MCQs in
Cell Injury
From
2004 to 2013
Prepared by
Dr.Hamza Kheder
‫حمزة خضر‬.‫د‬
1-All of the following examples of Hydropic (Cloudy) swelling, except:
a-Breast Fat necrosis.
2013-‫دور أول‬
b-Liver cell in viral hepatitis.
c-Burns affect epidermal cells.
d-Accumulation of water in kidney tubules.
2-The degree of cell injury depends:
a-On the type ,duration and severity of insult.
2013-‫دور أول‬
b-Only on the severity of causative agent.
c-Only on the duration of an insult.
d-All of the above.
3-Which of the following is Not associated with cell death?
a-Nuclear condensation (pyknosis).
13-11-2012
29-8-2010
b-Nuclear fragmentation (karyorrhexis).
c-Dissolution of the nucleus(karyolysis).
d-Decrease in intracellular Ca+ + .
4-Which of the following findings would appear in alcoholic liver disease:
13-12012
a-Steatosis in hepatocytes.
b- Bilirubin in canaliculi.
c-Amyloid in hepatocytes.
d-Glycogen in hepatocytes.
5-Mitochondria contain enzymes involved in:
18-6-2011
a-Activation and synthesis of some aminoacids.
b-Glycolysis.
c-Oxidative phosphorylation.
d-Fatty acid synthesis.
‫حمزة خضر‬.‫د‬
6-In hypoxia which one will result from decrease plasma membrane Na-K ATPase
function:
13-3-2012
a-Decrease Na+ ion inside cell, decrease K+ ion outside cell.
b-Decreased Na+ ions inside cell, increase K+ ions outside cell.
c-Increased Na+ ions inside cell, increase K+ ions outside cell.
d-Increase Na+ ions outside cell, increase K+ ions inside cell.
7-Which of the following is associated with nuclear changes in reversible cell injury:
a-Pyknosis.
18-6-2011
b-Karyolysis.
c-Apoptosis.
d-Swelling of rough endoplasmic reticulum.
8-Depletion of ATP results in the following biochemical changes except:
19-7-2009
a-Decreased cytosolic free calcium.
b-Reduced activity of sodium pump.
c-Decreased protein synthesis.
d-increased anaerobic glycolysis
9-Steatosis is caused by:
19-7-2009
a-Viral hepatitis.
b-Alcoholism.
c-Starvation.
d-All of the above.
10-Accumulation of lipid within the liver cells may be related to:
Quiz-2009
a-Starvation of the patient.
b-Excessive alcohol intake.
c-Obesity.
d-All of the above.
11-All of the following statements about Reversible cell injury are true except: Quiz-2009
a-Swelling of cell organelles and the entire cell.
19-7-2009
b-Dissociation of ribosomes from endoplasmic reticulum.
2008-‫دورأول‬
c-Decreased energy production by mitochondria.
d-Increased glycolysis → decreased PH → nuclear fragmentation.
‫حمزة خضر‬.‫د‬
12-These are true for diffuse fatty change of liver except:
a-Sharp border.
b-Increase in size.
c-Yellow in colour.
d-Soft in consistency.
2004-‫دور ثالث‬
15-5-2004
13-The commonest site of fatty change is:
a-Liver.
b-Spleen.
c-Kidney.
d-Heart.
13-3-2004
14-Regarding coagulative necrosis:
a-The denaturation process is more than autolysis.
b-Loss of nucleus with ghost outline of cells and tissue.
c-All of the above.
d-None of the above.
2013-‫دور أول‬
15-Micro Vesicular fatty change of the liver is characteristic for the following condition
except:
2007-‫دور أول‬
a-Rye syndrome.
b-Pregnancy.
c-Tetracyclin toxicity.
d-Alcoholic hepatitis.
16-Fat necrosis:
a-Hypoxia and protein malnutrition are the main causes.
b-Increases calcium level in the blood.
c-Histological may shows foreign body giant cell reaction.
d-Can occur in the liver tissue.
2013-‫دور أول‬
17-Councilman body is:
a-A type of endogenous pigment .
2013-‫نصفي‬
b-An example of pathological Apoptosis.
c-Usually found in the kidney parenchyma.
d-Appears as deep blue in the tissue section.
‫حمزة خضر‬.‫د‬
18-Involution of lactating breast occurs through a process of:
13-3-2012
a-Necrosis.
b-Hypoplasia.
c-Apoptosis.
d-Atrophy.
19-The following inflammation leads to fat necrosis:
a-Appendicitis.
13-3-2012
25-8-2008
b-Hepatitis.
c-Pancreatitis.
d-Pyelonephritis.
20-Myocardial infarction is a;
a-Coagulative necrosis.
13-3-2013
13-11-2013
b-Liquefactive necrosis.
c-Caseous necrosis.
d-Fat necrosis.
21-Active programmed cell death is called:
13-11-2012
a-Necrosis.
b-Apoptosis.
c-Autolysis.
d-Heterolysis.
22-Which of the following has a cheesy, yellow-white appearance at the area of necrosis?
a-Coagulative necrosis.
b-Liquefactive necrosis.
c-Caseous necrosis.
d-Fat necrosis.
29-8-2010
23-Which of the following occurs as a result of release of activated pancreatic enzymes
and can leave white,chalky deposits representing calcium soap?
29-8-2010
a-Coaqulative necrosis.
b-Liquefactive necrosis.
c-Causeous necrosis.
d-Fat necrosis.
‫حمزة خضر‬.‫د‬
24-All of the following statements about Apoptosis are true except:
a-Programmed cell death.
2008-‫دورأول‬
Quiz-2009
b-Large group of cells.
c-Gene activation.
d-No inflammatory response.
25-All of the following statements about Irreversible cell injury are true except: Quiz-2009
a-Swelling of cell organells.
25-8-2008
b-Release of lysosomal enzymes.
c-Nuclear fragmentation.
d-Normal cytosolic Ca+ + .
26-Liquifactive necrosis is found in:
Quiz-2009
a-Cerebral infarct.
b-Renal infarct.
c-Heart infarct.
d-Splenic infarct.
27-Which is Not evidence of irreversible cell injury?
a-Calcium chunks in the mitochondria.
2008-‫دور أول‬
27-9-2009
b-Acute cell swelling("cellular edema").
c-Nuclear pyknosis.
d-All the above are evidence of irreversible injury.
28-This is true about Apoptosis:
27-9-2009
a-Involves the death of large contiguous areas of cells.
b-Is caused by non-lysosomal endogenous endonuclease.
c-Is a pathological event.
d-Leaves a permanent clump of cellular debris.
29-This is true about Fibrinoid necrosis:
a-Occurs in arteriolar walls in malignant hypertension.
b-Is usually due to clostridial infection.
c-Is caused by enzymatic lysis of adipose tissue.
d-Is the characteristic appearance seen in tuberculosis.
27-9-2009
‫حمزة خضر‬.‫د‬
30-Loss of the nucleus with preserved cell shape is a feature of:
27-9-2009
a-Coagulative necrosis.
b-Apoptosis.
c-Liquifactive necrosis.
d-None of the above.
31-Which type of necrosis is most characteristic of ischemia involving the heart
2008-‫نصفي‬
or kidney?
a-Coagulative.
b-Liquifactive.
c-Caseous.
d-Fibrinoid.
32-Which of the following changes is not seen in apoptosis?
2008-‫نصفي‬
a-Cell shrinkage.
b-Cell fragmentation.
c-Active phagocytosis.
d-Inflammatory reaction.
33-Apoptosis is:
2008-‫نصفي‬
a-Programmed cell death.
b-Increase in number of cells.
c-Increase in bulk of cells.
d-None of the above.
34-Which of the following Nuclear changes is not seen in coagulative
necrosis?
2008-‫نصفي‬
a-Nuclear swelling.
b-Nuclear shrinkage.
c-Nuclear fragmentation.
d-Dark and dense chromatin.
‫حمزة خضر‬.‫د‬
35-Fibrinoid necrosis is found in the following conditions except:
2006-‫دور أول‬
a-Necrotizing arteriolitis in malignant hypertension.
b-Aschoff's nodule in the myocardium.
2007-‫دور أول‬
c-Cerebral infarct.
d-Subcutaneous rheumatoid nodule at the elbow.
36-Fat necrosis is usually due to:
a-Autoimmune reaction.
2006-‫دور ثاني‬
b-Trauma.
c-Infection.
d-Ischaemia.
37-Apoptosis occurs in all except:
2006-‫دور ثاني‬
a-During embryogenesis.
b-Viral hepatitis.
c-Some physiological conditions.
d-Tuberculosis.
38-Active programmed cell death is called:
a-Necrosis.
Quiz-2009
2004 ,2005
b-Apoptosis.
c-Autolysis.
d-Heterolysis.
39-Coagulative necrosis occurs in all except:
2004-‫دور ثاني‬
a-Kidney.
b-Heart.
c-Spleen.
d-Central nervous system.
‫حمزة خضر‬.‫د‬
2004-‫دور ثالث‬
40-Liquifactive ischaemic necrosis is especially seen in:
a-Heart.
b-Brain.
c-Spleen.
d-Kidney.
41-Calcification in multiple organs associated with wide spread bony
Metastasis is best described as:
13-3-2012
a-Dystrophic with decreased serum Ca++ .
b-Dystrophic with
increased serum Ca++ .
c-Metastatic with decreased serum Ca++.
d-Metastatic with increased serum Ca++ .
42-In metastatic calcification ,calcium is deposited in :
13-11-2012
a-Healthy tissue.
b-Dead tissue.
c-Degenerated tissue .
d-All of the above.
43-Dystrophic calcification:
18-6-2011
a-Occurs in normal tissues.
b-Is associated with hypercalcaemia .
c-Is seen in vitamin D related disease.
d-Occurs in atheromatous disease.
44-Dystrophic calcification occur in:
19-7-2009
a-Old scars.
b-Atherosclerosis.
c-Traumatic fat necrosis.
d-All of the above.
‫حمزة خضر‬.‫د‬
45-Metastatic calcification is caused by all except:
27-9-2009
a-Sarcoidosis.
b-Hypoparathyroidism.
c-Vitamin D intoxication.
d-Multiple myeloma.
46-In metastatic calcification ,calcium is deposited in:
25-8-2008
a-Old scar.
b-Dead tissue.
c-Degenerated tissue.
d-None of the above.
47-Causes of hypercalcemia include all except:
2008-‫دور أول‬
a-Hyperparathyroidism.
b-Hyperthyroidism.
c-Destructive bone diseases.
d-Increased absorption of calcium from the intestine.
48-Metastatic calcification is not seen in:
2008-‫نصفي‬
a-Kidney tubules.
b-Fundal glands of stomach.
c-Alveoli of lung.
d-Media of monkeberg degeneration.
49-In metastatic calcification, calcium is deposited in:
2006-‫دور ثاني‬
a-Healthy tissue.
b-Dead tissue.
c-Degenerated tissue.
d-All of the above.
50-The site in which metastatic calcification occurs is:
a-The kidney.
b-The wall of the inferior vena cava.
c-Old tuberculous lesions.
d-Atheroma.
2004-‫دور أول‬
‫حمزة خضر‬.‫د‬
51-Lipofuscin is:
2013-‫نصفي‬
a-An exogenous pigment.
b-Common in young age.
c-A marker of previous free radical injury.
d-Composed of soluble materials.
52-The followings are endogenous pigments except:
13-11-2012
a-Carbon.
b-Melanin.
c-Hemosiderin.
d-Lipofuscin.
53-Colour of atrophic tissue with residual bodies, such as lipofuscin granules, is:
a-Yellow.
13-11-2012
b-Blue.
29-8-2010
c-Brown.
d-White.
54-All are false about herediatory hemochromatosis except:
13-3-2012
a-Damage results from lead deposition.
b-It can progress to liver cirrhosis and diabetes.
c-Skin pigmentation is due to bilirubin deposition.
d-It is more commonly seen in young females.
55-Which of the following microscopic descriptions is most characteristic
of hyaline degeneration:
13-3-2012
a-Homogenous ground-glass , pink-staining appearance of cells.
b-Accumulation of lipids in cell.
c-Presence of calcium salts with loss of cellular detail.
d-Pyknotic densely stained nucleus.
‫حمزة خضر‬.‫د‬
56-Which of the following substances is most likely increased in the myocardial fibers
to produce small atrophic heart?
18-6-2011
a-Hemosiderin resulting from iron overload.
b-Lipochrome from "wear and tear" .
c-Glycogen resulting from a storage disease.
d-Cholesterol as a consequence of atherosclerosis.
57-The followings are endogenous pigments except:
19-7-2009
a-Carbon.
b-Melanin.
c-Hemosiderin.
d-Lipofuscin.
58-Corpora amylacea is an example of:
Quiz-2009
a-Fatty change.
b-Mucopolysaccharidosis.
c-Hyalinosis.
d-Cloudy swelling.
59-Bronzed diabetes is a manifestation of:
25-8-2008
a-Haemosiderosis.
b-Primary Haemochromatosis.
c-Secondary Haemochromatosis.
d-Porphyria.
60-Brown atrophy of the heart is characterized by all except:
25-8-2008
a-Occurs in old age.
b-The surfaces is wrinkled with tortuous coronaries.
c-The heart is brown.
d-Deposition of lipochrome pigment in the cardiac muscles.
‫حمزة خضر‬.‫د‬
61-Prussian blue is used for staining:
2008-‫نصفي‬
a-Haemosiderin.
b-Bone.
c-Muscle.
d-Fat.
62-Hyaline change occurs in all except:
a-Old connective tissue.
2006-‫دورثاني‬
b-Walls of blood vessels.
c-Chronic glomerulonephritis.
d-Chronic gastritis.
63-Heart failure cells contain:
2006-‫دورثاني‬
a-Melanin pigment.
b-Microorganisms.
c-Haemosiderin pigment.
d-Schistosomal pigment.
64-Albinism is characterized by:
2006-‫دور ثاني‬
a-Increased melanin pigment.
b-Lack of melanin pigment.
c-Abnormal haemoglobin metabolism.
dAbnormal porphyrin metabolism.
65-Brown atrophy of the heart results from deposition of:
13-3-2004
a-Melanin pigment.
b-Iron pigment.
c-Lipofuscin pigment.
d-All of the above.
66-The laminated eosinophilic material in the prostatic acini is called:
2004-‫دورثاني‬
a-Psammoma bodies.
2005-‫دور ثاني‬
b-Corpora albicantia.
c-Corpora amylacea.
d-Corpora lutea.
‫حمزة خضر‬.‫د‬
67-The pigment seen in brown atrophy of heart is:
15-5-2004
a-Melanin pigment.
b-Lipofuscin pigment.
c-Haemosidrin.
d-Malaria pigment.
2004-‫دور أول‬
68-Which one of the following is not true for haemochromatosis:
a-More common in the female than male.
b-An autosomal recessive disorder.
c-Complicated by malignancy.
d-Associated with arthritis.
69-Generalized pigmentation of the skin occurs in the following conditions except:
2004-‫دور أول‬
a-Carcinoma of the head of the pancreas.
b-Idiopathic hereditary haemochromatosis.
c-Addison's disease.
d-Arsenic poisoning.
70-All of the following are endogenous pigments, except:
a-Lipofuscin.
b-Carbon.
c-Melanin.
d-Haemosiderin.
27-10-2013
71-All are true for pathological calcification,except:
27-10-2013
a-The dystrophic is one of its types.
b-Some times associated with high calcium level.
c-Associated with renal calcification.
d-Related to bone formation following inflammation.
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‫حمزة خضر‬.‫د‬
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GOOD LUCK FOR ALL
‫حمزة خضر‬.‫د‬