1: a: constant temperature, to prevent denaturing of enzymes, active site shape damaged, fungus respires so it releases heat, so temperature in the fermenter increases that could kill fungus.so no penicillin (i): keeps the ph constant, enzymes work best at optimum ph so it slows to give maximum yield B(i): 40 to 80 hours (ii): mitosis (iii): limiting factors, nutrients are used up, waste products accumulate. C:(i) nutrients and fungus was added without penicillin so it grows without the presence of penicillin. (ii): Penicillin production stopped. D: separating penicillin from waste and for maintaining concentration. E: viruses are not cells, do not do metabolism. 2:a: a drug, which is a chemical substance used to kill bacteria that is made by organisms. B: (i): most was killed by the antibiotic (ii): more resistant bacteria in c but in b less resistant bacteria C: antibiotic cant kill resistant bacteria it kills non resistant bacteria but if it is used too often bacteria become resistant D: causes mutation which causes antibiotic resistance and change in dna.