Bio pwp notes: Slide 5: Prophase is the first stage of mitosis and consists of the following events. Slide 6: Metaphase begins after the nuclear membrane has broken down and is no longer visible. Spindle grows and forms attachments to the pairs of sister chromatids. at the centromere Slide 7: After the sister chromatid pairs have aligned at the equator, anaphase begins. The sister chromatids begin to separate, and the spindle fibers shorten. With the sister chromatids separated, we can return to calling them chromosomes. Slide 8: Telophase is the final stage of mitosis After finalizing slide restate: Telophase is the last stage of the M (mitosis) phase. After telophase and cytokinesis, the cells return to G1 of interphase .