Depth Filtration Normal Semi Depth Depth Type of Filter Depth Filter : • commonly used to remove high dirt contamination, such as for the first filtration process. • Pall’s Depth Filter provide a wide range of pore size that would be compatible for a broad spectrum of sample. The membrane of filter can be double or single layer, but for the better performances we suggested to used double layer. • The membrane is thicker than the “normal” filter. Type of Depth Modules Sheets Typical Depth Sheet Filter Materials Cellulose fibres extremely fine three dimensional sieve large internal surface area (void volume of 70-85 %) Filter aid Diatomaceous earth permeable, fine matrix Perlite - bulky, flaky particles Microfine cellulose Synthetic polymer positive zeta potential wet strength Trial Filter Format Scale-Up Filter Format Double Layer SUPRAdisc HP Graded Sheets Combination Media Type Top sheet – bottom sheet Application PDK5 K 900 P - K100P Post Fermenter PDH4 K 700 P - KS 50 P Post Fermenter PDE2 K 100 P - EKM-P Post Centrifuge PDD1 KS 50 P – EKS-P Post Centrifuge / Post TFF Top sheet - Coarse grade Bottom sheet - Fine grade Drainage plate Bottom sheet - Fine grade Top sheet - Coarse grade