QUESTION NO: 1
QUESTION NO:2
3. A drug was given IV to an experimental subject that weighed 70 kg. Dose of 2.5
mg/kg. Concentrations in the plasma were found to be as follows (mg/L):
2 hr = 7.07; 4 hr = 5.00; 6 hr = 3.54; 8 hr = 2.50.
a) What is the total dose?
b) What is the Cp(0)?
c) What is the Vd/kg?
d) What is the whole subject Vd?
4. Oral admiration of 50 mg is given to the patient and the plasma concentration vs
time is given below;
Time (hr)
Conc (mg/L)
0
0
1
2.3
2
4.7
4
5.2
8
4.0
12
2.8
24
0.6
36
0.14
48
0.03
5. A drug follows first order (i.e. linear) pharmacokinetics .A 1000 mg dose was
given by rapid IV administration to a patient determine the half-life, Vd, Ke,
AUC, MRT,Vss and clearance : the time vs plasma concentration is given
below;
6. An 80 kg patient was given a tablet containing 400 mg of a drug. The drug is
completely absorbed. Plasma and urine was assayed:
7. A 150 mg oral dose of a drug was administered to a healthy volunteer.
Blood samples were collected and plasma was separated from each blood
sample and analyzed for drug concentration. The collected data are shown
in the table below.
Estimate Ke, Vd, cl and half-life.