Stroke Study Guide
You should be able to answer the following questions.
1.
What is a stroke?
2. What are the two types of stroke and how are they different?
3. What are the types of Ischemic stroke?
4. What are the types of hemorrhagic stroke?
5. What are the major arteries of the brain and in general what regions do they supply? How do
collaterals influence blood flow during a stroke?
6. What are the major risk factors for stroke?
7. What is the infarct core? What is the penumbra?
8. Why does aging change neural cell function ?
9. What are the 3 basic phases of injury and/or repair that occur in the brain after a stroke and
what occurs during each phase?
10. Describe the differences between necrotic and apoptotic cell death
11. How do you visualize neural damage after stroke?
12. The role of glia in neurodegeneration & repair?
13. How does inflammation effect neurodegeneration & repair?
14. What is the role of growth factors in neurorepair?
15. What is the role of NF kappa B after stroke?
16. You are developing a new treatment for ischemic stroke. You believe that this treatment targets
inflammation. Knowing what you know about stroke pathology, how would you design an
experiment to test whether this treatment is effective in an animal model of stroke? If the
treatment is effective in animals, how would you design a study to test efficacy in people?