STARTE R List all the health issues you can see THE BIGGER PICTURE vaccination Antibiotics and painkillers Developing drugs Daily review • What is weight? • Give 2 ways energy transfers can be reduced in a home • What are communicable diseases? • Name the pathogen that causes AIDS. • How does malaria affect the body? VACCINATIONS Learning aim: Explain how vaccinations protect against disease Learning goals: 1-4 • Describe why people are vaccinated. • State that vaccines contain dead or inactive forms of a pathogen. 5-6 • Explain how vaccination works. • Describe what an antibody and an antigen are 7-8 • Explain why, if a large proportion of the population is vaccinated, the spread of the pathogen is reduced. • Apply ideas about specificity of antibodies. vaccination An estimated 300 million people died from smallpox in the 20th century alone. How could it have killed so many people? The earliest physical evidence of smallpox is the pustular rash on the mummified body of Pharaoh Ramesses V of Egypt, who died in 1157 BC. Traders carried the disease from Egypt to India during the 1st millennium BC. From there it swept into China in the 1st century AD and reached Japan in the 6th century. Returning crusaders provided a way for smallpox to spread through Europe in the 11th and 12th centuries. The Spanish inadvertently owe much of their success in conquering the Aztecs and Incas in Mexico in the 16th century to smallpox. Unlike the Spanish, the native Indians had no immunity to the disease, having never encountered it before. It wiped out huge numbers of them. A century later the North American Indians suffered a similar devastation. In the 18th century smallpox decimated the aborigines when it reached Australia, the last corner of the world to have escaped its ravages. vaccination SMALLPOX NOW In 1966 the World Health Assembly voted a special budget to eliminate smallpox from the world. At that time, smallpox was endemic in more than 30 countries. A major breakthrough for the eventual control of this disease was the discovery of an effective vaccine by Edward Jenner in 1796. Containment measures included ring vaccination and isolation of cases and contacts. The last case of wild smallpox occurred in Somalia in 1977. Surveillance was aided by extensive house-to-house searches and rewards offered for persons reporting smallpox cases. Mass vaccination programs were successful in many Western countries; however, a different approach was taken in developing countries. This approach was known as surveillance and containment. In 1966 the World Health Assembly voted a special budget to eliminate smallpox from the world. At that time, smallpox was endemic in more than 30 countries. A major breakthrough for the eventual control of this disease was the discovery of an effective vaccine by Edward Jenner in 1796. Containment measures included ring vaccination and isolation of cases and contacts. The last case of wild smallpox occurred in Somalia in 1977. Surveillance was aided by extensive house-to-house searches and rewards offered for persons reporting smallpox cases. 1 2 3 4 5 6 Mass vaccination programs were successful in many Western countries; however, a different approach was taken in developing countries. This approach was known as surveillance and containment. vaccination HOW? Sort the timeline into the right order A major breakthrough for the eventual control of this disease was the discovery of an effective vaccine by Edward Jenner in 1796. In 1966 the World Health Assembly voted a special budget to eliminate smallpox from the world. At that time, smallpox was endemic in more than 30 countries. Mass vaccination programs were successful in many Western countries; however, a different approach was taken in developing countries. This approach was known as surveillance and containment. Surveillance was aided by extensive house-to-house searches and rewards offered for persons reporting smallpox cases. Containment measures included ring vaccination and isolation of cases and contacts. The last case of wild smallpox occurred in Somalia in 1977. vaccination vaccination TASK Create a storyboard that explains what happened with small pox and how it was eradicated. You must explain how vaccines work. vaccination PLENARY Mumps is a disease caused by a virus. Mumps vaccine is usually given to children as part of the MMR vaccine. (a) What diseases, other than mumps, does the MMR vaccine protect against? (2) (b) Mumps vaccines contain mumps viruses. Suggest why these viruses do not cause mumps. (1) (c) Explain how the vaccine makes someone immune to mumps. To gain full marks in this question you should write your ideas in good English. Put them into a sensible order and use the correct scientific words. (5) (d) A child who has not been given the mumps vaccine catches mumps. Suggest why a doctor would not give antibiotics to cure the child of mumps. a) measles ignore mumps 1 rubella accept German measles 1 (b) viruses are ‘dead’ accept other viral treatments accept ‘non-virulent’ mild’ must be qualified do not accept ‘small dose’ 1 (c) The answer to this question requires good English in a sensible order with correct use of scientific terms. Quality of written communication should be considered in crediting points in the mark scheme. Maximum of 4 marks if ideas not well expressed any five from: contains antigens or proteins accept reference to immunological memory or memory cells’ white cells (accept lymphocytes) do not accept phagocytes idea of specificity in antibodies or antigens antibody production ignore engulfing antigens destroyed / virus destroyed rapid antibody production if infected max 5 (d) antibiotics do not kill / affect viruses 1