Endogenous infection Made by-Shubham Kadiwala,MDE2002 Endogenous antigens/infection • Endogenous antigens are the compounds that have been generated within the body. • A small fragment of bacteria causes disease in humans and many species colonize in the human body to create an ecosystem known as bacterial flora. • Bacterial flora is endogenous bacteria which naturally reside in a closed system. • Disease can occur when microbes included in normal bacteria flora enter a sterile area of the body such as the brain ,bladder,peritoneal cavity or muscle. • A prime example of this is when the residential bacterium E.coli of GI tract enters the urinary tract.this causes a urinary tract infection. Endogenous sourcemajor source of infection • The source of infection may be endogenous , resulting from the ubiquitous nature of Enterobacter species Endogenous infection examples • Metabolic disorders • Congenital abnormalites • Tumors • Infections caused by microorganisms within the body • Diabetes Mellitus • Hepatic Encephalopathy • Hypernatremia • Hypocalcemia Symptoms of endogenous infection • Endogenous infection is caused by one of the following: • A virus that is transmitted from human to human • A bacterium (bacteria that live in the human body) • A fungus • A parasite Endogenous infections can cause a wide range of symptoms. The symptoms can vary from mild to severe. Symptoms can also vary by the type of infection, the location of the infection, and the age of the person. The symptoms of endogenous infection can include: • Fever • Headache • Muscle aches • Diarrhea • Nausea • Vomiting • Sore throat • Rash • Fatigue • Runny nose Causes of endogenous infection • Endogenous infection is caused by one of four types of pathogens: • Viruses • Bacteria • Fungi • Parasites Viruses • Viruses are often spread through human-to-human contact. They may cause a wide range of symptoms and vary in severity. Viruses that cause infections that are spread from person to person include: • Human immunodeficiency virus (HIV) • Human herpesvirus 6 (HHV-6) • Human parvovirus B19 • Human parvovirus B5 Bacteria • Bacteria are usually spread through human-to-human contact. Bacteria that cause infections that are spread from person to person include: • Streptococcus pneumonia • Mycoplasma pneumonia • Salmonella • Listeria monocytogenes • Chlamydia • Yersinia • Fungi Fungi • Fungi are usually spread through human-to-human contact. They cause a wide range of illnesses and vary in severity. Fungi that cause infections that are spread from person to person include: • Aspergillus fumigatus • Candida • Cryptococcus • Histoplasma • Blastomyces Parasites • Parasites are usually transferred from person to person by direct or indirect contact. They are often spread by insect bites. Parasites that cause infections that are spread from person to person include: • Toxoplasma gondii • Leishmania • Trypanosoma cruzi • Giardia lamblia • Toxocara Thank you