CONSISTENCY OF NATURAL, PLANT-BASED PRESERVATIVE INGREDIENTS VIA CONVENTIONAL PLANT BREEDING TECHNOLOGIES Brooke Tjaden, Kemin May 2015 © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Plant Science Vertically integrated cultivation © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Plants are excellent sources of “Green” Chemistry • Harvest sunlight • Sequester CO2 • Renewable chemistry o o o o Complex molecules Huge variation Optimized via breeding Perennial options • Applications: o Human Health & Personal Care © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Focused on molecules… © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Fully Vertically Integrated Process Advanced techniques in conventional plant breeding (no GMOs) Breed Proprietary Clonal Lines Propagate Grow Extract © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Blend Product Development Market CLS Kemin’s Specialty Crop Development Process Breeding & Selection Research Agronomy © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Biochemical Screening Field Agronomy Services Breeding and Selection Breeding & Selection: Summerset Field Station, IA Plant Micro-Propagation Lab Kemin Molecular Advancement Center, Des Moines Hereford Greenhouse, Texas © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. In Field Testing SCI Kelley Research Farm, Iowa Spearmint Test Plot, Indiana Hereford Greenhouse, Texas Rosemary Field Testing, Texas © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. BIOACTIVES FROM OREGANO Borneol Carvacrol Thymol a-pinene High bioactive accumulation in Oregano Populations screened during selection process. © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Caryophyllene Monitoring Targeted Molecule for Activity Frequency distribution of the populations for carvacrol levels 90 80 70 60 Frequency 50 40 30 20 10 0 < 0.1 0.1-0.3 0.3-0.6 0.6-0.9 0.9-1.2 1.2-1.5 1.5-1.8 1.8-2.0 2.0-2.5 2.5-3.0 3.0-3.5 3.5-4.0 4.0-4.5 >5.0 Carvacrol % on dry matter basis Pop I Pop II Pop III Pop IV Pop V Pop VI Pop VIII Pop IX Pop XII Pop XIII PopXIV PopXV Pop VII © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Kemin Internal Document 10-00168 Chemotypic Differences Greek Oregano KI1850 KI1750 © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Kemin Internal Document 14-00122 © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Steam Distillation Lab scale (1 gallon) © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Field test scale (35 gallon) Planting & Growing Propagation Planting in Iowa Planting in Texas Field Establishment - Year 2 © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Monitoring Seasonal Variation in Targeted Bioactives Variation of Carvacrol/Thymol in selected oregano lines Carvacrol/thymol % 8 KIOv-1721 KIOv-1750 KIOv-1791 KIOv-1835 KIOv-1843 KIOv-1850 7 6 5 4 3 2 © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Kemin Internal Document 14-00122 Harvesting & Steam Distillation Harvest cut close to ground Dried in Field Collected in Steam Wagon Steam Distillation © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Raw Material Testing • State-of-the-art analytical testing laboratory operated by scientists o Highly-technical equipment can test for ultra-sensitive levels of contamination at parts per quadrillion o o Analysis capabilities: dioxins, PCBs and pesticides Quick turn around time allows for rapid detection and identification of potential contaminants (confirmatory) © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Focused on molecules… © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Natural Market Trends Naturalness Environment Climate change Sustainability Organic farming Lifestyle Localisation Healthier living Simplicity/ back to basics Nostalgia Varying levels of naturalness Mainstream naturals Speciality naturals Consumer is going to outsmart greenwashing at some point but critical to making that leap: THE PRODUCTS/INGREDIENTS HAVE TO BE EFFICACIOUS © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Source: Euromonitor, Natural Ingredients: A Sustained Push for Sustainable Options, February 2014 The Need for Natural Preservatives • • Cosmetic products are easily contaminated with micro-organisms Preservatives are included in formulation to: Prevent and protect from contamination Extend shelf life Ensure that products remain safe • Use of conventional synthetic preservatives: (paraben or phenoxyethanol) • Negative media • Alerted consumers pressure + • Natural trend • Demand of effective, safe and natural preservatives NATURAL BROAD-SPECTRUM PRESERVATIVE ALTERNATIVES © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Preservative Efficacy Testing (PET) - Results Treatments Untreated control 0.5% Caprylic Acid (and) Origanum vulgare Leaf Extract © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A. Caprylic Acid (and) Origanum vulgare Leaf Extract reduces: • Bacteria by 5 logs within 2 days • Yeast by 3 logs within 2 days • Mold by 4 logs within 14 days 1.0% Caprylic Acid (and) Origanum vulgare Leaf Extract 1.0% Phenoxyethanol (and) Ethylhexylglycerin Formulation pH: 5.5 * Please note that certain statements, product labelling and claims may differ by geography or as required by government requirements Source: Kemin Internal Document 14-00086 Questions? © Kemin Industries, Inc. and its group of companies 2015. All rights reserved. ®™ Trademarks of Kemin Industries, Inc., U.S.A.