Transplantation Humans have long realized the possibilities which transplantation of organs and tissue provides. In the 6th Century BC Indian surgeons described how to reconstruct facial wounds by transplanting skin from one place on the body to the other. During the middle age there were many references in historical medical literature of attempted blood transfusions as well as the transplantation of teeth. A skin transplant and a corneal transplant were reported in medical journals dating as far back as 1880. These early attempts were usually unsuccessful. Early in the twentieth century transplantation started to offer the promise of restored health and life. One of the exceptional medical advances of the twentieth century, organ transplantation has become a routine treatment for patients with organ failure which was a goal. I believe that now transplantation can rightly be considered one of the greatest achievements in history of medicine. It has overcome major technical limitations to become the success it is today. The results of organ transplantation continue to improve, both as a consequence of the innovations and the improvements in perioperative and postoperative management. Transplantation can save people from death, give them a chance to live a full life and improve its quality, but unfortunately, there are also downsides. One challenge that has remained from the outset is to overcome the shortage of suitable donor organs. Unfortunately, the need for organ donors is much greater than the number of people who actually donate. You often have to wait a long time for an organ transplant. Doctors must match donors to recipients to reduce the risk of transplant rejection. Then, if you have a transplant, you must take drugs the rest of your life to help keep your body from rejecting the new organ. Also, we should keep in mind the risks durings surgery and the side-effects. But, whether to do a transplantation or not is the decision of everyone who faces it.