FACULTY OF NURSING UNIVERSITY OF COLOMBO ADULT HEALTH NURSING - II CASE STUDY Deep vein thrombosis - DVT By Name : M.M.Fasleem Registration No: 2018N00120 Index No: N00105 Contents 1. Introduction ................................................................................................................................................ 1 2. Pathophysiology ......................................................................................................................................... 1 3. History ........................................................................................................................................................ 4 4. Current Treatment....................................................................................................................................... 4 5. Nursing Process .......................................................................................................................................... 5 Assessment ........................................................................................................................................... 5 Nursing Diagnosis ................................................................................................................................ 6 Planning ................................................................................................................................................ 6 Implementation ..................................................................................................................................... 7 Evaluation ............................................................................................................................................. 8 6. Recommendation for improvement ............................................................................................................ 8 Recommendation .................................................................................................................................. 8 Discharge Plan ...................................................................................................................................... 8 Conclusion ............................................................................................................................................ 9 7. References .................................................................................................................................................. 9 i|Page 1. Introduction Name : Mr. C.S.Rajapaksha Age : 73 years Sex : Male Religion : Buddhist Address : 327/1, Kudamagalkanda, maggona. Ward : 15 BHT No : 1931251 Date of admission : 20/08/2022 Marital status : Married Education Level : Graduate level Occupation : Lawyer (retired) He is admitted to the ward with the complain of Right lower limb edema with severe pain. Patient having diagnosed with right lower limb cellulitis with blistering wound and Deep vein thrombosis on warfarin. Today is the 7th day of admission patient cellulitis swelling condition is reduced but still having pain. other than that, the INR level is not achieved to a therapeutic level. 2. Pathophysiology The formation of a blood clot in a deep vein, most commonly in the legs or pelvis. Superficial veins are thick-walled muscular structures that lie just under the skin. Deep veins are thin walled and have less muscle in the media. They run parallel to arteries and bear the same names as the arteries. It has valves that permit unidirectional flow back to the heart. Other kinds of veins are known as perforating veins. These vessels have valves that allow one-way blood flow from the superficial system to the deep system 1|Page Three factors cause DVT • Stasis of blood (venous stasis) o Venous stasis occurs when blood flow is reduced, as in heart failure or shock; when veins are dilated, as with some medication therapies; and when skeletal muscle contraction is reduced, as in immobility, paralysis of the extremities, or anesthesia Ex: Bed rest or immobilization Obesity History of varicosities Spinal cord injury Age (greater than 65 years) • Vessel wall injury o Damage to the intimal lining of blood vessels creates a site for clot formation. Direct trauma to the vessels, as with fractures or dislocation, diseases of the veins, and chemical irritation of the vein from IV medications or solutions, can damage veins. Ex: Trauma Surgery Pacing wires Central venous catheters Dialysis access catheters Local vein damage Repetitive motion injury • Altered blood coagulation o Increased blood coagulability occurs most commonly in patients for whom anticoagulant medications have been abruptly withdrawn. o Oral contraceptive use and several blood dyscrasias (abnormalities) also can lead to hypercoagulability o Normal pregnancy is accompanied by an increase in clotting factors that may not return to baseline until longer than 8 weeks postpartum, increasing the risk of thrombosis Clinical Manifestations • • • • • • • severe pain fever chills malaise swelling / unilateral limb edema cyanosis of affected arm or leg tenderness (Homans’ sign – pain in the calf after the foot is sharply dorsiflexed) 2|Page Diagnostic Investigations • • • • • Venous duplex/color duplex ultrasound: noninvasive test allows for visualization of the thrombus Impedance plethysmography: a noninvasive measurement of changes in calf volume corresponding to changes in blood volume brought about by temporary venous occlusion with a high-pneumatic cuff. Radioactive fibrinogen testing: radioactive fibrinogen (fibrinogen I125) is administered via IV line. Images are taken through nuclear scanning at 12 to 24 hours Venography: IV injection of a radiocontrast agent. The vascular tree is visualized, and obstruction is identified. Coagulation profiles: PTT, PT/INR, circulating fibrin, monomer complexes, fibrinopeptide A, serum fibrin, D-dimer, proteins C and S, antithrombin III levels, factor V Leiden, prothrombin gene mutation. Detect intravascular coagulation or coagulopathies. Complications • Pulmonary embolism o A pulmonary embolism occurs when a blood vessel in your lung becomes blocked by a blood clot (thrombus) that travels to your lungs from another part of your body, usually your leg o A pulmonary embolism can be fatal. o Signs and symptoms of a pulmonary embolism include: ▪ Unexplained sudden onset of shortness of breath ▪ Chest pain or discomfort that worsens when you take a deep breath or when you cough ▪ Feeling lightheaded or dizzy, or fainting ▪ Rapid pulse ▪ Coughing up blood • Postphlebitic syndrome o A common complication that can occur after deep vein thrombosis is a condition known as postphlebitic syndrome, also called postthrombotic syndrome. o This syndrome is used to describe a collection of signs and symptoms, including: ▪ Swelling of your legs (edema) ▪ Leg pain ▪ Skin discoloration ▪ Skin sores o This syndrome is caused by damage to your veins from the blood clot. This damage reduces blood flow in the affected areas. The symptoms of postphlebitic syndrome may not occur until a few years after the DVT 3|Page Treatment • Blood thinners o Medications used to treat deep vein thrombosis include the use of anticoagulants, also sometimes called blood thinners, whenever possible. These are drugs that decrease your blood's ability to clot. • Clotbusters o doctor may prescribe different medications. more serious type of deep vein thrombosis or pulmonary embolism, or if other medications aren't working, Ex: thrombolytics called plasminogen activators given through IV • Filters o those who can't take medicines to thin your blood, a filter may be inserted into a large vein - the vena cava - in abdomen. o A vena cava filter prevents clots that break loose from lodging in your lungs • Compression stockings o These helps prevent swelling associated with deep vein thrombosis. These stockings are worn on your legs from your feet to about the level of your knees. o This pressure helps reduce the chances that your blood will pool and clot 3. History patient doesn’t have any other disease condition but patient having admitted to the ward several times. • • • • On 2016 with the complain of severe pain and swelling in the right lower limb diagnosed as DVT as first time. On 2018 for the thrombectomy surgery to the nagoda hospital. On 2019 with the complain of septic shock with right lower limb cellulitis On 15th February 2022 complain of right lower limb cellulitis with wound over gator area Patient has done surgical treatment thrombectomy on 2018 and following regular hematology clinic follow up for using warfarin for treatment for DVT 4. Current Treatment 7th days of admission (27.08.2022) Route Oral Oral Oral Oral Drug Paracetamol Pantaprazole Vitamin C Warfarin Local application Local application Solution IV Betamethasone cream Aquarin Fibogel (laxative) Pipracillin & Tazobactum Dosage 1g 40 mg 100 mg 7 mg (D1) 7 mg (D2) 8 mg (D3) 0.1% 1 sachet 4.5 g Time 6 hourly bd bd 6 pm 6 pm 6 pm bd bd bd 6 hourly 4|Page 5. Nursing Process Assessment Subjective data Today is the 7th day of admission, patient complaining of having pain in the right lower limb pain. patient doesn’t have any other disease condition. He is a long term DVT patient on warfarin treatment and following regular hematology clinic. He is having only one son he is living in Australia with his wife and children. Now he is living with his wife and she is having diabetic mallites with that he also controlled with diabetic diet. He is educated worked as a lawyer now retired. patient know very well about his disease condition and diet pattern. Objective data Physical assessment During the general examination, swelling observed in the right limb. patient having blisters wound in both lower limb; left limb is not infected, and right is limb is infected with cellulitis. redness observed in the right lower limb no any discharges from the wound. extra cellular fluid discharge observed from the right lower limb blister wound. No any pressure ulcers observed. Patient having tenderness BP: 115/70 mmHg PR: 81 beats/min RR: 24 res/min Temperature: 36.5 ºC Laboratory investigations FBC – Full blood count Para meter WBC Neutrophils RBC HGB PLT Result 17.86 14.71 5.18 15.9 151 CRP – C-reactive protein Unit 103/μl 103/μl 106/μl g/dl 103/μl 244 mg/L Ref.range 4.00 – 11.00 2.00 – 7.00 3.5 – 5.5 11.0 – 16.0 150 - 450 normal - <6.0 Renal profile Para meter Urea Serum creatinine Sodium Potassium Chloride Result 34 81 137 4.6 103 Unit Mg/dl μmol/L mmol/L mmol/L mmol/L Ref.range 17 - 45 65 - 104 136 – 145 3.5 – 5.3 97 - 111 5|Page Liver profile Para meter AST ALT Alkaline phosphate Total bilirubin Total protein Albumin Globulin Albumin/Globulin ratio Result 118 41.22 57 2.9 6.3 3.2 3.1 1.03 Unit U/L U/L U/L Mg/dL g/dL g/dL g/dL Ref.range 0-37 10-40 30-120 0.20-1.10 6.0-8.0 3.7-5.0 2.0-4.0 Clotting profile Para meter Result Unit Ref.range Prothrombin time Control result INR APTT Thrombin time ISI 17.8 13.4 1.35 27.6 15.3 1.06 Secs Secs 12-15 Secs Secs 22-36 15-21 CBS – 136 mg/dL Nursing Diagnosis ❖ Acute pain related to decreased venous blood flow & inflammation of subcutaneous as evidenced by investigations & diagnosis ❖ Risk for bleeding related to anticoagulant therapy ❖ Impaired physical mobility related to pain as evidenced by patient complain ❖ Risk for venous thromboembolism related to history of long-term use of warfarin ❖ Risk for impaired skin integrity related to infectious process ❖ Risk for pressure ulcer related to long term best rest Planning ❖ Acute pain related to decreased venous blood flow & inflammation of subcutaneous as evidenced by investigations & diagnosis Goal: To relieving pain o Elevate leg to promote venous drainage and reduce swelling o instruct the by stand to apply warm compress o administer analgesics according to medical order ❖ Risk for bleeding related to anticoagulant therapy Goal: To preventing Bleeding o observe the patient for bleeding manifestation in the wound site, gums and for blood with urine, blood with stool, blood with sputum o Handle the patient carefully while doing any daily activity o apply pressure on IV and venipuncture sites for at least 5 minutes 6|Page ❖ Impaired physical mobility related to pain as evidenced by patient complain Goal: Assist to mobility and prevent other hazards of immobility o provide wheelchair for mobility o arrange the things that patient can easily reach o keep the patient proper position to prevent venous stasis o avoid hyperflexion at knees as in jackknife position (head & knees are up; pelvis & legs are down) o encourage the patient to walk according to medical order o asses the patient for signs of pulmonary embolism such as chest pain, dyspnea, anxiety ❖ Risk for venous thromboembolism related to history of long-term use of warfarin Goal: To preventing from venous thromboembolism o assess for signs of venous embolism o assess for signs of pulmonary embolism o instruct the patient to regular clinic follow up o proper use of medication ❖ Risk for impaired skin integrity related to infectious process Goal: To protect skin integrity o apply moisturizing cream to prevent from skin drying o use antimicrobial cream to prevent from further infection to the left leg through the blister wound ❖ Risk for pressure ulcer related to long term best rest Goal: To prevent from pressure ulcer o asses the pressure point for sings of redness and skin changes o change the patient position every 2 hours o keep pillows at the pressure points to prevent pressure ulcers o giving back care and massage Implementation ❖ To relieving pain o Elevated the leg and administered analgesic according to medical order o giving instruction about the warm therapy and how it’ll reduce the pain ❖ To preventing Bleeding o Handled the patient carefully during the routine procedure and observed the patient for bleeding ❖ Assist to mobility and prevent other hazards of immobility o assist the patient with the help of by stand and teach the patient about the complication related to the long-term bed rest ❖ To preventing from venous thromboembolism o Assessed the patient for sings and symptoms of thromboembolism o given antiplatelet medication according to medical order 7|Page ❖ To protect skin integrity o Applied aqueous cream and betamethasone cream after the dressing procedure ❖ To prevent from pressure ulcer o changed the patient position with the help of by stand and assessed the pressure points o gave evening care with the support of by stand Evaluation ❖ ❖ ❖ ❖ ❖ ❖ Leg pain reduced No any active bleeding occurs Patient said thanks and patient understood well No any thromboembolic signs occur No any impaired skin integrity occurs Patient kept under different positions every 2 hours 6. Recommendation for improvement Recommendation 1) Daily usage of thrombolytic drugs without skip any of one day 2) Participate hematologic clinics regularly 3) Elevation of effected extremity: at least 10 to 20 degrees above the level of the heart to enhance venous return and decrease swelling 4) Use of compression stockings to increase venous return 5) Early ambulation 6) Active and passive leg exercises to increase venous flow. 7) Encourage walking without longer period standing 8) Discourage crossing of legs and long periods of sitting (more than an hour at a time) such as car and flight traveling 9) Avoid Potassium (K) contain foods such as green leafy vegetables, soybean oil and canola oil 10) Drink plenty of water 11) Avoid extra salt in food 12) limit animal fats in food 13) smoking cessation 14) avoid alcohol Discharge Plan • • • • • • • • There after don’t skip any medication of daily dose. If you think you will forget, maintain a note for that separately Use reminders in your smart phone to remember to take medications Keep the follow up regularly Wear stockings regularly Maintain your hygiene of your legs to prevent from further development of cellulitis condition as well as septic shock Keep your legs safely prevent from blister injuries and wounds Involve in regular exercise 8|Page Conclusion formation of a blood clot in a deep vein, most commonly in the legs or pelvis. Three factors cause DVT they are stasis of blood (venous stasis), vessel wall injury and altered blood coagulation. Clinical Manifestations are severe pain, fever, chills, malaise, swelling / unilateral limb edema, cyanosis of affected arm or leg and tenderness. Investigations for the diagnosis of the disease are Venous duplex, Impedance plethysmography, Radioactive fibrinogen testing, Venography and Coagulation profiles. Major complications are Pulmonary embolism and Postphlebitic syndrome. The treatment methods are Blood thinner medications, Clotbusters, Filter fixation into vena cava and wear Compression stockings. 7. References NETTINA, S. M., 2015. LIPPINCOTT MANUAL OF NURSING PRACTICE. Tenth Edition ed. New York: Wolters Kluwer Health | Lippincott Williams & Wilkins. Suzanne C. Smeltzer, E. R. F., Janice L. Hinkle, P. R. C., Brenda G. Bare, R. M. & Kerry H. Cheever, P. R., 2010. Brunner & Suddarth’s textbook of medical-surgical nursing. Twelfth Edition ed. Philadelphia, New York: Wolters Kluwer Health / Lippincott Williams & Wilkins. 9|Page