NAME OF
DRUG
Generic
Name:
• tranexamic
acid
Brand Name:
• Hemostan
Classification:
Pharmacotherapeutic:
• Synthetic
lysine amino
acid
derivative
Clinical:
• Antifibrinolytic
Pregnancy
Category: B
ROUTE,
DATE
DOSAGE
ADMINISAND FRETERED
QUENCY
May 3−, Tranexamic
acid
2021
100mg/5
ml per
ampule 1
ampule
SIVP every
6 hours
MECHANISM
OF ACTION
INDICATION
CONTRAINDICATION
Short-term • Hypersensitivity
management to
tranexamic
of
acid.
hemorrhage. • Active
thromboembolic
disease
• History
or
intrinsic risk of
thrombosis
or
Therapeutic
thromboEffect:
embolism,
Diminishes
including retinal
dissolution of
vein or artery
hemostatic
occlusion.
fibrin,
which
• Use
of
decreases
combination
bleeding.
hormonal
contraception.
Displaces
plasminogen
from surface of
fibrin
by
binding to highaffinity lysine
site
of plasminogen.
SIDE EFFECTS
• Visual
and
ocular
disturbance
(e.g., impaired
color vision)
• Retinal vein or
artery occlusion
• Ligneous
conjunctivitis
• Thromboembolic events
• Convulsions
Blood
lymphatic
system:
• Anemia.
CLIENT’S
RESPONSE
NURSING
RESPONSIBILITIES
The client’s
hemoglobin
level
was
improved
from
12.2
g/mL to 13.1
g/mL.
Before Administration:
• Check the doctor’s
order.
• Observe for the 12
rights
of
drug
administration.
• Assess blood pressure,
pulse, and respiratory
The client’s
status as indicated by
hematocrit,
severity of bleeding.
level was also • Assess
for
normalized
thromboembolic
from 35.9%
complications.
to
39.1%,
(especially in patients
and
with history).
The client’s
RBC count During Administration:
increased
• Administer
5
ml
from
slowly via intravenous
3.91x10^3/uL
push.
to
• Stabilize IV catheter to
4.7x10^3/uL.
minimize
• GI:
Cautions:
• Diarrhea
• Patients
with • Nausea
enormous
• Vomiting
hematuria from • Abdominal pain
upper
urinary
tract
• General:
• History
of
Fatigue.
thromboembolic
diseases.
Musculoskeletal:
thrombophlebitis.
• Monitor site closely.
After Administration:
• Women
with
subarachnoid
hemorrhage or
irregular
menstrual cycle.
• Mild to moderate
renal
impairment.
• Pregnancy and
lactation.
• Musculoskeletal
pain
• Muscle cramps
Nervous System:
• Headache
• Migraine.
Respi:
• Nasal and sinus
symptoms.
• Monitor for overt
bleeding every 15–30
min.
• Notify physician of
positive Homans’ sign,
leg pain hemorrhage,
edema,
hemoptysis,
dyspnea, or chest pain.
Client/Family
Education:
• Instruct patient to
swallow tranexamic
acid tablets whole,
without chewing or
breaking them.
• Caution patient to
make position changes
slowly
to
avoid
orthostatic
hypotension.
• Instruct to any signs of
allergic
reaction
immediately, and any
changes in vision or
ocular discomfort.