WCO-IOF-ESCEO
MILAN 2015
WORLD CONGRESS ON OSTEOPOROSIS,
OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES
MARCH 26-29, 2015 | MILAN ITALY
MiCo - Fiera Milano Congressi
www.wco-iof-esceo.org
Organized by Sinklar Conference Management B.V.
S354
36), and Hip disability and Osteoarthritis Outcome Score
(HOOS) and VAS score were used.
Results: Among patients who received preoperative
telerehabilitation a significant improvement was found for:
HOOS pain (p=0.0008), HOOS daily living (p=0.0043),
HOOS quality of life (p = 0.0028), WOMAC pain (p =
0.0006), WOMAC stiffness (p = 0.0166) and VAS (p =
0.0043). In physical examination significant differences were
found in hip adduction passive range of motion (p=0.028). No
treatment in the control group led to no significant differences
between two examinations (p>0.05).
Discussion: Patients receive no physiotherapy routinely immediately before THR. This study confirms that late preoperative telerehabilitation may improve musculoskeletal system status indicators and quality of life in hip osteoarthritis
patients awaiting surgery. It is anticipated that more fit patient
prior surgery may be better prepared for the fast track postoperative rehabilitation after THR.
Acknowledgement: This study was supported by the Project
NR13-0109-10/2010 is funded by National Center for Research and Development and partially supported by the Project CLEAR ((ICT-PSP-224985) Clinical Leading Environment for the Assessment and validation of Rehabilitation Protocols for home care).
P712
EFFECT OF ANGIOTENSIN II RECEPTOR
BLOCKER TELMISARTAN ON BONE FRACTURE
HEALING IN RATS: RELATIONSHIP BETWEEN
VEGF AND TELMISARTAN
A. Akoz1, Z. Halici2, E. Akpinar2, A. Topcu2, M. Yayla2, A.
Ali Aydin3, E. Karakus4, H. Tarik Atmaca5, Z. Bayraktutan6
1
Department of Emergency Medicine, Ataturk University
Faculty of Medicine, Erzurum, Turkey, 2Department of Pharmacology, Ataturk University Faculty of Medicine, Erzurum,
Turkey, 3Department of Orthopedics and Traumatology,
Ataturk University Faculty of Medicine, Erzurum, Turkey,
4
Department of Pharmacology and Toxicology, Ataturk University School of Veterinary Medicine, Erzurum, Turkey,
5
Department of Pathology, Kirikkale University School of
Veterinary Medicine, Kirikkale, Turkey, 6Department of Biochemistry, Regional Education and Research Hospital, Erzurum, Turkey
Objective: Bone tissue is the main element of the roof required for the proper functioning of organs and systems in
the human body. Although it has been determined that
telmisartan decreases fracture risk and increases bone density
telmisartan (1, 2), it is not completely clear how such medications work. The purpose of this study is to research the effects
of chronic telmisartan application in rats with experimental
fractures on bone healing and evaluate possible mechanisms
Osteoporos Int (2015) 26 (Suppl 1):S71–S380
Methods: The rats were randomly divided into three groups
(n=6 per group): femoral fracture control (Group 1), femoral
fracture+10 mg/kg Telmisartan (Group 2), and femoral fracture+20 mg/kg Telmisartan (Group 3). General anesthesia for
all operative procedures was achieved. Postoperative pain was
controlled using a peritoneal injection of 150 mg/kg
metamizole sodium initially.
Results: The fracture healing scores of both doses of
telmisartan groups were significantly better when compared
to the fracture control group. Also X-Ray, computed tomography and biomechanical testing results at 4 week after fracture induction demonstrated that telmisartan has fastened bone
healing. In immunohistochemical staining hypertrophic
chondrocytes were immunopositive for vascular endothelial
growth factor (VEGF). Remarkably, the semiquantitative
analysis shown higher VEGF positive cells in treatment group
compared with control animals. Mild to severe
immunopositivity for VEGF observed in treatment groups.
Control group animals immunohistochemistry for osteocalcin
showed mild positivity.
Conclusion: We demonstrated positive effects of telmisartan
on bone healing with radiomorphometric and
histomorphometric data. Relationship of telmisartan with
VEGF and osteocalcin during bone healing has also shown
by immunohistochemical methods. Bone fracture healing can
be boosted by telmisartan.
References: 1. Kang KY et al., J Korean Med Sci
2013;28:1139. 2. Solomon DH et al., J Bone Miner Res
2011;26:1561.
Acknowledgement: This work was supported by the Ataturk
University Medical Research Council (grant number
2013/031).
P713
OSTEOPOROSIS IN SYSTEMIC SCLEROSIS
I. Kostoglou-Athanassiou1, A. Tzanavari2, T. Banti2, C.
Katsavouni2, P. Athanassiou2
1
Department of Endocrinology, Red Cross Hospital, Athens,
Greece, 2Department of Rheumatology, St. Paul’s Hospital,
Thessaloniki, Greece
Systemic sclerosis is a systemic connective tissue disease
characterized by involvement of the skin, the lungs and other
organs. The relationship of systemic sclerosis with osteoporosis is not known, recent publications, however, are found related to the matter (Omair et al., Clin Exp Rheumatol 2013).
Aim: To assess the relationship of systemic sclerosis with
osteoporosis in a group of patients being cared for in a single
rheumatic diseases center - single center experience.
Methods: A group of 39 patients with systemic sclerosis,
36 women and 3 men, aged 21–78 (mean±SEM) 55.64±
2.31 years. Disease duration was 3–34 (mean ± SEM)