Gene Mutations
1. A geneticist found that a particular
mutation had no effect on the protein
coded by a gene. These mutations are
called silent mutations, because the protein
created will stay the same.
2. A point mutation is when one base is
substituted for another (substitution). This
type of mutation would NOT change the
remaining bases.
3. A frameshift mutation is when a base
is either added (Insertion) or deleted
(deletion). This type of mutation changes
the remaining order of the bases.
4. Do you think a point mutation or a
frameshift mutation would be more
harmful to the organism? Why?
Directions: Analyze the DNA sequences below. Highlight the location of the mutation and answer the
questions. REMEMBER: 3 types of mutations are insertion, deletion and substitution.
1.
Original DNA Sequence:
Mutated DNA Sequence:
AAT TAA CCG CCC
AAT TAA CCA CCC
What type of mutation is the mutation above?
_________________________________
Is the mutation a point or a frameshift mutation?
_________________________________
2.
Original DNA Sequence:
Mutated DNA Sequence:
AAA TTC CCG GGG
AAA TTG CCC GGG
What type of mutation is the mutation above?
_________________________________
Is the mutation a point or a frameshift mutation?
_________________________________
3.
Original DNA Sequence:
Mutated DNA Sequence:
AAT TAA CCG CCC
AAT TAA CCG CTC
What type of mutation is the mutation above?
_________________________________
Is the mutation a point or a frameshift mutation?
_________________________________
4.
Original DNA Sequence:
Mutated DNA Sequence:
TTT CCC GGC TTC
TTC CCG GCT TCA
What type of mutation is the mutation above?
_________________________________
Is the mutation a point or a frameshift mutation?
_________________________________