends to improve the individual’s beliefs that any changes made (e.g., drinking less) will have positive outcomes (e.g., more family time) o Cognitive-Behavioral Therapy (CBT) Addresses multiple aspects of the disorder, including a person’s reactions to cues that lead to substance use (e.g., being among certain friends) Addresses the problem of relapse GAMBLING DISORDER Treatment of Gambling Disorder - Treatment is often similar to substance dependence treatment - Gambler’s Anonymous o Incorporates the Twelve Step program - Cognitive-behavioral interventions o Setting financial limits o Planning alternative activities o Preventing relapse o Imaginal desensitization IMPULSE-CONTROL DISORDERS o o o Cocaine Anonymous and Narcotics Anonymous Rational Recovery Moderation Management Treatment of Impulse-Control Disorders Intermittent Explosive Disorder - Cognitive-behavioral interventions o Helping the person identify and avoid “triggers” for aggressive outbursts Kleptomania - Behavioral interventions - Antidepressant medication o Naltrexone – an opioid antagonist also used in the treatment of alcoholism Pyromania - Cognitive-behavioral interventions o Helping the person identify the signals that initiate the urges o Teaching coping strategies to resist the temptation to start fires PERSONALITY DISORDERS Treatment of Cluster A Personality Disorders Paranoid Personality Disorder - Unlikely to seek professional help - Therapists provide an atmosphere conducive to developing a sense of trust - Cognitive therapy o To counter the person’s mistaken assumptions about others, focusing on changing the person’s beliefs that all people are malevolent and most people cannot be trusted Schizoid Personality Disorder - Rare for a person with the disorder to seek treatment - Therapists point out the value in social relationships - May need to be taught the emotions felt by others to learn empathy - Receive social skills training - Role-playing o Therapist takes the part of a friend or significant other and help the patient practice establishing and maintaining social relationships Schizotypal Personality Disorder - Treatment includes some of the medical and psychological treatments for depression - Teaching social skills to reduce isolation and suspicion - Treating younger persons who have symptoms of the disorder with antipsychotic medication and CBT in order to avoid the onset of schizophrenia is proving to be a promising prevention strategy - Medical treatment o Haloperidol To reduce ideas of reference, odd communication, and isolation Treatment of Cluster B Personality Disorders Antisocial Personality Disorder - Rarely identify themselves as needing treatment - Most clinicians are pessimistic about the outcome of treatment for adults as they can be manipulative even with their therapists - In general, therapists agree with incarcerating (imprisoning) these people to defer future antisocial acts - Clinicians encourage identification of high-risk children so that treatment can be attempted before they become adults - Parent training for children - Prevention through preschool programs Borderline Personality Disorder - Patients appear quite distressed and are more likely to seek treatment - Symptomatic treatment - Drugs o Mood stabilizers Anticonvulsive and antipsychotic drugs – effective for disturbances in affect (e.g., anger, sadness) - Cognitive-Behavioral Therapy (CBT) o Dialectical Behavior Therapy (DBT) Involves helping people cope with the stressors that seem to trigger suicidal behaviors Histrionic Personality Disorder - A large part of therapy focuses on the problematic interpersonal relationships - People with the disorder need to be shown how the short-term gains derived from their various interactional styles (e.g., emotional crises, using charm, sex, seductiveness, or complaining) result in long-term costs, and be taught more appropriate ways of negotiating their wants and needs Narcissistic Personality Disorder - Therapy focuses on the person’s grandiosity, their hypersensitivity to evaluation, and their lack of empathy towards others - Cognitive therapy o Strives to replace the person’s fantasies with a focus on the day-to-day pleasurable experiences that truly attainable - Coping strategies such as relaxation training to help them face and accept criticism - Helping them focus on the feelings of others Treatment of Cluster C Personality Disorders Avoidant Personality Disorder - Behavioral intervention techniques for anxiety and social skills problems o Systematic desensitization o Behavioral rehearsal - Many of the same treatments used for social phobia - Therapeutic alliance o The collaborative connection between therapist and client o An important predictor for treatment success Dependent Personality Disorder - People with the disorder can appear to be ideal patients because of their attentiveness and eagerness to give responsibility for their problems to the therapist - This submissiveness, however, negates one of the major goals of therapy: make the person more independent and personally responsible - Therapy progresses gradually as the patient develops confidence in their ability to make decisions independently Obsessive-Compulsive Personality Disorder - Therapy often attacks the fears that seem to underlie the need for orderliness - Therapists help the individual relax or use distraction techniques to redirect the compulsive thoughts SCHIZOPHRENIA Treatment of Schizophrenia - In Kenya, Kisii tribal doctors listen to their patients to find the location of the noises in their heads (hallucinations), then get them drunk, cut out a piece of scalp, and scrape the skull in the area of the voices - Biological interventions o Insulin coma therapy Was thought for a time to be helpful, but closer examination showed it carried great risk of serious illness and death o Psychosurgery o Electroconvulsive Therapy (ECT) o Transcranial Magnetic Stimulation Treatment for hallucinations Uses wire coils to repeatedly generate magnetic fields-up to 50 times per second-that pass though the skull to the brain - Antipsychotic medications o Neuroleptics Meaning “taking hold of the nerves” Provided the first real hope Help people think more clearly and reduce hallucinations and delusions Dopamine antagonists Hadol and Thorazine – earliest neuroleptics drugs; called conventional or first-generation antipsychotics Risperidone and Olanzapine – newer medications; called atypical or secondgeneration antipsychotics - Psychosocial interventions o Clinicians attempt to reattach social skills such as basic conversation, assertiveness, and relationship building o Therapists divide complex social skills into their component parts, which clients model o Clients do role-playing and ultimately practice their new skills in the “real world” o Programs teach a range of ways people can adapt to their disorder yet live in the community o Virtual assessments and treatments Provide clinicians with controllable and safer environments in which to study and treat persons with schizophrenia o Behavioral family therapy Resembles classroom education Family members are informed about schizophrenia and its treatment, relieved of the myth that they caused the disorder - - Family members are taught practical facts about antipsychotic medications and their side effects Family members are helped with communication skills so that they can become more empathic listeners Help them learn constructive ways of expressing negative feelings to replace the harsh criticism that characterizes some family interactions Help them learn problem-solving skills to help them resolve conflicts that arise o Vocational rehabilitation Supportive employment – involves providing coaches who give on-the-job training o Assertive Community Treatment (ACT) Program Involves using a multidisciplinary team of professionals to provide broad-ranging treatment Across cultures o Xhosa people of South Africa Report using traditional healers who sometimes recommend the use of oral treatments to induce vomiting, enemas, and the slaughter of cattle to appease the spirits o Hispanics Family support o British Use more biological, psychological, and community treatments o Native Chinese Hold more religious beliefs about both the causes and treatments of schizophrenia Prevention o Identify and treat children who may be at risk of getting the disorder later in life o Treatment of persons in the prodromal stages NEURODEVELOPMENTAL DISORDERS Treatment of Neurodevelopmental Disorders Attention-Deficit/Hyperactivity Disorder - Psychosocial interventions o Improving academic performance o Decreasing disruptive behavior o Social skills training Teaching the child how to interact appropriately with peers o Reinforcement programs Rewarding the child for improvements Punishing misbehavior with loss of rewards o Parent education programs Teaching families how to respond constructively to their child’s behaviors and how to structure the child’s day to help prevent difficulties o Cognitive-Behavioral Therapy (CBT) For adults with ADHD To reduce distractibility and improve organizational skills - Biological interventions o Stimulants Methylphenidate (Ritalin, Adderall) and other non-stimulant medications such as atomoxetine (Strattera), guanfacine (Tenex), and clonidine – have proved helpful in reducing the core symptoms of hyperactivity and impulsivity, and in improving concentration on tasks Specific Learning Disorder - Educational intervention o Specific skills instruction Vocabulary Finding the main idea Finding facts in readings o Strategy instruction Includes efforts to improve cognitive skills through decision making and critical thinking o Direct Instruction A program Components: systematic instruction (using highly scripted lesson plans that place students together in small groups based on their progress) and teaching for mastery (teaching students until they understand all concepts) - Biological (drug) treatment o Methylphenidate (Ritalin, Adderall) o Restricted to individuals who may also have comorbid ADHD Autism Spectrum Disorder - No completely effective treatment exists - Psychosocial treatments o Behavioral approaches that focus on skill building and behavioral treatment of problem behaviors o Communication and socialization o Naturalistic teaching strategies Includes arranging the environment so that the child initiates an interest (e.g., placing a favorite toy just out of reach) o Incidental teaching o Pivotal response training o Milieu teaching - Biological treatments o Major tranquilizers and SSRIs Most helpful in decreasing agitation Unlikely that one drug will work for everyone Intellectual Disability (Intellectual Development Disorder) - Treatment of individuals with ID parallels that of people with more severe form of Autism Spectrum Disorder o Teaching individuals the skills they need to become more productive and independent - For individuals with mild ID, intervention is similar to that for people with learning disorders o Specific learning deficits are identified and addressed to help the student improve such skills are reading and writing - Communication training o Can be challenging for individuals with the most severe disabilities because they may have multiple physical or cognitive deficits that make spoken communication difficult or impossible Augmentative communication strategies – alternative system; may use picture books, teaching the person to make a request by pointing to a picture (e.g., pointing to a picture of a cup to request a drink) - Teaching people how to communicate their need or desire for such thing as attention as an alternative to punishment that may be equally effective in reducing behavior problems as aggression and self-injury - Biological treatment o Currently not a viable option Treatment of Common Communication and Motor Disorders Childhood-Onset Fluency Disorder - Psychosocial intervention o Parents are counseled about how to talk to their children - Behavioral intervention o Regulated-breathing method Person is instructed to stop speaking when a stuttering episode occurs and then to take a deep breath (exhale, then inhale) before proceeding o Altered auditory feedback Electronically changing speech feedback to people who stutter Can improve speech, as can using forms of self-monitoring, in which people modify their own speech for the words they stutter Language Disorder - May be self-correcting and may not require special intervention Social (Pragmatic) Communication Disorder - Individualized social skills training (e.g., modeling, role playing) with an emphasis on teaching important rules necessary for carrying on conversations with others (e.g., what is too much and too little information) Tourette’s Disorder - Psychological intervention o Self-monitoring o Relaxation training o Habit reversal NEUROCOGNITIVE DISORDERS Treatment of Neurocognitive Disorders Delirium - Haloperidol or other antipsychotic medication o Treatment for delirium brought on by withdrawal from alcohol o Can have a calming effect - Psychosocial intervention o Recommended first line of treatment o Goal is to reassure the individual to help them deal with the agitation, anxiety, and hallucinations of delirium o Patient who is included in all treatment decisions retains a sense of control Neurocognitive Disorder due to Alzheimer’s Disease - No cure so far, but hope lies in genetic research and amyloid protein - Management may include lists, maps, and notes to help maintain orientation - New medications that prevent acetylcholine breakdown and vitamin therapy delay but do not stop progression of decline