How Bad is The Mutation? HEYDIDTHEFATCATEATTHERAT Original HAYDIDTHEFATCATEATTHERAT Substitution (silent) HEYDIDTHEFATCATEATTHEBAT Substitution (Missense) HEYADIDTHEFATCATEATTHERAT Single nucleotide insertion (frameshift) EYDIDTHEFATCATEATTHERAT Single nucleotide deletion(frameshift) HEYDIDTHEFATCATEATTHRAT Single nucleotide deletion (downstream) H E Y YOU D I D T H E F A T C A T E A T T H E R A T Codon insertion HEYTHEFATCATEATTHERAT Codon deletion How Bad is The Mutation? HEYDIDTHEFATCATEATTHERAT Original HAYDIDTHEFATCATEATTHERAT Substitution (silent) HEYDIDTHEFATCATEATTHEBAT Substitution (Missense) HEYADIDTHEFATCATEATTHERAT Single nucleotide insertion (frameshift) EYDIDTHEFATCATEATTHERAT Single nucleotide deletion(frameshift) HEYDIDTHEFATCATEATTHRAT Single nucleotide deletion (downstream) H E Y YOU D I D T H E F A T C A T E A T T H E R A T Codon insertion HEYTHEFATCATEATTHERAT Codon deletion