Mission Slimpossible! Introduction In the UK obesity is on its rise and there is an increased concern to whether there are any efficient strategies to halt the problem. The U.S is estimated to be a decade ahead in terms of the evergrowing rise in obesity levels which is in-turn drastically increasing the rate of type 2 diabetes. Results show obesity contributes to £3.5bn in economy costs, 30,000 deaths and 18 million days off sick from work each year. It can also lead to major health problems such as diabetes, hypertension and several more. Obesity is an overabundance of body fat and can be defined in relation to body mass index (BMI), a BMI value >30 indicates an individual is obese and is reflected by an increased waist circumference (Haslam, Sattar, & Lean, 2006). Therefore, effective exercise prescription is essential to help with weight gain prevention and weight loss maintenance, although it is evident that encouraging obese individuals to partake in physical activity (PA) isn’t an easy task. Often people who are overweight or obese suffer from low selfesteem, possible eating disorders, depression, and anxiety (Ehrman, Gordon, Visich, & Keteyian, 2018). Low adherence to exercise is a common problem and can be due to high levels of displeasure, research states individuals perform better with self-selected intensities which elicit a more pleasurable response (Ekkekakis, 2009). Multi-component behavioural weight management programs (BWMP) have been developed and widely used most abundantly in primary care settings, they address physical activity, nutrition, and behaviour therapy, although, these programs have seen to have varied outcomes. Loveman, et al., (2011) conducted a systematic review on the effectiveness of long=term weight management schemes for adults and found the interventions had generally produced modest weight loss in overweight or obese subjects, however weight regain was common, additionally these interventions were likely to be cost-effective. An update review with a more calloborative approach used by NICE, (2013) reported the effectiveness of 44 different BWMP’s compared to control coniditons, participants in the control condition had produced acute weight loss over a 12+ month period, whereas the intervention groups produced signifcantly greater results in most cases, 2-3kg more weight reducution in a 12-18 month period. There had also been evidence that suggests interventions involving face-to-face contact, set goals and supervised exercise yielded the most benefit compared to other interventions, this indicates the the potential necessity for assistance and contact to elciit greater results. Overall, BWMP’s may play a crucial role in the assistance of adopting a healthier and active lifestyle. Referral Criteria Participants will be eligible for the program if they match the referral criteria, this criterion is evidence based using the guidelines associated with ACSM, (2013). Their body mass index (BMI) should indicate that they’re overweight or obese, 25 – 29.9 kg/m2 (overweight), ≥30kg/m2 (obese). In addition to BMI, waist girth measurements will also be taken, an obese individual will be measured at a waist girth >102cm(40inch) for men and >88cm(35inch) for women (Executive summary of the clinical guidelines, 1998). Old age, physical inactivity and race are some of the factors that can contribute to hypertension, participants may be referred if they have levels above normal, SBP – 120-139/ DBP – 80-89 (Prehypertension), Stage 1 & 2 hypertension are excluded from criteria. An unhealthy diet with an abundant quantity of processed foods containing high saturated fat or trans fats can increase cholesterol levels – leading to dyslipidaemia. Participants may be referred if their LDL cholesterol is 130-159 mg∙dL-1, total cholesterol is 200-239 mg∙dL-1 , HDL cholesterol ≥60 mg∙dL-1 and triglycerides are 150-199 mg∙dL-1 . Individuals at risk of Type 2 Diabetes with fasting plasma glucose levels exceeding optimal levels are also considered, this is largely subject to an individual’s weight and waist circumference which can lead to insulin resistance. Prediabetic plasma glucose ranges from 100 mg∙dL-1 to 125 mg∙dL-1 for impaired fasting glucose and 140 mg∙dL-1 to 199 mg∙dL-1 for impaired glucose tolerance. Individuals with higher values than prediabetic values will more than likely be diabetic and therefore excluded from the criteria. Cardiovascular disease (CVD) potential is exacerbated due to all above criteria; therefore, all are leading causes of CVD. Additionally, cigarette smoking (or recent cessation/ in the last 6 months) and sedentary lifestyle behaviours (failure to partake in at least 30 min of moderate intensity exercise 3 times per week) are considered lifestyle factors that may lead to increased risk of CVD – and are also considered as referral criteria for this program. Workshop entry process and progress monitoring Pre-Participation - Health Screening Participants are required to complete a range of pre-participation processes that indicate the physical readiness of the individual and to consider any metabolic complications one may have before engaging in physical activity. Following a similar approach to ACSM, (2013), there will be a multistage process, including AHA/ACSM Health/Fitness Facility Preparticipation Screening Questionnaire ACSM, (2009), an informed consent, a CVD risk factor assessment and classification, and medical evaluation (if required) that involves a physical examination and stress test by a reputable health care professional. All individuals will be required to complete at minimum, the health screening questionnaire and informed consent form. The AHA/ACSM Health/Fitness Facility Preparticipation Screening Questionnaire (see figure 1), allows individuals with multiple CVD risk factors to be properly assessed by a professional prior to engaging in physical activity, this is mandatory as part of regular effective medical practice and should progress incrementally alongside their prescribed exercise program (ACSM, 2009). A CVD risk factor assessment allows the health care professional to acquire relevant information regarding the patient’s development and on-going progression/regression. Determining the presence of metabolic and cardiovascular disease is essential for when making decisions regarding the level of medical clearance, the need for exercise testing and the level of exercise supervision and exercise frequency (ACSM, 2013). The informed consent is required before exercise in any health/fitness or clinical setting, this documentation is an important part of ethical and legal consideration. The form allows the participant to understand what is required of them and the purpose and risks associated with the exercise test/program (ACSM, 2013). Figure 1 AHA/ACSM Health/Fitness Facility Preparticipation Screening Questionnaire Note: Adopted from American College of Sports Medicine. (2013). ACSM's guidelines for exercise testing and prescription. Lippincott Williams & Wilkins. p25, fig 2.2. Figure 2 and 3 adopted from ACSM, (2013) are representative of the CVD assessments that the health practioner will require from each patient. This is necessary to identify the level of risk which will therefore determine the exercise regime. For example, if the patient has numerous CVD risk factors (≥2) they will likely be classified as moderate or high risk, or a combination of both, in this case, with the given referral criteria, the individuals will more than likely be classified as moderate risk. This can then be progressed to identify which level of intensity is or isn’t advised when working with patients, In Figure 3, this model allows the practioner to address whether a medical examination, exercise test and physician supervision are necessary for pre-participation health screening, however, if not required, the patient may still be eligible to request the examination if they believe they’re at risk. Figure 2 Logic model for classification of risk Note: Adopted from American College of Sports Medicine. (2013). ACSM's guidelines for exercise testing and prescription. Lippincott Williams & Wilkins. p26, fig 2.3. Figure 3 Medical examination based on risk classification Note: Adopted from American College of Sports Medicine. (2013). ACSM's guidelines for exercise testing and prescription. Lippincott Williams & Wilkins. p28, fig 2.4. If the patient has answered the CV assessment (see figure 2) and shows signs of metabolic complications, they will be required to consult a physician prior to starting an exercise program, there is evidence that if an individual of whom is unaccustomed to PA and performs bouts of vigorous intensity exercise, the likelihood of an exercise-related event such as sudden cardiac death or acute MI is increased (Giri, et al., 1999; Siscovick, et al., 1984). Therefore, the most appropriate approach would be to start with light-to-moderate intensity levels of exercise and progress incrementally as their physical fitness increases. Pre-participation – Assessments (Physiological, Psychological & Nutrition) Once the patient has completed their initial step within the pre-participation process, they will then be taken through various assessments that will be repeated throughout the 12-week intervention, patients will be required to take part in the tests at the start, after six weeks and the twelfth week – totalling three compulsory testing events. The patients will be asked to participate in a 6-month follow up post-intervention to highlight the long-term effects and thus asked to repeat all the range of assessments below to evaluate the long-term health effects of this program. Blood Pressure (BP) Patients will have their blood pressure measurement taken before exercise participation. This is an important factor to consider when addressing an individual’s health and well-being. Prehypertensive individuals included in the referral criteria require health-promoting lifestyle alterations to prevent the progressive rise in blood pressure, as this indefinitely increases the likelihood of developing CVD (Chobanian, et al., 2003). As this intervention involves overweight and obese patients, they will most likely need modifications when undergoing a blood pressure test, one main modification is that the individual will likely require a larger cuff size. Measurement of blood pressure will follow the same methodology from Prineas, (1991). It is expected that, by the halfway point of the program, patients will see a decrease in their BP, with further reductions by the end point of 12 weeks, with the future expectation to return to normal levels (<120 mm Hg SBP, <80 mm Hg DBP) (ACSM, 2013). Numerous substantial epidemiological studies have shown that a reduction in weight leads to a BP lowering effect, likely due to improving insulin sensitivity (Mertens and Van Gaal, 2000). Cholesterol Levels Next, the patients will be required to have their blood taken to examine cholesterol levels NHS (2019), with the aim to reduce low-density lipoproteins (LDL), as this is a major risk factor for CVD, thus lowering LDL results in a significant reduction in the incidence of CVD (12), further, to increase the levels of high-density lipoproteins (HDL) to combat the chances of developing CVD (ACSM, 2013). Smoking, overweight/obese status, sedentary lifestyle, and poor nutrition habits all contribute to the raise in cholesterol levels (NHS, 2019). The program hopes to reduce cholesterol levels, seeing a decline by week 6 and further reductions by week 12 – with the expectation to reach normal levels by the end of the intervention. Normal levels = LDL – 100-129 mg∙dL-1, Total cholesterol <200 mg∙dL1 , HDL – 40-60 mg∙dL-1, Triglycerides <150 mg∙dL-1 (NCEP, 2004). Plasma Glucose Levels Testing for glucose levels can be done via blood samples NHS (2020), like testing for cholesterol levels, therefore both can be checked simultaneously. Prediabetic patients within this program will have both impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) and are at a significantly high risk for developing diabetes (10). Reduction in weight can make it easier to achieve a lower blood sugar level, leading to improved insulin response and sensitivity, this program aims to reduce body weight and improve blood sugar levels week by week with appropriate diet and exercise. By the end of the 12 weeks, the patient will have lowered both (IGT & IFG) levels appropriately, aiming for close to 100 mg∙dL-1. Anthropometric Measures Patients would have already identified their BMI and waist circumference (WC) prior to joining the program, their BMI and (WC) will be recorded at the point of starting the program, in the middle and at the end (1,6,12 weeks). Along with BMI, circumference measures will be taken by the practioners using a measuring tape, measures of the waist, upper arm, hips, calf, mid-thigh, neck, and calf will all be required for recording at the same intervals throughout the program (1,6,12 weeks). Using the same methodology seen in the manual of Callaway and colleagues, (1988). It is essential that all patients achieve reduction in girth measurements, with the addition of a lower BMI score throughout the program, with the emphasis of reducing WC to prevent the probability of CVD, hypertension, diabetes, and early death (Pi-Sunyer, 2004). According to the guidelines addressed by ACSM (2013), normative values of WC for men and female are as follows: 28.5–35inch / 31.5– 39.0inch, therefore these values will be the target for individuals of this program, achieving a reduction in both BMI and WC respectfully. Resting Heart Rate (RHR) In addition to the measures above, practioners will need to take a resting heart rate from all participants, this is not included in the referral criteria, so a varied range of RHR are expected. However, it is known that a RHR ≥90 beats per min(bpm) compared to <60bpm yields at least a twofold increase in CVD mortality, the method associated with taken RHR is adopted from Cooney, et al., (2010). 6 Minute Walk Test (6MWT) To test exercise capacity, this program will involve a 6-minute walk test, the distance the individual covers is the prime outcome measure of the test, secondary measurements will include fatigue and dyspnoea that will be rated via a borg scale Williams (2017), and will be administered at the start, middle and end of the intervention. The method for this specific test is adopted from Enright (2003) and inherits a non-intrusive approach to gaining knowledge as to where the patient is in terms of their fitness level. Furthermore, this test requires no equipment and can be performed anywhere if the patient has a means of recording distance travelled via electronic device plus a stopwatch. The table below contains an equation that is an acceptable method to predict VO2 peak from the 6MWT: Table 1: VO2 peak equation Note: Adopted from Cahalin, et al., (1996) Strength Testing To test muscular strength, a gym facility will be used, all participants will partake in a six-repetition max test (6RM) using both a leg press and chest press machine. They will be supervised by a practioner to ensure adequate technique and methodology behind the test will be adopted from Logan and colleagues (2000). A 6RM can be deemed more appropriate than singular maximal rep due to the population used for this study; as they’re at risk to developing CVD and other health conditions. This test will commence at the start, middle and end of the exercise program, practioners will record the weights lifted for each patient and the goal will be to increase the weight used for each future test. Psychological Testing/Questionnaire Each patient will fill and complete a quality-of-life questionnaire (QOLQ) created by Moorehead and colleagues (2003). It will be assigned to patients at the start and end of the intervention, this questionnaire covers multiple areas of an individual’s life and can be used to assess whether some if not all elements have improved. Further, the QOLQ can be completed in less than one minute, and can be administer to patients via email, Nutritional Analysis Participants will be asked to provide a 3-day food diary at the start of the intervention for the health practioner to assess, it is very likely that there should be amendments to the participants eating habits to allow for progressive weight loss. The diary should provide all food and beverages with as close to exact measures of each. This will then be analysed and feedback will be provided during the intervention. 12-Week Program Content and Delivery Week 1: Day 1 Day 2 • Screening & Testing (3 Hours) • Group Nutrition Class (2hours) Day 3 • Group GymBased Exercise (60min) Day 4 • 1-to-1 with practioner (motivational interviewing) Day 5 • Self-pace walk ≥10mins Day 6 • Self-pace walk ≥10mins Week 2: Day 1 Day 2 • Online Educational Material • Self-pace walk ≥10mins Day 3 • Online Educational Material Day 4 • Group GymBased Exercise (60min) Day 5 • Self-pace walk ≥10mins Day 6 • Self-pace walk ≥10mins Week 3: Day 1 • 1-to-1 with practioner (motivational interviewing) Day 2 • Group GymBased Exercise (60min) Day 3 • Group Nutrition Class (2hours) Day 4 • Self-pace walk ≥10mins Day 5 • Group GymBased Exercise (60min) Day 6 • Online Educational Material Week 4: Day 1 Day 2 • Self pace walk ≥10mins Day 3 • Group GymBased Exercise (60min) Day 4 • Online Educational Material Day 5 • Self-pace walk ≥10mins Day 6 • Group GymBased Exercise (60min) • Self-pace walk ≥10mins Week 5: Day 1 Day 2 • 1-to-1 with practioner (motivational interviewing) + Self pace walk ≥15mins Day 3 • Group GymBased Exercise (60min) Day 4 Day 5 • Self-pace walk ≥15mins • Group Nutrition Class (2hours) Day 6 • Group GymBased Exercise (60min) • Self-pace walk ≥10mins + Online Educational Material Week 6: Day 1 Day 2 • Screening & Testing (3 Hours) • Group GymBased Exercise (60min) Day 3 • Online Educational Material + Self-pace walk ≥10mins Day 4 • Self-pace walk ≥10mins Day 5 • Group GymBased Exercise (60min) Day 6 • Self-pace walk ≥10mins Week 7: Day 1 Day 2 • Self-pace walk ≥15min + Online Educational Material • Group GymBased Exercise (60min) Day 3 • Group Nutrition Class (2hours) Day 4 • Self-pace walk ≥15mins Day 5 • Group GymBased Exercise (60min) Day 6 • 1-to-1 with practioner (motivational interviewing) + Self pace walk ≥15mins Week 8: Day 1 Day 2 • Online Educational Material • Group GymBased Exercise (60min) Day 3 • Self-pace walk ≥15mins Day 4 • Self-pace walk ≥15mins Day 5 • Group GymBased Exercise (60min) Day 6 • + Self pace walk ≥15mins Week 9: Day 1 • Group Nutrition Class (2hours) Day 2 • Group GymBased Exercise (60min) Day 3 • Self-pace walk ≥20mins Day 4 • Self-pace walk ≥15mins +Online Educational Material Day 5 • Group GymBased Exercise (60min) Day 6 • 1-to-1 with practioner (motivational interviewing) + Self pace walk ≥15mins Week 10: Day 1 Day 2 • Self-pace walk ≥15mins • Group GymBased Exercise (60min) Day 3 • Online Educational Material Day 4 • Self-pace walk ≥15mins Day 5 • Group GymBased Exercise (60min) Day 6 • + Self pace walk ≥20mins Week 11: Day 1 Day 2 • 1-to-1 with practioner (motivational interviewing) + Self- pace walk≥15mins • Group GymBased Exercise (60min) Day 3 • Group Nutrition Class (2hours) Day 4 • Online Educational Material +Self pace walk ≥20mins Day 5 • Group GymBased Exercise (60min) Day 6 • + Self pace walk ≥20mins Week 12: Day 2 Day 1 • Screening & Testing (3 Hours) • Group GymBased Exercise (60min) Day 3 • Online Educational Material + Self-pace walk ≥10mins Day 4 • Self-pace walk ≥20mins Day 5 • Group GymBased Exercise (60min) Day 6 • Self-pace walk ≥20mins + 1-to-1 with practioner (motivational interviewing) Break-down of Intervention The 12-week intervention above focuses on achieving a modest weight loss goal of 5-10% of the individual’s current weight, this plan comprises of several elements, targeting physical activity, nutritional education, progress monitoring and 1-to-1 behavioural management. Additionally, participants will be expected to move through different stages of change using the psychological model known as the Transtheoretical Model, Prochaska and Velicer (1997) an accurate presumption of the individual’s stage at the beginning of the intervention would include having initial thoughts about starting a weight loss program and has some knowledge of the pros and cons – they may have difficulties with committing to a long-term change and persists to have mixed feelings about a healthier way of life. This indicates the individual would be starting within the contemplation stage, this plan aims to progress the person/s to the maintenance stage, with a future aspiration for them to maintain positive habits (action stage). This plan seeks to use processes that are both behavioural and experiential to support the individual in their growth and to adopt healthier habits. Experiential: Consciousness Raising (Increasing awareness) o Self-evaluation questionnaire, using the QOLQ o Health education via online nutrition course Social Liberation o Gym discounts for patients participating in the program o Provision by health care professionals Behavioural: Helping Relationships (Supporting) o Group resistance exercise o 1-to-1 motivational interviewing o Support from exercise trainer Reinforcement Management (Rewarding) o Goal setting, 5-10% weight loss in 12 weeks o Individual goals, 3-month free gym membership if achieved 5-10% weight loss in 12 weeks Health Screening & Testing Patients will partake in health screening along with both aerobic and strength tests at three intervals within the intervention: the start, middle and end. This will take place in a local health practice and all patients eligible for the plan will be scheduled throughout the day. Group Nutrition Class/Workshop Nutrition workshops/seminars will be delivered via a nutrition specialist which will take place in a local community hall that has access to kitchen facilities. Within 2-hour period, patients will be able to socialise and talk about their personal barriers to healthy eating and have a chance to prepare and cook healthy meals instructed by the specialist. Nutrition education is a significantly important factor that is associated with health and well-being, previous studies have evaluated and confirmed the benefit of nutrition education (Au, et al., 2016; Wagner, et al., 2016). At the end of each workshop, the specialist will hand out informative material to promote healthy eating habits to each participant. The specialist will also encourage all participants to start tracking their food via MyFitnessPal App on mobile devices MyFitnessPal, (2022), and aim for a 500-calorie deficit, this can also be achieved via exercise, however a combination of exercise and food intake to produce a negative caloric balance is advised (Donnely, et al., 2009). Part-Time Online Nutrition Course To gain more of an understanding on the topic of healthy eating, the program will enrol all participants on an online nutrition course, this will be a part time course that lasts the duration of the intervention and will act as supplementary element to their learning. The course will be running by a renowned organisation named ‘Vision2learn’ and will go through topic areas such as Vision2learn, (2022): The principles of healthy eating The nutritional needs of individuals Planning a healthy diet Principles of weight management Understanding eating disorders Principles of food safety for the home environment Group-Based Resistance Training All participants are required to engage in physical activity, both aerobic (walking) and anaerobic (RT), as part of the exercise regime, a group-based resistance exercise routine will be prescribed under supervision by an exercise professional. This will take place in a private health centre gym that allows access to groups and has access to numerous fitness equipment. To give sense of togetherness and not isolation, the program encourages group-based exercise twice per week, every week. This is to build a social network, cohesion and thus improve self-efficacy beliefs via mutual support Christensen, et al (2006), both male and female participants in previous studies using a group exercise protocol benefitted with more positive psychological effects, feeling calmer, however the potential for competition may be apparent with other participants around, resulting in more tiredness (Plante, et al., 2001). Although this could be a benefit due to higher workloads. Furthermore, exercising in groups has be shown to elicit forms of social support in which strengthen exercise identity (Golaszewski, et al., 2021). The prescribed exercise program will include up to 10 different exercises; chest press, shoulder press, triceps extension, biceps curl, pulldowns, lower-back extension, ab crunch, leg press, leg curl and calf raise and should elicit a desirable outcome and improvement (Pollock, et al., 2000). Lack of time may be a barrier for some individuals due to lifestyle factors, so a single set of each exercise to volitional fatigue (8-12 repetitions, moderate intensity), with weight loads associated 50-60% of 1RM has been found as effective as multiple-set plans, thus the session may only last 20-30 minutes ACSM (1998), although being in a group scenario, this may take a little longer. The professional will record weights use and encourage the participants to incrementally increase weight/load over time. RT has shown to have a vast array of benefits, including enhancing cardiorespiratory fitness and improving body composition. Recent seminal research demonstrated that RT positively affects risk factors such as insulin resistance, resting metabolic rate, glucose metabolism, blood pressure and body fat (Winett and Carpinelli 2001). The same study also indicates almost all benefits from RT are likely obtained within the first 20 minutes of training, twice per week. Furthermore, Honkola, et al., 1997 reported than during circuit training RT, LDL cholesterol and fasting triglycerides were reduced compared with no exercising group, the results are parallel with that of Westcott, (2012) too. Self-Paced Walking Aerobic exercise is an important asset to one’s health and has been administered as self-pace walking (low intensity) on certain days with time progressions throughout the intervention, starting from 10 to 20-minute sessions. Aerobic exercise is a vital part of an exercise program, and has numerous health benefits, improving glucose control, improving insulin sensitivity, and improving CVD risk factors (Boulé, et al., 2001; Mourier, et al., 1997). The combination of both walking and RT exercise generate positive effects, Balducci, et al., (2004) demonstrated that a long-term intervention pairing both aerobic and RT exercise significantly improved metabolic and lipid profiles, adiposity, and blood pressure also, and when compared to a non-exercise group, fat mass was reduced, while fat-free mass was increased. In addition, fasting blood glucose, LDL cholesterol and total cholesterol were greatly reduced, while HDL cholesterol was increased. The program encourages self-selected pace walking to enhance the element of pleasure, overweight and obese individuals tend to experience feelings of displeasure when prescribed a specific intensity, and over time this could reduce adherence due to diminishing enjoyment (Ekkekakis and Lind, 2006). To further increase enjoyment and satisfaction, the participant can walk outdoors, this is known to increase symptoms of pleasure and distraction, reducing overall feelings of exertion (Krinski, et al., 2017). Recommended Exercise Guidelines Determined by the exercise instructor, the program is designed to gradually increase the time spent performing PA, in week one the prescribed amount of PA starts with just 80 minutes, after weeks of gradual increase, the amount of PA has increased to 170 minutes by week 12. This end figure represents an amount that is slightly greater than the recommended weekly PA, which is 150 minutes, this is justified as the minimum PA dose for significant health benefits Participants will be encouraged to continue their exercise plan after the intervention, gradually increasing to 200 minutes minimum PA per week to facilitate long-term maintenance of weight loss (Donnely, et al., 2009). 1-to-1 Motivational Interviewing Addressed by a weight management psychologist, this technique is used to address behavioural changes by improving intrinsic motivation and focusing on doubt and uncertainty (Barnes, 2015). The main topic of the 1-to-1 will be to discuss ‘change talk’, based on reasons and potential barriers to change, in a supportive setting. Other topics will include disinhibited eating, binge eating, eating in response to emotional states, being held accountable, internal motivators and self-efficacy (Greif and Miranda, 2010). 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