Questions to do with pharmacokinetics and
msk
10.What is anti-achr immunoglobin G’s?
•immunoglobin G’s are the antibodies to dampen down the autoimmune response , neutralise the
autoantibodies in the bloodstream and prevent further production. This helps relieve myasyntheia gravis
because it prevents the production of further antibodies to binding to nicotonic acetylcholine.
11.What is lambert eaton syndrome?
•NMJ disorder- causes muscle weakness.
•Antibodies bind to calcium channels of the NMJ, this then prevents pre-synaptic acetylcholine release
•Symtoms: Tendon reflexes absent or weak, dry mouth impotence proximal muscle weakness
12.Why is muscle relaxants needed for ET?
•Muscle relaxants are also used to relax the neck and throat and reduce the risk of injury when an endotracheal
(ET) tube is inserted. Also is used to prevent vomiting when the patient is paralysed.
13.where does lower exercise intensity come from in term of energy source and when does it convert to
carbohydrates forming the primary source?
•lower exercise intensity most of the energy comes from fatty acids , up when exercise reaches 70% maximum
exercise intensity, carbohydrates become the primary source
14.why does the muscle fibres not shorten during isotonic contraction?
•catch tension is the mechanism by which the actin myosin cross bridge kinetic resists stretching or unlinking
while maintaining force production, hence they do not shorten
15.what is the role of corticosteroids in Duchene Muscular dystrophy
•researchers think they may reduce inflammation in muscle tissue and strengthen muscle cell membranes,
which are otherwise damaged in DMD.