Cardiovascular Decreased cardiac output. Increased heart rate, contractility, arterial and venous vasoconstriction, and shunting to vital organs. SBP ≤ 90 mm Hg. Prolonged capillary refil. Neurological Change in level of consciousness Pulmonary Due to cardiovascular changes, and thirdspacing of fluid, oxygen therapy may be required. Monitor for PE. Limit myocardial oxygen demand. Renal Activation of the renin response, retention of sodium and water. Stimulation of the anterior pituitary and adrenal glands with ATCH released to raise blood sugar and release of catecholamines. Urinary output diminished or absent Haematological Switch to anaerobic metabolism with increased lactic acid production – elevated serum lactate. Base deficit. Serum creatinine elevated. Third-spacing of fluid. Gastrointestinal Increased oedema in the intestines, Third-spacing of fluid.