Medical treatments: Rickettsia: Doxycycline: 200mg/BD 5-7 days Chloramphenicol 500 mg 3 times a day 5-7 days Medical abortion: Mifepristone (anti progesterone) 200 mcg and Misoprostol e1 analogue 800 mcg (4tabs) 24-48hrs after mife pristoen 49-63 days after conception Rabies: Essen regime 5 injections Zagreb 4 injection 0,3,7, 14, 28 or two on day 0 day 7 and day 21 antitoxin and diazepam Tetanus: antitoxin, vaccine, diazepam Arrhythmia in damaged cardiac tissue: IB (Mexilitine, tocainide, lidocaine) Immediate anticoagulation: heparin Type 2 DM: Dietary intervention, oral hypoglycemics, insulin Ringworm: Terbinafine, griseofulvin and imidazole Candiasis: systemic Amphotericin B and Oral Nystatin Crytococcus Neoformans: fluconazole Patent ductus arteriosus closure: indomethacine 0.2mg/kg/12hrs for 3 doses Temporal Arteritis: High dose corticosteroids 40-60 mg/day 60-100mg/day Schizophrenia negative symptons: Serotonin 2A antagonist 2nd generation anti-pyschotics Aripiprazole, clonzapine, olanzapine, quetiapine, paliperidone, iloperidone, lurasidone, risperidone ziprasidone Alcohol abuse: Disulfiram and acamprosate Diabetes Insipidus: central: desmopressin nephrogic: amiloride, hydrochlorothiazide and indomethacin To keep PDA open: Alprostadil Cytomegalovirus: Ganciclovir Pnuemocystis jirovecii: TMP-SUX Benign Prostatic hyperplasia: Finasteride, Tamsulosin Buerger’s disease: smoking cessation Carcinoid syndrome: octreotides Malignant Hyperthermia: dantrolene Chronic Gout: Overproducer: allopurinol Under excretory: probenecid Acute gout: Nsaids and colchicine Neisseria Meningitis: Pencillin/ceftriazone, Rifampin Wegner’s Granulomatosis with polyangitis: cyclophosphamide and corticosteroids ER positive breast cancer: Tamoxifen Clostridium difficile: Metronidazole, Vancomycin Mutiple sclerosis: b-interferon, immunosuppression, natazlizumab Sickle cell Anemia: hydroxyurea Depression: SSRI Cytomegalovirus: Ganiclovir Streptococcus Bovis: pencillin prophylaxsis Bulimia: SSRI, Nystatin Alcohol Withdrawal: benzodiazepine Tonic Clonic: Phenytoin, valproate, carbamazepine Gonorrhea: Ceftriaxone cover doxycycline-chlamydia Generalized Anxiety Disorder: Buspirone Prostate cancer/fibrosis: leuprolide/GnRH continuous Malaria: chloroquine/mefloqine (blood schizont), primaquine (liver hypnozoite) Hypercholesterolemia: statin Hypertriglyceridemia: fibrate Chlamydia Trachomatis: Doxycycline (+ceftriaxone) erythromycin in eyes TB: RIPE rifampin, isoniazid, pyrazinamide, ethambutol Enterococci: vanco.amp, aminoglycoside Strep pneumonia: pen/cephalo, vanco(meningitis) Acute Promyelocytic Anemia: All-trans retinoic acid Infertility classic tm: leuprolide, pulsatile GnRH Wafarin toxicity: acute-FFP chronic-vitamin K Cystic Fibrosis: NAC, Anti-pseudomonas prophylaxis: Tobramycin/azithromycin Hypertensive mom: Hpt Mom Love Nifeipine, hydralazine, methydopa, labetolol, Nsaids in gastric ulcer: Celecoxib Heparin induced thrombocytopenia HIT: Direct thrombin inhibitor = agatroban Furosemide is a sulfa drug alternate: ethacrynic acid Gynaecomastia causative: spironolactone switch on eplerenone, ketoconazole Strep Pyogenes: Pencilin CML: imatinib Crohn’s: corticosteroids and infliximab Stable angina: sublingual nitroglycerine Hyperaldosteronism: spironolactone Long term anticoagulation: warfarin ED: sildenafil, verdanefil Ulcerative colitis: 5-ASA, infliximab SIADH: Demeclocycline, lithium and vasopressin receptor antagonist conivaptan, tolvaptan Cyclophosphamide induced hemorrhagic cystitis Mesna Antipsuedomonas antibiotics: Pip-tazo, cefepime, tobramycin, Cipro, tica-clav Prolactinoma: dopamine agonist aka bromocriptine Positive symptons of schiz: D2 receptor antagonist first and second generation anti pyschotics Osteoporosis: Bisphosphonates, calcium and vit D Trachomonas Vaginalis: Metronidazole Migrane: Sumatriptan Heparin : protamine sulphate DKA: fluids, insulin and K Hib: Rifampin Bipolar: Lithium, valproate, Carbamazepine, lamotrigine Prostate cancer: flutamide Pulmonary Arterial Hypertension: Sildenafil, bosentan, epoprostenol Her2/neu positive breast cancer: trastuzumab Chronic Hepatitis: IFN alpha Pheochormocytoma: a-antagonist phenoxybenzamine Treponema pallidum: pencillin Breats cancer on post menopausal women: anastrazole Sporothrix Schenckii: oral potassium iodide Toxoplasmosis Gondi: Sulfadiazine, pyrimethamine Osteomalacia/rickets: vitamin D Ethylene. methonal intoxication: fomepizole Prolactinoma: Bromocriptine (dopamine agonists) Osteoporosis: Bisphosphonates, vitamin D, calcium Trichomonas Vaginalis: metronidazole Neural tube defect: folic acid Migrane: sumatriptan Absence: Ethosuximide Heparin: Protamine sulphate DKA: K+, insulin, fluids Haemophilus influenza B: rifampin Bipolar: lithium, lamotrigine, valproate, carbamazepine Prostate cancer: flutanide Pulmonary arterial hypertension: sildenafil, bosentan, epoprostol Chronic hpt: IFN-a Pheochromocytoma: a-antagonists phenoxybenzamine MRSA: vancomycin Treponema Pallidum: pencillin Breast ca in postmenopausal women: aromatase inhibitor anastrozole Sporothrix schenckii: oral k iodide Toxoplasma gondii: sulphadiazine pyrimerhamine Osteomalacia/rickets: vit D Ethylene/methanol: fomepizole Anticoagulation: heparin Hyperaldosteronism: Spironolactone Wegener’s granulomatosis with polyangitis: cyclophosphamide, corticosteroid Arrhythmia in cardiac: lidocaine, mexiletine, tocanide Influenza: rimantidine, oseltamivir Long term anticoagulation: Warfarin Sickle cell anemia: Hydroxyurea Malignant hypertension: dantrolene Cml: imatinib Clostrium tetani: antitoxin, vaccine, diazepam UTI prophylaxsis: TMP-SUX Bulimia: SSRI Staph aureus: nafcillin, oxacillin, dicloxacillin mrsa: vanco SiADH: lithium, demeclocycline, vasopressin receptor antagonist Enterococci: vanco/ampi, Cyclophosphamide induced- hemorrhagic cystitis: mesna Tonic clonic: phenytoin, valproate, carbamazepine ER positive breast ca” tamoxifen ADHD: methylphenidate, amphetamines Legionella: erythromycin CLASSIC PRESENTATIONS: ANTI-TOPOISOMERASE: DIFFUSE SCLERODERMA Jaundice and non tender palpable gall bladder: distal Enlarged cells with intranuclear inclusions: owl eye cells in cml Renal epithelial casts in urine: acute toxic/viral nephrosis Butterfly rash raynauds in a girl: SLE Bacitracin sensitive: strep pyogenes Bacitracin resistant: strep agalactaie Rash on hands and feet: coxsackie A, secondary syphilis, rocky mountain spotted, Kawasaki Lucid interval after head trauma: Epidural hematoma Optochin sensitive: strep pneumonia Optochin resistant: viridans Intranuclear eosinophilic droplet bodies: cowdry type A cmv hsv Bloody LP: Subarachnoid haemorrhage if multiple if only one traumatic LP xanthochomic tap: previous subarachnoid heam