Principles and Practice of Hospital Medicine, 2e > Principles of EvidenceBased Medicine and Quality of Evidence Sylvia C. McKean, John J. Ross, Daniel D. Dressler, Danielle B. Scheurer+ TABLE 7-2Hierarchy of Evidence for Different Types of Clinical Questions Type of Clinical Question Best Types of Articles (Listed in Decreasing Level of Evidence) Therapy or harm 1. Systematic review/meta-analysis of randomized controlled trials 2. Randomized controlled trial 3. Cohort study 4. Case-control study 5. Case series 6. Case reports 7. Expert opinion Accuracy of a diagnostic test 1. Systematic review/meta-analysis 2. Prospective comparison against gold standard conducted in setting diagnostic test will be used in practice Prognosis 1. Systematic review/meta-analysis 2. Prospective cohort study of a representative, homologous patient group with appropriate follow-up and objective outcomes. 3. Retrospective case-controlled study Differential diagnosis of a condition 1. Systematic review/meta-analysis 2. Prospective evaluation of a representative sample that includes definitive diagnostic evaluation, performed in a setting similar to actual practice Date of download: 05/03/19 from AccessMedicine: accessmedicine.mhmedical.com, Copyright © McGraw-Hill Education. All rights reserved.