MOA for Quiz
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H2 receptors (END IN -tidine): Cimetidine; fomatidine
o MOA- acid secretion antagonist
 It blocks the H2 receptors of the parietal cell
 Decreases hydrogen ion secretion which then increases pH of the stomach to
relieve symptoms
 ONLY REDUCED ACID SECRETION IT DOES NOT COMPLETELY BLOCK IT FROM
MOVING OUTSIDE THE PARIETAL CELL
 Proton pump inhibitors (END IN -prazole): omeprazole; pantoprazole; esomeprazole
o MOA- binds to proton pump and inhibits enzyme action, this bond prevents movement
of hydrogen ions from the parietal cell into the stomach
 This results in achlorhydria (ALLLL gastric acid secretion is temporarily
blocked!!!)
 Misc. acid controlling drugs
o Sucralfate MOA- Cytoprotectant (meaning that it is forming a protectant layer over the
ulcer in the stomach so it is not painful when acid touches it)
 It binds to the base of the ulcers and erosions. Forms that protectant layer
forming a liquid bandage. Promotes the ulcer to heal also
 Acts locally not systemically
o Misoprotol MOA- synthetic prostaglandin E analog
 It inhibits gastric acid secretion
 Protects gastric mucosa
 Enhances production of mucus or bicarbonate
 Promotes cell regeneration
 DO NOT GIVE TO A PREGNANT LADY CAUSES FEDAL DEMISE
 Anti acids MOA- Neutralize stomach acid
o Does not prevent the overproduction of acid only neutralizes
o Promotes gastric mucosal defense mechanisms (reduces acid levels already present)
o Stimulates secretion of:
 Mucus- protective barrier against HCI
 Bicarbonate- helps buffer acidic properties of HCI
 Prostaglandins- prevents histamine from binging to the P cell receptors
 Anti acid meds:
o Aluminum hydroxide (amphojel)
o Magnesium hydroxide (milk of magnesium)
o Combination medication of aluminum and magnesium:
 Aluminum hydroxide and magnesium hydroxide (Maalox, mylanta)
o Calcium carbonate (Tums)
o Sodium bicarbonate (bicarbonate salts: alka-seltzer)
 MOA- BUFFERS the acidic properties of HCI, neutralizes acid (quick onset but
short duration)
Antidiarrheals
 Antiflatulents:
o Simethicone (mylicon) MOA- works by altering elasticity of the mucus coated gas
bubbles causing them to break into smaller ones.
o Breaks gas bubbles to help with pain
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o Given mainly to children
Absorbents:
o Bismuth subsalicylate (pepto-bismo is a form of aspirin so many f the dame drug effects
!! Be careful in children because of rye syndrome and patients who are taking warfarin
aspirin and any anti coagulation) MOA- coat the walls of the GI tract and bind to the
causative bacteria or toxin, which is then eliminated through the stool
o Activated charcoal (coats the wall of the GI tract, absorbs bacteria, useful in drug
overdose) MOA- coat the walls of the GI tract and bind to the causative bacteria or
toxin, which is then eliminated through the stool
o Cholestyramine (antilipemics and used to bind to diarrhea causing toxins) MOA- coat
the walls of the GI tract and bind to the causative bacteria or toxin, which is then
eliminated through the stool
Antimotility: anticholinergics
o Belladonna alkaloids (Donnatal) MOA- slows peristalsis, contractions and smooth muscle
tone of the GI tract as a result slows fecal movement through GI tract