The 3 lines of defense in a body First line of defense (natural barrier) Second line of defense (inflammatory reaction) Its nonspecific It's nonspecific because it is the same no matter what the pathogen is It prevents the entry of pathogen The organs of this lines are: skinsaliva-mucus- cilia- stomach acidtiny hairs-tears-earwax. Alerts the body about a pathogen invasion The effector cells are the macrophages and granulocytes. The last step in an inflammatory reaction is phagocytosis Third line of defense (specific immune response) Cell mediated specific immune response Humoral specific immune response T cells are the effectors cells B cells are the effectors cells Responsible for killing a rejected graft Responsible for the failure of blood transfusion Specific since the cells bind to a specific antigen (key-lock action)