Lung cancer Leeroy Munesi R2111173 Simbarashe Kasanzu R211841P Sharleen Global Distribution Worldwide, lung cancer is the most common malignancy and the most common cause of cancer deaths. Lung cancer in men worldwide has an age-standardized rate (ASR) of 33.8 per 100,000 It is the fourth most frequent cancer in women (13.5 per 100,000). Worldwide, approximately 70% of cancer deaths occur in LMICs, a large fraction of which is attributed to lung cancer.( World Economic Forum, 2021) The major types of lung cancer include adenocarcinoma, squamous cell carcinoma, small cell and large cell carcinoma Lung Cancer in Zimbabwe According to the latest World Health Organization data published in 2020 Lung Cancers Deaths in Zimbabwe reached 286 or 0.26% of total deaths. The age adjusted Death Rate is 4.78 per 100,000 Of population ranks, Zimbabwe is number 139 in the world for lung cancer. Spread of lung cancer Lung cancer can spread (metastasize) in several ways. Cancerous cells can grow into surrounding healthy tissues, including the lining of the lungs and nearby lobes. This is known as local metastasis. Or, cancerous cells can invade the lymph nodes and travel through the lymphatic system to other parts of the body. . Risk Factors The most important risk factor for lung cancer is tobacco smoking. Latent period of 30 years Other contributory factors include: environmental exposure to radon; asbestos(latent period of 30-40 years); certain metals such as chromium, cadmium and arsenic; some organic chemicals; radiation; coal smoke; as well as indoor emission of fuel burning Passive smoking Symptoms • A cough that does not go away or gets worse • Coughing up blood or rust-colored sputum (spit or phlegm) • Chest pain that is often worse with deep breathing, coughing, or laughing • Hoarseness • Loss of appetite • Unexplained weight loss • Shortness of breath • Feeling tired or weak • Infections such as bronchitis and pneumonia that don’t go away or keep coming back • New onset of wheezing • If lung cancer spreads to other parts of the body, it may cause: • Bone pain (like pain in the back or hips) • Nervous system changes (such as headache, weakness or numbness of an arm or leg, dizziness, balance problems, or seizures), from cancer spread to the brain • Yellowing of the skin and eyes (jaundice), from cancer spread to the liver • Swelling of lymph nodes (collection of immune system cells) such as those in the neck or above the collarbone Diagnosis CXR CT scans MRI SCANS Sputum cytology Fibreoptic bronchoscopy Healthcentral.com Prevention of lung cancer Primary Prevention: smoking cessation and clean air initiatives Avoid or limit exposure to cancer causing agents eg asbestors Consuming Vit. A, Vit E,, Vit C. Secondary Prevention: Aim is to early diagnose high risk populations via screening Chest X-Ray, MRI, CT scans, sputum cytology Tertiary prevention Targeted at people who survived a cancer disease Assists them to retain an optimal level of functioning regardless of their potential debilitating disease Legislative components/ policies Laws have been enforced/ enacted to: protect workers from being exposed to cancer-causing substances, such as asbestos, arsenic, nickel, and chromium, to help lower their risk of developing lung cancer. prevent smoking in the workplace and public space to lower the risk of lung cancer caused by secondhand smoke Policies The World Health Organization’s Framework Convention on Tobacco Control (FCTC), enforced on February 27, 2005 National Cancer Prevention and Control Strategy for Zimbabwe 2014 2018 References World Health Organization. WHO framework convention on tobacco control. Geneva; 2003. U.S. National Institutes of Health. National Cancer Institute. SEER Cancer Statistics Review, 1975–2011 World Health Organization. Non Communicable Diseases, 2022