Electron Microscopy
Electron Microscopy
What is Electron Microscopy?
What is Electron Microscopy?
Electron microscopy (EM) is a highly specialized
service that only a few laboratories in the US offer,
including DCPAH.
It allows the pathologist to
examine the ultrastructure of cells and pathogens
at magnifications up to 450,000 fold.
EM is
commonly used to identify pathogens (especially
novel ones) such as viruses, bacteria, fungi,
parasites, and microsporidia. EM also helps to
identify and characterize neoplastic cells and
define cellular degenerative processes (particularly
neurologic and renal diseases). For instance, many
glomerulopathopathies cannot be identified without
the benefit of EM.
Electron microscopy (EM) is a highly specialized
service that only a few laboratories in the US offer,
including DCPAH.
It allows the pathologist to
examine the ultrastructure of cells and pathogens
at magnifications up to 450,000 fold.
EM is
commonly used to identify pathogens (especially
novel ones) such as viruses, bacteria, fungi,
parasites, and microsporidia. EM also helps to
identify and characterize neoplastic cells and
define cellular degenerative processes (particularly
neurologic and renal diseases). For instance, many
glomerulopathopathies cannot be identified without
the benefit of EM.
Intratubular parasite in the kidney
of a frog
Sample Preparation
Intratubular parasite in the kidney
of a frog
Sample Preparation
Samples should be submitted formalin-fixed (however, we can work with
gluteraldehyde if especially high-quality images are needed). Preferably we
would like to get 3 cm diameter, well-fixed tissue samples, together with a
detailed report of the clinical presentation and gross and microscopic lesions.
We will cut submitted sections, paraffin embed half of the tissue to produce an
H&E slide and use this slide to identify the best location for further ultrastructural
examination by comparing the microscopic tissue half with the mirror image of
the remaining formalin-fixed tissue. For each submission, we will then cut four
trapezoidal 2-3 mm tissue samples to produce plastic embedded “thick” sections.
We also accept the submission of samples prepared in a similar manner by the
client for processing. We can also work with previously paraffin-embedded tissue
at an additional cost; however, image quality may be compromised. Negative
staining of samples and scanning EM can also be performed – please contact the
lab for further information and pricing for these services.
Samples should be submitted formalin-fixed (however, we can work with
gluteraldehyde if especially high-quality images are needed). Preferably we
would like to get 3 cm diameter, well-fixed tissue samples, together with a
detailed report of the clinical presentation and gross and microscopic lesions.
We will cut submitted sections, paraffin embed half of the tissue to produce an
H&E slide and use this slide to identify the best location for further ultrastructural
examination by comparing the microscopic tissue half with the mirror image of
the remaining formalin-fixed tissue. For each submission, we will then cut four
trapezoidal 2-3 mm tissue samples to produce plastic embedded “thick” sections.
We also accept the submission of samples prepared in a similar manner by the
client for processing. We can also work with previously paraffin-embedded tissue
at an additional cost; however, image quality may be compromised. Negative
staining of samples and scanning EM can also be performed – please contact the
lab for further information and pricing for these services.
Pricing and Turn-Around Time
Pricing and Turn-Around Time
For each case, two “thin” sections will be produced and examined by our team
of highly experienced pathologists. The current price for an electron microscopy
submission, including photomicrographs and interpretation, is available online at
animalhealth.msu.edu under Available Tests. Typically, initial results are available
within two weeks of submission.
For each case, two “thin” sections will be produced and examined by our team
of highly experienced pathologists. The current price for an electron microscopy
submission, including photomicrographs and interpretation, is available online at
animalhealth.msu.edu under Available Tests. Typically, initial results are available
within two weeks of submission.
For more information, please contact the Anatomic Pathology lab at 517.353.1683,
or visit our website at animalhealth.msu.edu.
For more information, please contact the Anatomic Pathology lab at 517.353.1683,
or visit our website at animalhealth.msu.edu.
Diagnostic Center for Population and Animal Health
Diagnostic Center for Population and Animal Health
4125 Beaumont Road, Lansing, MI 48910 | PH: 517.353.1683 | FX: 517.353.5096
4125 Beaumont Road, Lansing, MI 48910 | PH: 517.353.1683 | FX: 517.353.5096
Protecting Human and Animal Health | animalhealth.msu.edu
Protecting Human and Animal Health | animalhealth.msu.edu
DCPAH is a full-service veterinary diagnostic
laboratory, fully accredited by the AAVLD
for all species through 2017.
Sample Submission Forms
DCPAH is a full-service veterinary diagnostic
laboratory, fully accredited by the AAVLD
for all species through 2017.
Sample Submission Forms
Visit our website at animalhealth.msu.edu to access our most current submittal
forms. Customized forms preprinted with your clinic information are also available
at no cost via the Product Order Form.
Visit our website at animalhealth.msu.edu to access our most current submittal
forms. Customized forms preprinted with your clinic information are also available
at no cost via the Product Order Form.
Unbeatable Shipping
Unbeatable Shipping
DCPAH offers a variety of shipping options. Our mailers comply with U.S. Postal
Service, FedEx, UPS, and DHL regulations. All UPS mailers include prepaid
overnight weekday delivery. All U.S. Postal Service mailers include prepaid
delivery; delivery time will vary depending on your location.
DCPAH offers a variety of shipping options. Our mailers comply with U.S. Postal
Service, FedEx, UPS, and DHL regulations. All UPS mailers include prepaid
overnight weekday delivery. All U.S. Postal Service mailers include prepaid
delivery; delivery time will vary depending on your location.
Order Mailing Supplies
Order Mailing Supplies
Packaging and Mailing Samples
Packaging and Mailing Samples
Individual, insulated, and biopsy mailers
are available. Contact us at 517.353.1683 or
complete the Product Order Form available
online at animalhealth.msu.edu.
Individual, insulated, and biopsy mailers
are available. Contact us at 517.353.1683 or
complete the Product Order Form available
online at animalhealth.msu.edu.
For shipping recommendations for individual
tests, please refer to the information
provided at animalhealth.msu.edu under
“Available Tests.”
For shipping recommendations for individual
tests, please refer to the information
provided at animalhealth.msu.edu under
“Available Tests.”
Speak Directly to Experts
Our veterinary professionals are available for consultation and
can help you interpret your test results to better manage the
health of animals entrusted to you.
The
DCPAH
Advantage
Speak Directly to Experts
Our veterinary professionals are available for consultation and
can help you interpret your test results to better manage the
health of animals entrusted to you.
The
DCPAH
Advantage
Get Results by Email and Online
Get Results by Email and Online
All DCPAH clients also have free, quick access to view results online through
WebView. Reports are posted to the web hourly. Visit animalhealth.msu.edu and
click “Log In” to request access to your diagnostic results.
All DCPAH clients also have free, quick access to view results online through
WebView. Reports are posted to the web hourly. Visit animalhealth.msu.edu and
click “Log In” to request access to your diagnostic results.
Expect Quality in Testing and Service
Expect Quality in Testing and Service
Had it with the fax machine? Contact us at 517.353.1683 to have results delivered
by email.
DCPAH is a leader in establishing technical
guidelines for public veterinary diagnostic
laboratories in the United States and maintains a
quality assurance team dedicated to promoting
accuracy and reliability.
DCPAH is a leader in establishing technical
guidelines for public veterinary diagnostic
laboratories in the United States and maintains a
quality assurance team dedicated to promoting
accuracy and reliability.
Customer Service Hours
Monday through Friday, 7:30 a.m. to 5:30 p.m. EST
MKTG.CARD.ANATOMICPATHOLOGY.008.03
Had it with the fax machine? Contact us at 517.353.1683 to have results delivered
by email.
Issue Date: 09/03/14
Customer Service Hours
Monday through Friday, 7:30 a.m. to 5:30 p.m. EST
MKTG.CARD.ANATOMICPATHOLOGY.008.03
Issue Date: 09/03/14