Name: Lamies I. Anking
Year & Section: BSN-2B
GASTROINTESTINAL SYSTEM
DRUG STUDY:
Proton pump inhibitors
 suppress the secretion of hydrochloric acid into the lumen of the stomach.
Generic name:
 Dexlansoprazole,
Esomeprazole
(magnesium; sodium),
Omeprazole (magnesium), Pantoprazole sodium, RABEprazole
Lansoprazole,
INDICATIONS:
 Duodenal ulcers, gastric ulcers, erosive esophagitis, and GERD; hypersecretory
conditions (Zollinger-Ellison syndrome)
ACTION:
 The drugs reduce stomach acid production by combining with hydrogen,
potassium, and adenosine triphosphate in parietal cells of the stomach to block the
last step in gastric acid secretion.
ADVERSE REACTIONS:
 PPIs may cause abdominal pain, diarrhea, constipation, flatulence, nausea, dry
mouth, headache, asthenia, URI, abnormal LFT results, and hyperglycemia.
CONTRAINDICATIONS & CAUTIONS:
1)
2)
3)
4)
Contraindicated in patients hypersensitive to these drugs or their components.
Contraindicated in patients hypersensitive to these drugs.
Use cautiously in patients with renal or hepatic impairment.
Tetracyclines can cause fetal harm and should not be used in pregnant women.
Tetracyclines appear in human milk; the decision to continue or discontinue
breastfeeding should take into account benefits to the mother and risks to the
infant. Children younger than age 8 should not take tetracyclines; these drugs can
cause permanent tooth discoloration, enamel hypoplasia, and a reversible
decrease in bone calcification. Elderly patients may have de- creased esophageal
motility; use these drugs cautiously, and monitor patients for local irritation from
slow passage of oral forms.
NURSING CONSIDERATION:
Assess for possible contraindications and cautions: history of allergy to a proton
pump inhibitor to reduce the risk of hypersensitivity reaction and current status of
pregnancy or lactation because of the potential for adverse effects on the fetus or
nursing baby.
Perform a physical examination to establish baseline data before beginning
therapy to determine the effectiveness of the therapy and to evaluate for the
occurrence of any adverse effects associated with drug therapy.
Inspect the skin for lesions, rash, pruritus, and dryness to identify possible
adverse effects.
Assess neurological status, including level of orientation, affect and reflexes to
evaluate for CNS effects of the drug.
Inspect and palpate the abdomen to determine potential underlying medical
conditions; assess for changes in bowel elimination and GI upset to identify
possible adverse effects.
Assess respiratory status, including respiratory rate and rhythm; note evidence of
cough, hoarseness, and epistaxis, to monitor for potential adverse effects of the
drugs.
https://nurseslabs.com/proton-pump-inhibitors/