What are the actions of monoamine oxidase inhibitors (MAO inhibitors)?
bind to and inhibit monoamine oxidase thus preventing serotonin & norepinephrine breakdown that
result in greater stores of serotonin and norepinephrine available for release
What are the ways to increase serotonin?
- increase the signal
- stop/mitigate the re-uptake
- prevent the breakdown (MAO inhibitors)
What is the mechanism of action for tricyclic antidepressants?
inhibit the re-uptake of serotonin and norepinephrine by blocking their transporters
What other receptors can tricyclic antidepressants block?
- alpha receptors
- histamine
- muscarinic
Name the Selective Serotonin Reuptake Inhibitors (SSRIs)?
- citalopram (Celexa)
- fluvoxamine (Luvox)
- paroxetine (Paxil)
- sertraline (Zoloft)
- fluoxetine (Prozac)
Name the Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)?
- venlafaxine (Effexor)
- desvenlafaxine (Pristiq)
- duloxetine (Cymbalta)
Name the monoamine oxidase inhibitors (MAO inhibitors)?
- tranylcypromine (Parnate)
- phenelzine (Nardil)
Name the tricyclic antidepressants (TCAs) (tertiary)?
- imipramine (Tofranil)
- amitriptyline (Elavil)
Name the tricyclic antidepressants (TCAs) (secondary)?
- nortriptyline (Aventyl)
What are other antidepressants (no specific class)?
- bupropion (Wellbutrin)
What can make tricyclic antidepressants (TCAs) harmful/dangerous?
when they are combined with other depressants
What are the classifications of antiarrhythmic drugs?
- 1A - Na+ channel blockers (moderate)
- 1B - Na+ channel blockers (mild)
- 1C - Na+ channel blockers (marked)
- 2 - Beta 1 blockers
- 3 - K+ channel blockers
- 4 - Ca++ channel blockers
What are the main effects of 1A (Na+ channel blocker) drugs?
- moderate decrease in phase 0 depolarization
- QRS & QT prolongation
What are the main effects of 1B (Na+ channel blocker) drugs?
- mild decrease in phase 0 depolarization
- decrease in ventricular automaticity
What are the main effects of 1C (Na+ channel blocker) drugs?
- marked decrease in phase 0 depolarization
- QRS prolongation
How do class 1A drugs prolong repolarization?
by blocking some K+ channels