Amirkabir University of Technology A Review on Differences Found Poster Code: 487 between Conventional and High-Definition tDCS Golnaz Baghdadi, Farzad Towhidkhah Amirkabir University of Technology, Department of Biomedical Engineering Method Introduction Transcranial direct current stimulation (tDCS) is one of therapeutic methods that has been recently taken into consideration by researchers. In this method, the cerebral Anode Cathode C-tDCS Two electrodes: Anode and cathode 25 or 35 cm2 Sponge-based electrodes Size of electrodes: 25 or 35 cm2 cortex is stimulated using a very low electrical current Saline (about 1 to 2 mA). Considering the number of electrodes, tDCS devices can be categorized into conventional tDCS HD-tDCS More than two electrodes: Anode(s) and return(s) (C-tDCS) and high-definition tDCS (HD-tDCS). Anode Gel-based electrodes The aim of this paper is to provide a Size of electrodes: 1 to 2 cm2 1 or 2 cm2 brief review on differences have been found between C-tDCS and HD-tDCS. HD-tDCS vs. C-tDCS Return Conductive gel Results HD-tDCS can increase the focus of the current flow. Designing, manufacturing, and using the HD-tDCS have some considerable challenges: 1) Controlling the constant current, impedance level and synchronization of multi-channels (more than two) is harder. 2) Finding the appropriate place, fixation of several small gelbased electrodes, and keeping their contact with the head skin is a time consuming procedure in comparison with C-tDCS electrodes. Hence, the usage of HD-tDCS is less welcomed in clinical centers for therapeutic goals. However, 1) the higher tolerability of subjects, 2) more focused stimulation of region of interest, 3) lower and safer intensity of stimulation current, and 4) long lasting intervention effect of HD-tDCS have been reported in comparison with C-tDCS. Conclusion To study the role of a specific part of the cerebral cortex or to target one region of interest for therapeutic goals, using HD-tDCS is suggested to have focal brain stimulation. However, several consideration such as finding the appropriate place of each electrodes, checking the impedance of all electrodes, and keeping the total current of all channels bellow the 2 mA should be taken into account. Despite the problems of using the HD-tDCS and the higher cost of its devices, due to its benefits as well as the reported long-lasting effects, the arrival of HD-tDCS in healthcare and therapeutic centers is highly expected. Acknowledgment This research has been supported by the cognitive sciences and technologies council grant (#3175).