lOMoARcPSD|8521422
Drug excretion
Drug clearance cont.
- Effects of changes in dose and elimination rate:
- Drugs a and b differ only in their elimination t1/2
- Curve b’ shows the plasma conc time course for a smaller dose of b
- The t1/2 does not depend on the dose (= 0.693/Kel or Kel = 1/slope)
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