35 y/o old—4 serious suicide attempts on Haldol—due to recent suicide attempts what would be best option: CLOZARIL (for treatment resistant schizophrenia) Luvox can increase plasma concentration of clozaril Smoking cigs can lessen plasma concentration of clozaril—will require increased dose Clozarilïƒ minimize suicide risk Clozaril: - Check for ANC, Neutrophil, agranulocytosis (SORE THROAT) Abilify: - Better for negative sx of schizophrenia (blocks 5HT2A antag)allows for more dopamine in the pathways, prevents dopamine blockade throughout Abilify—most activating of antipsychotics CAMP –cycle adenosine monophosphate—2nd messenger Reuptake inhibition---Reuptake inhibit and agonist both inhibit NT reuptake Tardive dyskinesiaïƒ facial grimacing, frowning, choreathetoid movements (after years on antipsychotic) Tarisoff—Call police, call crisis, call spouse
