UK Purine Club 2011 Symposium
Wednesday 2nd November 2011, The Parc Thistle Hotel, Cardiff
Preliminary programme
09 00 Exhibitor and poster board set up
10.00 Registration, poster set up, tea/coffee
10 30 Welcome - Dr Bronwen Evans, Cardiff
10.32 Opening remarks – Professor Ole Petersen, Cardiff
10.40 Invited Lecture - Professor Chris McGuigan, Cardiff - Delivering nucleotides into cells: INX-189
as a highly potent and selective inhibitor of hepatitis C virus. From the lab to clinical trial
11.10 Oral communication 1 Y Pankratov (Warwick) Role for ATP in glia-neuron communication in
the neocortex
11 25 Oral communication 2 R Murrell-Lagnado (Cambridge) Splice-variants of the P2X7 receptor
reveal differential agonist-dependence and functional coupling with pannexin-1
11 40 Oral communication 3 M Young (Cardiff) Trimer stability, ATP binding, 3D structure and
molecular modelling of human P2X4 and D. discoideum P2XA
11 55 Oral communication 4 S Fountain (UEA) A mechanism of vesicular P2X receptor activation
12 10 Lunch, Poster Session and Exhibit viewing
13 30 Invited Lecture - Professor Maria P Abbracchio – The previously orphan P2Y-like GPR17
receptor as a new target for demyelinating diseases
14.00 Oral communication 5 S Gupta (Sheffield) The bone phenotype of the adult P2Y6R knockout
mouse
14.15 Oral communication 6 A Wesselius (Maastricht) Association of P2X7 receptor polymorphisms
with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients
14 30 Oral communication 7 M Adamczyk (Cardiff) Externalization of TG2 by activation of P2X7
receptor
14.45 Oral communication 8 K Such (Surrey) Extracellular ATP acting Via P2 receptors enhances proinflammatory cytokine secretion from human lung parenchyma: an important role in allergic asthma?
15.00 Tea/Coffee, Poster Session and Exhibit viewing
15.45 Invited lecture - Dr Stuart Mundell, Bristol - Please mind the GAPP: From patients with
platelet bleeding disorders to insights into P2Y12 purinergic receptor structure / function
16.15 Oral communication 9 R Corriden (Nottingham) Plaque-like A3 adenosine receptor
microdomains are associated with bacteria-tethering nanotubes in human neutrophils
16.30 Oral communication 10 E Barnard (Cambridge) Homo-dimers and hetero-dimers of P2Y
receptors, measured by fluorescence lifetime imaging microscopy
16.45 Oral communication 11 J Glenn (Nottingham) Adenosine derived from ADP can contribute to
inhibition of platelet aggregation in the presence of a P2Y12 antagonist
17.00 Concluding remarks and presentation of prizes - Professor Geoff Burnstock, London
17 20 Evening reception / UK Purine Club Committee Meeting
19.00 Conference dinner