More than 480,000 deaths annually (including deaths from secondhand smoke) 278,544 deaths annually among men (including deaths from secondhand smoke) 201,773 deaths annually among women (including deaths from secondhand smoke) Of the more than 7,000 chemicals in tobacco smoke, at least 250 are known to be harmful, including hydrogen cyanide, carbon monoxide, and ammonia (1, 2, 5). Among the 250 known harmful chemicals in tobacco smoke, at least 69 can cause cancer.Dec 19, 2017 Exposure to secondhand smoke causes an estimated 41,000 deaths each year among adults in the United States: Secondhand smoke causes 7,333 annual deaths from lung cancer.