ACTIVITY 18A – HEART Anterior Interventricular Sulcus Comment: • Surface projection at left 5th intercostal space in mid-clavicular line Description: • Groove on anterior surface of heart • Extends from coronary sulcus to inferior margin of heart • Marks position of interventricular septum Comment: • Contains anterior interventricular artery and great cardiac vein Chordae Tendineae Location: • Heart ventricles Description: • Fibrous strands that attach free edges of atrioventricular valve cusps to papillary muscles Aortic Valve • Composed of collagen Function: Location: • At junction of left ventricle (aortic • Prevent "flipping" of valve cusps into atrium vestibule) and ascending aorta Description: • Valve with three semilunar cusps Function: • Prevents reflux of blood into left ventricle Comment: • Valve closed during ventricular diastole • Coronary arteries branch from ascending Coronary Sulcus (Atrioventricular Sulcus) aorta just distal to aortic valve Description: • Surface groove surrounding heart • Marks junction between atria and ventricles Comment: • Contains right and left coronary arteries, circumflex branch of left coronary artery, and coronary sinus Apex of Heart Description: • Blunt tip of left ventricle Left Atrioventricular valve (Bicuspid or Mitral) Description: • Valve with two cusps between left atrium Function: • Contraction forces blood out of ventricle Comment: • Myocardium is thinner in atria and ventricle • Chordae tendineae attach free edges of cusps to papillary muscles Function: • Prevents reflux of blood into left atrium Comment: • Valve is open during ventricular diastole Myocardium of the Right Ventricle Description: • Muscle layer • Thicker in left ventricle • Between endocardium and epicardium • Inner surface has trabeculae carneae and papillary muscles Function: • Contraction forces blood out of ventricle Muscular Interventricular Septum Comment: • Myocardium is thinner in atria Location: • Heart ventricles Description: • Thick, muscular, inferior part of partition separating right and left ventricles • Forms majority of interventricular septum Opening of Coronary Sinus Drainage: • Receives venous blood from heart Tributaries: • Great, middle, and small cardiac veins Course: • Passes from left to right in posterior Myocardium of Left Ventricle Description: • Muscle layer • Thicker in left ventricle • Between endocardium and epicardium • Inner surface has trabeculae carneae and papillary muscles portion of coronary (atrioventricular) sulcus Termination: • Right atrium Opening of Inferior Vena Cava Pectinate mm. Location: Location: • Right atrium Description: • Opening to receive venous blood from • Heart (atria) Description: • Ridges of myocardium extending from regions of body inferior to diaphragm crista terminalis in right atrium • Ridges also occur in right and left auricles Pulmonary Trunk Origin: • Right ventricle Papillary mm. Course: • Ascends within pericardium Location: • Heart ventricles Description: • Conical elevations of myocardium in ventricular chambers • Chordae tendineae attached to apex • A type of trabeculae carneae Function: • Regulates movement of atrioventricular valve cusps • Helps assure proper closure of atrioventricular valves Comment: • Right ventricle has three, left ventricle has two (number corresponds to number of respective atrioventricular valve cusps) • Initially anterior to ascending aorta and then to its left and slightly posterior Distribution: • Lungs Branches: • Right pulmonary artery • Left pulmonary artery Comment: • Conveys oxygen-poor blood from right ventricle of heart • Has pulmonary (semilunar) valve at its origin • Large arteries do not by themselves supply structures, but do so through their branches Pulmonary Valve • Right atrium • Right ventricle Location: • At origin of pulmonary trunk from right ventricle Description: • Valve with three semilunar cusps Function: • Prevents reflux of blood into right ventricle Comment: • Valve closed during ventricular diastole • Interventricular septum • Left ventricle Branches: • Right atrial • Right marginal • Posterior interventricular Comment: • Large arteries do not by themselves supply structures, but do so through their branches Right Atrioventricular Valve Superior Vena Cava Location: • Heart (between right atrium and right ventricle) Description: • Valve with three cusps • Chordae tendineae attach free edges of cusps to papillary muscles Also known as: • Tricuspid valve Comment: • Valve is open during ventricular diastole Drainage: • Head • Upper limbs • Posterior thoracic walls • Mediastinal structures Tributaries: • Formed by union of right and left brachiocephalic veins • Arch of azygos vein Course: • Descends in mediastinum from level of right 1st costal cartilage Termination: • Right atrium Right Coronary a. Origin: • Ascending aorta Course: • Passes between pulmonary trunk and right auricle • Lies in coronary (atrioventricular) sulcus Distribution: Anterior Interventricular Branch of Left Coronary a. • Large arteries do not by themselves supply structures, but do so through their branches Origin: • Left coronary Course: • Descends in anterior interventricular sulcus toward apex of heart Distribution: • Right ventricle Great Cardiac v. • Left ventricle • Interventricular septum Also known as: • Left anterior descending branch of left coronary artery or LAD Drainage: • Left atrium • Left ventricle • Right ventricle Course: Comment: • Commonly crosses apex of heart and ascends in posterior interventricular sulcus • Anastomosis with posterior interventricular artery • Anastomosis refers to the end-to-end union of vessels • Ascends in anterior interventricular sulcus • Enters coronary sulcus Termination: • Coronary sinus Also known as: • Anterior interventricular vein Comment: • Companion to anterior interventricular artery Ascending Aorta Inferior Vena Cava Origin: • Left ventricle (aortic vestibule) Drainage: Course: • Ascends short distance (approx. 5 cm) within pericardium Distribution: • Heart (via coronary arteries) Branches: • Right and left coronary arteries • Continues as arch of aorta Comment: • Has aortic valve at origin • Everything inferior to diaphragm, except posterior abdominal wall, which drains into azygos system Tributaries: • Common iliac • Lumbar • Right testicular/ovarian • Renal • Right suprarenal • Inferior phrenic • Hepatic • Also called left diagonal artery Course: • Ascends from level of L4 vertebral body, through diaphragm, to heart Termination: • Right atrium of heart Comment: • Largest vein of body Small Cardiac v. Drainage: • Right atrium • Right ventricle Course: • Lies in coronary sulcus between right atrium and right ventricle Left Anterior Ventricular v. Termination: • Coronary sinus Drainage: • Left ventricle Course: • Ascends across anterior surface of left ventricle Termination: • Great cardiac vein Circumflex branch of Left Coronary a. Origin: • Left coronary Course: Left Lateral a. • Passes from anterior to posterior surface of heart in left portion of coronary sulcus Origin: Distribution: • Anterior interventricular branch (LAD) of left coronary artery Course: • Left ventricle Branches: • Courses laterally and obliquely (i.e., diagonally) to the anterior aspect of the left ventricle Distribution: • Left ventricle (anterior aspect) Comment: • Left atrium • Left marginal • May continue as posterior interventricular branch Left Atrial a. • Great cardiac Origin: • Right coronary Course: • Ascends across posterior surface of left atrium Distribution: • Left atrium Left Pulmonary vv. Drainage: • Lungs Tributaries: • Lobar veins Course: • Two veins pass through root of each lung (i.e., four pulmonary veins in total) and directly into left atrium Left Posterior Ventricular a. Termination: • Left atrium Comment: Origin: • Circumflex branch of left coronary artery • Carry oxygen-rich blood Course: • Courses across posterior surface of left ventricle Distribution: • Left ventricle Middle Cardiac v. Drainage: • Right ventricle • Left ventricle Course: • Ascends in posterior interventricular sulcus Left Posterior Ventricular v. from apex of heart Termination: Drainage: • Left ventricle Course: • Ascends across posterior surface of left ventricle Termination: • Coronary sinus Also known as: • Posterior interventricular vein Comment: • Companion to posterior interventricular artery Oblique v. of Left Atrium Posterior Interventricular sulcus Drainage: Description: • Left atrium • Groove on posterior surface of heart • Extends from coronary sulcus to apex of Course: • Descends across posterior surface of left atrium Termination: • Coronary sinus heart • Marks position of interventricular septum Comment: • Contains posterior interventricular artery and middle cardiac vein Posterior Interventricular a. ACTIVITY 18B – BLOOD VESSELS Origin: • Right coronary artery Arteriole Course: • Courses through posterior interventricular sulcus Location: • Connect muscular (distributing) arteries with capillaries Distribution: • Left ventricle • Right ventricle • Interventricular septum Description: • Arteries with overall diameter 40-200 µm • Tunica media has one to three layers of smooth muscle Comment: • Accompanies middle cardiac vein in posterior interventricular sulcus • Right dominant heart: Posterior interventricular artery derived from right coronary artery (80%) • Left dominant heart: Posterior interventricular artery derived from circumflex branch of left coronary artery (20%) Function: • Supplies blood to capillaries Comment: • Companion vessels to venules • Primary point for control of blood flow to organs Tunica Externa of Arteriole Location: • Outermost layer of vessel wall Description: • Composed of elastic and collagen fibers Tunica Intima of Arteriole Location: • Innermost layer of vessel wall Description: Function: • Anchor blood vessel to surrounding • Composed of endothelium and its basement membrane structures Also known as: • External limit formed by internal elastic • Tunica adventitia of arteriole lamina Function: Comment: • In arteries, tunica media is thickest layer; • Selectively permeable barrier to blood solutes in veins, thickest layer is tunica externa • Secretes vasoconstrictors and vasodilators • Provides smooth inner lining that repels blood cells and platelets Tunica Externa of Venule Location: • Outermost layer of vessel wall Description: • Minimal tunica externa with a few collagen fibers and some fibroblasts Tunica Intima of Venule Function: • Anchor blood vessel to surrounding structures Also known as: • Tunica adventitia of venule Location: • Innermost layer of vessel wall Description: • Composed of endothelium and its basement membrane Comment: • In arteries, tunica media is thickest layer; in veins, tunica externa is thickest layer Function: • Selectively permeable barrier to blood solutes • Secretes vasoconstrictors and vasodilators • Provides smooth inner lining that repels blood cells and platelets Function: • Vasoconstriction and vasodilation (when Comment: muscular tunica media present) • Tunica intima also known as tunica interna Comment: • In arteries, tunica media is thickest layer; in veins, tunica externa is thickest layer Tunica Media of Arteriole Location: Vasa Vasorum • Middle layer of vessel wall Description: • Composed of one to three layers of circularly arranged smooth muscle cells and connective tissue • External elastic lamina inconspicuous Function: Location: • Tunica externa Description: • Small blood vessels Function: • Supply outer 1/2-2/3 of tunica media • Vasoconstriction and vasodilation Comment: • In arteries, tunica media is thickest layer; in veins, tunica externa is thickest layer Venule Location: • Connects capillaries with small and Tunica Media of Venule medium-sized veins Description: • Veins with overall diameter 15-100 µm Location: • Middle layer of vessel wall • Acquires tunica media of smooth muscle in larger venules Description: • Small venules lack tunica media • Larger venules acquire incomplete tunica media of smooth muscle Function: • Exchange fluid with surrounding tissues • Diapedesis (migration of leukocytes from blood vessel into interstitial fluid) occurs in postcapillary venules Comment: • Companion vessels to arterioles • Smallest venules called postcapillary venules