WCO-IOF-ESCEO MILAN 2015 WORLD CONGRESS ON OSTEOPOROSIS, OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES MARCH 26-29, 2015 | MILAN ITALY MiCo - Fiera Milano Congressi www.wco-iof-esceo.org Organized by Sinklar Conference Management B.V. S354 36), and Hip disability and Osteoarthritis Outcome Score (HOOS) and VAS score were used. Results: Among patients who received preoperative telerehabilitation a significant improvement was found for: HOOS pain (p=0.0008), HOOS daily living (p=0.0043), HOOS quality of life (p = 0.0028), WOMAC pain (p = 0.0006), WOMAC stiffness (p = 0.0166) and VAS (p = 0.0043). In physical examination significant differences were found in hip adduction passive range of motion (p=0.028). No treatment in the control group led to no significant differences between two examinations (p>0.05). Discussion: Patients receive no physiotherapy routinely immediately before THR. This study confirms that late preoperative telerehabilitation may improve musculoskeletal system status indicators and quality of life in hip osteoarthritis patients awaiting surgery. It is anticipated that more fit patient prior surgery may be better prepared for the fast track postoperative rehabilitation after THR. Acknowledgement: This study was supported by the Project NR13-0109-10/2010 is funded by National Center for Research and Development and partially supported by the Project CLEAR ((ICT-PSP-224985) Clinical Leading Environment for the Assessment and validation of Rehabilitation Protocols for home care). P712 EFFECT OF ANGIOTENSIN II RECEPTOR BLOCKER TELMISARTAN ON BONE FRACTURE HEALING IN RATS: RELATIONSHIP BETWEEN VEGF AND TELMISARTAN A. Akoz1, Z. Halici2, E. Akpinar2, A. Topcu2, M. Yayla2, A. Ali Aydin3, E. Karakus4, H. Tarik Atmaca5, Z. Bayraktutan6 1 Department of Emergency Medicine, Ataturk University Faculty of Medicine, Erzurum, Turkey, 2Department of Pharmacology, Ataturk University Faculty of Medicine, Erzurum, Turkey, 3Department of Orthopedics and Traumatology, Ataturk University Faculty of Medicine, Erzurum, Turkey, 4 Department of Pharmacology and Toxicology, Ataturk University School of Veterinary Medicine, Erzurum, Turkey, 5 Department of Pathology, Kirikkale University School of Veterinary Medicine, Kirikkale, Turkey, 6Department of Biochemistry, Regional Education and Research Hospital, Erzurum, Turkey Objective: Bone tissue is the main element of the roof required for the proper functioning of organs and systems in the human body. Although it has been determined that telmisartan decreases fracture risk and increases bone density telmisartan (1, 2), it is not completely clear how such medications work. The purpose of this study is to research the effects of chronic telmisartan application in rats with experimental fractures on bone healing and evaluate possible mechanisms Osteoporos Int (2015) 26 (Suppl 1):S71–S380 Methods: The rats were randomly divided into three groups (n=6 per group): femoral fracture control (Group 1), femoral fracture+10 mg/kg Telmisartan (Group 2), and femoral fracture+20 mg/kg Telmisartan (Group 3). General anesthesia for all operative procedures was achieved. Postoperative pain was controlled using a peritoneal injection of 150 mg/kg metamizole sodium initially. Results: The fracture healing scores of both doses of telmisartan groups were significantly better when compared to the fracture control group. Also X-Ray, computed tomography and biomechanical testing results at 4 week after fracture induction demonstrated that telmisartan has fastened bone healing. In immunohistochemical staining hypertrophic chondrocytes were immunopositive for vascular endothelial growth factor (VEGF). Remarkably, the semiquantitative analysis shown higher VEGF positive cells in treatment group compared with control animals. Mild to severe immunopositivity for VEGF observed in treatment groups. Control group animals immunohistochemistry for osteocalcin showed mild positivity. Conclusion: We demonstrated positive effects of telmisartan on bone healing with radiomorphometric and histomorphometric data. Relationship of telmisartan with VEGF and osteocalcin during bone healing has also shown by immunohistochemical methods. Bone fracture healing can be boosted by telmisartan. References: 1. Kang KY et al., J Korean Med Sci 2013;28:1139. 2. Solomon DH et al., J Bone Miner Res 2011;26:1561. Acknowledgement: This work was supported by the Ataturk University Medical Research Council (grant number 2013/031). P713 OSTEOPOROSIS IN SYSTEMIC SCLEROSIS I. Kostoglou-Athanassiou1, A. Tzanavari2, T. Banti2, C. Katsavouni2, P. Athanassiou2 1 Department of Endocrinology, Red Cross Hospital, Athens, Greece, 2Department of Rheumatology, St. Paul’s Hospital, Thessaloniki, Greece Systemic sclerosis is a systemic connective tissue disease characterized by involvement of the skin, the lungs and other organs. The relationship of systemic sclerosis with osteoporosis is not known, recent publications, however, are found related to the matter (Omair et al., Clin Exp Rheumatol 2013). Aim: To assess the relationship of systemic sclerosis with osteoporosis in a group of patients being cared for in a single rheumatic diseases center - single center experience. Methods: A group of 39 patients with systemic sclerosis, 36 women and 3 men, aged 21–78 (mean±SEM) 55.64± 2.31 years. Disease duration was 3–34 (mean ± SEM)