Title (en)
METHODS AND COMPOSITIONS RELATING TO DIAGNOSING AND TREATING RECEPTOR TYROSINE KINASE RELATED CANCERS
Title (de)
VERFAHREN UND ZUSAMMENSETZUNGEN ZUR DIAGNOSE UND BEHANDLUNG VON REZEPTORTYROSINKINASE-BEDINGTEN
KREBSERKRANKUNGEN
Title (fr)
PROCÉDÉS ET COMPOSITIONS ASSOCIÉS AU DIAGNOSTIC ET AU TRAITEMENT DE CANCERS ASSOCIÉS À UN RÉCEPTEUR TYROSINE
KINASE
Publication
EP 2823065 A4 20160302 (EN)
Application
EP 13758525 A 20130308
Priority
• US 201261609069 P 20120309
• US 2013029969 W 20130308
Abstract (en)
[origin: WO2013134693A1] Disclosed are methods and compositions for detecting the presence of a cancer in a subject and assessing the efficacy
of treatments for the same. The disclosed method use reverse transcription polymerase chain reaction (RT-PCR), real time polymerase chain
reaction, and multiplex polymerase chain reaction techniques to detect fusions, over- expression, truncation, and nucleic acid variation of RET and
DEPDC1 in cancers.
Inventor
• HOUT DAVID (US)
• HANDSHOE JOHN (US)
Applicant
INSIGHT GENETICS INC (US)
IPC 8 full level (invention and additional information)
C12Q 1/68 (2006.01)
CPC (invention and additional information)
C12Q 1/6886 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01)
Citation (search report)
• [XI] WO 2009126271 A1 20091015 - CHINA SYNTHETIC RUBBER CORP [CN], et al
• [XI] WO 2007109026 A2 20070927 - UNIV COLUMBIA [US], et al
• [XI] SPARANO ET AL: "Genotypic characterization of phenotypically defined triple-negative breast cancer.", 2009 ASCO ANNUAL
MEETING, 1 January 2009 (2009-01-01), XP055215718
• [XI] KANEHIRA M ET AL: "Involvement of upregulation of DEPDC1 (DEP domain containing 1) in bladder carcinogenesis",
ONCOGENE, NATURE PUBLISHING GROUP, GB, vol. 26, no. 44, 27 September 2007 (2007-09-27), pages 6448 - 6455,
XP009111482, ISSN: 0950-9232, [retrieved on 20070423], DOI: :10.1038/SJ.ONC.1210466
• [XI] KRETSCHMER CÃ CR LINE ET AL: "Identification of early molecular markers for breast cancer", MOLECULAR CANCER,
BIOMED CENTRAL, LONDON, GB, vol. 10, no. 1, 11 February 2011 (2011-02-11), pages 15, XP021088444, ISSN: 1476-4598,
DOI: 10.1186/1476-4598-10-15
• [XI] Y. S. JU ET AL: "A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome
and transcriptome sequencing", GENOME RESEARCH, vol. 22, no. 3, 22 December 2011 (2011-12-22), pages 436 - 445,
XP055145939, ISSN: 1088-9051, DOI: 10.1101/gr.133645.111
• [XI] J.-Z. TANG ET AL: "Artemin-Stimulated Progression of Human Non-Small Cell Lung Carcinoma Is Mediated by BCL2",
MOLECULAR CANCER THERAPEUTICS, vol. 9, no. 6, 1 June 2010 (2010-06-01), pages 1697 - 1708, XP055065623, ISSN:
1535-7163, DOI: 10.1158/1535-7163.MCT-09-1077
• See also references of WO 2013134693A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
EPO simple patent family
WO 2013134693 A1 20130912; WO 2013134693 A8 20150129; EP 2823065 A1 20150114; EP 2823065 A4 20160302; US 2015232940 A1
20150820
INPADOC legal status
2016-03-02 [RA4] DATE AND KIND OF SUPPLEMENTARY SEARCH REPORT (CORRECTION)
- Effective date : 20160203
2016-03-02 [RIC1] CLASSIFICATION (CORRECTION)
- IPC : C12Q 1/68 20060101AFI20160128BHEP
2015-11-04 [RIC1] CLASSIFICATION (CORRECTION)
- IPC : C12Q 1/68 20060101AFI20150928BHEP
2015-06-17 [DAX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT (TO ANY COUNTRY) DELETED
2015-01-14 [17P] REQUEST FOR EXAMINATION FILED
- Effective date : 20141009
2015-01-14 [AK] DESIGNATED CONTRACTING STATES:
- Kind Code of Ref Document : A1
- Designated State(s) : AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL
PT RO RS SE SI SK SM TR
2015-01-14 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO
- Countries concerned : BA ME