REVIEW Systematic review and meta-analysis of the efficacy of tuina for cervical spondylosis Mei-Yeh Wang, Pei-Shan Tsai, Pi-Hsia Lee, Wen-Yin Chang and Che-Ming Yang Aims and objectives. This study performed a meta-analysis of seven parallel-group comparison studies evaluating the efficacy of tuina in treating cervical spondylosis. Background. Tuina is a form of Chinese manipulative therapy. It has been used as a modality for the treatment of symptoms associated with such a musculoskeletal condition as cervical spondylosis. However, evidence regarding the efficacy of tuina for cervical spondylosis has yet to be determined. Design. Systematic review. Methods. Cochrane library, Pubmed, MEDLINE, EBM review, ProQuest Medical Bundle and SCOPUS databases were searched using the following medical subject headings or key words: tuina, tuinaology, manual medicine, massotherapy, cervical spondylopathy, cervical spondylosis and cervical vertebrae. Chinese research papers were searched through the Chinese electronic periodical services and Wangfane database. The publication date was limited from 1996–2007. Studies were selected if they were written in English or Chinese, used tuina as a stand-alone modality, used a parallel-group comparison design and explicated raw data regarding symptoms relief. Two independent reviewers reviewed the selected studies based on the evidence rating system of the US Preventive Services Task Force. Studies with an evidence rating of II-2 fair or above were included in this review. Results. The direction of the effect size for the improvement of blood flow velocity of vertebral artery and basilar artery was not consistent across studies. Moreover, the pooled effect size was negligible. No evidence supported that tuina could improve headache and vertigo. A small effect of tuina on the viscosity of blood and plasma was found. Conclusion. Based on the results of this systematic review, a definitive conclusion regarding the effects of tuina on cervical spondylosis remains to be determined. Relevance to clinical practice. The efficacy of tuina is not supported by parallel-group comparison studies. Key words: complementary alternative medicines, literature review, nurses, nursing, Taiwan, tuina Accepted for publication: 24 March 2008 Introduction Cervical spondylosis is a chronic disease that commonly occurs in middle-aged and older people. The symptoms of cervical spondylosis might seriously affect the patients’ work Authors: Mei-Yeh Wang, MSN, Doctoral Student, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan, Instructor, Cardinal Tien College of Healthcare and Management, Taipei, Taiwan; Pei-Shan Tsai, PhD, Associate Professor, College of Nursing, Taipei Medical University, Taipei, Taiwan; Pi-Hsia Lee, EdD, Associate Professor, College of Nursing, Taipei Medical University, Taipei, Taiwan; Wen-Yin Chang, PhD, Associate Professor, College of Nursing, Taipei Medical University, and quality of life (Sari-Kouzel & Cooper 1999). The degenerative changes of the cervical spine may cause pressure on the nerve roots of the spinal cord in the cervical area, the vertebral artery and the sympathetic nerve (McCormack & Weinstein 1996). In addition, the blood flow velocity of the Taipei, Taiwan; Che-Ming Yang, MD, JD, PhD, Associate Professor, School of Health Care Administration, College of Medicine, Taipei Medical University, Taipei, Taiwan Correspondence: Pei-Shan Tsai, Associate Professor, College of Nursing, Taipei Medical University, 250 Wu Hsing St., Taipei 110, Taiwan. Telephone: 886 2 27361661. E-mail: ptsai@tmu.edu.tw Ó 2008 The Authors. Journal compilation Ó 2008 Blackwell Publishing Ltd, Journal of Clinical Nursing, 17, 2531–2538 doi: 10.1111/j.1365-2702.2008.02446.x 2531 M-Y Wang et al. vertebral artery may be pathologically reduced because of the degenerative changes in the cervical spine (Strek et al. 1998). A decreased blood flow velocity in the basilar artery has been found to be associated with spondylosis-induced vertebral arteries compression (Olszewski et al. 2006). An association between vertebral artery blood flow and vertigo has been demonstrated by Transcranial Doppler Sonography (TCD) Examination (Olszewski et al. 2006). The pathology can often be responsible for a range of symptoms such as dizziness, vertigo, headache, neck rigidity and numbness and pain in the shoulders, arms and fingers. In severe cases, paralysis in the limbs can occur (Zhou et al. 2006). Traditional Chinese medicine has been used to treat this condition. For example, beneficial effects of acupuncture in treating cervical spondylopathy have been reported (Dong et al. 2005, Wang 2005). In addition to acupuncture, tuina has also been used. Tuina is a traditional Chinese way of healing. It belongs to the curative manipulation category of alternative therapies. The basic modular components of tuina manipulation including pressing (an), kneading (rou), pushing (tui), grasping and pinching (nanie) and rolling (gun) have beneficial effects in unblocking the obstructions of blood circulation of the body (Zhou et al. 2006). Other massage manoeuvres including poking channels, rolling and rotating manipulation are adopted to reposition the slight displacement of joints, eliminate swelling and to ease the pressure on ganglion or other tissues (Li et al. 2006, Ma et al. 2006). It has been claimed that tuina may alleviate spasm of the soft tissues, neck and shoulder and compression of cervical blood vessels (Zhou et al. 2006). Thus, patients often use tuina as a complementary or alternative treatment for symptom relief and energy rebalance. However, patients who believed they were making a free choice might base on biased resources in the lay literature or limited information about the use and effectiveness. The efficacy has yet to be confirmed by rigorous scientific research (Ernst & FughBerman 2002). With patients’ increasing interest in tuina, nurses should evaluate the efficacy of tuina for treatment of illness-related symptoms. Aim The aim of this review was to provide the first systematic review and a meta-analysis of trials that assessed the efficacy of tuina in improving symptoms and the vertebral-basilar artery blood flow velocity and viscosity in individuals with cervical spondylosis. The specific tuina technique and dosage were examined. The results may facilitate both patients and nursing professionals in making informed decisions regarding the use of tuina in treating cervical spondylosis. 2532 Methods A systematic search of Cochrane library, Pubmed, MEDLINE, EBM review, ProQuest Medical Bundle and SCOPUS databases of papers published between 1996–2007 was conducted, using the following medical subject headings or key words: tuina, tuinaology, manual medicine, massotherapy, cervical spondylopathy, cervical spondylosis and cervical vertebrae. The Chinese articles were searched through the Chinese electronic periodical services and Wangfane database. The reference lists of included studies and reviews were also searched for additional studies. Inclusion/exclusion criteria and quality assessment Studies were selected if they were written in English or Chinese, used tuina as a stand-alone modality, used a parallel-group comparison design and explicitly presented data regarding symptoms relief. The evidence rating system of the US Preventive Services Task Force (USPSTE; Harris et al. 2001) was used to judge the quality of selected studies. Two independent reviewers reviewed the selected studies. The quality and strength of the studies were evaluated at two separate categories: study design and internal validity. Hierarchies of study design were classified into the following levels: I: Properly designed randomised controlled trial (RCT). II-1: Well-designed controlled trials without randomisation. II-2: Well-designed cohort or case-control analytic studies. II-3: Multiple time series with or without the intervention. III: Opinions of authorities, descriptive studies and case reports. The degree of internal validity was judged by three elements of the study design: randomisation, participation rate and the description of withdrawals and/or dropouts. The rating is divided into three categories: good, fair and poor. A good study meets all criteria; a fair study meets some of the criteria but has no fatal flaw; a poor study contains a fatal flaw. Studies with the evidence rating of II-2 fair or above were included in this review. Studies that evaluated a combination of tuina with other modalities, consisted of <10 subjects in each group, provide insufficient information regarding the principal measures of effect, or included a young-aged group were excluded. Data synthesis All outcome variables were assessed for the treatment effect size. The difference between the post-treatment means divided by the pooled standard deviation was used as the principal measurements of effect (Cohen 1988). For those Ó 2008 The Authors. Journal compilation Ó 2008 Blackwell Publishing Ltd, Journal of Clinical Nursing, 17, 2531–2538 Review Efficacy of tuina studies that only provided median, range and sample size, estimated mean and standard deviations were calculated following the formula proposed by Hozo et al. (2005). The principal meta-analysis was restricted to a homogenous aggregation of the data. Each outcome was computed if there were at least three primary studies with sufficient data. The heterogeneity between the trials was assessed and a random-effects model was adopted to calculate the pooled effect size. Meta-analytic software (MedCalc Software, Mariakerke, Belgium) was used to implement the calculation. For those data that the pooled effect size could not be computed, the individual effect sizes were presented. Interpretation of effect sizes was judged using the original criteria of effect magnitude proposed by Cohen (1988). Effects of 0Æ2–0Æ5 described as ‘small’, 0Æ51–0Æ8 described as ‘medium’ 0Æ8 and above defined as ‘large’. Results Abstraction of articles The initial search strategy generated 86 studies. After examining the titles and abstracts, 25 potentially relevant studies were retrieved. Most of these studies were written in Chinese (24/25). Two project members who were fluent in both English and Chinese independently reviewed each of the identified articles to determine eligibility. A total of 12 studies were excluded because of testing non-specific massage rather than tuina or using multiple treatment modalities. The remaining 13 papers were reviewed for study quality based on the evidence rating system of the USPSTE (Harris et al. 2001). Two studies with poor internal validity and four studies with insufficient outcome measurements related information were not selected. A summary of the excluded studies is presented in Table 1. Study quality A total of seven studies met the II-2 fair rating of methodological quality (Fu & Yuan 2001, Wei 2003, Yi & Song 2003, Zhang et al. 2005, Lin et al. 2006, Shao et al. 2006, Zhang & He 2006). All studies used a parallel-group comparison design. Among them, six studies randomised subjects to the treatment or the control group (Table 2). No study presented the information regarding the participation or dropout rate. Table 1 Overview of the excluded studies Reasons for excluded Study (year) Description A lack of a comparison group Shou (1999) A clinical observation of 40 patients with cervical spondylosis of vertebral artery type receiving tuina A clinical observation of 567 cases of with cervical spondylosis receiving tuina The author only provided the percentages of treatment success, symptom relief, and treatment failure but did not report the post-treatment means and the standard deviation The post-treatment means and the standard deviation were not reported. p-value for the group comparison was reported. However, information related to the classification of treatment response was lacking The author only provided the percentages of treatment success, symptom relief, and treatment failure but did not report the post-treatment means and the standard deviations The authors only provided the percentages of treatment success, symptom relief, and treatment failure but did not report the post-treatment means and the standard deviations Tuina was used in combination with Qigong Two modalities were employed including tuina and digital acupoint pressure Two modalities including acupuncture and tuina were used Two modalities including traction tuina and neck exercise were used The study evaluated the effect of cervical angle restoration therapy The study evaluated the effect of maneuver treatment The study evaluated the effect of maneuver treatment The study evaluated the effect of maneuver treatment The study evaluated the effect of Dian-xue massage therapy The study evaluated the effect of vertebral manipulation therapy The study evaluated the effect of vernier maneuver treatment The study evaluated the effect of reposition manipulation Insufficient outcome measurements-related information Zhang (2006) Cao (1999) Zheng et al. (2002) Shu (2004) Wang et al. (2006) Multiple treatment modalities Testing non-specific massage rather than tuina Lu (1996) Wei (2002) Lin et al. (2004) Yuan and Li (2005) Lin and Lin (2001) Li (2002) Qian (2002) Chan (2004) Zheng (2004) Hong et al. (2005) Luo and Wu (2005) Xiong (2006) Ó 2008 The Authors. Journal compilation Ó 2008 Blackwell Publishing Ltd, Journal of Clinical Nursing, 17, 2531–2538 2533 2534 Parallel-group comparison design (NR) Parallel-group comparison design (yes) Parallel-group comparison design (yes) Parallel-group comparison design (yes) Parallel-group comparison design (yes) Parallel–group comparison design (yes) Yi and Song (2003) (China) Zhang et al. (2005) (China) Lin et al. (2006) (China) Tuina manipulation (1) 240 (2) Intervention: 45Æ8 (25–70) Control: 50Æ5 (26–72) (1) 120 (2) 48Æ5 (22–72) Tuina manipulation Routine tuina manipulation Intervention: 15 (one day apart) Control: 15 (one day apart) Intervention: 10 (5 days a week for 2 weeks) Control: 20 (daily) Intervention: 21 days Control: 8 mg/day for 21 days Intervention: 21 (daily) Control: 21 (daily) Intervention: 10 days–10 years Control: 6 days–13 years NR Headache vertigo (Ques) Vertigo (Ques) Blood velocity of BA and VA (TCD) YiNao manipulation Neck traction (3–4 kg) plus selective calcium channel blockers Chinese herb (Danshen injection) Headache vertigo (Ques) Selective calcium channel blockers Blood velocity of BA and VA (TCD) Tun Du Acupressure massage (1) 110 (2) Intervention: 46Æ8 (14Æ6) Control: 47Æ6 (15Æ3) Routine tuina manipulation (1) 120 (2) Intervention: 47Æ6 Control: 49Æ3 (1) 160 (2) 47Æ5 (3Æ56) Headache vertigo (Ques) Physical traction plus pain killers Intervention: 20 (daily) Control: 20 (daily) (1) 234 (2) 44Æ5 (23–75) Routine tuina manipulation Tuina manipulation Blood and plasma viscosity Chinese herbs (Danshen injection) Intervention: <6 months (9) 6 months to 5 years (17) >5 years (7) Control: <6 months (8) 6 months to 5 years (16) >5 years (5) 0–6 months (91) 6–12 months (71) >12 months (27) Intervention: 3–24 months (49) >2 years (6) Control: 3–24 months (48) >2 years (5) Intervention: 10 days to 8 years Control: 7 days–10 years 2 days–6 years Intervention: 15 (daily) Control: (16 mg/day for 15 days) Yuan style tuina (1) 62 manipulation (2) Intervention: NR (20–70) Control: NR (20–70) Intervention: 30(daily) Control: 30 (daily) Main outcomes (tools) Control or comparison condition(s) Duration of illness (subjects) (1) Subjects N (total) (2) Age mean (SD)/mean (range) No. sessions (frequency) Treatment modality BA, basilar artery; NR, not reported; TCD, transcranial Doppler sonography; VA, vertebral artery; Ques, questionnaires. Zhang and He (2006) (China) Shao et al. (2006) (China) Wei (2003) (China) Parallel-group comparison design (yes) Study design (randomisation: yes/no) Fu and Yuan (2001) (China) Study (year) (country) Table 2 Characteristics of abstracted studies M-Y Wang et al. Ó 2008 The Authors. Journal compilation Ó 2008 Blackwell Publishing Ltd, Journal of Clinical Nursing, 17, 2531–2538 Review Efficacy of tuina Study characteristics Characteristics of all the studies reviewed are summarised in Table 2. All the studies were carried out in outpatient settings. The participants in the studies aged from 20–75 years with the majority (5/7) of the studies having a mean age in the 40s. The duration of illness ranged from 3 months–10 years. Three studies included individuals who were in the acute phase of the illness (Zhang et al. 2005, Shao et al. 2006, Zhang & He 2006). Tuina was implemented in individuals with the vertebral artery type of cervical spondylosis in most of the studies (Fu & Yuan 2001, Wei 2003, Zhang et al. 2005, Shao et al. 2006, Zhang & He 2006). The effects of tuina on the nerve root type and the sympathetic nerve type were assessed in one study (Yi & Song 2003). One study did not describe the specific subtype of cervical spondylosis examined (Lin et al. 2006). The diagnosis of cervical spondylosis was based on the diagnostic criteria reported by the State administration of traditional Chinese medicine of the People’s Republic of China (1994) in one study (Yi & Song 2003). One study adopted the diagnostic criteria proposed by the Symposium of Cervical Spondylopathy (1992) (Zhang et al. 2005, Zhang & He 2006). Two studies used a combination of two diagnostic criteria (Wei 2003, Shao et al. 2006). The efficacy of tuina was examined in comparison with other treatment modalities including neck traction, electrotherapy or medication (Fu & Yuan 2001, Yi & Song 2003, Zhang et al. 2005, Lin et al. 2006, Zhang & He 2006). The effects between different manual techniques of the tuina were compared in two studies (Wei 2003, Shao et al. 2006). With the exception of two studies (Yi & Song 2003, Lin et al. 2006), the control group underwent the same time-frame and the same number of contact sessions as the experimental group. No study assesses the long-term effect after the completion of the treatment sessions. All of the studies described the procedure in details but did not provide the reference regarding the rationale for the selection of the optimal treatment dosage. No study provided information regarding the credentials or experience of the tuina practitioners. Impact of tuina on the blood flow velocity and blood viscosity Two studies assessed the effects of tuina on the vertebralbasilar artery blood flow using the TCD (Wei 2003, Shao et al. 2006). TCD indices reported by these studies included blood flow velocity of the systolic peak period (Vs), blood flow velocity of the end-diastolic period (Vd) and the average blood flow velocity (Vm). One study examined the viscosity of whole blood and plasma (Fu & Yuan 2001). The pooled effect size of the blood flow velocity of the vertebral artery or basilar artery was analysed with a random-effects model Table 3 The blood flow velocity of the vertebral artery and basilar artery: total sample and subgroup meta-analysis results Variables Study Subjects VA VA-Vs All 980 380 110 110 160 110 110 380 110 110 160 650 110 160 110 110 160 VA-Vd Wei (2003)* Wei (2003) Shao et al. (2006) Wei (2003)* Wei (2003) VA-Vm BA BA-Vs BA-Vd BA-Vm Wei (2003)* Wei (2003) Shao et al. (2006) All Wei (2003) Shao et al. (2006) Wei (2003) Wei (2003) Shao et al. (2006) Hedgee’s g (95% CI) 0Æ25 0Æ24 0Æ71 0Æ51 0Æ48 0Æ24 0Æ26 0Æ25 0Æ26 0Æ46 0Æ10 0Æ05 0Æ57 0Æ92 0Æ21 0Æ26 0Æ07 ( 0Æ02 to 0Æ51) ( 0Æ52 to 1Æ00) (0Æ32 to 1Æ10) (0Æ13 to 0Æ90) ( 0Æ79 to 0Æ16) ( 0Æ14 to 0Æ62) ( 0Æ12 to 0Æ64) (0Æ04 to 0Æ46) ( 0Æ12 to 0Æ64) (0Æ08 to 0Æ84) ( 0Æ22 to 0Æ41) ( 0Æ56 to 0Æ45) (0Æ19 to 0Æ94) ( 1Æ25 to 0Æ60) ( 0Æ58 to 0Æ17) ( 0Æ12 to 0Æ63) ( 0Æ25 to 0Æ38) Test of homogeneity, Q-value (p-value) Heterogeneous, 29Æ56 (0Æ0001) Heterogeneous, 26Æ86 (<0Æ0001) Homogeneous, 2Æ12 (0Æ347) Heterogeneous, 40Æ93 (<0Æ0001) BA, basilar artery; VA, vertebral artery; Vs, blood flow velocity of systolic peak period; Vd, blood flow velocity of the end-diastolic period; Vm, average blood flow velocity. *Measured on the left vertebral artery. Measure the right vertebral artery. The pooled effect size did not compute because of there were <3 primary studies with sufficient data. Ó 2008 The Authors. Journal compilation Ó 2008 Blackwell Publishing Ltd, Journal of Clinical Nursing, 17, 2531–2538 2535 M-Y Wang et al. (Table 3). Meta-analysis revealed a small effect size of the overall blood flow velocity of the vertebral artery (0Æ25; 95% CI 0Æ02–0Æ51). However, test of homogeneity of variance was statistically significant (Q = 29Æ56, p = 0Æ0001), indicating heterogeneity of variance in this aggregation of categories. The pooled effect size can only be calculated in the variable of Vm (0Æ25; 95% CI 0Æ04–0Æ46; Table 3). The heterogeneous of variance in Vs was found in all of the subgroup (Table 3). Moreover, the direction of effect for Vs was not consistent across studies (Table 3). Similarly, the reviewed studies showed conflicting results in terms of the improvement in different periods of blood flow velocity of the basilar artery. In addition, small effects of tuina on the viscosity of blood and plasma were found (Table 4). Impact of tuina on the headache and vertigo The severity of headache and vertigo was evaluated by selfreported questionnaires developed by the authors (Yi & Song 2003, Zhang et al. 2005, Zhang & He 2006) or by the rating system developed by the State administration of traditional Chinese medicine of the People’s Republic of China (State Administration of TCM 1986, Lin et al. 2006). Because the heterogeneity test of headache and vertigo was statistically significant, the individual treatment effect size was calculated. Conflicting results in the improvement of vertigo were found. Tuina had no beneficial effect on headache (Table 5). Table 4 The effect size for the blood viscosity Variables Study (year) Hedgee’s g Subjects (95% CI) Blood Fu and 62 viscosity Yuan (2001) Plasma Fu and 62 viscosity Yuan (2001) Test of homogeneity 0Æ21 * ( 0Æ29 to 0Æ70) 0Æ18 * ( 0Æ32 to 0Æ67) *The pooled effect size did not compute because of there were <3 primary studies with sufficient data. Discussion It has been claimed that symptoms such as neck stiffness, dizzy and pain associated with cervical spondylosis might be improved following tuina. Although improvement in the blood flow velocity, blood viscosity, vertigo and headache were observed after tuina in the treatment group, however, both the TCD examination and the subjective reports demonstrated that tuina was no better than the control condition. Methodological issues in the included studies Several methodological issues might account for the negative results demonstrated by this review. Firstly, the duration of illness in those patients included in this review ranged from a few days to 13 years. Because of the prognostic nature of cervical spondylosis, the heterogeneity of participants might mask the therapeutic effects of tuina. For example, in one study the improvement rate was statistically significant higher in the group who suffered from cervical spondylosis for <six months compared with those who with illness duration of more than six months (Yi & Song 2003). The heterogeneity may be reduced by limiting the present meta-analysis to studies with specific characteristics. However, the sensitivity analysis that helps to identify moderating factors on the effects can not be carried out because insufficient original data on age groups and illness duration were available. Secondly, other curative interventions such as neck traction and medication were implemented as control conditions. These interventions might exert a mechanism that is similar to tuina in treating symptoms associated with cervical spondylosis. The outcome measurements for these studies might lack sensitivity and/or specificity to differentiate effects produced by tuina, acupuncture, neck traction or medication. Thirdly, the information regarding the credentials or experience of the tuina practitioners was lacking, which Table 5 Headache and vertigo: total sample and subgroup meta-analysis results Variables Study Subjects Vertigo All Yi and Song (2003) Zhang et al. (2005) Lin et al. (2006) Zhang and He (2006) All Yi and Song (2003) Zhang et al. (2005) Zhang and He (2006) 397 55 74 120 148 288 66 74 148 Headache 2536 Hedgee’s g (95% CI) Test of homogeneity, Q-value (p-value) Heterogeneous, 81Æ16 (<0Æ0001) 3Æ64 0Æ17 0Æ98 0Æ27 ( 4Æ65 to 2Æ64) ( 0Æ30 to 0Æ63) (0Æ60 to 1Æ37) ( 0Æ59 to 0Æ06) Heterogeneous, 70Æ80 (<0Æ0001) 6Æ99 ( 8Æ39 to 1Æ18 ( 1Æ68 to 0Æ93 ( 1Æ27 to 5Æ60) 0Æ67) 0Æ59) Ó 2008 The Authors. Journal compilation Ó 2008 Blackwell Publishing Ltd, Journal of Clinical Nursing, 17, 2531–2538 Review raise the doubt of whether the optimal therapeutic effects of tuina had been attained in the included studies. Finally, although six out of seven studies reported randomisation of group assignments pretreatment non-equivalence between comparison groups could not be ruled out. Future studies that adopt a randomised control design, an attention or sham-treatment control group and carefully selected outcome measurements may be helpful to clarify the specific therapeutic effects of tuina. Efficacy of tuina Acknowledgement This work was supported by a grant from the Department of Health, Executive Yuan, Taiwan (DOH96-TD-M-113-020). Contributions Study design: MW, PT; data collection: MW, PT; data analysis: MW, PT, PL, WC, CY and manuscript preparation: MW, PT. Limitations of the review The present review may be prone to a selection or source bias. Only articles published after 1996 and published in English or Chinese were selected. It cannot be ruled out that there were studies in which tuina demonstrated statistically significant effects on cervical spondylosis but were published in other languages. A definitive conclusion regarding the effects of tuina on cervical spondylosis remains to be determined. Relevance to clinical practice In most cases of cervical spondylosis, the conservative treatments are favourable than surgical intervention unless pain persists or the progressive neurological deficit is identified (Borghouts et al. 1998). Fear of medication side-effects and desire for symptom relief were possible reasons for the increasing use of complementary and alternative medicine (CAM) by patients (Vincent & Furnham 1999). Nurses should bear in mind that many patients chose tuina as a way to empower themselves in the management of their illness and therefore may not be seeking evidence of efficacy. Moreover, patient satisfaction and perceived effect have been identified as important criteria to judge the treatment outcome in treating neck disorders (Gross et al. 2002). Because symptoms associated with cervical spondylsis are complex, the change in blood flow velocity or pain may not be the only criterion to determine the success of treatment. The outcomes of complementary therapy for treating symptoms associated with chronic illness should include specific areas of patient concerns. For example, for those patients who were most bothered by increased muscle tension, a reduction in headache should be considered the primary outcome measure. In conclusion, the efficacy of tuina remains inconclusive based on the findings of this systematic review. Tuina might not have any effect that is superior to other available forms of treatments for treating symptoms associated with cervical spondylosis. 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