HALLUCINOGEN DRUGS PHARMACHOLOGY OF DRUGS (ABD 7153) FADILLA HANIM ARIFF (3191168) SUBASHINI RAMACHANDRAN (2191175) MAJIDAH MAT JUSOH (3191174) Our Topics TABLE OF CONTENTS Section 1 Section 2 Section 3 Asma’ Ahmad • • • Aqli & Naqli Introduction Conclusion Noor Azleen bt Yusop • • MECHANISM OF ACTION DISCUSSION Ahmad Syariffuddin Sarmin • Types Of Drug Uthaya Kumar a/l Paramasiwan • The Effect Of Drug Section 4 Credits Aqli & Naqli Introduction History Section 1 NAQLI EVIDENCES • Islam is a monotheistic religion based on revelations to the Prophet Muhammad 1400 years ago, which were recorded in the sacred Quran (Koran). • The word Islam in Arabic means “submission,” reflecting the central core of Islam, which is the submission to the will of God. • The Qur’an is reticent regarding drug use, although it discusses intoxicants (Khamr) and, more specifically, alcohol. • Any discussion on narcotics and addictions must start from the Qur’an, since it is the foundation of Islamic law, ethics, and theology. • Alcohol is prohibited in the Qur’an for recreational reasons; the Qur’an calls alcohol the “Handiwork of Satan” . NAQLI EVIDENCES The ban on drugs is compared to the ban on alcohol. Allah says: You who believe, intoxicants (khamr) and gambling, idolatrous practices, and (divining with) arrows are repugnant acts—Satan’s doing—shun them so that you may prosper. With intoxicants and gambling, Satan seeks only to incite enmity and hatred among you, and to stop you remembering God and prayer. Will you not give them up? (al-Ma’ida 5:90–91). WHAT DOES THE QUR’AN SAY ABOUT DRUGS AND OTHER FORMS OF INTOXICANTS? Some, such as the translator, Abdel Haleem, are of the opinion that the use of the word “Khamr”(alcohol/intoxicant) in the Qur’an is a composite term. Which includes all forms of intoxicants, despite the fact that the specific contexts in which the three verses were being discussed relate to alcohol drinking. Al-Tabari (d. 923) writes that “Khamr” is every drink that intoxicates the mind, veils it, and covers it . WHAT DOES THE QUR’AN SAY AND PROPHET MUHAMMAD SAW (PBUH) SAID ABOUT DRUGS AND OTHER FORMS OF INTOXICANTS? This argument is further strengthened by the words of the Prophet SAW. Meaning: Abu Burda reported from his father that Abu Musa al-Ash‘ari said that the Prophet (blessings and peace of Allah be upon him) had sent him to Yemen and he asked the Prophet about (alcoholic) drinks which used to be prepared there. The Prophet said: “What are they?” Abu Musa said: ‘al-Bit’i and al-Mizr.’ I (the narrator) said to Abu Burda: ‘What is al-Bit’i?’ He said: ‘al-Bit is an alcoholic drink made from honey, and alMizr is an alcoholic drink made from barley.’ The Prophet said: “Every intoxicant is Haram.” (Reported by al-Bukhari) TERMINOLOGIES Al-Bit`i: Al-Bit`i is a kind of intoxicants made from fermented honey and water in Yemen. In other words, it means honey wine or mead. Al-Mizr: Al-Mizr is an alcoholic drink made from fermented barley and water in Yemen. It is a kind of beer. From the Islamic point of view, despite the various names given to wine (inebriant, beer, whisky, scotch, port, rum, booze, champagne, etc.), all are considered alcoholic drinks or intoxicants. Thereupon, according to sound Hadith, “Every intoxicant is Khamr (wine), and every Khamr is Haram (forbidden).” (Muslim). “Wine is that which befogs the mind.” (Muslim) In simple words, the word Khamr (wine) in Arabic extends to any substance, which intoxicates, in whatever form or under whatever name it may appear. GUIDANCE AND MORALITIES This Prophetic Hadith constitutes a rule concerning prohibition of all kinds and forms of intoxicants, which befog the mind.Thus, becoming intoxicated causes mental disorder, which might drive one to commit some hostile acts against others, against their physical well-being or against their wealth. Khamr (Wine) is the mother of all evils. If one drinks it too much, one may kill, commit Zina or disbelieve in Allah. Khamr hinders people from remembering Allah and from all kinds of devotions, since it clouds one’s intellect and consciousness. Here, to consolidate the above-named concepts, it is important to record some Hadith that shed more light on this issue: 1- “Every intoxicating drink is forbidden.” (Al-Bukhari and Muslim) 2- “Allah’s Messenger prohibited each and every thing that induces drunkenness and mental numbness.” (Abu Dawood) View Of Islamic Scholars The 76th National Fatwa Committee on Islamic Religious Affairs (Committee of MKI) held on November 21-23, 2006 discussed Shabu and other types of drug abuse. The chemist has ruled that shabu and other newtype drugs have the same harmful effects as ecstasy, katamine and Gamma Hyroxybutyric Acid (GHB). Therefore, the drug abuseprohibited. of shabu and other new drugs is ILLEGAL and all activities related to drug abuse such as cultivating, processing, selling, distributing, buying or allowing premises to be used in abusive use are also General Knowledge • The Abbasid Caliphate of Baghdad enjoyed a long period of intellectual experimentation that lasted throughout the 10th and 11th centuries. • The extraordinary Ibn Sina, known in the West as Avicenna. • Already a doctor at age 18, his great volume Al-Qanun fi al-Tibb—Canon of Medicine—became one of the most famous medical works of all time, and an extraordinary exercise in the bringing together of different disciplines and cultures. Introduction of hallucinogenic drugs: 1 When under the influence of either type of drug, people often report rapid, intense emotional swings and seeing images, hearing sounds, and feeling sensations that seem real but are not. 4 The word “hallucination” itself was introduced into English Language from the derivation of the Latin word “alucinari” meaning to wander in mind. There are also other types of things that will effect to hallucinations – glue. Hallucinogens are a class of drugs that cause hallucinations. Hallucinogens 3 The word “hallucination” itself was introduced into English Language from the derivation of the Latin word “alucinari” meaning to wander in mind. 2 VIDEO HISTORY HALLUCINOGEN DRUGS AND THE SOURCES OF HALLUCINOGENS VIDEO THE USE OF HALLUCINOGEN DRUGS In Malaysia, hallucinogen is a scheduled medication under the control of the Ministry of Health. The drugs disable the brain's "filtering" ability to selectively prevent certain perceptions, emotions, memories and thoughts from ever reaching the conscious mind. DELIRIANTS (RARELY USED) DESSOCIATIVES PSYCHEDELICS (MOST POPULAR CLASSES OF HALLUCINOGEN DRUGS The drugs produce a sense of detachment from the surrounding environment, Dissociative symptoms include the disruption or compartmentalization of the usually integrated functions of consciousness, memory, identity or perception. Types of hallucinogenic drugs: PSYCHEDELICS DRUGS : LSD Albert Hofmann, a Swiss chemist working at the Sandoz pharmaceutical research laboratory, accidentally consumes LSD-25, a synthetic drug he had created in 1938 as part of his research It is synthetically made from lysergic acid, which is found in ergot, a fungus that grows on rye and other grains. 모바일 이미지 LSD is produced in crystalline form and then mixed with other inactive ingredients, or diluted as a liquid for production in ingestible forms. It is odorless, colorless and has a slightly bitter taste. LSD has a high potential for abuse PSYCHEDELICS DRUGS : LSD PSYCHEDELICS DRUGS : FORM OF LSD blotter paper (LSD soaked onto sheets of absorbent paper with colorful designs; cut into small, individual dosage units) - the most common form thin squares of gelatin (commonly referred to as window panes) tablet form (usually small tablets known as Microdots) or capsules liquid on sugar cubes . pure liquid form (may be extremely potent) PSYCHEDELICS DRUGS : LSD Route Of Administration Swallowing as tablets or pills, blotter paper Swallowing as liquid Inhale through the nose (snort) Injecting PSYCHEDELICS DRUGS : Psilocybin (Psilocin) Psilocybin (4-phosphoryloxy-N,Ndimethyltryptamine) and psilocin are chemical compounds obtained from certain types of dried or fresh hallucinogenic mushrooms found in Mexico, South America and the southern and northwest regions of the United States. There are over 180 species of mushrooms that contain the chemicals psilocybin or psilocin. 모바일 이미지 Both psilocybin and psilocin can also be produced synthetically in the lab. "Magic Mushrooms" have long, slender stems which may appear white or greyish topped by caps with dark gills on the underside. Dried mushrooms are usually a reddish rust brown color with isolated areas of off-white. Psilocybin has a bitter, unpalatable taste. PSYCHEDELICS DRUGS : Psilocybin (Psilocin) Street Name PSYCHEDELICS DRUGS : Form of Psilocybin Raw Dried Liquid Capsule Brewed in tea PSYCHEDELICS DRUGS : Psilocybin Route of Administration Consuming raw or dried Brewing into tea Swallowing as tablets or pills PSYCHEDELICS DRUGS : Mescaline Mescaline is a psychedelic hallucinogen obtained from the small, spineless cactus Peyote (Lophophora williamsi). It is also found in certain members of the Fabaceae (bean family) and can be produced synthetically. People have used hallucinogens for hundreds of year, mostly for religious rituals or ceremonies. Mescaline leads to rich visual hallucinations. 모바일 이미지 Mescaline is used primarily as a recreational drug and is also used to supplement various types of meditation and psychedelic therapy. It is classified as a schedule I drug in the U.S., making it illegal in all forms (including peyote); however, it remains legal in certain religious ceremonies PSYCHEDELICS DRUGS : Mescaline Street Name Big Chief Blue Caps Buttons Cactus Mescal Moon San Pedro Topi PSYCHEDELICS DRUGS : Form of Mescaline The top of the cactus above ground, or the crown, consists of disc-shaped buttons that are cut from the roots and dried. These buttons are generally chewed or soaked in water to produce an intoxicating tea. It can be consumed raw or dried but is extremely bitter. powder Capsule PSYCHEDELICS DRUGS : Mescaline Route Of Administration Swallowing as tablets or pills Swallowing as liquid Brewing into tea smoked with marijuana and tobacco. DESSOCIATIVES DRUGS : Ketamine Ketamine is an injectable and shortacting anesthetic in veterinary medicine and is used for some surgical procedures in humas. An anesthetic is technically a drug that results in a total or partial loss of sensation (importantly to pain) as well as the potential loss of consciousness. It is considered a “Club Drug” like ecstasy, and it has been abused as a date-rape drug. 모바일 이미지 Its chemical designation, dl 2-(0chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. In actuality, the formula for synthesizing ketamine entails a series of intricate steps that only the manufacturers of the drug can carry out. ketamine essentially “disconnects” the brain from the body’s sensations. The drug’s hallucinogenic effects stem from the expanded awareness that results when the brain no longer has to process incoming information from the body. KETAMINE: BASIC FACTS Active via the intravenous, intramuscular, subcutaneous, oral, rectal, topical, intranasal, sublingual, epidural and caudal routes AN ANALGESIC AN ANESTHETIC AND SEDATIVE For hemodynamically stable patients Preserves reflexes tends to reduce aspiration risk A key veterinary anesthetic A potent antidepressant that can induce a laboratory model of schizophrenia DESSOCIATIVES DRUGS : Form of Ketamine Ketamine is a white/transparent when pure, and often sold as a powder of tiny crystals. It is often crushed into a fine powder so it can be snorted up the nose. Occasionally the powder can be other colours, such as off-white or brown. Tablet pill Liquid DESSOCIATIVES DRUGS : Ketamine Route Of Administration Swallowing as tablets or pills Swallowing as liquid Inhale through the nose (snort) Injecting DESSOCIATIVES DRUGS : Phencyclidine (PCP) Phencyclidine (PCP) is a mindaltering drug that may lead to hallucinations (a profound distortion in a person’s perception of reality). 모바일 이미지 PCP was developed in the 1950s as an intravenous anesthetic, but due to the serious neurotoxic side effects, its development for human medical use was discontinued. It is considered a dissociative drug, leading to a distortion of sights, colors, sounds, self, and one's environment. DESSOCIATIVES DRUGS : PCP Street Name DESSOCIATIVES DRUGS : Form of PCP Liquid Tablet powder Capsule DESSOCIATIVES DRUGS : PCP Route Of Administration taken orally as tablets or pills For smoking, PCP is typically sprayed onto leafy material such as mint, parsley, oregano, or marijuana. Inhale through by the intranasal route ("snorted"). Injecting OTHER HALLUCINOGEN DRUGS : MDMA (Estacy) • 3,4-methylenedioxy-methamphetamine (MDMA) is a synthetic drug that alters mood and perception (awareness of surrounding objects and conditions). • It is chemically similar to both stimulants and hallucinogens, producing feelings of increased energy, pleasure, emotional warmth, and distorted sensory and time perception. • MDMA was initially popular in the nightclub scene and at all-night dance parties ("raves"), but the drug now affects a broader range of people who more commonly call the drug Ecstasy or Molly. • Some people take MDMA in combination with other drugs such as alcohol or marijuana. • In addition, because MDMA can promote trust and closeness, its use—especially combined with sildenafil (Viagra®)—may encourage unsafe sexual behavior. OTHER HALLUCINOGEN DRUGS : DMT(N,N-dimethyltryptamine) • DMT — or N, N-dimethyltryptamine in medical talk — is a hallucinogenic tryptamine drug. Sometimes referred to as Dimitri, this drug produces effects similar to those of psychedelics, like LSD and magic mushrooms. • DMT naturally occurs in many plant species, which have been used in religious ceremonies in some South American countries for centuries. • It can also be made in a laboratory. • DMT is the main active ingredient ayahuasca. • Ayahuasca is traditionally prepared using two plants called Banisteriopsis caapi and Psychotria viridis. The latter contains DMT while the former contains MAOIs, which prevent certain enzymes in your body from breaking down DMT. Street Name • fantasia • businessman’s trip • businessman’s special • 45-minute psychosis • spiritual molecule OTHER HALLUCINOGEN DRUGS : Salvia Divinorum • Salvia, or Salvia divinorum, is an herbal mint plant and a naturally occurring hallucinogen that is native to Mexico. • It is a member of the sage family. People use it as a recreational drug. • Salvia has become popular as a recreational drug among adolescents and young adults. It is fast acting and thought to have a low incidence of side effects. • Also, it has a low addiction potential, people can easily obtain it, and they do not consider it highly toxic. • Mazatec Indians have used salvia for centuries for spiritual divination, shamanism, and medical practices. Street Name • Diviner’s sage • Maria pastora • Ska pastora • hierba (yerba) Maria • Sally-D • Magic Mint • Shepherdess’s herb • Leaf of Prophecy • Lady Salvia • Lady Sally • Sage of the seers • Purple sticky • The female • Incense special OTHER HALLUCINOGEN DRUGS : Synthetic Cathinones : Bath Salts, Bliss, Cloud Nine, Flakka, Lunar Wave, Scarface, Vanilla Sky, White Lightning GHB (gamma-Hydroxybutyric) : Date Rape Drug, G, Geeb, Georgia Home Boy, Gina, Goop, Grievous Bodily Harm, Liquid E, Liquid X, Scoop Khat : Abyssinian Tea, African Salad, Catha, Chat, Kat, Oat, Qat Kratom : Biak-biak, Herbal Speedball, Ithang, Kahyam, Ketum, Thom Dextromethrophan (DXM) Methoxetamine (MXE) Marijuana Nitrous oxide OTHER HALLUCINOGEN DRUGS : DELIRIANTS (RARELY USED) ATROPINE SCOPOLAMINE (HYOSCINE) DIPHENHYDRAMINE (BENADRYL) OTHER HALLUCINOGEN DRUGS : DELIRIANTS (RARELY USED) Deliriants are a class of psychoactive drug that generally block the neurotransmitter acetylcholine from binding to receptors in the brain and central nervous system. While users of psychedelics and dissociatives often report having euphoric, spiritual experiences, users of deliriants almost universally report unpleasant effects and have no desire to use these drugs again. Despite the fully legal status of several common deliriant plants and drugs, substances which fall under this class are largely unpopular as recreational drugs due to the severe and unpleasant nature of the hallucinations produced. As recreational drugs, deliriants produce vivid and generally very unpleasant hallucinations in addition to potentially dangerous side-effects, even at lower dose Certain deliriants are poisonous and can cause death due to tachycardia-induced heart failure and hyperthermia even in small doses In addition it also has high potential in dangerous mental effects (accidents during deliriant experiences are common) ATROPINE Atropine is used to help reduce saliva, mucus, or other secretions in your airway during a surgery. Atropine is also used to treat spasms in the stomach, intestines, bladder, or other organs. Atropine is sometimes used as an antidote to treat certain types of poisoning. Other Names: Daturi SCOPOLAMINE Scopolamine is used to prevent nausea and vomiting caused by motion sickness or from anesthesia given during surgery. Scopolamine is also used to treat certain stomach or intestinal problems, muscle spasms, and Parkinson-like conditions. Scopolamine may also be used for purposes not listed in this medication guide. DIPHENHYDRAMINE Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes/nose/throat, cough, runny nose, and sneezing. It is also used to prevent and treat nausea, vomiting and dizziness caused by motion sickness. FORM OF HALLUCINOGEN DRUGS FORM TYPE OF DRUG LSD Psilocybin Mescaline Ketamine PCP MDMA √ √ √ Powders Gelatine Capsules √ √ √ √ Raw & Dried √ Salvia √ Tablets and pills Liquid forms √ DXM √ √ √ √ √ √ √ √ √ √ √ HALLUCINOGEN DRUGS: MECHANISM OF USE MECHANISM OF USE TYPES OF DRUGS LSD Swallowing as tablets or pills X Swallowing as liquid X Psilocybin Mescaline Ketamine X Consuming raw or dried X X X Brewing into tea X X Snorting Injecting Inhaling, vaporizing, or smoking MDMA DXM X X X X X X DMT Salvia X X X PCP X X X X X X X X X REACTION OF HALLUCINOGEN DRUGS DRUG DURATION TO REACT DURATION OF EFFECT LSD 30 to 60 minute 8 to 10 hour PSILOCYBIN 20 to 30 minit 5 to 6 hour MESCALINE 2 to 3 hour more than 12 hour KETAMINE 4 to 24 hour PCP 4 to 6 hour MDMA 3 to 6 hour The mechanism of actions hallucinogenic drugs: The mechanism of actions hallucinogenic drugs: https://study.com/academy/lesson/effectsof-hallucinogenic-drugs-on-the-mindbody.html The mechanism of actions hallucinogenic drugs: Serotonin in the synapse https://youtu.be/4D3IlIcqny4 Psychedelic Drugs and the Serotonergic System 1. Psychedelic drugs have a lot in common with antidepressants. Both work with neurotransmitter serotonin. 2. LSD binds to and activates a specific receptor for the neurotransmitter serotonin. 3. Normally, serotonin binds to and activates its receptors and then is taken back up into the neuron that released it. 4. In contrast, LSD binds very tightly to the serotonin receptor, causing a greater than normal activation of the receptor. 5. Because serotonin has a role in many of the brain’s functions, activation of its receptors by LSD produces widespread effects, including rapid emotional swings, and altered perceptions, and if taken in a large enough dose, delusions and visual hallucinations. How serotonin neurons avoid overstimulation • The brain can’t produce large quantities of serotonin at once • Therefore it doesn’t release large quantities of serotonin at once either. • In fact, serotonergic neurons have multiple ways of up and downregulating their serotonin response in order to maintain balance and protect themselves from overstimulation. Psychedelic drugs MDMA (MethylenedioxyMethamphetamine ) a. First, MDMA enters the neuron via the serotonin transporters (SERT). b. Once inside the neuron, it inhibits the vesicular transporters (VMAT2) which means that serotonin is not neatly packed within the vesicles anymore, but now accumulates within the cytosol. c. Then, MDMA reverses the direction of the SERT, meaning instead of transporting serotonin into the neuron, they now release it into the cleft and deny its reuptake. d. The result is a dramatic increase of serotonin levels in the synaptic cleft which makes the receptors on the postsynaptic membrane go haywire for a few hours. https://www.youtube.com/watch?v=bAmb42zpRls Dessociatives Drugs and the Glutamate Neurotransmitter 1. PCP and functioning glutamate Ketamine of the can affect the neurotransmitter 2. Ketamine binds the NMDA receptor within the ion channel preventing flow of cations through the channel and preventing neuronal activation required for awake state 3. With continued ketamine use, the glutamatergic system tries to compensate by three mechanisms: i. Increased glutamine release from presynaptic terminal ii. Decreased reuptake from synaptic cleft by the ports within the presynaptic membrane and surrounding glial cells iii. Increased number of NMDA receptors 4. When ketamine use is discontinued, the compensatory changes lead to hyperexcitability as there is now an imbalance between excitatory and inhibitory signaling. http://www.jnsci.org/files/html/2017/e450.htm The mechanism of actions hallucinogenic drugs: Summary 1 Psychedelics drugs modifies the normal transmission of serotonin within the central nervous system (CNS). Serotonin is responsible for a multitude of functions in the body, including mood balance and sensory perception. It is often referred to as the “happy chemical” due to its influence on feelings of happiness and wellbeing. . Summary 2 Dissociative drugs work primarily by disrupting the action of glutamate, a neurotransmitter, throughout the brain, thereby affecting the user's perception of pain, responses to environmental stimuli and memory. . THE EFFECTS OF HALLUCINOGENIC DRUGS: The Effects of Hallucinogenic Drugs: Hallucinogenic drugs are substances that distort the perception of objective reality. Under the influence of hallucinogens, the senses of direction, distance, and time become disoriented. These drugs can produce unpredictable, erratic, and violent behavior in users that sometimes leads to serious injuries and death. The effect of hallucinogens can last for 12 hours. Physical Effect increased heart rate and blood pressure sleeplessness and tremors lack of muscular coordination sparse, mangled, and incoherent speech decreased awareness of touch and pain that can result in self inflicted injuries convulsions coma; heart and lung failure Psychological Effect a sense of distance and estrangement depression, anxiety, and paranoia violent behavior confusion, suspicion, and loss of control flashbacks behavior similar to schizophrenic psychosis catatonic syndrome whereby the user becomes mute, lethargic, disoriented, and makes meaningless repetitive movements Everyone reacts differently to hallucinogens--there's no way to predict if you can avoid a "bad trip." Adverse Effects & Toxicity Effect Addiction Amnesia Impaired motor function High Blood Pressure Respiratory Problem Seizures Drowsiness Difficulty Thinking Or Learning Nausea Slurred Speech Numbness Slow Heart Beat Behavioral Changes Toxicity Can cause variety of neurological, cardiovascular, psychiatric, urogenital and abdominal symptoms which are dosedependent and whether ketamine administration was in an latrogenic or illicit context OVERALL EFFECTS OF LSD OVERALL EFFECTS OF PSILOCYBIN (Magic mushrooms) OVERALL EFFECTS OF PCP OVERALL EFFECTS OF KETAMINE HALLUCINOGENIC DRUGS TYPES OF HALLUCINATION TACTILE HALLUCINATION AUDITORY HALLUCINATION VISUAL HALLUCINATION OLFATORY HALLUCINATION VISUAL HALLUCINATION Involves seeing things that are not there. For example, you might see a person who is not in the room or flashing lights that no one else can see. AUDITORY HALLUCINATION Among the most common type of hallucinations. You might hear someone speaking to you or telling you to do certain things. TACTILE HALLUCINATION Involve the feeling of touch or movement in your body. For example, you might feel that bugs are crawling on your skin or that your internal organs are moving around. You might also feel the imagined touch of someone’s hand in your body OLFACTORY HALLUCINATION Involves your sense of smell. You might smell an unpleasant odor when waking up in the middle of the night or feel that your body smells bad when it doesn’t HALLUCINOGEN DRUGS WITHDRAWAL SYMPTOM Infographic Layout Quitting hallucinogens can be difficult, especially if someone experience severe withdrawal symptoms. . The hallucinogen withdrawal timeline varies greatly depending on the person and the type of hallucinogen drug that was used. if someone feels as though they can’t function normally without a hallucinogen drug or they have developed an extreme tolerance to it, PCP is addictive and its use often leads to psychological dependence, craving, and compulsive PCP-seeking behavior Withdrawal normally occurs when a person’s body has become so accustomed to the chemical and psychological effects of a drug that it cannot function without the continued presence of the drug. Despite the bitter taste and relatively low potency, tolerance to mescaline can develop very quickly. This means that someone who uses mescaline no longer gets the same psychedelic effects from their usual dose, so they take more and more mescaline to try and chase the original sensation. FLASHBACK FLASHBACK Physicians now diagnose this condition as hallucinogen persisting perception disorder (HPPD), also known as a flashback. A flashback is a traumatic recall of an intensely upsetting experience. The recollection of this upsetting experience during hallucinogen use would be a bad trip, or a hallucination that takes a disturbing turn. Some individuals experience more unpleasant effects than hallucinations, such as fear, agitation, confusion, delirium, psychosis, and syndromes that resemble schizophrenia BAD TRIP BAD TRIP A bad trip (also known as acute intoxication from hallucinogens, psychedelic crisis, or emergence phenomenon) is a frightening and unpleasant experience triggered by psychoactive drugs, especially psychedelic drugs such as LSD and Psilocybin mushroom. HALLUCINOGENIC DRUGS ABUSE TREATMENT & MANAGEMENT TREATMENT & MANAGEMENT Individual therapy Group therapy Family therapy 12-Step education Relapse-prevention instruction Cognitive Behavioral Therapy (CBT) Dialectical Behavioral Therapy (DBT) Biofeedback & Neurofeedback Medication management Anger management Hypnotherapy Recreation therapy TREATMENT & MANAGEMENT Patient must engage to safety detox programme for prevent self withdrawal symptoms Rehabilitation programs offer this form of therapy, along with other therapies that can moderate withdrawal symptoms, manage chronic health issues, and offer social support to maintain recovery. . 01 02 03 04 Benzodiazepines such as lorazepam and diazepam can alleviate agitation, psychomimetic effects, hypertension, hyperthermia and seizures Cognitive Behavioral Therapy in both individual and group settings has proven very effective at helping people change their behaviors around intoxicating substances TREATMENT DISCUSSION Hallucinogens as Therapeutic Drugs Ayahuasca - to help with addiction, anxiety, and depression. Psilocybin - It is being studied for its use in the treatment of addiction, anxiety, and depression. Psychedelic therapy is a technique that involves the use of psychedelic substances to aid the therapeutic process. Hallucinogenic substances have been used in holistic medicine and for spiritual practices by various cultures for thousands of years. Possible Risks LSD - Potential uses include the treatment of addiction and anxiety. MDMA (ecstasy)-. Research suggests it has therapeutic potential in the treatment of posttraumatic stress disorder (PTSD) Negative psychological reactions Possible personality changes Dangers of selftreatment What Can It Treat? Anxiety and Mood Disorders Alcohol and Substance Use Disorders Post-Traumatic Stress Disorder (PTSD) How Psychedelic Therapy Works Administration of a low to moderate dose of a psychedelic drug. Supervision by a professional during the psychedelic experience. Repeating the psychedelic dose with one to two weeks between sessions. Trend & Use of Hallucinogen Drug In Malaysia : NPS New psychoactive substances (NPS) are drugs which were designed to replicate the effects of illegal substances like cannabis, cocaine and ecstasy As of January 2020, 120 countries and territories have reported to United Nations Office of Drug Control (UNDOC) the emergence of 950 NPS Challenges of NPS o o o o Difficulty of obtaining prevalence data of national NPS data. Difficulty in classifying NPS legal status. Limited laboratory testing capacity Currently no treatment protocols developed. Hallucinogenic drugs is one class of the NPS that were abuse in Malaysia. These drugs mimic substances like LSD and include 25i-NBOMe, BromoDragonfly and the more ketamine-like methoxetamine. NPS can be categorised into the following groups: Synthetic cannabinoids Spice, K2, Kronic, Northern Lights, Kaos Phenethylamines 2C series (2C-E, 2C-B, 2C-I), 4-FMA, NBOMe series (25I, 25C, 25B), PMMA,5-APB, 6-APB, D series (DOI, DOC), benzodifurans (Bromo-Dragonfly) Synthetic cathinones Mephedrone (4-MMC; Meow Meow; M-CAT); Methylone (bk-MDMA); MDPV (Ivory wave); alpha-PVP (‘flakka’) Tryptamines DMT, 5-Meo-DMT, 5-Meo-DPT, AMT, 4-AcO-DMT CONTROVERSY OF FUTURE MUSIC FESTIVAL ASIA 2014 vs APPENDIX Conclusion Section Last “No Single treatment is appropriate for all individuals”NIDA (2009) RELIGIOUS REHABILITATION TREATMENT • Various methods of treatment have been introduced by the government such as : The Cure & Care Service Center (CCSC), the Caring Community House (CCH) and the Narcotics Treatment Center (PUSPEN). • In Malaysia, there are various Islamic drug rehabilation centres. Majority of them used healing verses. • There are definite and obvious data on stress reducing effect of the Quran on various organs of the body, possibly through the central and autonomic nervous systems (Elkadi, 1985). • According to Taharem (2004), spiritual rehabilitation treatment is the best way to address the problem of drug addiction Private bodies also play an important role in helping to reduce drug billing statistics. This is evidenced in the rehabilitation treatment performed at the Pondok Remaja Inabah (PRI), 61% recovered after undergoing a recovery method based on Islamic spiritual methods. This remedial treatment is regulated by the National Agencies Agency (AADK) under the Ministry of Home Affairs (GDP) This rehabilitation treatment utilizes a cottage (Pondok) approach, daily treatment center and treatment center using prayer-based methods, remembrance, bathing repentance and the guidance of the Quran and Fardu Ain. This remedial treatment is based on the Quran and the hadith by incorporating the Sufism method This is further reinforced by the message of Allah Almighty: Meaning: "And we derive from the Quran the healing and mercy of the believers." (al-Israk: 82) Video Referrence : Al-Quran Andrew Batchelder, Charlene Rodrigues, Ziad Alrifai & Adrian G. Staanley. (2019).Farmakologikal Klinikal Pantas, Formula Pelajar. Pernerbit USIM Kamisah Yusof, Norliza Muhammad, Nur Azlina Mohd. Fahami, Qodriyah Mohd Saad , Ahmad Nazrun Shuid, Azman Abdullah & Norazlina Mohamed. (2011). Farmakologi Dadah disalahguna. Penerbit USIM Bertram G. Katzung. (2018). Basic & Clinical Pharmacology, Fourteenth Edition. Mc Graw Hill Education National Drug Policy AKTA PENAGIH DADAH. (RAWATAN DAN PEMULIHAN). 1983 http://www.adk.gov.my/statistic https://health.usnews.com/doctors/steven-levine-10094 https://www.drugabuse.gov/publications/drugfacts/hallucinogens on 2021, January 24 https://www.drugabuse.gov/publications/drugfacts/hallucinogens https://en.wikipedia.org/wiki/Hallucinogen https://www.britannica.com/topic/drug-use/Hallucinogenic-drugsb https://www.dea.gov/taxonomy/term/321 https://www.drugabuse.gov/publications/research-reports/hallucinogens-dissociative-drugs/how-do-hallucinogens-lsdpsilocybin-peyote-dmt-ayahuasca-affect-brain-body https://www.verywellmind.com/psychedelic-therapy-how-does-it-work-5079161 https://adf.org.au/drug-facts/new-psychoactive-substances/ Elkadi, Ahmed. 1996. “Contemporary Definition of Islamic Medicine.” Journal of Islamic Medical Association 28:163–66. Thank You.