March 7-9, 2022 | Digital Event WELCOME www.ild-summit.com Register & Pay by Friday January 14 & Save $300 2nd Annual Advancing Therapies for Inflammatory & Progressive Fibrosing ILDs SPEAKERS Compare Fibrotic Versus Inflammatory ILDs to Accelerate Target Identification Advancing Therapies for Inflammatory & Progressive Fibrosing ILDs Define Progression in Progressive Fibrosis to Uncover Predictive Biomarkers & Streamline Stratification Advancing Therapies for Inflammatory & Progressive Fibrosing ILDs Nina Patel Director of Clinical Development & Medical Affairs ILD Boehringer Ingelheim Shannon Turley Vice President Cancer Immunology & Discovery Genentech Martin Kolb Professor & Chief Editor of European Respiratory Journal McMaster University Toby Maher Director Interstitial Lung, Disease Program USC Shane Olwill Senior Vice President & Chief Development Officer Pieris Pharmaceuticals +1 617 455 4188 @ info@hansonwade.com www.ild-summit.com REGISTER YOUR PLACE Cara Williams Vice President & Head of Preclinical Biology, Inflammation & Immunology Research Pfizer PARTNER WITH US 28 Expert Speakers Including: AGENDA Navigate Clinical Drug Development to Understand ILD Trial Design & Expand Your IPF Pipeline to Broader Indications Advancing Therapies for Inflammatory & Progressive Fibrosing ILDs March 7-9, 2022 | Digital Deepen Scientific Understanding of Inflammatory & Fibrotic ILDs, Investigate Biomarkers to Stratify Trial Populations and Identify Endpoints Which are Likely to Predict Clinical Success in Your Next Clinical Trial Built to identify and advance indication expansions of IPF pipeline into fibrotic and inflammatory ILDs; with scientific insight from the hottest ILD and IPF stakeholders in the space, the 2nd ILD Summit is uniquely positioned to translate biological insights into therapeutic development opportunity across NSIPs, CT-ILDs, Sarcoidosis, HP and more. From exploring machine learning for more innovative ILD imaging, to analyzing biologics, small molecules and antibodies to determine which one is most suited to streamline inhaled drug delivery, this comprehensive forum will unite 100+ ILD heavyweights to dissect and utilize pioneering scientific research to optimize their ILD drug development strategy. Acceleron Pharma The meeting provides a very thorough review of the ILD landscape from bench to bedside Lassen Therapeutics New learnings, confirmation of previous postulates and great opportunity to increase my network AbbVie AGENDA Join internationally renowned ILD, respiratory and fibrosis experts from Boehringer Ingelheim, Pfizer, Genentech, Novartis and more at this unique industry focused forum and leave with the expertise your team needs to optimize your ILD drug development approach for 2022 and beyond. The ILD summit was a high quality event bringing together leaders from academia and industry sharing the latest research and clinical learnings in the field of fibrotic pulmonary diseases. SPEAKERS With a clear path to approval set out for SSc-ILD opening opportunity to address progressive fibrotic phenotypes and the remaining populations with inflammatory drivers of ILD; the pulmonary fibrosis field is exploding with innovative attempts to do better and bring transformative therapies to more patients. Hear what previous ILD Summit attendees thought: WELCOME Welcome to the 2nd ILD Summit Your Top 5 Takeaways From Key Stakeholders: +1 617 455 4188 @ Discover how pneumoproteitns and cytokines can be used to strategically enrich SSc-ILD clinical trials with The University of Texas and uncover groundbreaking research on imaging based biomarkers, CT Scans/data collection with UCL to understand how it can be used to predict FVC decline info@hansonwade.com www.ild-summit.com Examine inflammatory interstitial lung disease from a drug development perspective with Pfizer to comprehensively understand the disease signatures, cellular pathways and disease mechanisms involved in inflammatory ILD development and progression Deep dive into the lumping versus splitting debate in the context of disease progression with McMaster University to hear how to evolve biomarkers in applying splitting strategies and understand the differences between targeted therapies and more broadly antifibrotic approaches REGISTER YOUR PLACE 2 Investigate emerging ILD therapeutic approaches with Saje Pharma and Pieris Pharmaceuticals to debate the merits of single versus multiple benefit drugs for ILD and discover how anticalins can be utilized to optimize treatment of lung fibrosis PARTNER WITH US Uncover the clinical research propelling ILD drug development forwards in 2022 with Boehringer Ingelheim and Novartis to further your understanding of the inflammatory/ progressive fibrosing ILD phenotype, identify novel outcomes and utilize clinical data to strategically inform your clinical trial design Craig Conoscenti Medical Expert ILD Respiratory Clinical Development & Medical Affairs Boehringer Ingelheim David Barber Professor of Machine Learning UCL Dinesh Khanna Professor University of Michigan Elizabeth Renzoni Consultant Respiratory Physician, Honorary Senior Lecturer Imperial College London Eric White Senior Clinical Program Lead Boehringer Ingelheim Farrell Simon Vice President & Head of US Marketing Trevi Therapeutics Glenn Rosen Chief Scientific Officer Optikira & Biomotiv Jason Laufer Chief Executive Officer Remedy Cell Majd Mouded Executive Director Novartis Margaret Neighbors Principle Scientist Genentech Martin Kolb Professor McMaster University Matt Bradley Founder, Chairman, President, & Chief Technical Officer SAJE Pharma Nicolas Guisot Research Fellow & Project Leader Redx Pharma Nina Patel Director – Clinical Development & Medical Affairs ILD Boehringer Ingelheim Paolo Cameli Pulmonologist University of Siena +1 617 455 4188 @ info@hansonwade.com www.ild-summit.com REGISTER YOUR PLACE Carsten Ehrhardt Professor of Pharmacy Trinity College Dublin PARTNER WITH US Cara Williams Vice President & Head of Preclinical Biology: Inflammation & Immunology Research Unit Pfizer AGENDA Adam Byrne Professor Imperial College London SPEAKERS 3 March 7-9, 2022 | Digital WELCOME Your 25+ Expert Speakers Advancing Therapies for Inflammatory & Progressive Fibrosing ILDs Rohit Batta Chief Scientific Officer Vicore Pharma Peter Fernandes Vice President & Chief Regulatory, Quality & Safety Officer Bellerophon Therapeutics March 7-9, 2022 | Digital Shane Olwill Senior Vice President & Chief Development Officer Pieris Pharmaceuticals Simon Walsh Consultant Thoracic Radiologist, Machine Learning Scientist & Imaging Chair Imperial College London Simona Spennato Head of Nonobstructive Disease Unit, Global Clinical Development, R&D Chiesi Steve Jones President EUIPFF Tejaswini Kulkarni Director of Interstitial Lung Disease Program University of Alabama Toby Maher Director Interstitial Lung, Disease Program USC Vanessa Neins Senior Scientist - Biology Lead Respiratory Pieris Pharmaceuticals Lung Therapeutics Synexus 4 +1 617 455 4188 @ info@hansonwade.com www.ild-summit.com REGISTER YOUR PLACE Great event exceptional networking opportunities. High quality of presentations. Very efficient way to spend my time PARTNER WITH US Overall I thought very highly of the conference and the job Hanson Wade did as an organizer. Great speakers, lots of useful information, very timely. Top KOLs in the field AGENDA Shervin Assassi Director of the Division of Rheumatology The University of Texas SPEAKERS Shannon Turley Vice President of Cancer Immunology Discovery Genentech WELCOME Your 25+ Expert Speakers Advancing Therapies for Inflammatory & Progressive Fibrosing ILDs Advancing Therapies for Inflammatory & Progressive Fibrosing ILDs March 7-9, 2022 | Digital 9.00-4.30 EDT | 6.00 - 1.30 PDT WELCOME Pre-Conference Day Monday, March 7 Our entire pre-conference discussions day morning is dedicated to analyzing and scrutinizing the latest progress in inhaled drug delivery followed by a quick lunch break to refuel and network with fellow ILD drug developers via our custom-built virtual event platform. After lunch, you can continue diving deeper into inhaled drug delivery or choose to attend our dedicated “Exploring Biomarkers for ILD Clinical Trials” afternoon workshop. The choice is yours! Take a look at our PreConference Day agenda at a glance to view the full format SPEAKERS Agenda at a Glance Inhaled Drug Delivery Morning Lunch & Networking OR Inhaled Drug Delivery Afternoon Biomarkers for ILD Clinical Trials Workshop 9.00 | 6.00 Registration & Networking 10.00 | 7.00 Deep Diving into Delivery Mechanisms: Comparing & Contrasting Inhaled vs Systemic Drug Delivery in the Context of ILD Treatment Carsten Ehrhardt Professor of Pharmacy Trinity College Dublin 11.00 | 8.00 • Evaluating the choice of treatment for ILD based on specific ILD diagnosis, - including both systemically delivered agents and inhaled delivered agents. • Recently approved for ILD is an inhaled pulmonary arterial vasodilator that is also available as systemic delivered doses to treat PAH. • Discussing the pros and cons of inhaled vs. systemic administration agents for ILD aimed at targeting the MOA, V/Q matching, ILD diagnosis and the recent clinical experience on these delivery options to date 10.30 | 10.30 Considerations for Inhaled Drug Delivery • Basic considerations for inhaled drug delivery • Inhaled drug delivery challenges and how to overcome • Inhaled drug delivery for ILD specifically PARTNER WITH US Peter Fernandes Vice President & Chief Regulatory, Quality & Safety Officer Bellerophon Therapeutics AGENDA Investigating Inhaled Drug Delivery for Interstitial Lung Disease Integrating Inhaled Therapeutics with ILD Mechanisms to Streamline Your Drug Delivery • Panel Discussion and Q&A with Preceding Speakers: 11.30 | 8.30 5 +1 617 455 4188 @ Morning Break & Networking info@hansonwade.com www.ild-summit.com Carsten Ehrhardt Professor of Pharmacy Trinity College Dublin REGISTER YOUR PLACE Peter Fernandes Vice President & Chief Regulatory, Quality & Safety Officer Bellerophon Therapeutics Advancing Therapies for Inflammatory & Progressive Fibrosing ILDs March 7-9, 2022 | Digital 9.00-4.30 EDT | 6.00 - 1.30 PDT 12.00 | 9.00 Exploring the Patient Perspective on Inhaled Drug Delivery • Reviewing the advantages and disadvantages from a patient perspective • How do patients perceive risks and benefits of inhaled drug delivery? • Understanding the patient experience for inhaled drug delivery Steve Jones President EUIPFF Lunch & Networking Investigating Inhaled Drug Delivery for Interstitial Lung Disease Afternoon OR Exploring Biomarkers for ILD Clinical Trials Afternoon 1.30 | 10.30 Audience Discussion: Utilizing Lessons Learned from Inhaled Pirfenidone for IPF to Strategize & Enhance Effective Inhaled Drug Delivery for Interstitial Lung Disease 1.30 | 10.30 Utilizing Biomarkers to Identify Patient Over the past few years, significant strides have been made in the delivery of inhaled pirfenidone for IPF, however this has not been without it’s fair share of setbacks. What can the ILD drug development community learn from this? Join this interactive audience discussion to deep dive into the success, failures and challenges of delivering inhaled pirfenidone to treat IPF and leave with the knowledge you need to strategically inform and optimize your inhaled drug delivery approach. • Review the evolution of molecular and imaging biomarkers in ILD • Discuss an overview of application of these biomarkers in personalizing ILD clinical trial designs and potentially, shorten trial time • Understand the challenges in clinic utility of these molecular and imaging biomarkers Tejaswini Kulkarni, Director of Interstitial Lung Disease Program, University of Alabama 2.00 | 11.00 Moderated Discussion: Analyzing Biologics, Small Molecules & Antibodies for the Treatment of ILD to Determine Which One is Most Easily Inhaled, Nebulized & Absorbed by the Alveoli 2.00 | 11.00 Learning how to Use Biomarkers to of Secretomes to Treat IPF & the Challenges of Optimizing Inhaled Drug Delivery • Lessons learned from SSc-ILD • Molecularly profiling across multiple interstitial lung diseases • Combining ILD biomarker knowledge and clinical utility where is the field at and where do we need to go next? Margaret Neighbors, Principle Scientist, Genentech 2.30 | 11.30 Considerations for Clinical Trial Biomarker Selection • Panel Discussion and Q&A with Preceding Speakers: Tejaswini Kulkarni, Director of Interstitial Lung Disease Program, University of Alabama Margaret Neighbors, Principle Scientist, Genentech 3.00 | 12.00 Afternoon Break & Networking +1 617 455 4188 @ info@hansonwade.com www.ild-summit.com REGISTER YOUR PLACE • Exploring the potential of Activated Remedy cell Secretome (ARcS) • Investigating the utility of the Secretome in murine bleomycin models • Analyzing the outcome of Secretome experiments in PCLS explants from end stage IPF patients Jason Laufer, Chief Executive Officer, Remedy Cell Ltd Distinguish Patients with Fibrotic vs Inflammatory ILD in Order to Strategically Stratify Trial Populations & Maximize Trial Efficiency PARTNER WITH US 2.30 | 11.30 Harnessing the Therapeutic Power Populations Which are More Receptive to Your ILD Therapeutic in Order to Design and Conduct Faster Trials in a Shorter Time Frame AGENDA • Discussing and debating the benefits and drawbacks of biologics, small molecules and antibodies for inhaled drug delivery • Understanding what characteristics give rise to more easily inhaled molecules • Exploring challenges associated with alveolar uptake of inhaled therapies in interstitial lung disease and understanding how to overcome them Shane Olwill, Senior Vice President & Chief Development Officer, Pieris Pharmaceuticals Carsten Ehrhardt, Professor of Pharmacy, Trinity College Dublin SPEAKERS 12.30 | 9.30 6 WELCOME Pre-Conference Day Monday, March 7 Advancing Therapies for Inflammatory & Progressive Fibrosing ILDs March 7-9, 2022 | Digital 9.00-4.30 EDT | 6.00 - 1.30 PDT 3.30 | 12.30 Advantages & Disadvantages of Different Molecule Types for Inhaled Drug Delivery 3.30 | 12.30 Audience Discussion: Systematically Identifying & Validating New Biomarkers for ILD: How to Select and Assess the Viability of Novel Biomarkers for More Effective ILD Drug Development The difference between a successful and unsuccessful clinical trial can come down to what biomarker you choose to measure the efficacy of your therapeutic which is why it’s critical to play close attention to how you incorporate them into you clinical trial design and execution. Join this structured audience discussion to debate how to strategically select your next ILD biomarker with fellow ILD experts and optimize your approach to tackling common challenges associated with utilizing biomarkers in ILD clinical trials. 4.00 | 1.00 Practical Experience of Delivering 4.00 | 1.00 Enrichment Strategies on SSc-ILD • Considerations when developing inhaled drugs for fibrotic ILD • Discussing experience from the topical IPF study • Assessing effectiveness of inhaled drug delivery Toby Maher, Director, Interstitial Lung, Disease Program USC • Impact of Background Treatment on SSc-ILD Trial Design • Role of pneumoproteitns for enrichment • Role of inflammatory cytokines for enrichment Shervin Assassi, Director of the Division of Rheumatology, The University of Texas Inhaled Drugs in Fibrotic Lung Disease Clinical Trials PureTech Health Tremendous program with excellent synergies across the disciplines... basic biology, preclinical science, and clinical directions for idiopathic pulmonary fibrosis @ info@hansonwade.com www.ild-summit.com REGISTER YOUR PLACE OptiKira PARTNER WITH US Great virtual summit with interesting speakers and a well-planned out digital platform AGENDA 4.30 | 1.30 End of Day +1 617 455 4188 SPEAKERS • Panel Discussion and Q&A with Preceding Speakers: Shane Olwill, Senior Vice President & Chief Development Officer, Pieris Pharmaceuticals Carsten Ehrhardt, Professor of Pharmacy, Trinity College Dublin Jason Laufer, Chief Executive Officer, Remedy Cell Ltd 7 WELCOME Pre-Conference Day Monday, March 7 Advancing Therapies for Inflammatory & Progressive Fibrosing ILDs March 7-9, 2022 | Digital 8.30 - 5.00 EDT | 5.30 - 2.00 PDT WELCOME Conference Day One Tuesday, March 8 Examining Inflammatory Interstitial Lung Disease from a Drug Development Perspective 8.25 | 5.25 Chair’s Opening Remarks 8.30 | 5.30 Registration & Networking Comparing & Contrasting Fibrotic & Inflammatory ILDs in Order to Comprehensively Understand Key Differences in Their Development & Progression & Learning How This Influences Drug Development 9.00 | 6.00 • Identifying disease signatures and key cellular players in fibrosis associated with ILDs • Examining Autoimmune versus Idiopathic progressive lung fibrosis • Assessing pan fibrotic mechanisms versus disease specific mechanisms – how best to treat pulmonary fibrosis 9.30 | 6.30 Nina Patel Director – Clinical Development & Medical Affairs ILD Boehringer Ingelheim Understanding How to Define Patient Populations, Select Optimal Intervention Points & Outline Clear Therapeutic Outcomes to Streamline the Design & Development of Therapies for Inflammatory ILDs • Utilizing clinical parameters versus radiographic parameters to define patient subgroups • Clinical versus physiologic versus radiologic parameters to determine timing of intervention • Choosing clinical trial outcomes in a heterogeneous trial population Dinesh Khanna Professor University of Michigan Designing Trials for Inflammatory ILDs in 2022 & Beyond: Spotlight on Ssc-ILD • Revealing lessons learned from recent scleroderma ILD clinical trials • Discussing trial design in at-risk population for ILD versus those with clinical or established ILDs • Understanding what factors you must consider to optimize success of your therapeutic during clinical trials 10.30 | 7.30 Overview of Respiratory clinical and pre-clinical pipeline 11.00 | 8.00 Morning Break & Speed Networking Biomarkers 101: Exploring the Emerging Consensus on Which Biomarker is the Most Useful for ILD Drug Development 12.00 | 9.00 David Barber Professor of Machine Learning UCL • Using a database to streamline IPF/ILD imaging • Using CT Scans to predict mortality • Encouraging data sharing to optimize effort to find useful CT based biomarkers Paolo Cameli Pulmonologist University of Siena Exploring Biomarkers for Differential Diagnosis of Interstitial Lung Diseases • Investigating the potential of biomarkers for ILD diagnosis • Analyzing multiple types of biomarkers for ILD diagnosis • Discussing advantages and disadvantages of biomarkers for ILD diagnosis 1.00 | 10.00 @ Lunch & Networking info@hansonwade.com www.ild-summit.com REGISTER YOUR PLACE 12.30 | 9.30 +1 617 455 4188 OSIC Project – Exploring Imaging Based Biomarkers, CT Scans/ Data Collection to Predict FVC Decline PARTNER WITH US • Exploring Chiesi’s mission as Research Group and key elements in several respiratory diseases • Overview of Respiratory clinical and pre-clinical pipeline, with a focus on IPF research commitment • Investigating pre-clinical imaging approaches translatable to the clinical setting (e.g. microCT, microPET) withsharing of examples from our internal research Simona Spennato Head of Nonobstructive Disease Unit, Global Clinical Development, R&D Chiesi AGENDA 10.00 | 7.00 8 SPEAKERS Cara Williams Vice President & Head of Preclinical Biology: Inflammation & Immunology Research Unit Pfizer Advancing Therapies for Inflammatory & Progressive Fibrosing ILDs March 7-9, 2022 | Digital 8.30 - 5.00 EDT | 5.30 - 2.00 PDT WELCOME Conference Day One Tuesday, March 8 Revealing Supportive Care & Symptom Management for ILD Treatment 1.30 | 10.30 Farrell Simon Vice President and Head of US Marketing Trevi Therapeutics Exploring the Impact & Importance of Quality of Life on the Patient Journey • What is the importance of inclusion of QoL measures in ILD trials? • How to choose meaningful QoL measures? • What are the linkages between QoL measures and impact on reimbursement? 2.00 | 11.00 Peter Fernandes Vice President & Chief Regulatory, Quality & Safety Officer Bellerophon Therapeutics • Robust clinical endpoints should be able to measure a clinically meaningful improvement in the disease being treated, that is sensitive and reproducible • Composite endpoints are gaining increasing use as they incorporate multiple domains of disease progression, enabling more events captured in a shorter period. But which ones to include that are realistic and achievable is open to debate • The recent introduction of a single phase 3 endpoint for improvement in physical activity using accelerometry has been gaining acceptance. Experience with both the composite or single (old or new) will be discussed 2.30 | 11.30 Exploring Endpoints in the Context of Inflammatory ILDs: Debating Which Factors You Must Measure to Accurately Assess the Efficacy of Treatment in Inflammatory vs Fibrotic ILDs • Learning how to distinguish which endpoints to use for fibrotic vs inflammatory ILDs • How to effectively utilize endpoints to measure treatment efficacy in interstitial lung disease • Exploring challenges associated with utilizing endpoints for ILDs in 2022 and beyond 3.00 | 12.00 Afternoon Break & Networking 4.00 | 1.00 Machine Learning & Interstitial Lung Disease: A Deep Dive • Understanding how machine learning can be utilized to inform respiratory drug development • Exploring computer-aided image analysis, machine learning and computer vision for interstitial lung disease • Looking into the crystal ball: Uncovering the future of imaging for ILDs PARTNER WITH US Innovative Imaging for Interstitial Lung Disease Simon Walsh Consultant Thoracic Radiologist, Machine Learning Scientist & Imaging Chair Imperial College London AGENDA Elizabeth Renzoni Consultant Respiratory Physician, Honorary Senior Lecturer Imperial College London Devising & Developing Composite Endpoints Which are Realistic & Achievable to Use in Your Next Clinical Trial SPEAKERS Exploring Endpoints for Clinical Trials Discovering Lumping vs Splitting Through a Wider Lens 4.30 | 1.30 • Understanding the difference between targeted therapies and more broadly antifibrotic approaches • How to evolve biomarkers in applying splitting strategies • Lumping as a means to speed up patient recruitment 5.00 | 2.00 9 +1 617 455 4188 @ End of Conference Day One info@hansonwade.com www.ild-summit.com REGISTER YOUR PLACE Martin Kolb Professor McMaster University Scrutinizing the Practicalities of Deciding When to Lump or Split in the Context of Disease Progression in Order to Inform & Optimize Your ILD Drug Development Strategy Advancing Therapies for Inflammatory & Progressive Fibrosing ILDs March 7-9, 2022 | Digital 8.30 - 5.30 EDT | 5.30 - 2.30 PDT WELCOME Conference Day Two Wednesday, March 9 Uncovering the Clinical Research Propelling ILD Drug Development Forwards in 2022 & Beyond Registration & Networking 8.55 | 5.55 Chair’s Opening Remarks 9.00 | 6.00 Strategically Leveraging ILD Clinical Trials to Further Our Understanding of The Progressive Pulmonary Fibrosis Phenotype & Identify Novel Outcomes in Clinical Trials Craig Conoscenti Medical Expert ILD Respiratory Clinical Development & Medical Affairs Boehringer Ingelheim • Looking at previous clinical studies to understand primary, secondary and exploratory outcomes and how these may help to better characterize the progressive phenotype • Looking at response rates of differing ILD diagnosis’ within previous clinical trials in patients with the progressive phenotype • Investigating previous exploratory/new composite outcomes and understanding how to use them in new clinical trails given the existing standard of care 9.30 | 6.30 Looking Beyond IPF: Utilizing Lessons Learned from IPF Clinical Trials to Inform & Optimize Your ILD Trial Design & Execution • Discussing the applicability of extrapolating data from IPF to other disease • Defining which ILD states are most believable to lump together with IPF • Evaluating criteria used to lump and split, spotlight on CT imaging, clinical characteristics, lung limited disease and more 10.00 | 7.00 Majd Mouded Executive Director Novartis Uncovering Trial Design Considerations in Sarcoid • Investigating the complexities of Sarcoid trial design • Examining CMK-389 in sarcoid • Gaining a high level overview of clinical trial design and execution 10.30 | 7.30 Speed Networking 11.00 | 8.00 Morning Break & Networking AGENDA Eric White Senior Clinical Program Lead Boehringer Ingelheim SPEAKERS 8.30 | 5.30 Uncovering Emerging ILD Therapeutic Approaches Vanessa Neins Senior Scientist - Biology Lead Respiratory Pieris Pharmaceuticals 10 +1 617 455 4188 12.00 | 9.00 Lunch Break & Networking 1.00 | 10.00 Single vs Multiple Benefit Drugs for ILD • Is it better to have a single target with multiple benefits? • Investigating GSNOR inhibition • Exploring single targets with no known safety issues 1.30 | 10.30 Update on Inhaled Drug Delivery: The Application of Anticalins in the Treatment of Lung Fibrosis • Highlighting the benefits of local intervention via inhalation versus systemic administration • Inhaled Anticalin antagonists for respiratory disease • Reviewing the development of PRS-220, a potential best-in-class, inhaled CTGF inhibitor for the treatment of IPF @ info@hansonwade.com www.ild-summit.com REGISTER YOUR PLACE Matt Bradley Founder, Chairman, President, and Chief Technical Officer SAJE Pharma Developing Therapies for Rare Lung Diseases: ILD 101 • Discovering VP01 (C21) for interstitial lung disease • Outlining our therapeutic approach for interstitial lung disease – how we strategized our ILD drug development • Exploring challenges associated with ILD drug development and learning how to overcome them PARTNER WITH US 11.30 | 8.30 Rohit Batta Chief Scientific Officer Vicore Pharma Advancing Therapies for Inflammatory & Progressive Fibrosing ILDs March 7-9, 2022 | Digital 8.30 - 5.30 EDT | 5.30 - 2.30 PDT WELCOME Conference Day Two Wednesday, March 9 Analyzing & Scrutinizing ILD Mechanisms 2.00 | 11.00 Evolution of Multicellular Hubs in the Tumor Microenvironment & their Relevance for ILD Drug Development • Investigating fibroblasts as drivers of fibrotic indications for lung diseases • Exploring tools/pharmacologic agents to target fibrotic pathways/ inflammatory pathways • Understanding the similarities and differences between cellular interactions and molecular pathways in cancer and ILDs 2.30 | 11.30 The Role of Macrophage Metabolic Reprogramming During Pulmonary Fibrosis • Macrophages play a key role in the pathogenesis of IPF, but the role of macrophage metabolism is not well understood. • We have found that macrophages in IPF are metabolically reprogrammed with alterations in iron (Allden et al, AJRCCM 2019), glycolysis (McErlean et al, AJRCCM 20201) and TCA cycle (Ogger et al, Science immunology 2020) pathways • Macrophage metabolism therefore represents an exciting therapeutic target in IPF Adam Byrne Professor Imperial College London 3.00 | 12.00 Afternoon Break & Networking Nicolas Guisot Research Fellow & Project Leader Redx Pharma Selective Inhibition of ROCK2: Promising Approach to Target Fibrosis • Understand the rationale for ROCK2 in lung fibrosis • Assess the development of RXC007, a highly selective ROCK2 inhibitor • Review preclinical studies in rodents and in Human Precision Cut Lung Slices (PCLS) 4.30 | 1.30 • Examine interactions between injury repair cascade and fibrosis in IPF/ILD • Evaluate druggability of pathways which target lung epithelial injury, repair and regeneration • How to kickstart your ILD drug discovery program 5.00 | 2.00 Chair’s Closing Remarks 5.05 | 2.05 End of Conference Day Two University of Oxford 11 +1 617 455 4188 @ info@hansonwade.com www.ild-summit.com REGISTER YOUR PLACE Excellent panel of speakers, thought provoking discussions PARTNER WITH US Glenn Rosen Chief Scientific Officer Optikira & Biomotiv Revealing What Steps You Must Take to Successfully Identify & Validate Novel ILD Therapeutic Targets which Target Lung Epithelial injury AGENDA Strategizing New Target Identification for Novel Therapies 101 4.00 | 1.00 SPEAKERS Shannon Turley Vice President of Cancer Immunology Discovery Genentech An Interactive Online Experience Advancing Therapies for Inflammatory & Progressive Fibrosing ILDs March 7-9, 2022 | Digital WELCOME The Digital 2nd ILD Summit will provide industry’s best opportunity for knowledge exchange and networking to ensure you don’t miss out on timely scientific insights, data, and key lessons learned whilst variants and vaccines remain a concern. Join your peers on our evolving and improving platform, and immerse yourself in the industry’s most comprehensive ILD drug development conference without the risk of having to isolate in the spring! SPEAKERS Our virtual platform has been upgraded for 2022 and has been specifically tailored to facilitate personal online interactions and streamlined content to support ILD drug sponsors from target identification through to regulatory approval, so you can make strategic decisions, overcome critical challenges and accelerate pipeline success Key Features & Functionalities: Delegate Profile Set up personalized profiles to easily identify the name, job title and company of other attendees Sessions Area Most presentations will be delivered in the ‘Stage’ area, much like the main conference room onsite Smaller groups can get together in this breakout area for panel discussions and other interactive sessions Chat Rooms Visit the virtual exhibition area to explore the solutions our specialist vendors have on offer Connect with your peers and start conversations with individuals or all attendees in private and public chatrooms Speed Networking This virtual networking session will connect you with other attendees to establish new industry contacts AGENDA Demo Area Stage Area What You Can Expect from a Digital Event: 2+ Hours of Networking Join smaller, informal group chats or video calls designed to spark crucial conversations around key challenges for the industry Facilitated and informal networking breaks will allow you to connect 1-2-1 with other attendees and kick start critical discussions Content Available Post-Event On conclusion of the event, presentations will be made available to attendees where possible If you have any other questions about the platform, please get in touch via info@hansonwade.com 12 +1 617 455 4188 @ info@hansonwade.com www.ild-summit.com REGISTER YOUR PLACE Ask your burning questions directly to our expert speakers in real-time, just as you would at a physical conference Audience Discussions PARTNER WITH US Live Q&As with Speakers Why Partner? March 7-9, 2022 | Digital WELCOME Proud to Partner With: The trailblazing 2nd ILD Summit is no doubt your best opportunity to meet and develop lasting relationships with organizations specifically seeking solutions in developing therapies against inflammatory and fibrotic interstitial lung disease. We understand every business is different and have the expertise to create a bespoke package to align with your commercial strategy. Get in touch today learn more about our exclusive partnership opportunities to accelerate the process of establishing your business as thought leaders and foster long-term partnerships with fast growing ILD drug development companies today! Attending Seniority Breakdown from ILD Summit from 2021 5% 25% 5% C-level Attending Companies Breakdown from ILD Summit from 2021 20% Executive Vice President Pharma & Biotech Senior Director Academics Head / Project Team Leader 30% 15% 80% Principal / Senior Scientist AGENDA 15% SPEAKERS Capitalize on our audience of highly engaged pulmonary fibrosis experts and proudly showcase your company, your brand, and your services in front of the largest gathering of senior decision makers in the ILD drug development space this year. Professor *Based ILD Summit from 2021 *Based ILD Summit from 2021 Hanson Wade did a phenomenal job! Definitely the most productive conference so far this year regarding the number of leads and quality of networking opportunities PARTNER WITH US Snapshot of Attending Companies in the Fibrosis Event Series Vitalograph, IPF Summit Partner 13 +1 617 455 4188 @ info@hansonwade.com www.ild-summit.com REGISTER YOUR PLACE Interested in becoming a partner? Nicholas Ramovic Senior Partnerships Manager - Fibrosis Tel: +1 617 455 4188 Email: sponsor@hansonwade.com Ready to Register? www.ild-summit.com/take-part/register Tel: +1 617 455 4188 Email: register@hansonwade.com Conference Only Service Provider Pricing Conference Only Academic Pricing Conference & Investigating Inhaled Drug Delivery Day Conference & Exploring Biomarkers for ILD Clinical Trials Workshop On the Door Price $2,647 (save $300) $2,947 $2,398 (save $300) $2,698 $1,799 (save $300) $2,099 Register & Pay By Friday, January 14 On the Door Price $3,097 (save $400) $3,497 $2,828 (save $400) $3,228 $2,199 (save $400) $2,599 Register & Pay By Friday, January 14 On the Door Price $2,097 (save $300) $2,397 $1,888 (save $300) $2,188 $1,399 (save $300) $1,699 * Please note: If you are a UK or EU-based company, you may be subject to 20% VAT in addition to the price advertised. If you qualify for a reverse charge, you will have the option to provide your VAT number and the charge will be automatically deducted at checkout. *You must currently be developing drug candidate/s publicly (evidence on company website required). ** Reduced rates are available for full-time academics and startups (established for 5 years or less) and are subject to the organizer’s approval, please get in touch at info@hansonwade.com for more information. Team Discounts* To qualify for group discounts, all passes must be purchased at the same time. Group discounts will automatically be applied at checkout if registering online. A customer service representative will be in touch within one working day to confirm your registration. Email info@hansonwade.com for more information on eligibility criteria. T&Cs apply. TERMS & CONDITIONS Full payment is due on registration. Cancellation and Substitution Policy: Cancellations must be received in writing. If the cancellation is received more than 14 days before the conference attendees will receive a full credit to a future conference. Cancellations received 14 days or less (including the fourteenth day) prior to the conference will be liable for the full fee. A substitution from the same organization can be made at any time. 14 +1 617 455 4188 @ Changes to Conference & Agenda: Every reasonable effort will be made to adhere to the event programme as advertised. However, it may be necessary to alter the advertised content, speakers, date, timing, format and/or location of the event. We reserve the right to amend or cancel any event at any time. Hanson Wade is not responsible for any loss or damage or costs incurred as a result of substitution, alteration, postponement or cancellation of an event for any reason and including causes beyond its control including without limitation, acts of God, natural disasters, sabotage, accident, trade or industrial disputes, terrorism or hostilities.tage, accident, trade or industrial disputes, terrorism or hostilities. info@hansonwade.com www.ild-summit.com Data Protection: The personal information shown and/or provided by you will be held in a database. It may be used to keep you up to date with developments in your industry. Sometimes your details may be obtained or made available to third parties for marketing purposes. If you do not wish your details to be used for this purpose, please write to: Database Manager, Hanson Wade, Suite A, 6 Honduras Street, London EC1Y 0TH REGISTER YOUR PLACE • 10% discount – 3 Attendees • 15% discount – 4 Attendees • 20% discount – 5 or more Attendees PARTNER WITH US Conference Only Register & Pay By Friday, January 14 AGENDA Conference & Investigating Inhaled Drug Delivery Day Conference & Exploring Biomarkers for ILD Clinical Trials Workshop Compare and contrast fibrotic and inflammatory ILDs in order to comprehensively understand key differences in their development and progression, and learn how this influences drug development SPEAKERS Conference & Investigating Inhaled Drug Delivery Day Conference & Exploring Biomarkers for ILD Clinical Trials Workshop Uncover anticalins, GSNOR’s and other emerging therapeutics to inspire and revive your therapeutic approach to treat ILD more successfully Learn how to use biomarkers to distinguish patients with fibrotic vs inflammatory ILD in order to strategically stratify trial populations and maximize trial efficiency Secure Your Place Now Drug Developer Pricing March 7-9, 2022 | Digital WELCOME 3 Easy Ways To Book Advancing Therapies for Inflammatory & Progressive Fibrosing ILDs