•Cell Adhesion
in Cancer
• Benign tumor – a tumor that slowly grows at its site of origin and
and is well circumscribed.
• Malignant tumor – a rapidly spreading tumor.
• Metastasis – a tumor growing within another organ of the body.
Adhesive
Interactions with
extra cellular matrix
Altered stroma
contributes to
malignancy
•The epithelial tumor cells
have a dominant influence
over the stroma, driving it
to assist the cancer cell’s
mission for dissemination
•In some situations, the
stroma can contribute
directly toward the
advancement of epithelial
malignancy