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Analysis of Primary Literature on Microbiome - Google Docs
Hikaru Koga Dr. Knuth AP Biology 13 November 2018 Analysis of Current Evidence in Delivery and Therapeutic Uses of Fecal Microbiota Transplantation in Human Disease ­ Clostridium difficile Disease and Beyond Stripling and Rodriguez’s central purpose is to examine the therapeutic uses of fecal microbiota transplantation, specifically its use to treat Clostridium difficile disease. They also reviewed the preparation process, the safety, and the donor screening of FMT. In order to assess if fecal microbiota transplantation was effective, control and experimental groups of people with Clostridium difficile disease were examined. The report summarized three studies and they all concluded the general success of FMT. However, all the varying preparation and delivery processes makes it challenging to generalize any theory. There are varying ways to deliver the FMT for the recipient. The degree of success of each way: colonoscopy, retention enema, or oral capsules, depends on its ability to deliver the specified bacteria to a specific location and its safety. Colonoscopy has been the most used and the most effective because its able to deliver the fecal transplant directly into the desired location. However, the patient has to be sedated which causes other safety issues. Retention enema was also proven effective but it has its drawbacks because the elderly are not able to retain the enema. Oral capsules were also efficient and is widely appreciated by its recipients. The safety of FMT and the rigorous process of donor screening is tightly connected. Many are wary about FMT because its ability to transfer harmful pathogens or increase the https://docs.google.com/document/d/1DZA5P5kj2e7sNUvz5DJ892X1jC0Gx4lTxXFDkkBur54/edit
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1/13/2019
Analysis of Primary Literature on Microbiome - Google Docs
chance of the development of new diseases. In order to prevent this issue, the donor screening has become a tight process. The donator is screened for specific medical histories such as chronic pain, major surgery, etc. The stool is then tested for typical enteric bacterial pathogens, parasites, viral Hepatitis, and others. Less than 10% of donated stool passes the screening. The in­depth research on fecal microbiota transplantation provides a new and effective treatment for diseases such as Clostridium difficile. Such diseases do not have alternative treatments. FMT is the only way that restores the patient’s microbiome effectively in these cases. By providing more research on FMT, it can become more mainstream and accepted. Other treatments such as antibiotics will not have to be exhausted. https://docs.google.com/document/d/1DZA5P5kj2e7sNUvz5DJ892X1jC0Gx4lTxXFDkkBur54/edit
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