x C E L L I GE N C E S Y S T E M
P U B L I C AT I O N L IS T
RELEVANT DATA, REMARKABLE PUBLICATIONS
Accelerate your research and increase your productivity with pioneering real -time cellular analysis
Researchers are successfully using the xCELLigence RTCA Systems in a wide variety of scientific disciplines. We are
proud to share this list of publications from the growing community of xCELLigence customers and collaborators. If
we missed one, please send the citation to publications@aceabio.com.
CELL ADHESION AND SPREADING
1. G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil. Ahmed, S. M.,
Daulat, A. M., Meunier, A., & Angers, S. (2010).The Journal of biological chemistry, 285(9), 6538–51.
doi:10.1074/jbc.M109.069948
2. S-glutathionylation regulates inflammatory activities of S100A9. Lim, S. Y., Raftery, M. J., Goyette, J., & Geczy, C.
L. (2010).The Journal of biological chemistry, 285(19), 14377–88. doi:10.1074/jbc.M109.075242
3. Adhesion Protein Protocols IN Series Editor. Coutts, A. S., & Walker, J. M. (n.d.).
4. Indirubin derivative 6BIO suppresses metastasis. Braig, S., Kressirer, C. a, Liebl, J., Bischoff, F., Zahler, S., Meijer,
L., & Vollmar, A. M. (2013).Cancer research, 73(19), 6004–12. doi:10.1158/0008-5472.CAN-12-4358
5. Measurement of the effect of platelet activators and heparin on adhesion and spreading of human platelets
using impedimetry. L. Polgar, L. Kohidai, E. Lajko, O. Lang, B. Merkely, P. S. (2013).European Heart Journal,
34(suppl 1), 801–1092. doi:10.1093/eurheartj/eht310
6. Trimeric Tn antigen on Syndecan-1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex
formation with integrin α5β1 and matrix metalloproteinase 9. Matsumoto, Y., Zhang, Q., Akita, K., Nakada,
H., Hamamura, K., Tsuchida, A., Okajima, T., et al. (2013).The Journal of biological chemistry.
doi:10.1074/jbc.M113.455006
7. Real-time monitoring of hematopoietic cell interaction with fibronectin fragment: The effect of histone
deacetylase inhibitors. Obr, A., Röselová, P., Grebeňová, D., & Kuželová, K. (2013).Cell adhesion & migration,
7(3), 275–82. doi:10.4161/cam.24531
8. Binding of a sialic acid-recognizing lectin Siglec-9 modulates adhesion dynamics of cancer cells via calpainmediated protein degradation. Sabit, I., Hashimoto, N., Matsumoto, Y., Yamaji, T., Furukawa, K., & Furukawa,
K. (2013).The Journal of biological chemistry, 288(49), 35417–27. doi:10.1074/jbc.M113.513192
1
9. New blocking antibodies impede adhesion, migration and survival of ovarian cancer cells, highlighting MFGE8
as a potential therapeutic target of human ovarian carcinoma. Tibaldi, L., Leyman, S., Nicolas, A., Notebaert,
S., Dewulf, M., Ngo, T. H., Zuany-Amorim, C., et al. (2013).PloS one, 8(8), e72708.
doi:10.1371/journal.pone.0072708
10. The carcinoembryonic antigen IgV-like N domain plays a critical role in the implantation of metastatic tumor
cells. Abdul-Wahid, A., Huang, E. H.-B., Cydzik, M., Bolewska-Pedyczak, E., & Gariépy, J. (2014).Molecular
oncology, 8(2), 337–50. doi:10.1016/j.molonc.2013.12.002
11. Effects of ECM protein mimetics on adhesion and proliferation of chorion derived mesenchymal stem cells.
Kim, J.-H., Jekarl, D. W., Kim, M., Oh, E.-J., Kim, Y., Park, I. Y., & Shin, J. C. (2014).International journal of
medical sciences, 11(3), 298–308. doi:10.7150/ijms.6672
12. Neutrophil elastase-dependent cleavage compromises the tumor suppressor role of EMILIN1. Pivetta, E.,
Danussi, C., Wassermann, B., Modica, T. M. E., Del Bel Belluz, L., Canzonieri, V., Colombatti, A., et al.
(2014).Matrix biology : journal of the International Society for Matrix Biology, 34, 22–32.
doi:10.1016/j.matbio.2014.01.018
13. Using real-time impedance based assay to monitor the effects of fibroblast derived media on the adhesion,
proliferation, migration, and invasion of colon cancer cells. Kiely, P. (2014).Bioscience Reports.
14. xCELLigence system for real-time label-free monitoring of growth and viability of cell lines from hematological
malignancies. Martinez-Serra, J., Gutierrez, A., Muñoz-Capó, S., Navarro-Palou, M., Ros, T., Amat, J. C., Lopez,
B., et al. (2014).OncoTargets and therapy, 7, 985–94. doi:10.2147/OTT.S62887
15. Aliskiren inhibits prorenin-induced human aortic smooth muscle cell migration. Ferri, N., Panariti, F., Ricci, C.,
Maiocchi, G., & Corsini, A. (2014).Journal of the renin-angiotensin-aldosterone system : JRAAS.
doi:10.1177/1470320314528364
16. Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner. Sipilä, K.,
Haag, S., Denessiouk, K., Käpylä, J., Peters, E. C., Denesyuk, A., Hansen, U., et al. (2014).FASEB journal : official
publication of the Federation of American Societies for Experimental Biology, 28(8), 3758–68.
doi:10.1096/fj.13-247767
17. Promoting cell proliferation using water dispersible germanium nanowires. Bezuidenhout, M., Liu, P., Singh, S.,
Kiely, M., Ryan, K. M., & Kiely, P. a. (2014).PloS one, 9(9), e108006. doi:10.1371/journal.pone.0108006
18. Statins Enhance Rotator Cuff Healing by Stimulating the COX2/PGE2/EP4 Pathway: An In Vivo and In Vitro
Study. Dolkart, O., Liron, T., Chechik, O., Somjen, D., Brosh, T., Maman, E., & Gabet, Y. (2014).The American
journal of sports medicine. doi:10.1177/0363546514545856
19. The interaction between uPAR and vitronectin triggers ligand‐independent adhesion signalling by integrins.
Ferraris, G., & Schulte, C. (2014).The EMBO …, 33(21), 2458–2473. Retrieved from
http://onlinelibrary.wiley.com/doi/10.15252/embj.201387611/full
20. Targeted subendothelial matrix oxidation by myeloperoxidase triggers myosin II-dependent de-adhesion and
alters signaling in endothelial cells. Rees, M. D., Dang, L., Thai, T., Owen, D. M., Malle, E., & Thomas, S. R.
(2012).Free radical biology & medicine, 53(12), 2344–56. doi:10.1016/j.freeradbiomed.2012.10.002
2
21. PDK1 regulates focal adhesion disassembly through modulation of  v  3 integrin endocytosis Accepted
manuscript. Blasio, L., Gagliardi, P. A., Puliafito, A., & Sessa, R. (2015)., (January).
*22. Histatin-1, a histidine-rich peptide in human saliva, promotes cell-substrate and cell-cell adhesion. van Dijk, I.
a., Nazmi, K., Bolscher, J. G. M., Veerman, E. C. I., & Stap, J. (2015).The FASEB Journal, 29, 3124–3132.
doi:10.1096/fj.14-266825
*23. The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in
acute lymphoblastic leukaemia cells. Lysaght, J., Verma, N. K., Maginn, E. N., Ryan, J. M., Campiani, G.,
Zisterer, D. M., Williams, D. C., et al. (2013).International Journal of Oncology, 42, 239–246.
doi:10.3892/ijo.2012.1688
CELL BARRIER FUNCTION
1. Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein
endothelial cells. Li, H.-B., Ge, Y.-K., Zhang, L., & Zheng, X.-X. (2006).Life Sciences, 79(12), 1186–93.
doi:10.1016/j.lfs.2006.03.041
2. Analysis of the passage of the marine biotoxin okadaic acid through an in vitro human gut barrier. Ehlers, A.,
Scholz, J., These, A., Hessel, S., Preiss-Weigert, A., & Lampen, A. (2011).Toxicology, 279(1-3), 196–202.
doi:10.1016/j.tox.2010.11.001
3. The small GTPase Rap1 is a novel regulator of RPE cell barrier function. Wittchen, E. S., & Hartnett, M. E.
(2011).Investigative ophthalmology & visual science, 52(10), 7455–63. doi:10.1167/iovs.11-7295
4. Guanine nucleotide-binding protein Gαi2: a new partner of claudin-5 that regulates tight junction integrity in
human brain endothelial cells. Luissint, A.-C., Federici, C., Guillonneau, F., Chrétien, F., Camoin, L., Glacial, F.,
Ganeshamoorthy, K., et al. (2012, May).Journal of cerebral blood flow and metabolism : official journal of the
International Society of Cerebral Blood Flow and Metabolism. doi:10.1038/jcbfm.2011.202
5. Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1.
Beale, T. M., Bond, P. J., Brenton, J. D., Charnock-Jones, D. S., Ley, S. V, & Myers, R. M. (2012).Bioorganic &
Medicinal Chemistry, 20(5), 1749–59. doi:10.1016/j.bmc.2012.01.010
6. VEGF-induced vascular permeability is mediated by FAK. Chen, X. L., Nam, J.-O., Jean, C., Lawson, C., Walsh, C.
T., Goka, E., Lim, S.-T., et al. (2012).Developmental cell, 22(1), 146–57. doi:10.1016/j.devcel.2011.11.002
7. The effect of sucrose esters on a culture model of the nasal barrier. Kürti, L., Veszelka, S., Bocsik, A., Dung, N. T.
K., Ozsvári, B., Puskás, L. G., Kittel, A., et al. (2012).Toxicology in vitro : an international journal published in
association with BIBRA, 26(3), 445–54. doi:10.1016/j.tiv.2012.01.015
8. Retinoic acid and hydrocortisone strengthen the barrier function of human RPMI 2650 cells, a model for nasal
epithelial permeability. Kürti, L., Veszelka, S., Bocsik, A., Ozsvári, B., Puskás, L. G., Kittel, A., Szabó-Révész, P.,
et al. (2012).Cytotechnology. doi:10.1007/s10616-012-9493-7
3
9. An inverted blood-brain barrier model that permits interactions between glia and inflammatory stimuli.
Sansing, H. a, Renner, N. a, & MacLean, A. G. (2012).Journal of neuroscience methods, 207(1), 91–6.
doi:10.1016/j.jneumeth.2012.03.015
10. A dynamic real-time method for monitoring epithelial barrier function in vitro. Sun, M., Fu, H., Cheng, H., Cao,
Q., Zhao, Y., Mou, X., Zhang, X., et al. (2012).Analytical biochemistry, 425(2), 96–103.
doi:10.1016/j.ab.2012.03.010
11. Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation. Twiss, F., Le
Duc, Q., Van Der Horst, S., Tabdili, H., Van Der Krogt, G., Wang, N., Rehmann, H., et al. (2012).Biology open,
1(11), 1128–40. doi:10.1242/bio.20122428
12. The effect of 7-ketocholesterol and 25-hydroxycholesterol on the integrity of the human aortic endothelial
and intestinal epithelial barriers. Chalubinski, M., Zemanek, K., Skowron, W., Wojdan, K., Gorzelak, P., &
Broncel, M. (2013).Inflammation research : official journal of the European Histamine Research Society ... [et
al.]. doi:10.1007/s00011-013-0660-x
13. CCM1-ICAP-1 complex controls 1 integrin-dependent endothelial contractility and fibronectin remodeling.
Faurobert, E., Rome, C., Lisowska, J., Manet-Dupe, S., Boulday, G., Malbouyres, M., Balland, M., et al.
(2013).The Journal of Cell Biology, 202(3), 545–561. doi:10.1083/jcb.201303044
14. Inflammatory effects of resistin on human smooth muscle cells: up-regulation of fractalkine and its receptor,
CX3CR1 expression by TLR4 and Gi-protein pathways. Gan, A.-M., Butoi, E. D., Manea, A., Simion, V., Stan, D.,
Parvulescu, M.-M., Calin, M., et al. (2013).Cell and tissue research, 351(1), 161–74. doi:10.1007/s00441-0121510-9
15. Prostaglandin D2-DP Signaling Promotes Endothelial Barrier Function via the cAMP/PKA/Tiam1/Rac1
Pathway. Kobayashi, K., Tsubosaka, Y., Hori, M., Narumiya, S., Ozaki, H., & Murata, T. (2013).Arteriosclerosis,
thrombosis, and vascular biology, 33(3), 565–71. doi:10.1161/ATVBAHA.112.300993
16. Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal
enhancement. Murata, T., Aritake, K., Tsubosaka, Y., Maruyama, T., Nakagawa, T., Hori, M., Hirai, H., et al.
(2013).Proceedings of the National Academy of Sciences of the United States of America, 110(13), 5205–10.
doi:10.1073/pnas.1218091110
17. Interaction of HIF-1 and Notch3 Is Required for the Expression of Carbonic Anhydrase 9 in Breast Carcinoma
Cells. Shareef, M. M., Udayakumar, T. S., Sinha, V. K., Saleem, S. M., & Griggs, W. W. (2013).Genes & Cancer.
doi:10.1177/1947601913481670
18. The Wnt/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain
endothelial cells. Artus, C., Glacial, F., Ganeshamoorthy, K., Ziegler, N., Godet, M., Guilbert, T., Liebner, S., et
al. (2014).Journal of cerebral blood flow and metabolism : official journal of the International Society of
Cerebral Blood Flow and Metabolism, 34(3), 433–40. doi:10.1038/jcbfm.2013.213
19. Stimulation of G protein-coupled bile acid receptor enhances vascular endothelial barrier function via
activation of protein kinase A and Rac1. Kida, T., Omori, K., Hori, M., Ozaki, H., & Murata, T. (2014).The
Journal of pharmacology and experimental therapeutics, 348(1), 125–30. doi:10.1124/jpet.113.209288
4
20. A Real Time Impedance-Based Screening Assay For Drug-Induced Vascular Leakage. Kustermann, S., Manigold,
T., Ploix, C., Skubatz, M., Heckel, T., Hinton, H., Weiser, T., et al. (2014).Toxicological sciences : an official
journal of the Society of Toxicology, 138(2), 1–27. doi:10.1093/toxsci/kft336
21. Spire-1 contributes to the invadosome and its associated invasive properties. Lagal, V., Abrivard, M., Gonzalez,
V., Perazzi, A., Popli, S., Verzeroli, E., & Tardieux, I. (2014).Journal of cell science, 127(Pt 2), 328–40.
doi:10.1242/jcs.130161
22. Opposing immunomodulatory roles of prostaglandin D2 during the progression of skin inflammation.
Sarashina, H., Tsubosaka, Y., Omori, K., Aritake, K., Nakagawa, T., Hori, M., Hirai, H., et al. (2014).Journal of
immunology (Baltimore, Md. : 1950), 192(1), 459–65. doi:10.4049/jimmunol.1302080
23. Deoxynivalenol: a trigger for intestinal integrity breakdown. Akbari, P., Braber, S., Gremmels, H., Koelink, P. J.,
Verheijden, K. a T., Garssen, J., & Fink-Gremmels, J. (2014).FASEB journal : official publication of the
Federation of American Societies for Experimental Biology, 28(6), 2414–29. doi:10.1096/fj.13-238717
24. Studies towards biocompatibility of PAMAM dendrimers - Overall hemostasis potential and integrity of the
human aortic endothelial barrier. Markowicz-Piasecka, M., Luczak, E., Chałubiński, M., Broncel, M., MikiciukOlasik, E., & Sikora, J. (2014).International journal of pharmaceutics, 473(1-2), 158–69.
doi:10.1016/j.ijpharm.2014.07.002
25. Human Vascular Tissue Models Formed from Human Induced Pluripotent Stem Cell Derived Endothelial Cells.
Belair, D. G., Whisler, J. a, Valdez, J., Velazquez, J., Molenda, J. a, Vickerman, V., Lewis, R., et al. (2014).Stem
cell reviews. doi:10.1007/s12015-014-9549-5
26. Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of
vascular integrity. Stavenuiter, F., & Mosnier, L. O. (2014).Blood, 124(23), 3480–9. doi:10.1182/blood-201406-582775
CELL INVASION & MIGRATION
1. A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorageindependent growth by a novel mechanism involving p130Cas cleavage. Daouti, S., Li, W., Qian, H., Huang,
K.-S., Holmgren, J., Levin, W., Reik, L., et al. (2008).Cancer research, 68(4), 1162–9. doi:10.1158/00085472.CAN-07-2349
2. New technology for investigating trophoblast function. Keogh, R. J. (2010).Placenta, 31(4), 347–50.
doi:10.1016/j.placenta.2010.02.008
3. Melanoblasts in culture as an in vitro system to determine molecular changes in melanoma. Bosserhoff, A. K.,
Ellmann, L., & Kuphal, S. (2011).Experimental dermatology, 20(5), 435–40. doi:10.1111/j.16000625.2011.01271.x
4. Keratinocyte-derived laminin-332 promotes adhesion and migration in melanocytes and melanoma. Chung, H.,
Suh, E.-K., Han, I.-O., & Oh, E.-S. (2011).The Journal of biological chemistry, 286(15), 13438–47.
doi:10.1074/jbc.M110.166751
5
5. Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α. Coutts, A S, Pires, I. M., Weston, L.,
Buffa, F. M., Milani, M., Li, J.-L., Harris, A. L., et al. (2011).Oncogene, 30(48), 4835–42.
doi:10.1038/onc.2011.188
6. Mechanistic modeling of the effects of myoferlin on tumor cell invasion. Eisenberg, M. C., Kim, Y., Li, R.,
Ackerman, W. E., Kniss, D. a, & Friedman, A. (2011).Proceedings of the National Academy of Sciences of the
United States of America, 108(50), 20078–83. doi:10.1073/pnas.1116327108
7. Silencing of the SEC62 gene inhibits migratory and invasive potential of various tumor cells. Greiner, M.,
Kreutzer, B., Jung, V., Grobholz, R., Hasenfus, A., Stöhr, R. F., Tornillo, L., et al. (2011).International journal of
cancer. Journal international du cancer, 128(10), 2284–95. doi:10.1002/ijc.25580
8. Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1)
expression: role of chelatable iron. Hickok, J. R., Sahni, S., Mikhed, Y., Bonini, M. G., & Thomas, D. D.
(2011).The Journal of biological chemistry, 286(48), 41413–24. doi:10.1074/jbc.M111.287052
9. Non-canonical pathways of HIF1-alpha regulation in ovarian cancer implications for tumor angiogenesis and
metastasis. Joshi, H. P. (2011)., (October). Retrieved from http://purl.umn.edu/123380
10. sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1
stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration. Martin-Manso, G., Calzada, M. J.,
Chuman, Y., Sipes, J. M., Xavier, C. P., Wolf, V., Kuznetsova, S. a, et al. (2011).Archives of biochemistry and
biophysics, 509(2), 147–56. doi:10.1016/j.abb.2011.03.004
11. YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion. Rahim, S., Beauchamp, E. M., Kong, Y.,
Brown, M. L., Toretsky, J. a, & Ü ren, A. (2011).PloS one, 6(4), e19343. doi:10.1371/journal.pone.0019343
12. A real-time electrical impedance based technique to measure invasion of endothelial cell monolayer by
cancer cells. Rahim, S., & Ü ren, A. (2011).Journal of visualized experiments : JoVE, (50), 2–5. doi:10.3791/2792
13. Ionizing radiation induces migration of glioblastoma cells by activating BK K(+) channels. Steinle, M., Palme, D.,
Misovic, M., Rudner, J., Dittmann, K., Lukowski, R., Ruth, P., et al. (2011).Radiotherapy and oncology : journal
of the European Society for Therapeutic Radiology and Oncology, 101(1), 122–6.
doi:10.1016/j.radonc.2011.05.069
14. Differential roles of Src in transforming growth factor-ß regulation of growth arrest, epithelial-tomesenchymal transition and cell migration in pancreatic ductal adenocarcinoma cells. Ungefroren, H.,
Sebens, S., Groth, S., Gieseler, F., & Fändrich, F. (2011).International journal of oncology, 38(3), 797–805.
doi:10.3892/ijo.2011.897
15. Adhesion Protein Protocols IN Series Editor. Coutts, Amanda S, & Walker, J. M. (n.d.).
16. Transient invasive migration in mouse cumulus oocyte complexes induced at ovulation by luteinizing
hormone. Akison, L. K., Alvino, E. R., Dunning, K. R., Robker, R. L., & Russell, D. L. (2012).Biology of
reproduction, 86(4), 125. doi:10.1095/biolreprod.111.097345
17. The Src family kinase inhibitors PP2 and PP1 effectively block TGF-beta1-induced cell migration and invasion
in both established and primary carcinoma cells. Bartscht, T., Lehnert, H., Gieseler, F., & Ungefroren, H.
(2012).Cancer chemotherapy and pharmacology, 70(2), 221–30. doi:10.1007/s00280-012-1904-0
6
18. Hierarchy between the transmembrane and cytoplasmic domains in the regulation of syndecan-4 functions.
Choi, Y., Kang, D., Han, I.-O., & Oh, E.-S. (2012).Cellular signalling, 24(8), 1522–30.
doi:10.1016/j.cellsig.2012.03.020
19. Systemic shRNA mediated knock-down of S100A4 in colorectal cancer xenografted mice reduces metastasis
formation ABSTRACT : Dahlmann, M., Sack, U., Herrmann, P., Lemm, M., Fichtner, I., Schlag, P. M., & Stein, U.
(2012).Oncotarget, 3(8), 783–797.
20. The renal v-ATPase a4 subunit is expressed in specific subtypes of human gliomas. Gleize, V., Boisselier, B.,
Marie, Y., Poëa-Guyon, S., Sanson, M., & Morel, N. (2012).Glia, 60(6), 1004–12. doi:10.1002/glia.22332
21. Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive
capacity is reduced. Hellevik, T., Pettersen, I., Berg, V., Winberg, J. O., Moe, B. T., Bartnes, K., Paulssen, R. H.,
et al. (2012).Radiation oncology (London, England), 7(1), 59. doi:10.1186/1748-717X-7-59
22. MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins
FHOD1 and PPM1F. Jurmeister, S., Baumann, M., Balwierz, A., Keklikoglou, I., Ward, A., Uhlmann, S., Zhang, J.
D., et al. (2012).Molecular and cellular biology, 32(3), 633–51. doi:10.1128/MCB.06212-11
23. 3T3 cell lines stably expressing Pax6 or Pax6(5a)--a new tool used for identification of common and isoform
specific target genes. Kiselev, Y., Eriksen, T. E., Forsdahl, S., Nguyen, L. H. T., & Mikkola, I. (2012).PloS one,
7(2), e31915. doi:10.1371/journal.pone.0031915
24. c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast
cancer cell invasion and metastasis. Knopfová, L., Beneš, P., Pekarčíková, L., Hermanová, M., Masařík, M.,
Pernicová, Z., Souček, K., et al. (2012).Molecular cancer, 11(1), 15. doi:10.1186/1476-4598-11-15
25. Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment. Lal, S., La
Du, J., Tanguay, R. L., & Greenwood, J. a. (2012).Journal of neuroscience research, 90(4), 769–81.
doi:10.1002/jnr.22794
26. Raf-1 oncogenic signaling is linked to activation of mesenchymal to epithelial transition pathway in metastatic
breast cancer cells. Leontovich, A. a, Zhang, S., Quatraro, C., Iankov, I., Veroux, P. F., Gambino, M. W.,
Degnim, A., et al. (2012).International journal of oncology, 40(6), 1858–64. doi:10.3892/ijo.2012.1407
27. Comparative analysis of dynamic cell viability, migration and invasion assessments by novel real-time
technology and classic endpoint assays. Limame, R., Wouters, A., Pauwels, B., Fransen, E., Peeters, M.,
Lardon, F., De Wever, O., et al. (2012).PloS one, 7(10), e46536. doi:10.1371/journal.pone.0046536
28. Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in
vivo. Liu, N.-C., Hsieh, P.-F., Hsieh, M.-K., Zeng, Z.-M., Cheng, H.-L., Liao, J.-W., & Chueh, P. J. (2012).Journal of
agricultural and food chemistry, 60(10), 2758–65. doi:10.1021/jf204869w
29. Cortisol-mediated adhesion of synovial fibroblasts is dependent on the degradation of anandamide and
activation of the endocannabinoid system. Lowin, T., Zhu, W., Dettmer-Wilde, K., & Straub, R. H.
(2012).Arthritis and rheumatism, 1–35. doi:10.1002/art.37684
7
30. Tumor vascular responses to antivascular and antiangiogenic strategies: looking for suitable models. Mriouah,
J., Boura, C., Thomassin, M., Bastogne, T., Dumas, D., Faivre, B., & Barberi-Heyob, M. (2012).Trends in
biotechnology, 30(12), 649–58. doi:10.1016/j.tibtech.2012.08.006
31. Macrophage migration inhibitory factor (MIF) promotes cell survival and proliferation of neural
stem/progenitor cells. Ohta, S., Misawa, A., Fukaya, R., Inoue, S., Kanemura, Y., Okano, H., Kawakami, Y., et al.
(2012).Journal of cell science, (March). doi:10.1242/jcs.102210
32. Lack of CCR7 expression is rate limiting for lymphatic spread of pancreatic ductal adenocarcinoma.
Sperveslage, J., Frank, S., Heneweer, C., Egberts, J., Schniewind, B., Buchholz, M., Bergmann, F., et al.
(2012).International journal of cancer. Journal international du cancer, 131(4), E371–81. doi:10.1002/ijc.26502
33. Chemotherapeutic agents enhance cell migration and epithelial-to-mesenchymal transition through transient
up-regulation of tNOX (ENOX2) protein. Su, Y.-C., Lin, Y.-H., Zeng, Z.-M., Shao, K.-N., & Chueh, P. J.
(2012).Biochimica et biophysica acta, 1820(11), 1744–52. doi:10.1016/j.bbagen.2012.07.009
34. Nuclear envelope-localized EGF family protein amphiregulin activates breast cancer cell migration in an EGFlike domain independent manner. Tanaka, H., Nishioka, Y., Yokoyama, Y., Higashiyama, S., Matsuura, N.,
Matsuura, S., & Hieda, M. (2012).Biochemical and biophysical research communications, 420(4), 721–6.
doi:10.1016/j.bbrc.2012.03.045
35. Endothelial cells obtained from patients affected by chronic venous disease exhibit a pro-inflammatory
phenotype. Tisato, V., Zauli, G., Voltan, R., Gianesini, S., di Iasio, M. G., Volpi, I., Fiorentini, G., et al.
(2012).PloS one, 7(6), e39543. doi:10.1371/journal.pone.0039543
36. Silencing of Glucose-Regulated Protein 78 (GRP78) Enhances Cell Migration Through the Upregulation of
Vimentin in Hepatocellular Carcinoma Cells. Wei, P.-L., Kuo, L.-J., Wang, W., Lin, F.-Y., Liu, H.-H., How, T., Ho,
Y.-S., et al. (2012).Annals of surgical oncology, 19 Suppl 3, 572–9. doi:10.1245/s10434-011-2055-y
37. NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery.
Xu, H., Gu, N., Liu, Z.-B., Zheng, M., Xiong, F., Wang, S.-Y., Li, N., et al. (2012).Oncology letters, 3(1), 39–44.
doi:10.3892/ol.2011.441
38. Rhodocetin-αβ-induced Neuropilin-1-cMet Association Triggers Restructuring of Matrix Contacts in
Endothelial Cells. Niland, S., Ditkowski, B., Parrandier, D., Roth, L., Augustin, H., & Eble, J. a. (2013,
March).Arteriosclerosis, thrombosis, and vascular biology. doi:10.1161/ATVBAHA.112.00006
39. The collagen-binding integrin α2β1 is a novel interaction partner of the trimeresurus flavoviridis venom
protein flavocetin-A. Arlinghaus, F. T., & Eble, J. a. (2013, January 11).The Journal of biological chemistry.
doi:10.1074/jbc.M112.399618
40. Characterization of Spontaneous and TGF-β-Induced Cell Motility of Primary Human Normal and Neoplastic
Mammary Cells In Vitro Using Novel Real-Time Technology. Mandel, K., Seidl, D., Rades, D., Lehnert, H.,
Gieseler, F., Hass, R., & Ungefroren, H. (2013, January).PloS one. doi:10.1371/journal.pone.0056591
41. Regulation of the Src Kinase-Associated Phosphoprotein 55 Homologue by the protein tyrosine phosphatase
PTP-PEST in the control of cell motility. Ayoub, E., Hall, A., Scott, A. M., Chagnon, M. M., Miquel, G., Halle, M.,
Noda, M., et al. (2013).The Journal of biological chemistry. doi:10.1074/jbc.M113.501007
8
42. Control of extravillous trophoblast function by the eotaxins CCL11, CCL24 and CCL26. Chau, S. E., Murthi, P.,
Wong, M. H., Whitley, G. S., Brennecke, S. P., & Keogh, R. J. (2013).Human reproduction (Oxford, England),
28(6), 1497–507. doi:10.1093/humrep/det060
43. Systemically Circulating Viral and Tumor-Derived MicroRNAs in KSHV-Associated Malignancies. Chugh, P. E.,
Sin, S.-H., Ozgur, S., Henry, D. H., Menezes, P., Griffith, J., Eron, J. J., et al. (2013).PLoS pathogens, 9(7),
e1003484. doi:10.1371/journal.ppat.1003484
44. The Rho Guanine Nucleotide Exchange Factor Syx Regulates the Balance of Dia and ROCK Activities To
Promote Polarized-Cancer-Cell Migration. Dachsel, J. C., Ngok, S. P., Lewis-Tuffin, L. J., Kourtidis, A., Geyer, R.,
Johnston, L., Feathers, R., et al. (2013).Molecular and cellular biology, 33(24), 4909–18.
doi:10.1128/MCB.00565-13
45. Effect of aluminium on migratory and invasive properties of MCF-7 human breast cancer cells in culture.
Darbre, P. D., Bakir, A., & Iskakova, E. (2013).Journal of inorganic biochemistry, 5–9.
doi:10.1016/j.jinorgbio.2013.07.004
46. Protein Kinase D1 mediated phosphorylations regulate vasodilator-stimulated phosphoprotein (VASP)
localization and cell migration. Doeppler, H. R., Bastea, L. I., Lewis-Tuffin, L. J., Anastasiadis, P. Z., & Storz, P.
(2013).The Journal of biological chemistry. doi:10.1074/jbc.M113.474676
47. Neuregulin mediates F-actin-driven cell migration through inhibition of protein kinase D1 via Rac1 protein.
Döppler, H., Bastea, L. I., Eiseler, T., & Storz, P. (2013).The Journal of biological chemistry, 288(1), 455–65.
doi:10.1074/jbc.M112.397448
48. AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in
early stage colon cancer. Dunne, P., McArt, D. G., Blayney, J. K., Kalimutho, M., Greer, S., Wang, T., Srivastava,
S., et al. (2013).Clinical cancer research : an official journal of the American Association for Cancer Research.
doi:10.1158/1078-0432.CCR-13-1354
49. An essential role for decorin in bladder cancer invasiveness. El Behi, M., Krumeich, S., Lodillinsky, C., Kamoun,
A., Tibaldi, L., Sugano, G., De Reynies, A., et al. (2013).EMBO molecular medicine, 5(12), 1835–51.
doi:10.1002/emmm.201302655
50. Axl Mediates Acquired Resistance of Head and Neck Cancer Cells to the Epidermal Growth Factor Receptor
Inhibitor Erlotinib. Giles, K. M., Kalinowski, F. C., Candy, P. a, Epis, M. R., Zhang, P. M., Redfern, A. D., Stuart, L.
M., et al. (2013).Molecular cancer therapeutics, 2541–2558. doi:10.1158/1535-7163.MCT-13-0170
51. Growth differentiation factor 15 stimulates rapamycin-sensitive ovarian cancer cell growth and invasion.
Griner, S. E., Joshi, J. P., & Nahta, R. (2013).Biochemical pharmacology, 85(1), 46–58.
doi:10.1016/j.bcp.2012.10.007
52. Impact of MACC1 on human malignant glioma progression and patients’ unfavorable prognosis. Hagemann,
C., Fuchs, S., Monoranu, C. M., Herrmann, P., Smith, J., Hohmann, T., Grabiec, U., et al. (2013).Journal of
Neuro-Oncology, 1–14.
53. Identification of the C3a Receptor ( C3AR1 ) as the Target of the VGF-derived Peptide TLQP-21 in Rodent Cells.
Hannedouche, S., Beck, V., Beibel, M., Oakeley, E. J., Lannoy, V., Bernard, J., Hamon, J., et al. (2013).
doi:10.1074/jbc.M113.497214
9
54. A Real Time Chemotaxis Assay Unveils Unique Migratory Profiles amongst Different Primary Murine
Macrophages. Iqbal, A. J., Regan-Komito, D., Christou, I., White, G. E., McNeill, E., Kenyon, A., Taylor, L., et al.
(2013). (J. Wallace, Ed.)PLoS ONE, 8(3), e58744. doi:10.1371/journal.pone.0058744
55. Cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells. Jevnikar, Z.,
Rojnik, M., Jamnik, P., Doljak, B., Fonovic, U. P., & Kos, J. (2013).The Journal of Biological Chemistry, 288(4),
2201–9. doi:10.1074/jbc.M112.436394
56. Down-regulation of the cancer/testis antigen 45 (CT45) is associated with altered tumor cell morphology,
adhesion and migration. Koop, A., Sellami, N., Adam-Klages, S., Lettau, M., Kabelitz, D., Janssen, O., &
Heidebrecht, H.-J. (2013).Cell communication and signaling : CCS, 11(1), 41. doi:10.1186/1478-811X-11-41
57. Rab25 regulates integrin expression in polarized colonic epithelial cells. Krishnan, M., Lapierre, L. a, Knowles, B.
C., & Goldenring, J. R. (2013).Molecular biology of the cell, 24(6), 818–31. doi:10.1091/mbc.E12-10-0745
58. Optimizing patient derived mesenchymal stem cells as virus carriers for a phase I clinical trial in ovarian
cancer. Mader, E. K., Butler, G., Dowdy, S. C., Mariani, A., Knutson, K. L., Federspiel, M. J., Russell, S. J., et al.
(2013).Journal of translational medicine, 11(1), 20. doi:10.1186/1479-5876-11-20
59. A complex containing LPP and α-actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing
breast cancer cells. Ngan, E., Northey, J. J., Brown, C. M., Ursini-Siegel, J., & Siegel, P. M. (2013).Journal of cell
science, 126(Pt 9), 1981–91. doi:10.1242/jcs.118315
60. A novel snRNA-like transcript affects amyloidogenesis and cell cycle progression through perturbation of
Fe65L1 (APBB2) alternative splicing. Penna, I., Vassallo, I., Nizzari, M., Russo, D., Costa, D., Menichini, P.,
Poggi, A., et al. (2013).Biochimica et biophysica acta, 1833(6), 1511–26. doi:10.1016/j.bbamcr.2013.02.020
61. Osteocyte-induced angiogenesis via VEGF-MAPK-dependent pathways in endothelial cells. Prasadam, I., Zhou,
Y., Du, Z., Chen, J., Crawford, R., & Xiao, Y. (2013).Molecular and cellular biochemistry. doi:10.1007/s11010013-1840-2
62. MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma. Redova, M.,
Poprach, A., Besse, A., Iliev, R., Nekvindova, J., Lakomy, R., Radova, L., et al. (2013).Tumour biology : the
journal of the International Society for Oncodevelopmental Biology and Medicine, 34(1), 481–91.
doi:10.1007/s13277-012-0573-2
63. Consistency of the proteome in primary human keratinocytes with respect to gender, age, and skin
localization. Sprenger, A., Weber, S., Zarai, M., Engelke, R., Nascimento, J. M., Gretzmeier, C., Hilpert, M., et
al. (2013).Molecular & cellular proteomics : MCP, 12(9), 2509–21. doi:10.1074/mcp.M112.025478
64. New blocking antibodies impede adhesion, migration and survival of ovarian cancer cells, highlighting MFGE8
as a potential therapeutic target of human ovarian carcinoma. Tibaldi, L., Leyman, S., Nicolas, A., Notebaert,
S., Dewulf, M., Ngo, T. H., Zuany-Amorim, C., et al. (2013).PloS one, 8(8), e72708.
doi:10.1371/journal.pone.0072708
65. Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53
mutant cells. van Oosterwijk, J. G., van Ruler, M. a J. H., Briaire-de Bruijn, I. H., Herpers, B., Gelderblom, H.,
van de Water, B., & Bovée, J. V. M. G. (2013).British journal of cancer, (August), 1–9. doi:10.1038/bjc.2013.451
10
66. Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage
retention. Wanschel, A., Seibert, T., Hewing, B., Ramkhelawon, B., Ray, T. D., van Gils, J. M., Rayner, K. J., et al.
(2013).Arteriosclerosis, thrombosis, and vascular biology, 33(5), 886–93. doi:10.1161/ATVBAHA.112.300941
67. Withania somnifera Root Extract Inhibits Mammary Cancer Metastasis and Epithelial to Mesenchymal
Transition. Yang, Z., Garcia, A., Xu, S., Powell, D. R., Vertino, P. M., Singh, S., & Marcus, A. I. (2013).PloS one,
8(9), e75069. doi:10.1371/journal.pone.0075069
68. Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes
medulloblastoma migration. Yuan, L., Zhang, H., Liu, J., Rubin, J. B., Cho, Y.-J., Shu, H. K., Schniederjan, M., et
al. (2013).Molecular cancer, 12(1), 18. doi:10.1186/1476-4598-12-18
69. Regulation of CXCR4-mediated invasion by DARPP-32 in gastric cancer cells. Zhu, S., Hong, J., Tripathi, M. K.,
Sehdev, V., Belkhiri, A., & El-Rifai, W. (2013).Molecular cancer research : MCR, 11(1), 86–94.
doi:10.1158/1541-7786.MCR-12-0243-T
70. Induction of tumor stem cell differentiation-novel strategy to overcome therapy resistance in gastric cancer.
Zieker, D., Bühler, S., Ustündag, Z., Königsrainer, I., Manncke, S., Bajaeifer, K., Vollmer, J., et al.
(2013).Langenbeck’s archives of surgery / Deutsche Gesellschaft fur Chirurgie, 4–9. doi:10.1007/s00423-0131058-5
71. 12-O-tetradecanoylphorbol-13-acetate promotes breast cancer cell motility by increasing S100A14 level in a
Kruppel-like transcription factor 4 (KLF4)-dependent manner. He, H., Li, S., Chen, H., Li, L., Xu, C., Ding, F.,
Zhan, Y., et al. (2014).The Journal of biological chemistry, 289(13), 9089–99. doi:10.1074/jbc.M113.534271
72. Exposure to parabens at the concentration of maximal proliferative response increases migratory and
invasive activity of human breast cancer cells in vitro. Khanna, S., Dash, P. R., & Darbre, P. D. (2014).Journal
of applied toxicology : JAT, (January). doi:10.1002/jat.3003
73. Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in
fibroblast-like synoviocytes from patients with rheumatoid arthritis. Lahoti, T. S., Hughes, J. M., Kusnadi, A.,
John, K., Zhu, B., Murray, I. a, Gowda, K., et al. (2014).The Journal of pharmacology and experimental
therapeutics, 348(2), 236–45. doi:10.1124/jpet.113.209726
74. Olive oil compounds inhibit vascular endothelial growth factor receptor-2 phosphorylation. Lamy, S.,
Ouanouki, A., Béliveau, R., & Desrosiers, R. R. (2014).Experimental cell research, 322(1), 89–98.
doi:10.1016/j.yexcr.2013.11.022
75. Regulation and function of the atypical cadherin FAT1 in hepatocellular carcinoma. Valletta, D., Czech, B.,
Spruss, T., Ikenberg, K., Wild, P., Hartmann, A., Weiss, T. S., et al. (2014).Carcinogenesis, 00(00), 1–9.
doi:10.1093/carcin/bgu054
76. G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate cancer.
Chakraborty, P. K., Zhang, Y., Coomes, A. S., Kim, W.-J., Stupay, R., Lynch, L. D., Atkinson, T., et al.
(2014).Cancer research, 74(13), 3489–500. doi:10.1158/0008-5472.CAN-13-2708
77. A Homozygous Missense Mutation in the Ciliary Gene TTC21B Causes Familial FSGS. Cong, E. H., Bizet, A. a,
Boyer, O., Woerner, S., Gribouval, O., Filhol, E., Arrondel, C., et al. (2014).Journal of the American Society of
Nephrology : JASN, 1–9. doi:10.1681/ASN.2013101126
11
78. Using real-time impedance based assay to monitor the effects of fibroblast derived media on the adhesion,
proliferation, migration, and invasion of colon cancer cells. Kiely, P. (2014).Bioscience Reports.
79. Placental expression of aminopeptidase-Q (laeverin) and its role in the pathophysiology of preeclampsia.
Nystad, M., Sitras, V., Larsen, M., & Acharya, G. (2014).American journal of obstetrics and gynecology.
doi:10.1016/j.ajog.2014.06.047
80. The glycosphingolipid P1 is an ovarian cancer-associated carbohydrate antigen involved in migration. Jacob,
F., Anugraham, M., Pochechueva, T., Tse, B. W. C., Alam, S., Guertler, R., Bovin, N. V, et al. (2014).British
journal of cancer, 3(August), 1–12. doi:10.1038/bjc.2014.455
81. Human Vascular Tissue Models Formed from Human Induced Pluripotent Stem Cell Derived Endothelial Cells.
Belair, D. G., Whisler, J. a, Valdez, J., Velazquez, J., Molenda, J. a, Vickerman, V., Lewis, R., et al. (2014).Stem
cell reviews. doi:10.1007/s12015-014-9549-5
82. Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain-offunction capacity. Nguyen, K.-Q. N., Tsou, W.-I., Calarese, D. a, Kimani, S. G., Singh, S., Hsieh, S., Liu, Y., et al.
(2014).The Journal of biological chemistry, 289(37), 25737–49. doi:10.1074/jbc.M114.570838
83. CUB Domain Containing Protein 1 (CDCP1) modulates adhesion and motility in colon cancer cells. OrchardWebb, D. J., Lee, T. C., Cook, G. P., & Blair, G. E. (2014).BMC cancer, 14(1), 754. doi:10.1186/1471-2407-14754
84. miR-146a functions as a tumor suppressor in prostate cancer by targeting Rac1. Sun, Q., Zhao, X., Liu, X., Wang,
Y., Huang, J., Jiang, B., Chen, Q., et al. (2014).The Prostate, 74(16), 1613–21. doi:10.1002/pros.22878
85. ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling. Gee, H., Saisawat, P., &
Ashraf, S. (2013).The Journal of …, 123(8), 3243–3253. doi:10.1172/JCI69134.Research
86. Cotylenin A and arsenic trioxide cooperatively suppress cell proliferation and cell invasion activity in human
breast cancer cells. Kasukabe, T., Okabe-Kado, J., Kato, N., Honma, Y., & Kumakura, S. (2015).International
journal of oncology, 46(2), 841–8. doi:10.3892/ijo.2014.2760
87. Protective Effects of Ginsenoside Rg1 on Astrocytes and Cerebral Ischemic-Reperfusion Mice. Sun, C., Lai, X.,
Huang, X., & Zeng, Y. (2014)., 37(December), 1891–1898.
88. Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative
breast cancer cells. Bilir, B., Kucuk, O., & Moreno, C. S. (2013).Journal of translational medicine, 11(1), 280.
doi:10.1186/1479-5876-11-280
89. Pharmacogenomic profiling and pathway analyses identify MAPK-dependent migration as an acute response
to SN38 in p53 null and p53-mutant colorectal cancer cells. Allen, W. L., Turkington, R. C., Stevenson, L.,
Carson, G., Coyle, V. M., Hector, S., Dunne, P., et al. (2012).Molecular cancer therapeutics, 11(8), 1724–34.
doi:10.1158/1535-7163.MCT-12-0207
90. High nuclear level of Vav1 is a positive prognostic factor in early invasive breast tumors : a role in modulating
genes related to the efficiency of metastatic process. Grassilli, S., Brugnoli, F., Lattanzio, R., Rossi, C.,
Mottolese, M., Marchisio, M., Palomba, M., et al. (n.d.)., 5(12).
12
91. Carcinoembryonic Antigen Cell Adhesion Molecule 1 long isoform modulates malignancy of poorly
differentiated colon cancer cells. Arabzadeh, a., Dupaul-Chicoine, J., Breton, V., Haftchenary, S., Yumeen, S.,
Turbide, C., Saleh, M., et al. (2015).Gut, (L), 1–9. doi:10.1136/gutjnl-2014-308781
92. [44-or] Statins reduce soluble Flt1, and quench endothelial dysfunction in primary human tissues, but increase
soluble endoglin release. Brownfoot, F. C., Kaitu’u-Lino, T. J., Hannan, N., Hastie, R., Cannon, P., Onda, K., &
Tong, S. (2015).Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health, 5(1), 22–
23. doi:10.1016/j.preghy.2014.10.048
93. Peripheral Blood Derived Mononuclear Cells Enhance the Migration and Chondrogenic Differentiation of
Multipotent Mesenchymal Stromal Cells. Hopper, N., Wardale, J., Howard, D., Brooks, R., Rushton, N., &
Henson, F. (2015)., 2015.
94. [28-or] The newly described primate and placental specific sFlt1 isoform - e15a is biologically active and
antagonises VEGF. Kaitu’u-Lino, T., Palmer, K., Hastie, R., Cannon, P., Hannan, N. J., & Tong, S.
(2015).Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health, 5(2015), 14.
doi:10.1016/j.preghy.2014.10.032
95. Altered expression of platelet factor 4 and basic fibroblast growth factor correlates with the inhibition of
tumor growth in mice. Mabeta, P., & Pepper, M. S. (2015).Biomedicine & Pharmacotherapy, 69, 186–190.
doi:10.1016/j.biopha.2014.11.018
96. Activation of β2-adrenergic receptor by (R,R′)-4′-methoxy-1-naphthylfenoterol inhibits proliferation and
motility of melanoma cells. Wnorowski, A., Sadowska, M., Paul, R. K., Singh, N. S., Boguszewska-Czubara, A.,
Jimenez, L., Abdelmohsen, K., et al. (2015).Cellular Signalling, 27, 997–1007. doi:10.1016/j.cellsig.2015.02.012
97. Anti-cancer potential of MAPK pathway inhibition in paragangliomas-effect of different statins on mouse
pheochromocytoma cells. Fliedner, S. M. J., Engel, T., Lendvai, N. K., Shankavaram, U., Nölting, S., Wesley, R.,
Elkahloun, A. G., et al. (2014).PLoS ONE, 9(5), 1–9. doi:10.1371/journal.pone.0097712
98. Stress-Induced CXCR4 Promotes Migration and Invasion of Ewing Sarcoma. Krook, M. a, Nicholls, L. a, &
Scannell, C. a. (2014)., 953–964. doi:10.1158/1541-7786.MCR-13-0668
99. Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human
macrophages. Preuss, I., Ludwig, M.-G., Baumgarten, B., Bassilana, F., Gessier, F., Seuwen, K., & Sailer, A. W.
(2014).Biochemical and biophysical research communications, 446(3), 663–8. doi:10.1016/j.bbrc.2014.01.069
100. Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing
Smad signalling. Ungefroren, H., Sebens, S., Giehl, K., & Helm, O. (2014).Oncotarget, 5(1), 1–28. Retrieved
from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960208/
101. Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell
migration in pancreatic ductal adenocarcinoma cells: control by Rac1. Ungefroren, H., Groth, S., Sebens, S.,
Lehnert, H., Gieseler, F., & Fändrich, F. (2011).Molecular cancer, 10(1), 67. doi:10.1186/1476-4598-10-67
*102. Real-time monitoring of cell protrusion dynamics by impedance responses. Armando Gagliardi, P., Puliafito,
A., di Blasio, L., Chianale, F., Somale, D., Seano, G., Bussolino, F., et al. (2015).Scientific Reports, 5, 10206.
doi:10.1038/srep10206
13
*103. Slow binding kinetics of secreted protein, acidic, rich in cysteine-VEGF interaction limit VEGF activation of
VEGF receptor 2 and attenuate angiogenesis. Cydzik, M., Abdul-Wahid, a., Park, S., Bourdeau, a., Bowden, K.,
Prodeus, a., Kollara, a., et al. (2015).The FASEB Journal, 29, 3493–3505. doi:10.1096/fj.15-271775
*104. The ubiquitin ligase CHIP inactivates NF-κB signaling and impairs the ability of migration and invasion in
gastric cancer cells. Liu, F., Zhou, J., Zhou, P., Chen, W., & Guo, F. (2015).International Journal of Oncology,
2(10), 2096–2106. doi:10.3892/ijo.2015.2893
*105. Particle-induced cell migration assay (PICMA): A new in vitro assay for inflammatory particle effects based
on permanent cell lines. Westphal, G. a., Schremmer, I., Rostek, A., Loza, K., Rosenkranz, N., Brüning, T.,
Epple, M., et al. (2015).Toxicology in Vitro, 29(5), 997–1005. doi:10.1016/j.tiv.2015.04.005
*106. Cyclization of the Urokinase Receptor-Derived Ser-Arg-Ser-Arg-Tyr Peptide Generates a Potent Inhibitor of
Trans-Endothelial Migration of Monocytes. Yousif, A. M., Minopoli, M., Bifulco, K., Ingangi, V., Di Carluccio,
G., Merlino, F., Motti, M. L., et al. (2015).Plos One, 10, e0126172. doi:10.1371/journal.pone.0126172
*107. Cooperative interactions between p53 and NFκB enhance cell plasticity. Bisio, A., Zámborszky, J., Zaccara, S.,
Lion, M., Sharma, V., Raimondi, I., Alessandrini, F., et al. (2014)., 5(23).
*108. HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and
defense escape. Conte, M., Aversana, C. D., Benedetti, R., Carissimo, A., Petrizzi, V. B., Arco, A. M. D.,
Abbondanza, C., et al. (2014)., 6(2).
*109. Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells.
Gao, R., Singh, R., Kaul, Z., Kaul, S. C., & Wadhwa, R. (2014).The journals of gerontology. Series A, Biological
sciences and medical sciences, 701–713. doi:10.1093/gerona/glu019
*110. In triple negative breast tumor cells , PLC-β2 promotes the conversion of CD133 high to CD133 low
phenotype and reduces the CD133-related invasiveness. Brugnoli, F., Grassilli, S., Piazzi, M., Palomba, M.,
Nika, E., Bavelloni, A., Capitani, S., et al. (2013)., 1–15. doi:10.1186/1476-4598-12-165
*111. Membrane-type matrix metalloproteinase 1 regulates trophoblast functions and is reduced in fetal growth
restriction. Hiden, U., Ghaffari-Tabrizi, N., Gauster, M., Tam-Amersdorfer, C., Cetin, I., Dieber-Rotheneder, M.,
Lang, U., et al. (2013).American Journal of Pathology, 182(5), 1563–1571. doi:10.1016/j.ajpath.2013.01.011
*112. Identification of cbx3 and abca5 as putative biomarkers for tumor stem cells in osteosarcoma. Saini, V.,
Hose, C. D., Monks, A., Nagashima, K., Han, B., Newton, D. L., Millione, A., et al. (2012).PLoS ONE, 7(8), 1–14.
doi:10.1371/journal.pone.0041401
*113. Urokinase receptor promotes ovarian cancer cell dissemination through its 84-95 sequence ABSTRACT :.
Bifulco, K., Votta, G., Ingangi, V., Carluccio, G. Di, Rea, D., Losito, S., Montuori, N., et al. (n.d.)., 5(12).
14
CELL PROLIFERATION
1. Dynamic monitoring of cell adhesion and spreading on microelectronic sensor arrays. Atienza, J. M., Zhu, J.,
Wang, X., Xu, X., & Abassi, Y. (2005).Journal of biomolecular screening, 10(8), 795–805.
doi:10.1177/1087057105279635
2. Targeting the Enhancer of Zeste Homologue 2 in Medulloblastoma. Alimova, I., Venkataraman, S., Harris, P.,
Marquez, V. E., Northcott, P. A., Dubuc, A., Taylor, M. D., et al. (n.d.).,
3. Validation of the glaucoma filtration surgical mouse model for antifibrotic drug evaluation. Seet, L.-F., Lee, W.
S., Su, R., Finger, S. N., Crowston, J. G., & Wong, T. T. (n.d.).Molecular medicine (Cambridge, Mass.), 17(5-6),
557–67. doi:10.2119/molmed.2010.0018
4. Live cell quality control and utility of real-time cell electronic sensing for assay development. Kirstein, S. L.,
Atienza, J. M., Xi, B., Zhu, J., Yu, N., Wang, X., Xu, X., et al. (2006).Assay and drug development technologies,
4(5), 545–53. doi:10.1089/adt.2006.4.545
5. Down-regulation of hepatoma-derived growth factor inhibits anchorage-independent growth and invasion of
non-small cell lung cancer cells. Zhang, J., Ren, H., Yuan, P., Lang, W., Zhang, L., & Mao, L. (2006).Cancer
research, 66(1), 18–23. doi:10.1158/0008-5472.CAN-04-3905
6. Role of Gab2 in mammary tumorigenesis and metastasis. Ke, Y., Wu, D., Princen, F., Nguyen, T., Pang, Y.,
Lesperance, J., Muller, W. J., et al. (2007).Oncogene, 26(34), 4951–60. doi:10.1038/sj.onc.1210315
7. Combination therapy targeting the tumor microenvironment is effective in a model of human ocular
melanoma. Mangiameli, D. P., Blansfield, J. a, Kachala, S., Lorang, D., Schafer, P. H., Muller, G. W., Stirling, D.
I., et al. (2007).Journal of translational medicine, 5, 38. doi:10.1186/1479-5876-5-38
8. T-Cadherin Stimulates Melanoma Cell Proliferation and Mesenchymal Stromal Cell Recruitment , but Inhibits
Angiogenesis in a Mouse Melanoma Model. Rubina, K. A., Yurlova, E. I., Sysoeva, V. Y., Semina, E. V, Kalinina,
N. I., Poliakov, A. A., Mikhaylova, I. N., et al. (2007).
9. Delta DNMT3B variants regulate DNA methylation in a promoter-specific manner. Wang, J., Bhutani, M.,
Pathak, A. K., Lang, W., Ren, H., Jelinek, J., He, R., et al. (2007).Cancer research, 67(22), 10647–52.
doi:10.1158/0008-5472.CAN-07-1337
10. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy
through antiproliferative and antiangiogenic mechanisms. Zou, H. Y., Li, Q., Lee, J. H., Arango, M. E.,
McDonnell, S. R., Yamazaki, S., Koudriakova, T. B., et al. (2007).Cancer research, 67(9), 4408–17.
doi:10.1158/0008-5472.CAN-06-4443
11. Functional evidence implicating S100P in prostate cancer progression. Basu, G. D., Azorsa, D. O., Kiefer, J. a,
Rojas, A. M., Tuzmen, S., Barrett, M. T., Trent, J. M., et al. (2008).International journal of cancer. Journal
international du cancer, 123(2), 330–9. doi:10.1002/ijc.23447
12. Breast carcinoma-associated fibroblasts and their counterparts display neoplastic-specific changes. Hawsawi,
N. M., Ghebeh, H., Hendrayani, S.-F., Tulbah, A., Al-Eid, M., Al-Tweigeri, T., Ajarim, D., et al. (2008).Cancer
research, 68(8), 2717–25. doi:10.1158/0008-5472.CAN-08-0192
15
13. Suppressive action of pituitary adenylate cyclase activating polypeptide (PACAP) on proliferation of immature
mouse Leydig cell line TM3 cells. Matsumoto, S., Arakawa, Y., Ohishi, M., Yanaihara, H., Iwanaga, T., &
Kurokawa, N. (2008).Biomedical research (Tokyo, Japan), 29(6), 321–30. Retrieved from
http://www.ncbi.nlm.nih.gov/pubmed/19129676
14. Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation.
Tucker, L. a, Zhang, Q., Sheppard, G. S., Lou, P., Jiang, F., McKeegan, E., Lesniewski, R., et al. (2008).Oncogene,
27(28), 3967–76. doi:10.1038/onc.2008.14
15. RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth. Al-Ahmadi, W., Al-Haj, L., AlMohanna, F. a, Silverman, R. H., & Khabar, K. S. a. (2009).Oncogene, 28(15), 1782–91.
doi:10.1038/onc.2009.16
16. Dynamic monitoring of changes in endothelial cell-substrate adhesiveness during leukocyte adhesion by
microelectrical impedance assay. Ge, Y., Deng, T., & Zheng, X. (2009)., 256–262.
doi:10.1093/abbs/gmp009.Dynamic
17. Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells
Proliferation. Guo, Dadong, Wu, C., Li, J., Guo, A., Li, Q., Jiang, H., Chen, B., et al. (2009).Nanoscale research
letters, 4(12), 1395–402. doi:10.1007/s11671-009-9411-x
18. A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes
proliferation of host cells. Smout, M. J., Laha, T., Mulvenna, J., Sripa, B., Suttiprapa, S., Jones, A., Brindley, P.
J., et al. (2009).PLoS pathogens, 5(10), e1000611. doi:10.1371/journal.ppat.1000611
19. Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK. Xu, J., Liao, L.,
Qin, J., Xu, J., Liu, D., & Songyang, Z. (2009).The Journal of biological chemistry, 284(21), 14377–85.
doi:10.1074/jbc.M807770200
20. Novel Small-Molecule Inhibitor of Apurinic / Apyrimidinic Endonuclease 1 Blocks Proliferation and Reduces
Viability of. Cells, G., Bapat, A., Glass, L. S., Luo, M., Fishel, M. L., Long, E. C., Georgiadis, M. M., et al.
(2010).Journal of Pharmacholgy and Experimental Therapeautics, 18, 988–998. doi:10.1124/jpet.110.169128.
21. The Photodynamic Effect of Different Size ZnO Nanoparticles on Cancer Cell Proliferation In Vitro. Li, J., Guo,
D., Wang, X., Wang, H., Jiang, H., & Chen, B. (2010).Nanoscale research letters, 5(6), 1063–71.
doi:10.1007/s11671-010-9603-4
22. EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation. Danussi, C.,
Petrucco, A., Wassermann, B., Pivetta, E., Modica, T. M. E., Del Bel Belluz, L., Colombatti, A., et al. (2011,
October 3).The Journal of cell biology. doi:10.1083/jcb.201008013
23. MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports
neural differentiation in medulloblastoma. Antonellis, P. De, Medaglia, C., Cusanelli, E., Andolfo, I., Liguori, L.,
Vita, G. De, Carotenuto, M., et al. (2011).PloS one, 6(9), e24584. doi:10.1371/journal.pone.0024584
24. Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic
profiles of SerpinE1 and SerpinB2 in cancer. Cochran, B. J., Croucher, D. R., Lobov, S., Saunders, D. N., &
Ranson, M. (2011).The Journal of biological chemistry, 286(27), 24467–75. doi:10.1074/jbc.M111.225706
16
25. NKX3.1 contributes to S phase entry and regulates DNA damage response (DDR) in prostate cancer cell lines.
Erbaykent-Tepedelen, B., Ozmen, B., Varisli, L., Gonen-Korkmaz, C., Debelec-Butuner, B., Muhammed Syed, H.,
Yilmazer-Cakmak, O., et al. (2011).Biochemical and biophysical research communications, 414(1), 123–8.
doi:10.1016/j.bbrc.2011.09.035
26. Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth. Fishel, M. L., Jiang, Y., Rajeshkumar, N. V,
Scandura, G., Sinn, A. L., He, Y., Shen, C., et al. (2011).Molecular cancer therapeutics, 10(9), 1698–708.
doi:10.1158/1535-7163.MCT-11-0107
27. Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells
regardless of their p53 status. Hammerová, J., Uldrijan, S., Táborská, E., & Slaninová, I. (2011).Journal of
dermatological science, 62(1), 22–35. doi:10.1016/j.jdermsci.2011.01.006
28. Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo. Jiang, A.,
Gao, H., Kelley, M. R., & Qiao, X. (2011).Vision research, 51(1), 93–100. doi:10.1016/j.visres.2010.10.008
29. SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2. Kim, H. J., Yun, J., Lee, J.,
Hong, H., Jeong, J., Kim, E., Bae, Y. S., et al. (2011).Biochemical and biophysical research communications,
410(3), 555–62. doi:10.1016/j.bbrc.2011.06.025
30. Tetradecylthioacetic acid inhibits proliferation of human SW620 colon cancer cells--gene expression profiling
implies endoplasmic reticulum stress. Lundemo, A. G., Pettersen, C. H. H., Berge, K., Berge, R. K., &
Schønberg, S. a. (2011).Lipids in health and disease, 10(1), 190. doi:10.1186/1476-511X-10-190
31. Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme.
Mannes, A. M., Seiler, A., Bosello, V., Maiorino, M., & Conrad, M. (2011).FASEB journal : official publication of
the Federation of American Societies for Experimental Biology, 25(7), 2135–44. doi:10.1096/fj.10-177147
32. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Ren, D.,
Villeneuve, N. F., Jiang, T., Wu, T., Lau, A., Toppin, H. a, & Zhang, D. D. (2011).Proceedings of the National
Academy of Sciences of the United States of America, 108(4), 1433–8. doi:10.1073/pnas.1014275108
33. New 4-maleamic acid and 4-maleamide peptidyl chalcones as potential multitarget drugs for human prostate
cancer. Rodrigues, J., Abramjuk, C., Vásquez, L., Gamboa, N., Domínguez, J., Nitzsche, B., Höpfner, M., et al.
(2011).Pharmaceutical research, 28(4), 907–19. doi:10.1007/s11095-010-0347-8
34. In vitro effects of an in silico-modelled 17β-estradiol derivative in combination with dichloroacetic acid on
MCF-7 and MCF-12A cells. Stander, X. X., Stander, B. a, & Joubert, a M. (2011).Cell proliferation, 44(6), 567–
81. doi:10.1111/j.1365-2184.2011.00789.x
35. Impact of fibroblast growth factor-binding protein-1 expression on angiogenesis and wound healing. Tassi, E.,
McDonnell, K., Gibby, K. a, Tilan, J. U., Kim, S. E., Kodack, D. P., Schmidt, M. O., et al. (2011).The American
journal of pathology, 179(5), 2220–32. doi:10.1016/j.ajpath.2011.07.043
36. Functional efficacy of adenosine A₂A receptor agonists is positively correlated to their receptor residence
time. Guo, Dong, Mulder-Krieger, T., IJzerman, A. P., & Heitman, L. H. (2012, July).British journal of
pharmacology. doi:10.1111/j.1476-5381.2012.01897.x
17
37. Soluble TRAIL is elevated in recurrent miscarriage and inhibits the in vitro adhesion and migration of HTR8
trophoblastic cells. Agostinis, C., Bulla, R., Tisato, V., De Seta, F., Alberico, S., Secchiero, P., & Zauli, G.
(2012).Human reproduction (Oxford, England), 27(10), 2941–7. doi:10.1093/humrep/des289
38. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Caltová, K., &
Cervinka, M. (2012).Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové,
55(3), 116–24. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23297519
39. Quercetin-induced inhibition and synergistic activity with cisplatin - a chemotherapeutic strategy for
nasopharyngeal carcinoma cells. Daker, M., Ahmad, M., & Khoo, A. S. (2012).Cancer cell international, 12(1),
34. doi:10.1186/1475-2867-12-34
40. Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others
specific for tumor related c-MET. Greenall, S. a, Gherardi, E., Liu, Z., Donoghue, J. F., Vitali, A. a, Li, Q.,
Murphy, R., et al. (2012).PloS one, 7(4), e34658. doi:10.1371/journal.pone.0034658
41. Effects of different setting of diode laser on the mRNA expression of growth factors and type I collagen of
human gingival fibroblasts. Hakki, S. S., & Bozkurt, S. B. (2012).Lasers in medical science, 27(2), 325–31.
doi:10.1007/s10103-010-0879-5
42. GIT1 phosphorylation on serine 46 by PKD3 regulates paxillin trafficking and cellular protrusive activity. Huck,
B., Kemkemer, R., Franz-Wachtel, M., Macek, B., Hausser, A., & Olayioye, M. a. (2012).The Journal of biological
chemistry, 287(41), 34604–13. doi:10.1074/jbc.M112.374652
43. Estrogen is increased in male cholangiocarcinoma patients’ serum and stimulates invasion in
cholangiocarcinoma cell lines in vitro. Hunsawong, T., Singsuksawat, E., In-Chon, N., Chawengrattanachot,
W., Thuwajit, C., Sripa, B., Paupairoj, A., et al. (2012).Journal of cancer research and clinical oncology, 138(8),
1311–20. doi:10.1007/s00432-012-1207-1
44. Androgen-independent effects of Serenoa repens extract (Prostasan®) on prostatic epithelial cell proliferation
and inflammation. Iglesias-Gato, D., Carsten, T., Vesterlund, M., Pousette, A., Schoop, R., & Norstedt, G.
(2012).Phytotherapy research : PTR, 26(2), 259–64. doi:10.1002/ptr.3537
45. Vasohibin-1 and Retinal Pigment Epithelium. Ishikawa, Y., Nagai, N., Onami, H., Kumasaka, N., Wakusawa, R.,
Sonoda, H., Sato, Y., et al. (2012). (M. M. LaVail, J. D. Ash, R. E. Anderson, J. G. Hollyfield, & C. Grimm, Eds.),
723, 305–310. doi:10.1007/978-1-4614-0631-0
46. Proliferative and apoptotic effects of olive extracts on cell lines and healthy human cells. Işık, S., Karagöz, A.,
Karaman, Ş., & Nergiz, C. (2012).Food Chemistry, 134(1), 29–36. doi:10.1016/j.foodchem.2012.02.020
47. Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer
cells. Kaschula, C. H., Hunter, R., Stellenboom, N., Caira, M. R., Winks, S., Ogunleye, T., Richards, P., et al.
(2012).European journal of medicinal chemistry, 50, 236–54. doi:10.1016/j.ejmech.2012.01.058
48. Ciprofloxacin is a potential topoisomerase II inhibitor for the treatment of NSCLC. Kloskowski, T., Gurtowska,
N., Olkowska, J., Nowak, J. M., Adamowicz, J., Tworkiewicz, J., Dębski, R., et al. (2012).International journal of
oncology, 41(6), 1943–9. doi:10.3892/ijo.2012.1653
18
49. Basic cell physiological activities (cell adhesion, chemotaxis and proliferation) induced by selegiline and its
derivatives in Mono Mac 6 human monocytes. Lajkó, E., Polgár, L., Láng, O., Lengyel, J., Kőhidai, L., & Magyar,
K. (2012).Journal of neural transmission (Vienna, Austria : 1996), 119(5), 545–56. doi:10.1007/s00702-0110735-1
50. Aldehyde dehydrogenase 1, a potential marker for cancer stem cells in human sarcoma. Lohberger, B., Rinner,
B., Stuendl, N., Absenger, M., Liegl-Atzwanger, B., Walzer, S. M., Windhager, R., et al. (2012).PloS one, 7(8),
e43664. doi:10.1371/journal.pone.0043664
51. (19)F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells. Malaisse, W. J., Zhang, Y.,
Louchami, K., Sharma, S., Dresselaers, T., Himmelreich, U., Novotny, G. W., et al. (2012).Archives of
biochemistry and biophysics, 517(2), 138–43. doi:10.1016/j.abb.2011.11.014
52. Antiaging effect of pine pollen in human diploid fibroblasts and in a mouse model induced by D-galactose.
Mao, G.-X., Zheng, L.-D., Cao, Y.-B., Chen, Z.-M., Lv, Y.-D., Wang, Y.-Z., Hu, X.-L., et al. (2012).Oxidative
medicine and cellular longevity, 2012, 750963. doi:10.1155/2012/750963
53. Monitoring of the prostate tumour cells redox state and real-time proliferation by novel biophysical
techniques and fluorescent staining. Masarik, M., Gumulec, J., Hlavna, M., Sztalmachova, M., Babula, P.,
Raudenska, M., Pavkova-Goldbergova, M., et al. (2012).Integrative biology : quantitative biosciences from
nano to macro, 4(6), 672–84. doi:10.1039/c2ib00157h
54. Optimization and Scale-up Culture of Human Endometrial Multipotent Mesenchymal Stromal Cells: Potential
for Clinical Application. Rajaraman, G., Ph, D., White, J., Sci, B. A., Tan, K. S., Sc, M., Ulrich, D., et al.
(2012).Tissue Engineering: Part C, 00(00). doi:10.1089/ten.tec.2011.0718
55. Effect of butyrate on aromatase cytochrome P450 levels in HT29, DLD-1 and LoVo colon cancer cells.
Rawłuszko, A. A., Sławek, S., Gollogly, A., Szkudelska, K., & Jagodziński, P. P. (2012).Biomedicine &
pharmacotherapy = Biomédecine & pharmacothérapie, 66(2), 77–82. doi:10.1016/j.biopha.2011.12.001
56. Evolutionary approaches to prolong progression-free survival in breast cancer. Silva, A. S., Kam, Y., Khin, Z. P.,
Minton, S. E., Gillies, R. J., & Gatenby, R. a. (2012).Cancer research, 72(24), 6362–70. doi:10.1158/00085472.CAN-12-2235
57. Notch signaling pathway in keloid disease: Enhanced fibroblast activity in a Jagged-1 peptide-dependent
manner in lesional vs. extralesional fibroblasts. Syed, F., & Bayat, A. (2012).Wound repair and regeneration :
official publication of the Wound Healing Society [and] the European Tissue Repair Society, 20(5), 688–706.
doi:10.1111/j.1524-475X.2012.00823.x
58. In vitro study of novel collagenase (XIAFLEX®) on Dupuytren’s disease fibroblasts displays unique drug related
properties. Syed, F., Thomas, A. N., Singh, S., Kolluru, V., Emeigh Hart, S. G., & Bayat, A. (2012).PloS one, 7(2),
e31430. doi:10.1371/journal.pone.0031430
59. Androgen regulated HN1 leads proteosomal degradation of androgen receptor (AR) and negatively influences
AR mediated transactivation in prostate cells. Varisli, L., Gonen-Korkmaz, C., Syed, H. M., Bogurcu, N.,
Debelec-Butuner, B., Erbaykent-Tepedelen, B., & Korkmaz, K. S. (2012).Molecular and cellular endocrinology,
350(1), 107–17. doi:10.1016/j.mce.2011.11.027
19
60. Nanobodies targeting the hepatocyte growth factor: potential new drugs for molecular cancer therapy.
Vosjan, M. J. W. D., Vercammen, J., Kolkman, J. a, Stigter-van Walsum, M., Revets, H., & van Dongen, G. a M.
S. (2012).Molecular cancer therapeutics, 11(4), 1017–25. doi:10.1158/1535-7163.MCT-11-0891
61. A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma
angiogenesis. Abuhusain, H. J., Matin, A., Qiao, Q., Shen, H., Kain, N., Day, B. W., Stringer, B. W., et al.
(2013).The Journal of biological chemistry, 288(52), 37355–64. doi:10.1074/jbc.M113.494740
62. Nature-inspired antimicrobial polymers - assessment of their potential for biomedical applications. Al-Ahmad,
A., Laird, D., Zou, P., Tomakidi, P., Steinberg, T., & Lienkamp, K. (2013).PloS one, 8(9), e73812.
doi:10.1371/journal.pone.0073812
63. The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclindependent kinase 4 to transactivate microRNA-141 and microRNA-146b-5p spontaneously and in response
to ultraviolet light-induced DNA damage. Al-Khalaf, H. H., Mohideen, P., Nallar, S. C., Kalvakolanu, D. V, &
Aboussekhra, A. (2013).The Journal of biological chemistry, 288(49), 35511–25. doi:10.1074/jbc.M113.512640
64. [O-128] Real-time analysis of the growth of human granulosa cells using an impednace-based signal
processing system: a new technology for translational research in human reproduction. O. Oktem, M.
Muftuoglu, F. S. and B. U. (2013), (July), 52–55.
65. Site-Specific Keloid Fibroblasts Alter the Behaviour of Normal Skin and Normal Scar Fibroblasts through
Paracrine Signalling. Ashcroft, K. J., Syed, F., & Bayat, A. (2013).PloS one, 8(12), e75600.
doi:10.1371/journal.pone.0075600
66. GSK-3α Promotes Oncogenic KRAS Function in Pancreatic Cancer via TAK1-TAB Stabilization and Regulation of
Noncanonical NF-κB. Bang, D., Wilson, W., Ryan, M., Yeh, J. J., & Baldwin, A. S. (2013).Cancer discovery, 690–
703. doi:10.1158/2159-8290.CD-12-0541
67. Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice. Barathi, V. a,
Kwan, J. L., Tan, Q. S. W., Weon, S. R., Seet, L. F., Goh, L. K., Vithana, E. N., et al. (2013).Disease models &
mechanisms, 1158, 1146–1158. doi:10.1242/dmm.010967
68. A urokinase receptor-derived peptide inhibiting VEGF-dependent directional migration and vascular
sprouting. Bifulco, K., Longanesi-Cattani, I., Liguori, E., Arra, C., Rea, D., Masucci, M. T., De Rosa, M., et al.
(2013).Molecular cancer therapeutics, 12(10), 1981–93. doi:10.1158/1535-7163.MCT-13-0077
69. Cry1Ab treatment has no effects on viability of cultured porcine intestinal cells, but triggers Hsp70 expression.
Bondzio, A., Lodemann, U., Weise, C., & Einspanier, R. (2013).PloS one, 8(7), e67079.
doi:10.1371/journal.pone.0067079
70. Combinations of parabens at concentrations measured in human breast tissue can increase proliferation of
MCF-7 human breast cancer cells. Charles, A. K., & Darbre, P. D. (2013).Journal of applied toxicology : JAT,
33(5), 390–8. doi:10.1002/jat.2850
71. Lamin B1 fluctuations have differential effects on cellular proliferation and senescence. Dreesen, O.,
Chojnowski, A., Ong, P. F., Zhao, T. Y., Common, J. E., Lunny, D., Lane, E. B., et al. (2013).The Journal of cell
biology, 200(5). doi:10.1083/jcb.201206121
20
72. Impact of MACC1 on human malignant glioma progression and patients’ unfavorable prognosis. Hagemann,
C., Fuchs, S., Monoranu, C. M., Herrmann, P., Smith, J., Hohmann, T., Grabiec, U., et al. (2013).Journal of
Neuro-Oncology, 1–14.
73. DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma. Hauer, K., Calzada-Wack, J.,
Steiger, K., Grunewald, T. G. P., Baumhoer, D., Plehm, S., Buch, T., et al. (2013).Cancer research, 73(2), 967–77.
doi:10.1158/0008-5472.CAN-12-1492
74. SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer. IglesiasGato, D., Chuan, Y.-C., Wikström, P., Augsten, S., Jiang, N., Niu, Y., Seipel, A., et al. (2013).Carcinogenesis,
00(00), 1–10. doi:10.1093/carcin/bgt304
75. MicroRNA 299-3p modulates replicative senescence in endothelial cells. Jong, H.-L., Mustafa, M. R., Vanhoutte,
P. M., AbuBakar, S., & Wong, P.-F. (2013).Physiological genomics, 45(7), 256–67.
doi:10.1152/physiolgenomics.00071.2012
76. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from
lysophospholipids. Kamphorst, J. J., Cross, J. R., Fan, J., de Stanchina, E., Mathew, R., White, E. P., Thompson,
C. B., et al. (2013).Proceedings of the National Academy of Sciences of the United States of America.
doi:10.1073/pnas.1307237110
77. The RUNX1 transcription factor is expressed in serous epithelial ovarian carcinoma and contributes to cell
proliferation, migration and invasion. Keita, M., Bachvarova, M., Morin, C., Plante, M., Gregoire, J., Renaud,
M.-C., Sebastianelli, A., et al. (2013).Cell cycle (Georgetown, Tex.), 12(6), 972–86. doi:10.4161/cc.23963
78. Substitution p.A350V in Na+/Mg2+ exchanger SLC41A1, potentially associated with Parkinson’s disease, is a
gain-of-function mutation. Kolisek, M., Sponder, G., Mastrototaro, L., Smorodchenko, A., Launay, P.,
Vormann, J., & Schweigel-Röntgen, M. (2013).PloS one, 8(8), e71096. doi:10.1371/journal.pone.0071096
79. Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics. Lion, M.,
Bisio, A., Tebaldi, T., De Sanctis, V., Menendez, D., Resnick, M. a, Ciribilli, Y., et al. (2013).Cell cycle
(Georgetown, Tex.), 12(8), 1211–24. doi:10.4161/cc.24309
80. The novel myxofibrosarcoma cell line MUG-Myx1 expresses a tumourigenic stem-like cell population with
high aldehyde dehydrogenase 1 activity. Lohberger, B., Stuendl, N., Wolf, E., Liegl-Atzwanger, B., Leithner, A.,
& Rinner, B. (2013).BMC cancer, 13, 563. doi:10.1186/1471-2407-13-563
81. Oncogene PKCε controls INrf2-Nrf2 interaction in normal and cancer cells through phosphorylation of INrf2.
Niture, S. K., Gnatt, A., & Jaiswal, A. K. (2013).Journal of cell science, 126(Pt 24), 5657–69.
doi:10.1242/jcs.133819
82. N’-Formyl-2-(5-nitrothiophen-2-yl)benzothiazole-6-carbohydrazide as a potential anti-tumour agent for
prostate cancer in experimental studies. Rodrigues, J. R., Charris, J., Camacho, J., Barazarte, A., Gamboa, N.,
Nitzsche, B., Höpfner, M., et al. (2013).The Journal of pharmacy and pharmacology, 65(3), 411–22.
doi:10.1111/j.2042-7158.2012.01607.x
83. Anoctamin 1 dysregulation alters bronchial epithelial repair in cystic fibrosis. Ruffin, M., Voland, M., Marie, S.,
Bonora, M., Blanchard, E., Blouquit-Laye, S., Naline, E., et al. (2013).Biochimica et biophysica acta, 1832(12),
2340–51. doi:10.1016/j.bbadis.2013.09.012
21
84. MIR-143 AND MIR-145 OVEREXPRESSION IMPROVE THE RESPONSE TO CETUXIMAB IN HCT116 KRAS MUTANT
COLON CANCER CELLS. S. E. Gomes, A. E. S. Simoes, D. M. Pereira, P. M. Borralho, C. M., & Rodrigues, P.
(2013).United European Gastroenterology Journal (Vol. 1, pp. A1–A134). doi:10.1177/2050640613502899
85. Synthetic Lethal Targeting of Superoxide Dismutase 1 Selectively Kills RAD54B-Deficient Colorectal Cancer
Cells. Sajesh, B. V, Bailey, M., Lichtensztejn, Z., Hieter, P., & McManus, K. J. (2013).Genetics, 195(3), 757–67.
doi:10.1534/genetics.113.156836
86. Wnt6 Is Expressed in Granulomatous Lesions of Mycobacterium tuberculosis-Infected Mice and Is Involved in
Macrophage Differentiation and Proliferation. Schaale, K., Brandenburg, J., Kispert, A., Leitges, M., Ehlers, S.,
& Reiling, N. (2013).Journal of immunology (Baltimore, Md. : 1950), 191(10), 5182–95.
doi:10.4049/jimmunol.1201819
87. FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential
relevance to Alzheimer’s disease. Schrötter, A., Mastalski, T., Nensa, F. M., Neumann, M., Loosse, C., Pfeiffer,
K., Magraoui, F. El, et al. (2013).Journal of cell science, 2480–2492. doi:10.1242/jcs.121004
88. Comparison of Tobacco-Containing and Tobacco-Free Waterpipe Products: Effects on Human Alveolar Cells.
Shihadeh, A., Eissenberg, T., Rammah, M., Salman, R., Jaroudi, E., & El-Sabban, M. (2013).Nicotine & tobacco
research : official journal of the Society for Research on Nicotine and Tobacco, 1–4. doi:10.1093/ntr/ntt193
89. Autotaxin-lysophosphatidic acid signaling axis mediates tumorigenesis and development of acquired
resistance to sunitinib in renal cell carcinoma. Su, S.-C., Hu, X., Kenney, P. a, Merrill, M. M., Babaian, K. N.,
Zhang, X.-Y., Maity, T., et al. (2013).Clinical cancer research : an official journal of the American Association for
Cancer Research, 19(23), 6461–72. doi:10.1158/1078-0432.CCR-13-1284
90. Tumor-derived hydrogen sul fi de, produced by cystathionine- β -synthase, stimulates bioenergetics, cell
proliferation, and angiogenesis in colon cancer. Szabo, C., Coletta, C., Chao, C., Módis, K., Szczesny, B., &
Papapetropoulos, A. (2013).PNAS Pharmacology, 110(30). doi:10.1073/pnas.1306241110//DCSupplemental.www.pnas.org/cgi/doi/10.1073/pnas.1306241110
91. Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis. Teng, Y.-C., Lee, C.-F., Li, Y.S., Chen, Y.-R., Hsiao, P.-W., Chan, M.-Y., Lin, F.-M., et al. (2013).Cancer research, 73(15), 4711–4721.
doi:10.1158/0008-5472.CAN-12-3165
92. GM-CSF exhibits anti-inflammatory activity on endothelial cells derived from chronic venous disease patients.
Tisato, V., Secchiero, P., Rimondi, E., Gianesini, S., Menegatti, E., Casciano, F., Zamboni, P., et al.
(2013).Mediators of inflammation, 2013, 561689. doi:10.1155/2013/561689
93. Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication
complexes of semliki forest virus. Varjak, M., Saul, S., Arike, L., Lulla, A., Peil, L., & Merits, A. (2013).Journal of
virology, 87(18), 10295–312. doi:10.1128/JVI.01105-13
94. Hypermethylation reduces expression of tumor-suppressor PLZF and regulates proliferation and apoptosis in
non-small-cell lung cancers. Wang, X., Wang, L., Guo, S., Bao, Y., Ma, Y., Yan, F., Xu, K., et al. (2013).FASEB
journal : official publication of the Federation of American Societies for Experimental Biology, 27(10), 4194–
203. doi:10.1096/fj.13-229070
22
95. Identification of FGFR4 as a Potential Therapeutic Target for Advanced-Stage, High-Grade Serous Ovarian
Cancer. Zaid, T. M., Yeung, T.-L., Thompson, M. S., Leung, C. S., Harding, T., Co, N.-N., Schmandt, R. S., et al.
(2013).Clinical cancer research : an official journal of the American Association for Cancer Research, 19(4),
809–20. doi:10.1158/1078-0432.CCR-12-2736
96. Enhancement of cell viability after treatment with polyunsaturated fatty acids. Bartl, J., Walitza, S., &
Grünblatt, E. (2014).Neuroscience letters, 559, 56–60. doi:10.1016/j.neulet.2013.11.023
97. Leptin induces a proliferative response in breast cancer cells but not in normal breast cells. Dubois, V., Jardé,
T., Delort, L., Billard, H., Bernard-Gallon, D., Berger, E., Geloen, A., et al. (2014).Nutrition and cancer, 66(4),
645–55. doi:10.1080/01635581.2014.894104
98. Effects of passage number on proliferation and store-operated calcium entry in A7r5 vascular smooth muscle
cells. Erac, Y., Selli, C., Filik, P., & Tosun, M. (2014).Journal of pharmacological and toxicological methods,
70(1), 1–5. doi:10.1016/j.vascn.2014.03.001
99. Effect of S-adenosyl-l-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on
colorectal cancer cell proliferation and bioenergetics in vitro. Módis, K., Coletta, C., Asimakopoulou, A.,
Szczesny, B., Chao, C., Papapetropoulos, A., Hellmich, M. R., et al. (2014).Nitric oxide : biology and chemistry /
official journal of the Nitric Oxide Society, 1–11. doi:10.1016/j.niox.2014.03.001
100. In vitro endothelial cell proliferation assay reveals distinct levels of proangiogenic cytokines characterizing
sera of healthy subjects and of patients with heart failure. Voltan, R., Zauli, G., Rizzo, P., Fucili, A., Pannella,
M., Marci, R., Tisato, V., et al. (2014).Mediators of inflammation, 2014, 257081. doi:10.1155/2014/257081
101. mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy. Weiler, M., Blaes, J.,
Pusch, S., Sahm, F., Czabanka, M., Luger, S., Bunse, L., et al. (2014).Proceedings of the National Academy of
Sciences of the United States of America, 111(1), 409–14. doi:10.1073/pnas.1314469111
102. Indomethacin Treatment Prevents High Fat Diet-induced Obesity and Insulin Resistance but Not Glucose
Intolerance in C57BL/6J Mice. Fjæ re, E., Aune, U. L., Røen, K., Keenan, A. H., Ma, T., Borkowski, K., Kristensen,
D. M., et al. (2014).The Journal of biological chemistry, 289(23), 16032–45. doi:10.1074/jbc.M113.525220
103. Soluble factors secreted into cardiac veins during PICSO enhance cardiomyocyte proliferation. Soluble factors
secreted into cardiac veins during PICSO enhance cardiomyocyte proliferation. (2014)., (July), 2014.
doi:10.1093/cvr/cvu082
104. OP17 Cystathionine-β-synthase (CBS) is upregulated in colorectal cancer cells and promotes their
proliferation. Coletta, C., Chao, C., Módis, K., Papapetropoulos, A., Hellmich, M., & Szabo, C. (2013).Nitric
Oxide, 31(2013), S26–S27. doi:10.1016/j.niox.2013.06.047
105. Common variation at BARD1 results in the expression of an oncogenic isoform that influences
neuroblastoma susceptibility and oncogenicity. Bosse, K. R., Diskin, S. J., Cole, K. a, Wood, A. C., Schnepp, R.
W., Norris, G., Nguyen, L. B., et al. (2012).Cancer research, 72(8), 2068–78. doi:10.1158/0008-5472.CAN-113703
106. An oncogenic role for the multiple endocrine neoplasia type 1 gene in prostate cancer. Paris, P. L., Sridharan,
S., Hittelman, a B., Kobayashi, Y., Perner, S., Huang, G., Simko, J., et al. (2009).Prostate cancer and prostatic
diseases, 12(2), 184–91. doi:10.1038/pcan.2008.45
23
107. AurkA inhibitors enhance the effects of B-RAF and MEK inhibitors in melanoma treatment. Caputo, E., Miceli,
R., Motti, M., Taté, R., Fratangelo, F., Botti, G., Mozzillo, N., et al. (2014).Journal of translational medicine,
12(1), 216. doi:10.1186/s12967-014-0216-z
108. New metal based drugs: Spectral, electrochemical, DNA-binding, surface morphology and anticancer activity
properties. Ceşme, M., Gölcü, A., & Demirtaş, I. (2014).Spectrochimica acta. Part A, Molecular and
biomolecular spectroscopy, 135C, 887–906. doi:10.1016/j.saa.2014.06.144
109. Early Targets of miR-34a in Neuroblastoma. De Antonellis, P., Carotenuto, M., Vandenbussche, J., De Vita, G.,
Ferrucci, V., Medaglia, C., Boffa, I., et al. (2014).Molecular & cellular proteomics : MCP, 13(8), 2114–31.
doi:10.1074/mcp.M113.035808
110. Promoting cell proliferation using water dispersible germanium nanowires. Bezuidenhout, M., Liu, P., Singh,
S., Kiely, M., Ryan, K. M., & Kiely, P. a. (2014).PloS one, 9(9), e108006. doi:10.1371/journal.pone.0108006
111. Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain-offunction capacity. Nguyen, K.-Q. N., Tsou, W.-I., Calarese, D. a, Kimani, S. G., Singh, S., Hsieh, S., Liu, Y., et al.
(2014).The Journal of biological chemistry, 289(37), 25737–49. doi:10.1074/jbc.M114.570838
112. CUB Domain Containing Protein 1 (CDCP1) modulates adhesion and motility in colon cancer cells. OrchardWebb, D. J., Lee, T. C., Cook, G. P., & Blair, G. E. (2014).BMC cancer, 14(1), 754. doi:10.1186/1471-2407-14754
113. MicroRNA library-based functional screening identified miR-137 as a suppresser of gastric cancer cell
proliferation. Zheng, X., Dong, J., Gong, T., Zhang, Z., Wang, Y., Li, Y., Shang, Y., et al. (2014).Journal of cancer
research and clinical oncology. doi:10.1007/s00432-014-1847-4
114. Sensitization of melanoma cells for TRAIL-induced apoptosis by BMS-345541 correlates with altered
phosphorylation and activation of Bax. Berger, a, Quast, S., Plötz, M., Kammermeier, a, & Eberle, J.
(2013).Cell death & disease, 4, e477. doi:10.1038/cddis.2012.198
115. ROS-dependent phosphorylation of Bax by wortmannin sensitizes melanoma cells for TRAIL-induced
apoptosis. Quast, S., Berger, a, & Eberle, J. (2013).Cell death & disease, 4(10), e839.
doi:10.1038/cddis.2013.344
116. Increased expression of 17-beta-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer.
Drzewiecka, H., Gałęcki, B., Jarmołowska-Jurczyszyn, D., Kluk, A., Dyszkiewicz, W., & Jagodziński, P. P.
(2015).Lung cancer (Amsterdam, Netherlands), 87(2), 107–16. doi:10.1016/j.lungcan.2014.12.012
117. Mesenchymal stromal cell labeling by new uncoated superparamagnetic maghemite nanoparticles in
comparison with commercial Resovist – an initial in vitro study. Polakova, K., Havrdova, M., Justan, I., Magro,
M., Milde, D., Knopfova, L., Smarda, J., et al. (2014)., 5355–5372.
118. Boronate Cross-linked ATP- and pH-Responsive Nanogels for Intracellular Delivery of Anticancer Drugs.
Zhang, X., Achazi, K., & Haag, R. (2014).Advanced healthcare materials. doi:10.1002/adhm.201400550
119. Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists : a
clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells. Linxweiler, M.,
Schorr, S., Schäuble, N., Jung, M., Linxweiler, J., Langer, F., Schäfers, H., et al. (2013)., 1–14.
24
120. Carcinoembryonic Antigen Cell Adhesion Molecule 1 long isoform modulates malignancy of poorly
differentiated colon cancer cells. Arabzadeh, a., Dupaul-Chicoine, J., Breton, V., Haftchenary, S., Yumeen, S.,
Turbide, C., Saleh, M., et al. (2015).Gut, (L), 1–9. doi:10.1136/gutjnl-2014-308781
121. Analysis of inter-/intra-E-plate repeatability in the real-time cell analyzer. Chen, J., Pan, T., Devendran, B. D.,
Xi, Z., Khare, S., Huang, B., Zhang, W., et al. (2015).Analytical Biochemistry, 477, 98–104.
doi:10.1016/j.ab.2015.01.026
122. A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small
RNAs for broad applications. Chen, Q.-X., Wang, W.-P., Zeng, S., Urayama, S., & Yu, a.-M. (2015).Nucleic Acids
Research, 1–13. doi:10.1093/nar/gkv228
123. Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic
therapy for pancreatic adenocarcinoma. Guillaumond, F., Bidaut, G., Ouaissi, M., Servais, S., Gouirand, V.,
Olivares, O., Lac, S., et al. (2015).Proceedings of the National Academy of Sciences, 201421601.
doi:10.1073/pnas.1421601112
124. Activation of β2-adrenergic receptor by (R,R′)-4′-methoxy-1-naphthylfenoterol inhibits proliferation and
motility of melanoma cells. Wnorowski, A., Sadowska, M., Paul, R. K., Singh, N. S., Boguszewska-Czubara, A.,
Jimenez, L., Abdelmohsen, K., et al. (2015).Cellular Signalling, 27, 997–1007. doi:10.1016/j.cellsig.2015.02.012
*125. Slow binding kinetics of secreted protein, acidic, rich in cysteine-VEGF interaction limit VEGF activation of
VEGF receptor 2 and attenuate angiogenesis. Cydzik, M., Abdul-Wahid, a., Park, S., Bourdeau, a., Bowden, K.,
Prodeus, a., Kollara, a., et al. (2015).The FASEB Journal, 29, 3493–3505. doi:10.1096/fj.15-271775
*126. In-vitro study on proliferation kinetics of oral mucosal keratinocytes. Dickhuth, J., Koerdt, S., Kriegebaum,
U., Linz, C., Müller-Richter, U. D., Ristow, O., Kübler, A. C., et al. (2015).Oral Surgery, Oral Medicine, Oral
Pathology and Oral Radiology, 1–7. doi:10.1016/j.oooo.2015.06.001
*127. Application of xCELLigence RTCA Biosensor Technology for Revealing the Profile and Window of Drug
Responsiveness in Real Time. Kho, D., MacDonald, C., Johnson, R., Unsworth, C., O’Carroll, S., Mez, E., Angel,
C., et al. (2015).Biosensors, 5(1), 199–222. doi:10.3390/bios5020199
*128. Factor-inhibiting HIF-1 (FIH-1) is required for human vascular endothelial cell survival. Kiriakidis, S., Henze,
a.-T., Kruszynska-Ziaja, I., Skobridis, K., Theodorou, V., Paleolog, E. M., & Mazzone, M. (2015).The FASEB
Journal, 1. doi:10.1096/fj.14-252379
*129. The ubiquitin ligase CHIP inactivates NF-κB signaling and impairs the ability of migration and invasion in
gastric cancer cells. Liu, F., Zhou, J., Zhou, P., Chen, W., & Guo, F. (2015).International Journal of Oncology,
2(10), 2096–2106. doi:10.3892/ijo.2015.2893
*130. ROS-induced nanotherapeutic approach for ovarian cancer treatment based on the combinatorial effect of
photodynamic therapy and DJ-1 gene suppression. Schumann, C., Taratula, O., Khalimonchuk, O., Palmer, A.
L., Cronk, L. M., Jones, C. V., Escalante, C. a., et al. (2015).Nanomedicine: Nanotechnology, Biology and
Medicine. doi:10.1016/j.nano.2015.07.005
*131. Analysis of impedance-based cellular growth assays. Witzel, F., Fritsche-guenther, R., Lehmann, N., Sieber,
A., & Bl, N. (2015)., 1–9.
25
*132. Cyclization of the Urokinase Receptor-Derived Ser-Arg-Ser-Arg-Tyr Peptide Generates a Potent Inhibitor of
Trans-Endothelial Migration of Monocytes. Yousif, A. M., Minopoli, M., Bifulco, K., Ingangi, V., Di Carluccio,
G., Merlino, F., Motti, M. L., et al. (2015).Plos One, 10, e0126172. doi:10.1371/journal.pone.0126172
*133. A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction. Carotenuto, M.,
de Antonellis, P., Chiarolla, C. M., Attanasio, C., Damiani, V., Boffa, I., Aiese, N., et al. (2014).NaunynSchmiedeberg’s Archives of Pharmacology, 388, 257–269. doi:10.1007/s00210-014-1035-8
*134. H-Prune through GSK-3β interaction sustains canonical WNT/β-catenin signaling enhancing cancer
progression in NSCLC. Carotenuto, M., De Antonellis, P., Liguori, L., Benvenuto, G., Magliulo, D., Alonzi, A.,
Turino, C., et al. (2014).Oncotarget, 5(14), 5736–49. Retrieved from
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4170634&tool=pmcentrez&rendertype=abstract
*135. HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and
defense escape. Conte, M., Aversana, C. D., Benedetti, R., Carissimo, A., Petrizzi, V. B., Arco, A. M. D.,
Abbondanza, C., et al. (2014)., 6(2).
*136. Dichloroacetate , a selective mitochondria-targeting drug for oral squamous cell carcinoma : a metabolic
perspective of treatment. Ruggieri, V., Agriesti, F., Scrima, R., Laurenzana, I., Perrone, D., Tataranni, T.,
Mazzoccoli, C., et al. (2014)., 6(2).
*137. A unique co-culture model for fundamental and applied studies of human fetoplacental steroidogenesis
and interference by environmental chemicals. Thibeault, A. A. H., Deroy, K., Vaillancourt, C., & Sanderson, J.
T. (2014).Environmental Health Perspectives, 122(4), 371–377. doi:10.1289/ehp.1307518
*138. In triple negative breast tumor cells , PLC-β2 promotes the conversion of CD133 high to CD133 low
phenotype and reduces the CD133-related invasiveness. Brugnoli, F., Grassilli, S., Piazzi, M., Palomba, M.,
Nika, E., Bavelloni, A., Capitani, S., et al. (2013)., 1–15. doi:10.1186/1476-4598-12-165
*139. Membrane-type matrix metalloproteinase 1 regulates trophoblast functions and is reduced in fetal growth
restriction. Hiden, U., Ghaffari-Tabrizi, N., Gauster, M., Tam-Amersdorfer, C., Cetin, I., Dieber-Rotheneder, M.,
Lang, U., et al. (2013).American Journal of Pathology, 182(5), 1563–1571. doi:10.1016/j.ajpath.2013.01.011
*140. PRIMA-1 induces autophagy in cancer cells carrying mutant or wild type p53. Russo, D., Ottaggio, L.,
Foggetti, G., Masini, M., Masiello, P., Fronza, G., & Menichini, P. (2013).Biochimica et Biophysica Acta Molecular Cell Research, 1833(8), 1904–1913. doi:10.1016/j.bbamcr.2013.03.020
*141. Urokinase receptor promotes ovarian cancer cell dissemination through its 84-95 sequence ABSTRACT :.
Bifulco, K., Votta, G., Ingangi, V., Carluccio, G. Di, Rea, D., Losito, S., Montuori, N., et al. (n.d.)., 5(12).
26
CELLULAR CARDIOLOGY RESEARCH
1. Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced
hypertrophic response in cardiac myocytes. Sin, Y. Y., Edwards, H. V, Li, X., Day, J. P., Christian, F., Dunlop, a
J., Adams, D. R., et al. (2011, May).Journal of molecular and cellular cardiology.
doi:10.1016/j.yjmcc.2011.02.006
2. Impedance-based detection of beating rhythm and proarrhythmic effects of compounds on stem cell-derived
cardiomyocytes. Jonsson, M. K. B., Wang, Q.-D., & Becker, B. (2011).Assay and drug development
technologies, 9(6), 589–99. doi:10.1089/adt.2011.0396
3. Functional cardiotoxicity profiling and screening using the xCELLigence RTCA Cardio System. Xi, B., Wang, T., Li,
N., Ouyang, W., Zhang, W., Wu, J., Xu, X., et al. (2011).Journal of laboratory automation, 16(6), 415–21.
doi:10.1016/j.jala.2011.09.002
4. Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for
preclinical safety assessment. Abassi, Y. a, Xi, B., Li, N., Ouyang, W., Seiler, A., Watzele, M., Kettenhofen, R., et
al. (2012).British journal of pharmacology, 165(5), 1424–41. doi:10.1111/j.1476-5381.2011.01623.x
5. Meeting Highlight 2011 Annual Meeting of the Safety Pharmacology Society : an overview. Cavero, I. (2012).,
(September 2011), 341–353.
6. In vitro Model for Assessing Arrhythmogenic Properties of Drugs Based on High-resolution Impedance
Measurements. Nguemo, F., Šaric, T., Pfannkuche, K., Reppel, M., & Hescheler, J. (2012).Cellular Physiology
and Biochemistry, 819–832.
7. Evaluation of cellular impedance measures of cardiomyocyte cultures for drug screening applications. Peters,
M. F., Scott, C. W., Ochalski, R., & Dragan, Y. P. (2012).Assay and drug development technologies, 10(6), 525–
32. doi:10.1089/adt.2011.442
8. Cardiotoxic effects of venom fractions from the Australian box jellyfish Chironex fleckeri on human
myocardiocytes. Saggiomo, S. L. a, & Seymour, J. E. (2012).Toxicon : official journal of the International Society
on Toxinology, 60(3), 391–5. doi:10.1016/j.toxicon.2012.03.025
9. Impact of human autoantibodies on β1-adrenergic receptor conformation, activity, and internalization.
Bornholz, B., Weidtkamp-Peters, S., Schmitmeier, S., Seidel, C. a M., Herda, L. R., Felix, S. B., Lemoine, H., et al.
(2013, March 1).Cardiovascular research. doi:10.1093/cvr/cvs350
10. Coronary Microvascular Pericytes Are the Cellular Target of Sunitinib Malate-Induced Cardiotoxicity.
Chintalgattu, V., Rees, M. L., Culver, J. C., Goel, a., Jiffar, T., Zhang, J., Dunner, K., et al. (2013).Science
Translational Medicine, 5(187), 187ra69–187ra69. doi:10.1126/scitranslmed.3005066
11. Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human
cardiomyocytes. Doherty, K. R., Wappel, R. L., Talbert, D. R., Trusk, P. B., Moran, D. M., Kramer, J. W., Brown,
A. M., et al. (2013).Toxicology and applied pharmacology. doi:10.1016/j.taap.2013.04.027
12. Refining the Human iPSC-Cardiomyocyte Arrhythmic Risk Assessment Model. Guo, L., Coyle, L., Abrams, R. M.
C., Kemper, R., Chiao, E. T., & Kolaja, K. L. (2013).Toxicological sciences : an official journal of the Society of
Toxicology. doi:10.1093/toxsci/kft205
27
13. Drug-induced functional cardiotoxicity screening in stem cell-derived human and mouse cardiomyocytes:
Effects of reference compounds. Himmel, H. M. (2013).Journal of pharmacological and toxicological methods.
doi:10.1016/j.vascn.2013.05.005
14. Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity.
Lamore, S. D., Kamendi, H. W., Scott, C. W., Dragan, Y. P., & Peters, M. F. (2013).Toxicological sciences : an
official journal of the Society of Toxicology, 135(2), 402–13. doi:10.1093/toxsci/kft167
15. The effects of jaspamide on human cardiomyocyte function and cardiac ion channel activity. Schweikart, K.,
Guo, L., Shuler, Z., Abrams, R., Chiao, E. T., Kolaja, K. L., & Davis, M. (2013).Toxicology in vitro : an international
journal published in association with BIBRA, 27(2), 745–51. doi:10.1016/j.tiv.2012.12.005
16. A cardiomyocyte-based biosensor for antiarrhythmic drug evaluation by simultaneously monitoring cell
growth and beating. Wang, T., Hu, N., Cao, J., Wu, J., Su, K., & Wang, P. (2013).Biosensors & bioelectronics,
49C, 9–13. doi:10.1016/j.bios.2013.04.039
17. Rapid short term and gradual permanent cardiotoxic effects of vertebrate toxins from Chironex fleckeri
(Australian box jellyfish) venom. Chaousis, S., Smout, M., Wilson, D., Loukas, A., Mulvenna, J., & Seymour, J.
(2014).Toxicon : official journal of the International Society on Toxinology, 80(January), 17–26.
doi:10.1016/j.toxicon.2014.01.007
18. Human Stem Cell-Derived Cardiomyocytes in Cellular Impedance Assays: Bringing Cardiotoxicity Screening to
the Front Line. Peters, M. F., Lamore, S. D., Guo, L., Scott, C. W., & Kolaja, K. L. (2014).Cardiovascular
toxicology. doi:10.1007/s12012-014-9268-9
19. Examining the Protective Role of ErbB2 Modulation in Human Induced Pluripotent Stem Cell-Derived
Cardiomyocytes. Eldridge, S., Guo, L., Mussio, J., Furniss, M., Hamre, J., & Davis, M. (2014).Toxicological
sciences : an official journal of the Society of Toxicology, 2014(Cdi). doi:10.1093/toxsci/kfu150
20. The proliferative and chronotropic effects of Brillantaisia nitens Lindau (Acanthaceae) extracts on pluripotent
stem cells and their cardiomyocytes derivatives. Nembu, E. N., Dimo, T., Bopda, M. O. S., Hescheler, J., &
Nguemo, F. (2014).Journal of ethnopharmacology, 1–9. doi:10.1016/j.jep.2014.07.046
21. An impedance-based cellular assay using human iPSC-derived cardiomyocytes to quantify modulators of
cardiac contractility. Clay W Scott, Xiaoyu Zhang, Najah Abi-Gerges, Sarah D. Lamore, Yama A. Abassi, M. F. P.
(2014).ToxSci Adcanced Access, 1–29.
22. A multi-parameter in vitro screen in human stem cell-derived cardiomyocytes identifies ponatib-induced
structural and functional cardiac toxicity. Talbert, D. R., Doherty, K. R., Trusk, P. B., Moran, D. M., Scott, A.,
Bacus, S., Translational, R., et al. (2014).Oxford Journals, 1–25.
23. Integrin-linked kinase mediates force transduction in cardiomyocytes by modulating SERCA2a/PLN function.
Traister, A., Li, M., Aafaqi, S., Lu, M., Arab, S., Radisic, M., Gross, G., et al. (2014).Nature communications, 5,
4533. doi:10.1038/ncomms5533
24. Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells. Han, L., Li,
Y., Tchao, J., Kaplan, a. D., Lin, B., Li, Y., Mich-Basso, J., et al. (2014).Cardiovascular Research, 104, 258–269.
doi:10.1093/cvr/cvu205
28
*25. Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes
accurately identifies cardiotoxicity of multiple drug types. Doherty, K. R., Talbert, D. R., Trusk, P. B., Moran,
D. M., Shell, S. a., & Bacus, S. (2015).Toxicology and Applied Pharmacology, 285(1), 51–60.
doi:10.1016/j.taap.2015.03.008
*26. Specific Uptake and Genotoxicity Induced by Polystyrene Nanobeads with Distinct Surface Chemistry on
Human Lung Epithelial Cells and Macrophages. Paget, V., Dekali, S., Kortulewski, T., Grall, R., Gamez, C., Blazy,
K., Aguerre-Chariol, O., et al. (2015).Plos One, 10, e0123297. doi:10.1371/journal.pone.0123297
*27. Cardiomyocyte Impedance Assays Assay Guidance Manual. Lamore, S. D., & Scott, C. W. (n.d.).
CO-CULTURE
1. Dynamic assessment of cell viability, proliferation and migration using real time cell analyzer system (RTCA).
Roshan Moniri, M., Young, A., Reinheimer, K., Rayat, J., Dai, L.-J., & Warnock, G. L. (2014).Cytotechnology.
doi:10.1007/s10616-014-9692-5
*2. A unique co-culture model for fundamental and applied studies of human fetoplacental steroidogenesis and
interference by environmental chemicals. Thibeault, A. A. H., Deroy, K., Vaillancourt, C., & Sanderson, J. T.
(2014).Environmental Health Perspectives, 122(4), 371–377. doi:10.1289/ehp.1307518
CYTOTOXICITY AND CELL DEATH
1. Application of real-time cell electronic sensing (RT-CES) technology to cell-based assays. Solly, K., Wang, X., Xu,
X., Strulovici, B., & Zheng, W. (2004).Assay and drug development technologies, 2(4), 363–72.
doi:10.1089/1540658041850544
2. The ribonucleotide reductase subunit M2B subcellular localization and functional importance for DNA
replication in physiological growth of KB cells. Liu, X., Zhou, B., Xue, L., Shih, J., Tye, K., Qi, C., & Yen, Y.
(2005).Biochemical pharmacology, 70(9), 1288–97. doi:10.1016/j.bcp.2005.08.005
3. Dynamic monitoring of cytotoxicity on microelectronic sensors. Xing, James Zan, Zhu, L., Jackson, J. A., Gabos, S.,
Sun, X.-J., Wang, X.-B., & Xu, X. (2005).Chemical research in toxicology, 18(2), 154–61. doi:10.1021/tx049721s
4. Synthesis and anti-tumor evaluation of new trisulfide derivatives. An, H., Zhu, J., Wang, X., & Xu, X.
(2006).Bioorganic & medicinal chemistry letters, 16(18), 4826–9. doi:10.1016/j.bmcl.2006.06.070
5. Yeast beta-glucan amplifies phagocyte killing of iC3b-opsonized tumor cells via complement receptor 3-Sykphosphatidylinositol 3-kinase pathway. Li, B., Allendorf, D. J., Hansen, R., Marroquin, J., Ding, C., Cramer, D.
E., & Yan, J. (2006).Journal of immunology (Baltimore, Md. : 1950), 177(3), 1661–9. Retrieved from
http://www.ncbi.nlm.nih.gov/pubmed/16849475
29
6. Microelectronic cell sensor assay for detection of cytotoxicity and prediction of acute toxicity. Xing, James Z,
Zhu, L., Gabos, S., & Xie, L. (2006).Toxicology in vitro : an international journal published in association with
BIBRA, 20(6), 995–1004. doi:10.1016/j.tiv.2005.12.008
7. Combined yeast {beta}-glucan and antitumor monoclonal antibody therapy requires C5a-mediated neutrophil
chemotaxis via regulation of decay-accelerating factor CD55. Li, B., Allendorf, D. J., Hansen, R., Marroquin, J.,
Cramer, D. E., Harris, C. L., & Yan, J. (2007).Cancer research, 67(15), 7421–30. doi:10.1158/0008-5472.CAN-071465
8. A cell-microelectronic sensing technique for profiling cytotoxicity of chemicals. Boyd, J. M., Huang, L., Xie, L.,
Moe, B., Gabos, S., & Li, X.-F. (2008).Analytica chimica acta, 615(1), 80–7. doi:10.1016/j.aca.2008.03.047
9. Cell-electronic sensing of particle-induced cellular responses. Huang, L., Xie, L., Boyd, J. M., & Li, X.-F. (2008).The
Analyst, 133(5), 643–8. doi:10.1039/b714384b
10. Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of
differentiated U937 cells. Martin-Manso, G., Galli, S., Ridnour, L. a, Tsokos, M., Wink, D. a, & Roberts, D. D.
(2008).Cancer research, 68(17), 7090–9. doi:10.1158/0008-5472.CAN-08-0643
11. REIC/Dkk-3 induces cell death in human malignant glioma. Mizobuchi, Y., Matsuzaki, K., Kuwayama, K.,
Kitazato, K., Mure, H., Kageji, T., & Nagahiro, S. (2008).Neuro-oncology, 10(3), 244–53. doi:10.1215/152285172008-016
12. Critical role of △DNMT3B4/2 in regulating RASSF1A promoterspecific DNA methylation in non-small cell lung
cancer. WANG Shu-hang, LIU Nin-hong, WANG Jie, B. H. and M. L. (2008).Chinese Medical Journal,
121(30572104), 1712–1721.
13. Compound cytotoxicity profiling using quantitative high-throughput screening. Xia, M., Huang, R., Witt, K. L.,
Southall, N., Fostel, J., Cho, M.-H., Jadhav, A., et al. (2008).Environmental health perspectives, 116(3), 284–91.
doi:10.1289/ehp.10727
14. Dynamic Cytotoxic Response to Sensor Arrays. Microelectronic, M. U., Mock, M., Hagenbuch, B., Chan, S. I. U.,
Dmitrovic, J., Gabos, S., & Kinniburgh, D. (2009).Environmental science & technology, 7803–7809.
15. Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of beta-tubulin
at Cys 12 and suppression of microtubule dynamics. Xu, W., Xi, B., Wu, J., An, H., Zhu, J., Abassi, Y., Feinstein,
S. C., et al. (2009).Molecular cancer therapeutics, 8(12), 3318–30. doi:10.1158/1535-7163.MCT-09-0548
16. PAX3-FKHR sensitizes human alveolar rhabdomyosarcoma cells to camptothecin-mediated growth inhibition
and apoptosis. Zeng, F.-Y., Cui, J., Liu, L., & Chen, T. (2009).Cancer letters, 284(2), 157–64.
doi:10.1016/j.canlet.2009.04.016
17. Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2. Ark, M.,
Ozdemir, A., & Polat, B. (2010).Apoptosis : an international journal on programmed cell death, 15(12), 1494–
506. doi:10.1007/s10495-010-0529-1
18. Antivascular and anticancer activity of dihalogenated A-ring analogues of combretastatin A-4. Beale, T. M.,
Myers, R. M., Shearman, J. W., Charnock-Jones, D. S., Brenton, J. D., Gergely, F. V., & Ley, S. V.
(2010).MedChemComm, 1(3), 202. doi:10.1039/c0md00095g
30
19. Regulation of translesion synthesis DNA polymerase eta by monoubiquitination. Bienko, M., Green, C. M.,
Sabbioneda, S., Crosetto, N., Matic, I., Hibbert, R. G., Begovic, T., et al. (2010).Molecular cell, 37(3), 396–407.
doi:10.1016/j.molcel.2009.12.039
20. Toxicity of smoke extracts towards A549 lung cells: role of acrolein and suppression by carbonyl scavengers.
Burcham, P. C., Raso, A., & Thompson, C. a. (2010).Chemico-biological interactions, 183(3), 416–24.
doi:10.1016/j.cbi.2009.12.006
21. Embryotoxic effects of the marine biotoxin okadaic acid on murine embryonic stem cells. Ehlers, A., Stempin,
S., Al-Hamwi, R., & Lampen, A. (2010).Toxicon : official journal of the International Society on Toxinology,
55(4), 855–63. doi:10.1016/j.toxicon.2009.12.008
22. Enhanced death ligand-induced apoptosis in cutaneous SCC cells by treatment with diclofenac/hyaluronic acid
correlates with downregulation of c-FLIP. Fecker, L. F., Stockfleth, E., Braun, F. K., Rodust, P. M., Schwarz, C.,
Köhler, A., Leverkus, M., et al. (2010).The Journal of investigative dermatology, 130(8), 2098–109.
doi:10.1038/jid.2010.40
23. The effectiveness of oracin in enhancing the cytotoxicity of doxorubicin through the inhibition of doxorubicin
deactivation in breast cancer MCF7 cells. Hanusová, V., Králová, V., Schröterová, L., Trilecová, L., Pakostová,
a, & Skálová, L. (2010).Xenobiotica; the fate of foreign compounds in biological systems, 40(10), 681–90.
doi:10.3109/00498254.2010.508821
24. Through its nonstructural protein NS1, parvovirus H-1 induces apoptosis via accumulation of reactive oxygen
species. Hristov, G., Krämer, M., Li, J., El-Andaloussi, N., Mora, R., Daeffler, L., Zentgraf, H., et al.
(2010).Journal of virology, 84(12), 5909–22. doi:10.1128/JVI.01797-09
25. Early determination of toxicant concentration in water supply using MHE. Ibrahim, F., Huang, B., Xing, J., &
Gabos, S. (2010).Water research, 44(10), 3252–60. doi:10.1016/j.watres.2010.03.010
26. Screening and identification of small molecule compounds perturbing mitosis using time-dependent cellular
response profiles. Ke, N., Xi, B., Ye, P., Xu, W., Zheng, M., Mao, L., Wu, M.-J., et al. (2010).Analytical chemistry,
82(15), 6495–503. doi:10.1021/ac1007877
27. Metastatic breast tumors express increased tau, which promotes microtentacle formation and the
reattachment of detached breast tumor cells. Matrone, M. a, Whipple, R. a, Thompson, K., Cho, E. H., Vitolo,
M. I., Balzer, E. M., Yoon, J. R., et al. (2010).Oncogene, 29(22), 3217–27. doi:10.1038/onc.2010.68
28. A cell-microelectronic sensing technique for the screening of cytoprotective compounds. Ó zsvári, B., Puskás, L.
G., Nagy, L. I., Kanizsai, I., Gyuris, M., Madácsi, R., Fehér, L. Z., et al. (2010).International Journal of Molecular
Medicine, 525–530. doi:10.3892/ijmm
29. In vitro-Ishikawa cell test for assessing tissue-specific chemical effects on human endometrium. Schaefer, W.
R., Fischer, L., Deppert, W. R., Hanjalic-Beck, a, Seebacher, L., Weimer, M., & Zahradnik, H. P.
(2010).Reproductive toxicology (Elmsford, N.Y.), 30(1), 89–93. doi:10.1016/j.reprotox.2010.02.002
30. Daunomycin-polypeptide conjugates with antitumor activity. Szabó, R., Bánóczi, Z., Mezo, G., Láng, O., Kohidai,
L., & Hudecz, F. (2010).Biochimica et biophysica acta, 1798(12), 2209–16. doi:10.1016/j.bbamem.2010.07.023
31
31. Real-time xCELLigence impedance analysis of the cytotoxicity of dental composite components on human
gingival fibroblasts. Urcan, E., Haertel, U., Styllou, M., Hickel, R., Scherthan, H., & Reichl, F. X. (2010).Dental
materials : official publication of the Academy of Dental Materials, 26(1), 51–8.
doi:10.1016/j.dental.2009.08.007
32. Probing the dynamic effect of cys-CdTe quantum dots toward cancer cells in vitro. Wu, C., Shi, L., Li, Q., Jiang,
H., Selke, M., Ba, L., & Wang, X. (2010).Chemical research in toxicology, 23(1), 82–8. doi:10.1021/tx900291c
33. Formulation and Delivery of Splice-Correction Antisense Oligonucleotides by Amino Acid Modified. Zaghloul,
E. M., Viola, J. R., Zuber, G., Smith, C. I. E., & Lundin, K. E. (2010).Molecular Pharmaceutics, (2), 1288–1293.
34. Increased expression of transcription factor TFAP2α correlates with chemosensitivity in advanced bladder
cancer. Nordentoft, I., Dyrskjøt, L., Bødker, J. S., Wild, P. J., Hartmann, A., Bertz, S., Lehmann, J., et al. (2011,
January).BMC cancer. doi:10.1186/1471-2407-11-135
35. TGFbeta/TNF(alpha)-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a
claudin-low phenotype. Asiedu, M. K., Ingle, J. N., Behrens, M. D., Radisky, D. C., & Knutson, K. L.
(2011).Cancer research, 71(13), 4707–19. doi:10.1158/0008-5472.CAN-10-4554
36. Synthesis and biological activity of bimorpholine and its carbanucleoside. Ausmees, K., Selyutina, A., Kütt, K.,
Lippur, K., Pehk, T., Lopp, M., Zusinaite, E., et al. (2011).Nucleosides, nucleotides & nucleic acids, 30(11), 897–
907. doi:10.1080/15257770.2011.621919
37. Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activation
status. Buontempo, F., Ersahin, T., Missiroli, S., Senturk, S., Etro, D., Ozturk, M., Capitani, S., et al.
(2011).Investigational new drugs, 29(6), 1303–13. doi:10.1007/s10637-010-9486-3
38. Panduratin A inhibits the growth of A549 cells through induction of apoptosis and inhibition of NF-kappaB
translocation. Cheah, S.-C., Appleton, D. R., Lee, S.-T., Lam, M.-L., Hadi, a H. a, & Mustafa, M. R.
(2011).Molecules (Basel, Switzerland), 16(3), 2583–98. doi:10.3390/molecules16032583
39. Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic
adenocarcinoma PC-3 cells. Lee, S.-T., Wong, P.-F., Cheah, S.-C., & Mustafa, M. R. (2011).PloS one, 6(4),
e18915. doi:10.1371/journal.pone.0018915
40. Cytotoxicity of water-soluble fraction from biodiesel and its diesel blends to human cell lines. Leme, D. M.,
Grummt, T., Heinze, R., Sehr, A., Skerswetat, M., de Marchi, M. R. R., Machado, M. C., et al.
(2011).Ecotoxicology and environmental safety, 74(8), 2148–55. doi:10.1016/j.ecoenv.2011.08.012
41. Transcriptional signatures of regulatory and toxic responses to benzo-[a]-pyrene exposure. Michaelson, J. J.,
Trump, S., Rudzok, S., Gräbsch, C., Madureira, D. J., Dautel, F., Mai, J., et al. (2011).BMC genomics, 12(1), 502.
doi:10.1186/1471-2164-12-502
42. MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis. Niemi, N. M.,
Lanning, N. J., Klomp, J. a, Tait, S. W., Xu, Y., Dykema, K. J., Murphy, L. O., et al. (2011).Molecular and cellular
biology, 31(7), 1357–68. doi:10.1128/MCB.00788-10
43. Real-time cell analysis of the cytotoxicity of the components of orthodontic acrylic materials on gingival
fibroblasts. Ö ztürk, F., Malkoc, S., Ersöz, M., Hakki, S. S., & Bozkurt, B. S. (2011).American journal of
32
orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its
constituent societies, and the American Board of Orthodontics, 140(5), e243–9.
doi:10.1016/j.ajodo.2011.05.019
44. Digitoxin-induced cytotoxicity in cancer cells is mediated through distinct kinase and interferon signaling
networks. Prassas, I., Karagiannis, G. S., Batruch, I., Dimitromanolakis, A., Datti, A., & Diamandis, E. P.
(2011).Molecular cancer therapeutics, 10(11), 2083–93. doi:10.1158/1535-7163.MCT-11-0421
45. Arsenic alters ATP-dependent Ca2+ signaling in human airway epithelial cell wound response. Sherwood, C. L.,
Lantz, R. C., Burgess, J. L., & Boitano, S. (2011).Toxicological sciences : an official journal of the Society of
Toxicology, 121(1), 191–206. doi:10.1093/toxsci/kfr044
46. New potential anticancer agent of carborane derivatives: selective cellular interaction and activity of
ferrocene-substituted dithio-o-carborane conjugates. Wu, C., Ye, H., Bai, W., Li, Q., Guo, D., Lv, G., Yan, H., et
al. (2011).Bioconjugate chemistry, 22(1), 16–25. doi:10.1021/bc100158b
47. Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2. Ark, M.,
48. Dynamic monitoring of β-cell injury with impedance and rescue by glucagon-like peptide-1. Guan, N., Gao, W.,
He, M., Zheng, M., Xu, X., Wang, X., & Wang, M.-W. (2012, April 1).Analytical biochemistry.
doi:10.1016/j.ab.2012.01.014
49. TNF-α Gene Knockout in Triple Negative Breast Cancer Cell Line Induces Apoptosis. Pileczki, V., Braicu, C.,
Gherman, C. D., & Berindan-Neagoe, I. (2012, January).International journal of molecular sciences.
doi:10.3390/ijms14010411
50. A focused immune response targeting the homotypic binding domain of the carcinoembryonic antigen blocks
the establishment of tumor foci in vivo. Abdul-Wahid, A., Huang, E. H.-B., Lu, H., Flanagan, J., Mallick, A. I., &
Gariépy, J. (2012).International journal of cancer. Journal international du cancer, 000, 18–22.
doi:10.1002/ijc.27582
51. The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.
Adams, C. J., Pike, A. C. W., Maniam, S., Sharpe, T. D., Coutts, A. S., Knapp, S., La Thangue, N. B., et al.
(2012).Proceedings of the National Academy of Sciences of the United States of America, 109(10), 3778–83.
doi:10.1073/pnas.1113731109
52. Real-time monitoring of photocytotoxicity in nanoparticles-based photodynamic therapy: a model-based
approach. Benachour, H., Bastogne, T., Toussaint, M., Chemli, Y., Sève, A., Frochot, C., Lux, F., et al.
(2012).PloS one, 7(11), e48617. doi:10.1371/journal.pone.0048617
53. Gene network analysis leads to functional validation of pathways linked to cancer cell growth and survival.
Berger, E., Vega, N., Vidal, H., & Geloën, A. (2012).Biotechnology journal, 7(11), 1395–404.
doi:10.1002/biot.201200188
54. Cytotoxicity of peptide-coated silver nanoparticles on the human intestinal cell line Caco-2. Böhmert, L.,
Niemann, B., Thünemann, A. F., & Lampen, A. (2012).Archives of toxicology, 86(7), 1107–15.
doi:10.1007/s00204-012-0840-4
33
55. Evaluation of the cytotoxicity of cigarette smoke condensate by a cellular impedance biosensor. Chen, H., Cui,
L., Jiang, X.-Y., Pang, Y.-Q., Tang, G.-L., Hou, H.-W., Jiang, J.-H., et al. (2012).Food and chemical toxicology : an
international journal published for the British Industrial Biological Research Association, 50(3-4), 612–8.
doi:10.1016/j.fct.2011.11.040
56. Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral
gene LANA, of the viral co-receptor EphA2 as well as other client proteins. Chen, W., Sin, S.-H., Wen, K. W.,
Damania, B., & Dittmer, D. P. (2012).PLoS pathogens, 8(11), e1003048. doi:10.1371/journal.ppat.1003048
57. Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy. Ciravolo, V.,
Huber, V., Ghedini, G. C., Venturelli, E., Bianchi, F., Campiglio, M., Morelli, D., et al. (2012).Journal of cellular
physiology, 227(2), 658–67. doi:10.1002/jcp.22773
58. Development of tetravalent IgG1 dual targeting IGF-1R-EGFR antibodies with potent tumor inhibition.
Croasdale, R., Wartha, K., Schanzer, J. M., Kuenkele, K.-P., Ries, C., Mayer, K., Gassner, C., et al.
(2012).Archives of biochemistry and biophysics, 1–13. doi:10.1016/j.abb.2012.03.016
59. Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy342 beta-amyloids.pdf. Denise Galante, Alessandro Corsaro, Tullio Florio, Serena Vella, A. P., & Francesca
Sbrana, Massimo Vassalli, Angelo Perico, C. D. (2012).The international journal of biochemistry & cell biology.
60. In vitro drug treatments reduce the deleterious effects of aggregates containing polyAla expanded PHOX2B
proteins. Di Zanni, E., Bachetti, T., Parodi, S., Bocca, P., Prigione, I., Di Lascio, S., Fornasari, D., et al.
(2012).Neurobiology of disease, 45(1), 508–18. doi:10.1016/j.nbd.2011.09.007
61. Determining Optimal Cytotoxic Activity of Human Her2neu Specific CD8 T cells by Comparing the Cr51 Release
Assay to the xCELLigence System. Erskine, C. L., Henle, A. M., & Knutson, K. L. (2012).Journal of visualized
experiments : JoVE, (66), 1–6. doi:10.3791/3683
62. Local Treatment of Hand-Foot Syndrome with Uridine/Thymidine: In Vitro Appraisal on a Human Keratinocyte
Cell Line HaCaT. Hartinger, J., Veselý, P., Matoušková, E., Argalacsová, S., Petruželka, L., & Netíková, I.
(2012).TheScientificWorldJournal, 2012, 421325. doi:10.1100/2012/421325
63. Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity. Hu, Q.,
Zhang, D. D., Wang, L., Lou, H., & Ren, D. (2012).Food and chemical toxicology : an international journal
published for the British Industrial Biological Research Association, 50(6), 1927–32.
doi:10.1016/j.fct.2012.03.059
64. Reprogramming urokinase into an antibody-recruiting anticancer agent. Jakobsche, C. E., McEnaney, P. J.,
Zhang, A. X., & Spiegel, D. a. (2012).ACS chemical biology, 7(2), 316–21. doi:10.1021/cb200374e
65. Selective killing of p53-deficient cancer cells by SP600125. Jemaà, M., Vitale, I., Kepp, O., Berardinelli, F.,
Galluzzi, L., Senovilla, L., Mariño, G., et al. (2012).EMBO molecular medicine, 4(6), 500–14.
doi:10.1002/emmm.201200228
66. A label-free, impedance-based real time assay to identify drug-induced toxicities and differentiate cytostatic
from cytotoxic effects. Kustermann, S., Boess, F., Buness, a, Schmitz, M., Watzele, M., Weiser, T., Singer, T., et
al. (2012).Toxicology in vitro : an international journal published in association with BIBRA, (September), 1–7.
doi:10.1016/j.tiv.2012.08.019
34
67. GnRH-III based multifunctional drug delivery systems containing daunorubicin and methotrexate. Leurs, U.,
Lajkó, E., Mező, G., Orbán, E., Öhlschläger, P., Marquardt, A., Kőhidai, L., et al. (2012).European journal of
medicinal chemistry, 52, 173–83. doi:10.1016/j.ejmech.2012.03.016
68. Cellular response to antitumor cis-Dichlorido platinum(II) complexes of CDK inhibitor Bohemine and its
analogues. Liskova, B., Zerzankova, L., Novakova, O., Kostrhunova, H., Travnicek, Z., & Brabec, V.
(2012).Chemical research in toxicology, 25(2), 500–9. doi:10.1021/tx200525n
69. Depletion of SLC4A11 causes cell death by apoptosis in an immortalized human corneal endothelial cell line.
Liu, J., Seet, L.-F., Koh, L. W., Venkatraman, A., Venkataraman, D., Mohan, R. R., Praetorius, J., et al.
(2012).Investigative ophthalmology & visual science, 53(7), 3270–9. doi:10.1167/iovs.11-8724
70. Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions. Moraes,
M. C. S., de Andrade, A. Q., Carvalho, H., Guecheva, T., Agnoletto, M. H., Henriques, J. a P., Sarasin, A., et al.
(2012).Cancer letters, 314(1), 108–18. doi:10.1016/j.canlet.2011.09.019
71. Application and Validation of an Impedance-Based Real Time Cell Analyzer to Measure the Toxicity of
Nanoparticles Impacting Human Bronchial Epithelial Cells. Otero-González, L., Sierra-Alvarez, R., Boitano, S.,
& Field, J. a. (2012).Environmental science & technology, 2012(1). doi:10.1021/es301599f
72. Ouabain Targets the Unfolded Protein Response for Selective Killing of HepG2 Cells During Glucose
Deprivation. Ozdemir, T., Nar, R., Kilinc, V., Alacam, H., Salis, O., Duzgun, A., Gulten, S., et al. (2012).Cancer
biotherapy & radiopharmaceuticals, 00(00), 1–7. doi:10.1089/cbr.2011.1138
73. Phenethyl isothiocyanate-induced cytoskeletal changes and cell death in lung cancer cells. Pawlik, A.,
Szczepanski, M. A., Klimaszewska, A., Gackowska, L., Zuryn, A., & Grzanka, A. (2012).Food and chemical
toxicology : an international journal published for the British Industrial Biological Research Association, 50(10),
3577–3594. doi:10.1016/j.fct.2012.07.043
74. Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA. Prabhu, A.,
Sarcar, B., Kahali, S., Shan, Y., & Chinnaiyan, P. (2012).PloS one, 7(12), e52265.
doi:10.1371/journal.pone.0052265
75. In vitro cytotoxicity and mutagenicity of mainstream waterpipe smoke and its functional consequences on
alveolar type II derived cells. Rammah, M., Dandachi, F., Salman, R., Shihadeh, A., & El-Sabban, M.
(2012).Toxicology letters, 211(3), 220–31. doi:10.1016/j.toxlet.2012.04.003
76. Bioengineering functional copolymers. XXI. Synthesis of a novel end carboxyl-trithiocarbonate functionalized
poly(maleic anhydride) and its interaction with cancer cells. Rzayev, Z. M. O., Tűrk, M., & Söylemez, E. a.
(2012).Bioorganic & medicinal chemistry, 20(16), 5053–61. doi:10.1016/j.bmc.2012.05.058
77. Cytotoxicity of new duplex drugs linking 3’-C-ethynylcytidine and 5-fluor-2'-deoxyuridine against human
melanoma cells. Schott, S., Niessner, H., Sinnberg, T., Venturelli, S., Berger, A., Ikenberg, K., Villanueva, J., et
al. (2012).International journal of cancer. Journal international du cancer, 000, 1–10. doi:10.1002/ijc.27476
78. Cytotoxicity of the new antimetabolite-bisphosphonate (5-FdU-alendronate) in comparison to standard
therapeutics on breast and ovarian cancer cell lines in the ATP tumor chemosensitivity assay. Schott, S.,
Wallwiener, M., Kootz, B., Seeger, H., Fehm, T., & Neubauer, H. (2012).Investigational new drugs, 30(4), 1750–
5. doi:10.1007/s10637-011-9688-3
35
79. Toxicity and Genotoxicity of Nano-SiO2 on Human Epithelial Intestinal HT-29 Cell Line. Sergent, J.-A., Paget, V.,
& Chevillard, S. (2012).The Annals of occupational hygiene, 56(5), 622–30. doi:10.1093/annhyg/mes005
80. Identification of pigment epithelium-derived factor protein forms with distinct activities on tumor cell lines.
Subramanian, P., Deshpande, M., Locatelli-Hoops, S., Moghaddam-Taaheri, S., Gutierrez, D., Fitzgerald, D. P.,
Guerrier, S., et al. (2012).Journal of biomedicine & biotechnology, 2012, 425907. doi:10.1155/2012/425907
81. Cytotoxic cyclic depsipeptides from the Australian marine sponge Neamphius huxleyi. Tran, T. D., Pham, N. B.,
Fechner, G., Zencak, D., Vu, H. T., Hooper, J. N. a, & Quinn, R. J. (2012).Journal of natural products, 75(12),
2200–8. doi:10.1021/np3006474
82. Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune
in breast cancer. Virgilio, A., Spano, D., Esposito, V., Di Dato, V., Citarella, G., Marino, N., Maffia, V., et al.
(2012).European journal of medicinal chemistry, 57, 41–50. doi:10.1016/j.ejmech.2012.08.020
83. Sulphamoylated estradiol analogue induces antiproliferative activity and apoptosis in breast cell lines. Visagie,
M., Mqoco, T., & Joubert, A. (2012).Cellular & molecular biology letters, (March). doi:10.2478/s11658-0120030-7
84. Influence of five potential anticancer drugs on wnt pathway and cell survival in human biliary tract cancer
cells. Wachter, J., Neureiter, D., Alinger, B., Pichler, M., Fuereder, J., Oberdanner, C., Di Fazio, P., et al.
(2012).International journal of biological sciences, 8(1), 15–29. Retrieved from
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3226029&tool=pmcentrez&rendertype=abstract
85. Nature-inspired antimicrobial polymers - assessment of their potential for biomedical applications. Al-Ahmad,
A., Laird, D., Zou, P., Tomakidi, P., Steinberg, T., & Lienkamp, K. (2013).PloS one, 8(9), e73812.
doi:10.1371/journal.pone.0073812
86. Therapeutic Potential of an Anti-diabetic Drug, Metformin: Alteration of miRNA expression in Prostate Cancer
Cells. Avci, C. B., Harman, E., Dodurga, Y., Susluer, S. Y., & Gunduz, C. (2013).Asian Pacific journal of cancer
prevention : APJCP, 14(2), 765–8. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23621234
87. The plant alkaloid and anti-leukemia drug homoharringtonine sensitizes resistant human colorectal carcinoma
cells to TRAIL-induced apoptosis via multiple mechanisms. Beranova, L., Pombinho, A. R., Spegarova, J., Koc,
M., Klanova, M., Molinsky, J., Klener, P., et al. (2013).Apoptosis : an international journal on programmed cell
death, 18(6), 739–50. doi:10.1007/s10495-013-0823-9
88. Polo-like Kinase Inhibitor Ro5203280 Has Potent Antitumor Activity in Nasopharyngeal Carcinoma. Cheung, A.
K. L., Yan Ip, J. C., Lung, H. L., Wu, J. Z., Tsao, S. W., & Lung, M. L. (2013).Molecular cancer therapeutics, 12(8),
1393–401. doi:10.1158/1535-7163.MCT-12-1219
89. Ring-substituted analogs of 3,3’-diindolylmethane (DIM) induce apoptosis and necrosis in androgendependent and -independent prostate cancer cells. Goldberg, a a, Titorenko, V. I., Beach, a, Abdelbaqi, K.,
Safe, S., & Sanderson, J. T. (2013).Investigational new drugs, (Dim). doi:10.1007/s10637-013-9979-y
90. M1 muscarinic receptor activation mediates cell death in M1-HEK293 cells. Graham, E. S., Woo, K. K.,
Aalderink, M., Fry, S., Greenwood, J. M., Glass, M., & Dragunow, M. (2013).PloS one, 8(9), e72011.
doi:10.1371/journal.pone.0072011
36
91. Progesterone and estrogen prevent cisplatin-induced apoptosis of lung cancer cells. Grott, M., Karakaya, S.,
Mayer, F., Baertling, F., Beyer, C., Kipp, M., & Kopp, H.-G. (2013).Anticancer research, 33(3), 791–800.
Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23482746
92. Nanoformulation of paclitaxel to enhance cancer therapy. Gu, Q., Xing, J. Z., Huang, M., Zhang, X., & Chen, J.
(2013).Journal of biomaterials applications, 28(2), 298–307. doi:10.1177/0885328212446822
93. Efficacy of cetuximab and panitumumab in oral squamous cell carcinoma cell lines: Prognostic value of MAGEA subgroups for treatment success. Hartmann, S., Kriegebaum, U., Lessner, G., Brands, R. C., Linz, C.,
Schneider, T., Kübler, A. C., et al. (2013).Journal of cranio-maxillo-facial surgery : official publication of the
European Association for Cranio-Maxillo-Facial Surgery, 1–7. doi:10.1016/j.jcms.2012.12.006
94. Quantitative Detection of Vibrio cholera Toxin by Real-Time and Dynamic Cell Cytotoxicity Monitoring. Jin, D.,
Luo, Y., Zheng, M., Li, H., Zhang, J., Stampfl, M., Xu, X., et al. (2013).Journal of clinical microbiology.
doi:10.1128/JCM.01959-13
95. A bacterial RTX toxin causes programmed necrotic cell death through calcium-mediated mitochondrial
dysfunction. Kim, Y. R., Lee, S. E., Kang, I.-C., Nam, K. Il, Choy, H. E., & Rhee, J. H. (2013).The Journal of
infectious diseases, 207(9), 1406–15. doi:10.1093/infdis/jis746
96. Cytotoxicity and genotoxicity of phenazine in two human cell lines. McGuigan, C. F., & Li, X.-F.
(2013).Toxicology in vitro : an international journal published in association with BIBRA, (January).
doi:10.1016/j.tiv.2013.12.007
97. Suitability of cell-based label-free detection for cytotoxicity screening of carbon nanotubes. Meindl, C.,
Absenger, M., Roblegg, E., & Fröhlich, E. (2013).BioMed research international, 2013, 564804.
doi:10.1155/2013/564804
98. Real-time cell-microelectronic sensing of nanoparticle-induced cytotoxic effects. Moe, B., Gabos, S., & Li, X.-F.
(2013).Analytica chimica acta, 789, 83–90. doi:10.1016/j.aca.2013.06.002
99. Phenotypic profiling of DPYD variations relevant to 5-fluorouracil sensitivity using real-time cellular analysis
and in vitro measurement of enzyme activity. Offer, S. M., Wegner, N. J., Fossum, C., Wang, K., & Diasio, R. B.
(2013).Cancer research, 73(6), 1958–68. doi:10.1158/0008-5472.CAN-12-3858
100. Carboxylated nanodiamonds are neither cytotoxic nor genotoxic on liver, kidney, intestine and lung human
cell lines. Paget, V., Sergent, J. a, Grall, R., Altmeyer-Morel, S., Girard, H. a, Petit, T., Gesset, C., et al.
(2013).Nanotoxicology, 5390, 1–11. doi:10.3109/17435390.2013.855828
101. Chemosensitivity induced by down-regulation of microRNA-21 in gemcitabine-resistant pancreatic cancer
cells by indole-3-carbinol. Paik, W. H., Kim, H. R., Park, J. K., Song, B. J., Lee, S. H., & Hwang, J.-H.
(2013).Anticancer research, 33(4), 1473–81. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23564788
102. Cytotoxicity assessment based on the AUC(50) using multi-concentration time-dependent cellular response
curves. Pan, T., Huang, B., Zhang, W., Gabos, S., Huang, D. Y., & Devendran, V. (2013).Analytica chimica acta,
764, 44–52. doi:10.1016/j.aca.2012.12.047
37
103. In vitro cytotoxicity assessment based on KC(50) with real-time cell analyzer (RTCA) assay. Pan, T., Khare, S.,
Ackah, F., Huang, B., Zhang, W., Gabos, S., Jin, C., et al. (2013).Computational biology and chemistry, 47, 113–
20. doi:10.1016/j.compbiolchem.2013.08.008
104. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Rader, J., Russell, M.
R., Hart, L. S., Nakazawa, M. S., Belcastro, L. T., Martinez, D., Li, Y., et al. (2013).Clinical cancer research : an
official journal of the American Association for Cancer Research, 6173–6182. doi:10.1158/1078-0432.CCR-131675
105. Optimization of cytotoxicity assay by real-time, impedance-based cell analysis. Ramis, G., Martínez-Alarcón,
L., Quereda, J. J., Mendonça, L., Majado, M. J., Gomez-Coelho, K., Mrowiec, a, et al. (2013).Biomedical
microdevices. doi:10.1007/s10544-013-9790-8
106. Real-Time Growth Kinetics Measuring Hormone Mimicry for ToxCast Chemicals in T-47D Human Ductal
Carcinoma Cells. Rotroff, D. M., Dix, D. J., Houck, K. a, Kavlock, R. J., Knudsen, T. B., Martin, M. T., Reif, D. M.,
et al. (2013).Chemical research in toxicology. doi:10.1021/tx400117y
107. MIR-143 AND MIR-145 OVEREXPRESSION IMPROVE THE RESPONSE TO CETUXIMAB IN HCT116 KRAS
MUTANT COLON CANCER CELLS. S. E. Gomes, A. E. S. Simoes, D. M. Pereira, P. M. Borralho, C. M., &
Rodrigues, P. (2013).United European Gastroenterology Journal (Vol. 1, pp. A1–A134).
doi:10.1177/2050640613502899
108. Synthetic Lethal Targeting of Superoxide Dismutase 1 Selectively Kills RAD54B-Deficient Colorectal Cancer
Cells. Sajesh, B. V, Bailey, M., Lichtensztejn, Z., Hieter, P., & McManus, K. J. (2013).Genetics, 195(3), 757–67.
doi:10.1534/genetics.113.156836
109. The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and
synergizes with conventional chemotherapy. Simioni, C., Martelli, A., & Cani, A. (2013).Oncotarget, 4(9),
1496–1506. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824526/
110. Platinum compounds sensitize ovarian carcinoma cells to ABT-737 by modulation of the Mcl-1/Noxa axis.
Simonin, K., N’Diaye, M., Lheureux, S., Loussouarn, C., Dutoit, S., Briand, M., Giffard, F., et al.
(2013).Apoptosis : an international journal on programmed cell death, 18(4), 492–508. doi:10.1007/s10495012-0799-x
111. Dipyridamole prevents triple-negative breast-cancer progression. Spano, D., Marshall, J.-C., Marino, N., De
Martino, D., Romano, A., Scoppettuolo, M. N., Bello, A. M., et al. (2013).Clinical & experimental metastasis,
30(1), 47–68. doi:10.1007/s10585-012-9506-0
112. Differential induction of apoptosis and senescence by the DNA methyltransferase inhibitors 5-azacytidine
and 5-aza-2’-deoxycytidine in solid tumor cells. Venturelli, S., Berger, A., Weiland, T., Essmann, F., Waibel,
M., Nuebling, T., Häcker, S., et al. (2013).Molecular cancer therapeutics, 12(10), 2226–36. doi:10.1158/15357163.MCT-13-0137
113. Icariside II Induces Apoptosis of Melanoma Cells Through the Downregulation of Survival Pathways. Wu, J.,
Xu, J., Eksioglu, E. a, Chen, X., Zhou, J., Fortenbery, N., Wei, S., et al. (2013).Nutrition and cancer, 65(1), 110–7.
doi:10.1080/01635581.2013.741745
38
114. Cytotoxicity of hemostatic agents on the human gingival fibroblast. Yalçin, M., Barutcigil, C., Umar, I., Bozkurt,
B. S., & Hakki, S. S. (2013).European review for medical and pharmacological sciences, 17(7), 984–8. Retrieved
from http://www.ncbi.nlm.nih.gov/pubmed/23640448
115. A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and
overcomes drug resistance. Zhou, B., Su, L., Hu, S., Hu, W., Yip, M., & Wu, J. (2013).Cancer research.
doi:10.1158/0008-5472.CAN-13-1094
116. Anticancer Effect of COX-2 Inhibitor DuP-697 Alone and in Combination with Tyrosine Kinase Inhibitor
(E7080) on Colon Cancer Cell Lines. Altun, A., Turgut, N. H., & Kaya, T. T. (2014).Asian Pacific journal of cancer
prevention : APJCP, 15(7), 3113–21. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/24815456
117. Liposome encapsulation of curcumin: Physico-chemical characterizations and effects on MCF7 cancer cell
proliferation. Hasan, M., Belhaj, N., Benachour, H., Barberi-Heyob, M., Kahn, C. J. F., Jabbari, E., Linder, M., et
al. (2014).International journal of pharmaceutics, 461(1-2), 519–28. doi:10.1016/j.ijpharm.2013.12.007
118. NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies.
Hirose, T., Virnicchi, G., Tanigawa, A., Naganuma, T., Li, R., Kimura, H., Yokoi, T., et al. (2014).Molecular biology
of the cell, 25(1), 169–83. doi:10.1091/mbc.E13-09-0558
119. A novel assay for high-throughput screening of anti-Alzheimer’s disease drugs to determine their efficacy by
real-time monitoring of changes in PC12 cell proliferation. Hou, X.-Q., Yan, R., Yang, C., Zhang, L., Su, R.-Y.,
Liu, S.-J., Zhang, S.-J., et al. (2014).International journal of molecular medicine, 33(3), 543–9.
doi:10.3892/ijmm.2013.1608
120. Real-time cellular analysis coupled with a specimen enrichment accurately detects and quantifies
Clostridium difficile toxins in stool. Huang, B., Jin, D., Zhang, J., Sun, J. Y., Wang, X., Stiles, J., Xu, X., et al.
(2014).Journal of clinical microbiology, 52(January), 1105–11. doi:10.1128/JCM.02601-13
121. Silencing RBBP6 (Retinoblastoma Binding Protein 6) sensitises breast cancer cells MCF7 to staurosporine and
camptothecin-induced cell death. Moela, P., Choene, M. M. S., & Motadi, L. R. (2014).Immunobiology, 6.
doi:10.1016/j.imbio.2014.03.002
122. Cellular responses of BRCA1-defective and triple-negative breast cancer cells and in vitro BRCA1 interactions
induced by metallo-intercalator ruthenium(II) complexes containing chloro-substituted phenylazopyridine.
Nhukeaw, T., Temboot, P., Hansongnern, K., & Ratanaphan, A. (2014).BMC cancer, 14(1), 73.
doi:10.1186/1471-2407-14-73
123. Mode of action classification of chemicals using multi-concentration time-dependent cellular response
profiles. Xi, Z., Khare, S., Cheung, A., Huang, B., Pan, T., Zhang, W., Ibrahim, F., et al. (2014).Computational
biology and chemistry, 49, 23–35. doi:10.1016/j.compbiolchem.2013.12.004
124. In vitro biocompatibility and cellular interactions of a chitosan/dextran-based hydrogel for postsurgical
adhesion prevention. Aziz, M. a, Cabral, J. D., Brooks, H. J. L., McConnell, M. a, Fitzpatrick, C., Hanton, L. R., &
Moratti, S. C. (2014).Journal of biomedical materials research. Part B, Applied biomaterials, 1–10.
doi:10.1002/jbm.b.33206
125. An Evaluation of Dose Equivalence between Synchrotron Microbeam Radiation Therapy and Conventional
Broadbeam Radiation Using Clonogenic and Cell Impedance Assays. Ibahim, M. J., Crosbie, J. C., Yang, Y.,
39
Zaitseva, M., Stevenson, A. W., Rogers, P. a W., & Paiva, P. (2014).PloS one, 9(6), e100547.
doi:10.1371/journal.pone.0100547
126. xCELLigence system for real-time label-free monitoring of growth and viability of cell lines from
hematological malignancies. Martinez-Serra, J., Gutierrez, A., Muñoz-Capó, S., Navarro-Palou, M., Ros, T.,
Amat, J. C., Lopez, B., et al. (2014).OncoTargets and therapy, 7, 985–94. doi:10.2147/OTT.S62887
127. Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced
toxicity. Oppermann, S., Schrader, F. C., Elsässer, K., Dolga, A. M., Kraus, A. L., Doti, N., Wegscheid-Gerlach, C.,
et al. (2014).The Journal of pharmacology and experimental therapeutics, 350(2), 273–89.
doi:10.1124/jpet.114.213777
128. Real-time cell analysis: sensitivity of different vertebrate cell cultures to copper sulfate measured by
xCELLigence(®). Rakers, S., Imse, F., & Gebert, M. (2014).Ecotoxicology (London, England), (1983).
doi:10.1007/s10646-014-1279-6
129. A Novel Glycoengineered Bispecific Antibody Format for Targeted Inhibition of Epidermal Growth Factor
Receptor (EGFR) and Insulin-like Growth Factor Receptor Type I (IGF-1R) Demonstrating Unique Molecular
Properties. Schanzer, J. M., Wartha, K., Croasdale, R., Moser, S., Künkele, K.-P., Ries, C., Scheuer, W., et al.
(2014).The Journal of biological chemistry, 289(27), 18693–706. doi:10.1074/jbc.M113.528109
130. Quality fluctuation detection of an herbal injection based on biological fingerprint combined with chemical
fingerprint. Zhang, L., Ma, L., Feng, W., Zhang, C., Sheng, F., Zhang, Y., Xu, C., et al. (2014).Analytical and
bioanalytical chemistry, 406(20), 5009–18. doi:10.1007/s00216-014-7918-1
131. Dynamic monitoring of the cytotoxic effects of protoberberine alkaloids from Rhizoma Coptidis on HepG2
cells using the xCELLigence system. Zhang, L.-L., Ma, L.-N., Yan, D., Zhang, C.-E., Gao, D., Xiong, Y., Sheng, F.Y., et al. (2014).Chinese journal of natural medicines, 12(6), 428–35. doi:10.1016/S1875-5364(14)60067-4
132. Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against
cervical and pancreatic carcinomas. Li, J., Bonifati, S., Hristov, G., Marttila, T., Valmary-Degano, S., Stanzel, S.,
Schnölzer, M., et al. (2013).EMBO molecular medicine, 5(10), 1537–55. doi:10.1002/emmm.201302796
133. Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b
expression in liver cancer cell lines. Di Fazio, P., Montalbano, R., Neureiter, D., Alinger, B., Schmidt, A.,
Merkel, A. L., Quint, K., et al. (2012).Experimental cell research, 318(15), 1832–43.
doi:10.1016/j.yexcr.2012.04.018
134. Generation of an adenovirus-parvovirus chimera with enhanced oncolytic potential. El-Andaloussi, N.,
Bonifati, S., Kaufmann, J. K., Mailly, L., Daeffler, L., Deryckère, F., Nettelbeck, D. M., et al. (2012).Journal of
virology, 86(19), 10418–31. doi:10.1128/JVI.00848-12
135. Inhibition of N-linked glycosylation impairs ALK phosphorylation and disrupts pro-survival signaling in
neuroblastoma cell lines. Del Grosso, F., De Mariano, M., Passoni, L., Luksch, R., Tonini, G. P., & Longo, L.
(2011).BMC cancer, 11(1), 525. doi:10.1186/1471-2407-11-525
136. Dose and time dependence of box jellyfish antivenom. Andreosso, A., Smout, M. J., & Seymour, J. E.
(2014).Journal of Venomous Animals and Toxins including Tropical Diseases, 20(1), 34. doi:10.1186/16789199-20-34
40
137. AurkA inhibitors enhance the effects of B-RAF and MEK inhibitors in melanoma treatment. Caputo, E., Miceli,
R., Motti, M., Taté, R., Fratangelo, F., Botti, G., Mozzillo, N., et al. (2014).Journal of translational medicine,
12(1), 216. doi:10.1186/s12967-014-0216-z
138. New metal based drugs: Spectral, electrochemical, DNA-binding, surface morphology and anticancer activity
properties. Ceşme, M., Gölcü, A., & Demirtaş, I. (2014).Spectrochimica acta. Part A, Molecular and
biomolecular spectroscopy, 135C, 887–906. doi:10.1016/j.saa.2014.06.144
139. Comparison of the toxicity of aluminum oxide nanorods with different aspect ratio. Park, E.-J., Lee, G.-H.,
Shim, J.-H., Cho, M.-H., Lee, B.-S., Kim, Y.-B., Kim, J.-H., et al. (2014).Archives of toxicology, 2014.
doi:10.1007/s00204-014-1332-5
140. Development and characterization of magnetic iron oxide nanoparticles with a cisplatin-bearing polymer
coating for targeted drug delivery. Unterweger, H., Tietze, R., Janko, C., Zaloga, J., Lyer, S., Dürr, S., Taccardi,
N., et al. (2014).International journal of nanomedicine, 9, 3659–76. doi:10.2147/IJN.S63433
141. Label-free in vitro toxicity and uptake assessment of citrate stabilised gold nanoparticles in three cell lines.
Vetten, M. a, Tlotleng, N., Tanner Rascher, D., Skepu, A., Keter, F. K., Boodhia, K., Koekemoer, L.-A., et al.
(2013).Particle and fibre toxicology, 10(1), 50. doi:10.1186/1743-8977-10-50
142. Combination of unsaturated fatty acids and ionizing radiation on human glioma cells: cellular, biochemical
and gene expression analysis. Antal, O., Hackler, L., Shen, J., Mán, I., Hideghéty, K., Kitajka, K., & Puskás, L. G.
(2014).Lipids in health and disease, 13, 142. doi:10.1186/1476-511X-13-142
143. Identification of eusynstyelamide B as a potent cell cycle inhibitor following the generation and screening of
an ascidian-derived extract library using a real time cell analyzer. Liberio, M. S., Sadowski, M. C., Nelson, C.
C., & Davis, R. a. (2014).Marine drugs, 12(10), 5222–39. doi:10.3390/md12105222
144. Chemical Induction of Unfolded Protein Response Enhances Cancer Cell Killing through Lytic Virus Infection.
Prasad, V., Suomalainen, M., Pennauer, M., Yakimovich, A., Andriasyan, V., Hemmi, S., & Greber, U. F.
(2014).Journal of virology, 88(22), 13086–98. doi:10.1128/JVI.02156-14
145. Cytotoxic Effect of Fluvastatin on MCF-7 Cells Possibly Through a Reduction of the mRNA Expression Levels
of SGK1 and CAV1. Salis, O., Bedir, A., Gulten, S., Okuyucu, A., Kulcu, C., & Alacam, H. (2014).Cancer
biotherapy & radiopharmaceuticals, 29(9), 1–8. doi:10.1089/cbr.2013.1593
146. Toxicological effect of single contaminants and contaminant mixtures associated with plant ingredients in
novel salmon feeds. Søfteland, L., Kirwan, J. a, Hori, T. S. F., Størseth, T. R., Sommer, U., Berntssen, M. H. G.,
Viant, M. R., et al. (2014).Food and chemical toxicology : an international journal published for the British
Industrial Biological Research Association. doi:10.1016/j.fct.2014.08.008
147. CD47 in the tumor microenvironment limits cooperation between anti-tumor T cell immunity and radiation
therapy. Soto-Pantoja, D. R., Terabe, M., Ghosh, A., Ridnour, L. a, DeGraff, W. G., Wink, D. a, Berzofsky, J. a, et
al. (2014).Cancer research. doi:10.1158/0008-5472.CAN-14-0037-T
148. Sensitization of melanoma cells for TRAIL-induced apoptosis by BMS-345541 correlates with altered
phosphorylation and activation of Bax. Berger, a, Quast, S., Plötz, M., Kammermeier, a, & Eberle, J.
(2013).Cell death & disease, 4, e477. doi:10.1038/cddis.2012.198
41
149. Charge-conversional and reduction-sensitive poly(vinyl alcohol) nanogels for enhanced cell uptake and
efficient intracellular doxorubicin release. Chen, W., Achazi, K., Schade, B., & Haag, R. (2014).Journal of
controlled release : official journal of the Controlled Release Society. doi:10.1016/j.jconrel.2014.11.012
150. Cyclodextrin-polysaccharide-based, in situ-gelled system for ocular antifungal delivery. Fernández-Ferreiro,
A., Fernández Bargiela, N., Varela, M. S., Martínez, M. G., Pardo, M., Piñeiro Ces, A., Méndez, J. B., et al.
(2014).Beilstein journal of organic chemistry, 10, 2903–11. doi:10.3762/bjoc.10.308
151. Novel polycarbo-substituted alkyl (thieno[3,2-c]quinoline)-2-carboxylates: synthesis and cytotoxicity studies.
Mphahlele, M. J., Maluleka, M. M., Makhafola, T. J., & Mabeta, P. (2014).Molecules (Basel, Switzerland),
19(11), 18527–42. doi:10.3390/molecules191118527
152. Human Cell Line-Dependent WC-Co Nanoparticle Cytotoxicity and Genotoxicity: A Key Role of ROS
Production. Paget, V., Moche, H., Kortulewski, T., Grall, R., Irbah, L., Nesslany, F., & Chevillard, S.
(2014).Toxicological sciences : an official journal of the Society of Toxicology, 1–13. doi:10.1093/toxsci/kfu238
153. Mesenchymal stromal cell labeling by new uncoated superparamagnetic maghemite nanoparticles in
comparison with commercial Resovist – an initial in vitro study. Polakova, K., Havrdova, M., Justan, I., Magro,
M., Milde, D., Knopfova, L., Smarda, J., et al. (2014)., 5355–5372.
154. γδ T Cell-Mediated Antibody-Dependent Cellular Cytotoxicity with CD19 Antibodies Assessed by an
Impedance-Based Label-Free Real-Time Cytotoxicity Assay. Seidel, U. J. E., Vogt, F., Grosse-Hovest, L., Jung,
G., Handgretinger, R., & Lang, P. (2014).Frontiers in immunology, 5(December), 618.
doi:10.3389/fimmu.2014.00618
155. Protective Effects of Ginsenoside Rg1 on Astrocytes and Cerebral Ischemic-Reperfusion Mice. Sun, C., Lai, X.,
Huang, X., & Zeng, Y. (2014)., 37(December), 1891–1898.
156. Real-Time Cell Analysis for Monitoring Cholera Toxin-Induced Human Intestinal Epithelial Cell Response. Ye,
J., Luo, Y., Fang, W., Pan, J., Zhang, Z., Zhang, Y., Chen, Z., et al. (2014).Current microbiology.
doi:10.1007/s00284-014-0752-z
157. Boronate Cross-linked ATP- and pH-Responsive Nanogels for Intracellular Delivery of Anticancer Drugs.
Zhang, X., Achazi, K., & Haag, R. (2014).Advanced healthcare materials. doi:10.1002/adhm.201400550
158. Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists : a
clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells. Linxweiler, M.,
Schorr, S., Schäuble, N., Jung, M., Linxweiler, J., Langer, F., Schäfers, H., et al. (2013)., 1–14.
159. Modulation of induced cytotoxicity of Doxorubicin by using apoferritin and liposomal cages. Gumulec, J.,
Fojtu, M., Raudenska, M., Sztalmachova, M., Skotakova, A., Vlachova, J., Skalickova, S., et al.
(2014).International journal of molecular sciences, 15(12), 22960–77. doi:10.3390/ijms151222960
160. Glucose-regulated protein 78 mediates the anticancer efficacy of shikonin in hormone-refractory prostate
cancer cells. Kuo, L.-J., Huang, C.-Y., Cheng, W.-L., Hung, C.-S., Wu, C.-T., Lin, F.-Y., Chang, Y.-J., et al.
(2015).Tumor Biology. doi:10.1007/s13277-015-3157-0
42
161. High-throughput screening assay for the environmental water samples using cellular response profiles. Pan,
T., Li, H., Khare, S., Huang, B., Yu Huang, D., Zhang, W., & Gabos, S. (2015).Ecotoxicology and Environmental
Safety, 114, 134–142. doi:10.1016/j.ecoenv.2015.01.020
162. Targeting specificity of dendritic cells on breast cancer stem cells : in vitro and in vivo evaluations. Pham, P.
Van. (2015)., 323–334.
*163. Combination treatment of TRAIL, DFMO and radiation for malignant glioma cells. Alexiou, G. a., Tsamis, K. I.,
Vartholomatos, E., Peponi, E., Tzima, E., Tasiou, I., Lykoudis, E., et al. (2015).Journal of Neuro-Oncology, 123,
217–224. doi:10.1007/s11060-015-1799-9
*164. Model-based assessment of erlotinib effect in vitro measured by real-time cell analysis. Benay, S., Meille, C.,
Kustermann, S., Walter, I., Walz, A., Gonsard, P. A., Pietilae, E., et al. (2015).Journal of Pharmacokinetics and
Pharmacodynamics, 42, 275–285. doi:10.1007/s10928-015-9415-3
*165. Anticancer, photoluminescence and electrochemical properties of structurally characterized two imine
derivatives. Ceyhan, G., Köse, M., Tümer, M., & Demirtaş, İ. (2015).Spectrochimica Acta Part A: Molecular and
Biomolecular Spectroscopy, 149, 731–743. doi:10.1016/j.saa.2015.05.021
*166. Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes
accurately identifies cardiotoxicity of multiple drug types. Doherty, K. R., Talbert, D. R., Trusk, P. B., Moran,
D. M., Shell, S. a., & Bacus, S. (2015).Toxicology and Applied Pharmacology, 285(1), 51–60.
doi:10.1016/j.taap.2015.03.008
*167. Electrophoretic mobility as a tool to separate immune adjuvant saponins from Quillaja saponaria Molina.
Gilabert-Oriol, R., Weng, A., von Mallinckrodt, B., Stöshel, A., Nissi, L., Melzig, M. F., Fuchs, H., et al.
(2015).International Journal of Pharmaceutics, 487(1-2), 39–48. doi:10.1016/j.ijpharm.2015.03.063
*168. MAGE-A expression clusters and antineoplastic treatment in head and neck cancer. Hartmann, S., Meyer, T.,
Brands, R., Haubitz, I., Linz, C., Seher, A., K� bler, A., et al. (2015).International Journal of Molecular
Medicine, 1675–1682. doi:10.3892/ijmm.2015.2174
*169. Real-time cell analysis of the inhibitory effect of vitamin K2 on adhesion and proliferation of breast cancer
cells. Kiely, M., Hodgins, S. J., Merrigan, B. A., Tormey, S., Kiely, P. a., & O’Connor, E. M. (2015).Nutrition
Research, 35, 736–743. doi:10.1016/j.nutres.2015.05.014
*170. The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis. Lou, G., Liu, Y., Wu, S., Xue,
J., Yang, F., Fu, H., Zheng, M., et al. (2015).Cellular Physiology and Biochemistry, 35, 2192–2202.
doi:10.1159/000374024
*171. High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells:
grasping complex toxicity with a great depth of field. Pisani, C., Gaillard, J.-C., Nouvel, V., Odorico, M.,
Armengaud, J., & Prat, O. (2015).BMC Genomics, 16, 1–14. doi:10.1186/s12864-015-1521-5
*172. Cytometric analysis, genetic manipulation and antibiotic selection of the snail embryonic cell line Bge from
Biomphalaria glabrata, the intermediate host of Schistosoma mansoni. Rinaldi, G., Yan, H., Nacif-Pimenta, R.,
Matchimakul, P., Bridger, J., Mann, V. H., Smout, M. J., et al. (2015).International Journal for Parasitology,
45(8), 527–535. doi:10.1016/j.ijpara.2015.02.012
43
*173. P6.07 * Real Time Photodynamic Therapy Analysis of ICG Loaded Modified Magnetic Nanoparticles on MCF7 Cells. Sagir, T., Alt kardes, M., Burgucu, N., Karakas, N., Tabakoglu, O., Is k, S., & Senel, M. (2015).Annals of
Oncology, 26(Supplement 2), ii29–ii29. doi:10.1093/annonc/mdv095.5
*174. Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule.
Shan, C., Lin, J., Hou, J.-Q., Liu, H.-Y., Chen, S.-B., Chen, a.-C., Ou, T.-M., et al. (2015).Nucleic Acids Research, 1–
15. doi:10.1093/nar/gkv641
*175. A 2-methoxyestradiol bis-sulphamoylated derivative induces apoptosis in breast cell lines. Visagie, M. H.,
Birkholtz, L.-M., & Joubert, A. M. (2015).Cell & Bioscience, 5, 19. doi:10.1186/s13578-015-0010-5
DERMATOLOGY
1. Characterization of N-Acetyltransferase 1 Activity in Human Keratinocytes and Modulation by paraPhenylenediamine. Bonifas, J., Scheitza, S., Clemens, J., & Blo, B. (2010)., 334(1), 318–326.
doi:10.1124/jpet.110.167874.NAT
2. Efficient and selective tumor cell lysis and induction of apoptosis in melanoma cells by a conditional
replication-competent CD95L adenovirus. Fecker, L. F., Schmude, M., Jost, S., Hossini, A. M., Picó, A. H.,
Wang, X., Schwarz, C., et al. (2010).Experimental dermatology, 19(8), e56–66. doi:10.1111/j.16000625.2009.00977.x
3. New caspase-independent but ROS-dependent apoptosis pathways are targeted in melanoma cells by an ironcontaining cytosine analogue. Franke, J. C., Plötz, M., Prokop, A., Geilen, C. C., Schmalz, H.-G., & Eberle, J.
(2010).Biochemical pharmacology, 79(4), 575–86. doi:10.1016/j.bcp.2009.09.022
4. Synthesis of thia-analogous indirubin N-Glycosides and their influence on melanoma cell growth and apoptosis.
Kunz, M., Driller, K. M., Hein, M., Libnow, S., Hohensee, I., Ramer, R., Hinz, B., et al. (2010).ChemMedChem,
5(4), 534–9. doi:10.1002/cmdc.200900506
5. Real-time monitoring of membrane cholesterol reveals new insights into epidermal differentiation. Spörl, F.,
Wunderskirchner, M., Ullrich, O., Bömke, G., Breitenbach, U., Blatt, T., Wenck, H., et al. (2010).The Journal of
investigative dermatology, 130(5), 1268–78. doi:10.1038/jid.2009.412
6. Efficient melanoma cell killing and reduced melanoma growth in mice by a selective replicating adenovirus
armed with tumor necrosis factor-related apoptosis-inducing ligand. Fecker, L. F., Rückert, S., Kurbanov, B.
M., Schmude, M., Stockfleth, E., Fechner, H., & Eberle, J. (2011).Human gene therapy, 22(4), 405–17.
doi:10.1089/hum.2010.108
7. Pros and cons of fish skin cells in culture: long-term full skin and short-term scale cell culture from rainbow
trout, Oncorhynchus mykiss. Rakers, S., Klinger, M., Kruse, C., & Gebert, M. (2011).European journal of cell
biology, 90(12), 1041–51. doi:10.1016/j.ejcb.2011.08.003
44
8. Effects of lunar and mars dust simulants on HaCaT keratinocytes and CHO-K1 fibroblasts. Rehders, M.,
Grosshäuser, B. B., Smarandache, A., Sadhukhan, A., Mirastschijski, U., Kempf, J., Dünne, M., et al.
(2011).Advances in Space Research, 47(7), 1200–1213. doi:10.1016/j.asr.2010.11.033
9. The expressions of ABCC4 and ABCG2 xenobiotic transporters in human keratinocytes are proliferation-related.
Bebes, A., Kis, K., Nagy, T., Kurunczi, A., Polyánka, H., Bata-Csörgo, Z., Kemény, L., et al. (2012).Archives of
dermatological research, 304(1), 57–63. doi:10.1007/s00403-011-1174-4
IMMUNOLOGY
1. Label-free, real-time monitoring of IgE-mediated mast cell activation on microelectronic cell sensor arrays.
Abassi, Y. a, Jackson, J. A., Zhu, J., O’Connell, J., Wang, X., & Xu, X. (2004).Journal of immunological methods,
292(1-2), 195–205. doi:10.1016/j.jim.2004.06.022
2. Cytotoxicity and Cell Adhesion by Electrical. Glamann, J., & Hansen, A. J. (2006)., 4(5).
3. Dynamic and label-free monitoring of natural killer cell cytotoxic activity using electronic cell sensor arrays.
Zhu, J., Wang, X., Xu, X., & Abassi, Y. a. (2006).Journal of immunological methods, 309(1-2), 25–33.
doi:10.1016/j.jim.2005.10.018
4. A novel impedance-based cellular assay for the detection of anti-calcium channel autoantibodies in type 1
diabetes. Jackson, M. W., & Gordon, T. P. (2010).Journal of immunological methods, 361(1-2), 31–6.
doi:10.1016/j.jim.2010.07.005
5. S-glutathionylation regulates inflammatory activities of S100A9. Lim, S. Y., Raftery, M. J., Goyette, J., & Geczy, C.
L. (2010).The Journal of biological chemistry, 285(19), 14377–88. doi:10.1074/jbc.M109.075242
6. Breast tumor cells isolated from in vitro resistance to trastuzumab remain sensitive to trastuzumab anti-tumor
effects in vivo and to ADCC killing. Kute, T. E., Savage, L., Stehle, J. R., Kim-Shapiro, J. W., Blanks, M. J., Wood,
J., & Vaughn, J. P. (2009).Cancer immunology, immunotherapy : CII, 58(11), 1887–96. doi:10.1007/s00262009-0700-0
7. Cytoprotective effect of γ-tocopherol against tumor necrosis factor α induced cell dysfunction in L929 cells.
Oláh, G., Módis, K., Gero, D., Suzuki, K., Dewitt, D., Traber, D. L., & Szabó, C. (2011, November).International
journal of molecular medicine. doi:10.3892/ijmm.2011.765
8. Benzo[a]pyrene and tumor necrosis factor-α coordinately increase genotoxic damage and the production of
proinflammatory mediators in alveolar epithelial type II cells. Umannová, L., Machala, M., Topinka, J.,
Schmuczerová, J., Krčmář, P., Neča, J., Šujanová, K., et al. (2011, October 10).Toxicology letters.
doi:10.1016/j.toxlet.2011.06.029
9. A role for specific collagen motifs during wound healing and inflammatory response of fibroblasts in the teleost
fish gilthead seabream. Castillo-Briceño, P., Bihan, D., Nilges, M., Hamaia, S., Meseguer, J., García-Ayala, A.,
Farndale, R. W., et al. (2011).Molecular immunology, 48(6-7), 826–34. doi:10.1016/j.molimm.2010.12.004
45
10. Unique functional status of natural killer cells in metastatic stage IV melanoma patients and its modulation by
chemotherapy. Fregni, G., Perier, A., Pittari, G., Jacobelli, S., Sastre, X., Gervois, N., Allard, M., et al.
(2011).Clinical cancer research : an official journal of the American Association for Cancer Research, 17(9),
2628–37. doi:10.1158/1078-0432.CCR-10-2084
11. Isolation and characterization of IgG1 with asymmetrical Fc glycosylation. Ha, S., Ou, Y., Vlasak, J., Li, Y., Wang,
S., Vo, K., Du, Y., et al. (2011).Glycobiology, 21(8), 1087–96. doi:10.1093/glycob/cwr047
12. Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1
cells. Kollar, P., Závalová, V., Hošek, J., Havelka, P., Sopuch, T., Karpíšek, M., Třetinová, D., et al.
(2011).International immunopharmacology, 11(8), 997–1001. doi:10.1016/j.intimp.2011.02.016
13. T cells contribute to tumor progression by favoring pro-tumoral properties of intra-tumoral myeloid cells in a
mouse model for spontaneous melanoma. Lengagne, R., Pommier, A., Caron, J., Douguet, L., Garcette, M.,
Kato, M., Avril, M.-F., et al. (2011).PloS one, 6(5), e20235. doi:10.1371/journal.pone.0020235
14. Myeloid angiogenic cells act as alternative M2 macrophages and modulate angiogenesis through interleukin8. Medina, R. J., O’Neill, C. L., O’Doherty, T. M., Knott, H., Guduric-Fuchs, J., Gardiner, T. a, & Stitt, A. W.
(2011).Molecular medicine (Cambridge, Mass.), 17(9-10), 1045–55. doi:10.2119/molmed.2011.00129
15. Real-time profiling of NK cell killing of human astrocytes using xCELLigence technology. Moodley, K., Angel, C.
E., Glass, M., & Graham, E. S. (2011).Journal of neuroscience methods, 200(2), 173–80.
doi:10.1016/j.jneumeth.2011.07.005
16. Mutations of the von Hippel-Lindau gene confer increased susceptibility to natural killer cells of clear-cell
renal cell carcinoma. Perier, a, Fregni, G., Wittnebel, S., Gad, S., Allard, M., Gervois, N., Escudier, B., et al.
(2011).Oncogene, 30(23), 2622–32. doi:10.1038/onc.2010.638
17. Responses after one dose of a monovalent influenza A (H1N1) 2009 inactivated vaccine in Chinese population-a practical observation. Sun, F., Zhang, Y., Tian, D., Zheng, M., Liu, L., Zhang, R., Dai, Z., et al. (2011).Vaccine,
29(38), 6527–31. doi:10.1016/j.vaccine.2011.07.006
18. Site-Directed Mutagenesis of the CC Chemokine Binding Protein 35K-Fc Reveals Residues Essential for Activity
and Mutations That Increase the Potency of CC Chemokine. White, G. E., Mcneill, E., Christou, I., Channon, K.
M., & Greaves, D. R. (2011)., 328–336. doi:10.1124/mol.111.071985.
19. Pertuzumab in combination with trastuzumab shows significantly enhanced antitumor activity in HER2positive human gastric cancer xenograft models. Yamashita-Kashima, Y., Iijima, S., Yorozu, K., Furugaki, K.,
Kurasawa, M., Ohta, M., & Fujimoto-Ouchi, K. (2011).Clinical cancer research : an official journal of the
American Association for Cancer Research, 17(15), 5060–70. doi:10.1158/1078-0432.CCR-10-2927
20. Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not
require receptor preactivation. Nissinen, L., Koivunen, J., Käpylä, J., Salmela, M., Nieminen, J., Jokinen, J.,
Sipilä, K., et al. (2012, December 28).The Journal of biological chemistry. doi:10.1074/jbc.M111.309450
21. Epigenetic modulation to enable antigen-specific T-cell therapy of colorectal cancer. Chou, J., Voong, L. N.,
Mortales, C. L., Towlerton, A. M. H., Pollack, S. M., Chen, X., Yee, C., et al. (2012).Journal of immunotherapy
(Hagerstown, Md. : 1997), 35(2), 131–41. doi:10.1097/CJI.0b013e31824300c7
46
22. Mapping of potent and specific binding motifs, GLOGEN and GVOGEA, for integrin α1β1 using collagen
toolkits II and III. Hamaia, S. W., Pugh, N., Raynal, N., Némoz, B., Stone, R., Gullberg, D., Bihan, D., et al.
(2012).The Journal of biological chemistry, 287(31), 26019–28. doi:10.1074/jbc.M112.353144
23. Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2
positive breast cancer cells. Kute, T., Stehle Jr, J. R., Ornelles, D., Walker, N., Delbono, O., & Vaughn, J. P.
(2012).Oncoimmunology, 1(6), 810–821. doi:10.4161/onci.20447
24. Hydrogen sulfide is an endogenous potentiator of T cell activation. Miller, T. W., Wang, E. a, Gould, S., Stein, E.
V, Kaur, S., Lim, L., Amarnath, S., et al. (2012).The Journal of biological chemistry, 287(6), 4211–21.
doi:10.1074/jbc.M111.307819
25. Assessment of In Vitro Heparin Complement Regulation Capacity During Real-Time Cell Analyzer AntibodyMediated Cytolysis Assay: Compatibility Studies for Pig-to-Baboon Xenotransplantation. Ramis, G.,
Martínez-Alarcón, L., Majado, M. J., Quereda, J. J., Mendonça, L., Herrero-Medrano, J. M., Abellaneda, J. M.,
et al. (2012).Transplantation proceedings, 44(6), 1584–8. doi:10.1016/j.transproceed.2012.05.015
26. A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation
mediated via integrin α(2) β(1).pdf. A role for adhesion and degranulation-promoting adapter protein in
collagen-induced platelet activation mediated via integrin α(2) β(1).pdf. (n.d.).
27. Phenotypic and functional characteristics of blood natural killer cells from melanoma patients at different
clinical stages. Fregni, G., Messaoudene, M., Fourmentraux-Neves, E., Mazouz-Dorval, S., Chanal, J., Maubec,
E., Marinho, E., et al. (2013).PloS one, 8(10), e76928. doi:10.1371/journal.pone.0076928
28. Label-free monitoring of T cell activation by the impedance-based xCELLigence system. Guan, N., Deng, J., Li,
T., Xu, X., Irelan, J. T., & Wang, M.-W. (2013).Molecular bioSystems, 9(5), 1035–43. doi:10.1039/c3mb25421f
29. Enzymatic discovery of a her-2/neu epitope that generates cross-reactive T cells. Henle, A. M., Erskine, C. L.,
Benson, L. M., Clynes, R., & Knutson, K. L. (2013).Journal of immunology (Baltimore, Md. : 1950), 190(1), 479–
88. doi:10.4049/jimmunol.1201264
30. A Real Time Chemotaxis Assay Unveils Unique Migratory Profiles amongst Different Primary Murine
Macrophages. Iqbal, A. J., Regan-Komito, D., Christou, I., White, G. E., McNeill, E., Kenyon, A., Taylor, L., et al.
(2013). (J. Wallace, Ed.)PLoS ONE, 8(3), e58744. doi:10.1371/journal.pone.0058744
31. Blocking the attachment of cancer cells in vivo with DNA aptamers displaying anti-adhesive properties against
the carcinoembryonic antigen. Orava, E. W., Abdul-Wahid, A., Huang, E. H.-B., Mallick, A. I., & Gariépy, J.
(2013).Molecular oncology, 1–13. doi:10.1016/j.molonc.2013.03.005
32. Evaluation of NK cell function by flowcytometric measurement and impedance based assay using real-time
cell electronic sensing system. Park, K.-H., Park, H., Kim, M., Kim, Y., Han, K., & Oh, E.-J. (2013).BioMed
research international, 2013, 210726. doi:10.1155/2013/210726
33. Chronic arsenic exposure in nanomolar concentrations compromises wound response and intercellular
signaling in airway epithelial cells. Sherwood, C. L., Lantz, R. C., & Boitano, S. (2013).Toxicological sciences :
an official journal of the Society of Toxicology, 132(1), 222–34. doi:10.1093/toxsci/kfs331
47
34. Mature Cytotoxic CD56bright/CD16+ Natural Killer Cells Can Infiltrate Lymph Nodes Adjacent to Metastatic
Melanoma. Messaoudene, M., Fregni, G., Fourmentraux-Neves, E., Chanal, J., Maubec, E., Mazouz-Dorval, S.,
Couturaud, B., et al. (2014).Cancer research, 74(1), 81–92. doi:10.1158/0008-5472.CAN-13-1303
35. Novel bispecific antibodies increase γδ T-cell cytotoxicity against pancreatic cancer cells. Oberg, H.-H., Peipp,
M., Kellner, C., Sebens, S., Krause, S., Petrick, D., Adam-Klages, S., et al. (2014).Cancer research, 74(5), 1349–
60. doi:10.1158/0008-5472.CAN-13-0675
36. An impedance-based cytotoxicity assay for real-time and label-free assessment of T-cell-mediated killing of
adherent cells. Peper, J. K., Schuster, H., Löffler, M. W., Schmid-Horch, B., Rammensee, H.-G., & Stevanović, S.
(2014).Journal of immunological methods, 405, 192–8. doi:10.1016/j.jim.2014.01.012
37. Inhibition of mesenchymal stromal cells by pre-activated lymphocytes and their culture media. Valencic, E.,
Loganes, C., Cesana, S., Piscianz, E., Gaipa, G., Biagi, E., & Tommasini, A. (2014).Stem cell research & therapy,
5(1), 3. doi:10.1186/scrt392
38. A Novel Glycoengineered Bispecific Antibody Format for Targeted Inhibition of Epidermal Growth Factor
Receptor (EGFR) and Insulin-like Growth Factor Receptor Type I (IGF-1R) Demonstrating Unique Molecular
Properties. Schanzer, J. M., Wartha, K., Croasdale, R., Moser, S., Künkele, K.-P., Ries, C., Scheuer, W., et al.
(2014).The Journal of biological chemistry, 289(27), 18693–706. doi:10.1074/jbc.M113.528109
39. Generation of an adenovirus-parvovirus chimera with enhanced oncolytic potential. El-Andaloussi, N.,
Bonifati, S., Kaufmann, J. K., Mailly, L., Daeffler, L., Deryckère, F., Nettelbeck, D. M., et al. (2012).Journal of
virology, 86(19), 10418–31. doi:10.1128/JVI.00848-12
40. A simple in vitro method for evaluating dendritic cell-based vaccinations. Pham, P. Van, Nguyen, N. T., Nguyen,
H. M., Khuat, L. T., Le, P. M., Pham, V. Q., Nguyen, S. T., et al. (2014).OncoTargets and therapy, 7, 1455–64.
doi:10.2147/OTT.S67057
41. Dynamic detection of natural killer cell-mediated cytotoxicity and cell adhesion by electrical impedance
measurements. Glamann, J., & Hansen, A. (2006).Assay and drug development …, 4(5). Retrieved from
http://online.liebertpub.com/doi/abs/10.1089/adt.2006.4.555
42. CD47 in the tumor microenvironment limits cooperation between anti-tumor T cell immunity and radiation
therapy. Soto-Pantoja, D. R., Terabe, M., Ghosh, A., Ridnour, L. a, DeGraff, W. G., Wink, D. a, Berzofsky, J. a, et
al. (2014).Cancer research. doi:10.1158/0008-5472.CAN-14-0037-T
48. γδ T Cell-Mediated Antibody-Dependent Cellular Cytotoxicity with CD19 Antibodies Assessed by an
Impedance-Based Label-Free Real-Time Cytotoxicity Assay. Seidel, U. J. E., Vogt, F., Grosse-Hovest, L., Jung,
G., Handgretinger, R., & Lang, P. (2014).Frontiers in immunology, 5(December), 618.
doi:10.3389/fimmu.2014.00618
49. Targeting specificity of dendritic cells on breast cancer stem cells : in vitro and in vivo evaluations. Pham, P.
Van. (2015)., 323–334.
50. Hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in ER+ breast cancer. Cook,
K. L., Wärri, A., Soto-Pantoja, D. R., Clarke, P. a G., Cruz, M. I., Zwart, A., & Clarke, R. (2014).Clinical Cancer
Research, 20(12), 3222–3232. doi:10.1158/1078-0432.CCR-13-3227
48
*51. Enhanced antitumor activity of trastuzumab emtansine (T-DM1) in combination with pertuzumab in a HER2positive gastric cancer model. Yamashita-Kashima, Y., Shu, S., Harada, N., & Fujimoto-Ouchi, K.
(2013).Oncology Reports, 30, 1087–1093. doi:10.3892/or.2013.2547
MICROBIOLOGY VIROLOGY PARASITOLOGY
1. An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins. He, X., Wang, J.,
Steele, J., Sun, X., Nie, W., Tzipori, S., & Feng, H. (2009).Journal of microbiological methods, 78(1), 97–100.
doi:10.1016/j.mimet.2009.04.007
2. Bluetongue virus infection alters the impedance of monolayers of bovine endothelial cells as a result of cell
death. Drew, C. P., Gardner, I. a, Mayo, C. E., Matsuo, E., Roy, P., & MacLachlan, N. J. (2010).Veterinary
immunology and immunopathology, 136(1-2), 108–15. doi:10.1016/j.vetimm.2010.03.005
3. Assessment of Clostridium difficile infections by quantitative detection of tcdB toxin by use of a real-time cell
analysis system. Ryder, A. B., Huang, Y., Li, H., Zheng, M., Wang, X., Stratton, C. W., Xu, X., et al. (2010).Journal
of clinical microbiology, 48(11), 4129–34. doi:10.1128/JCM.01104-10
4. Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage
of occludin: a role for MMP-8. Schubert-Unkmeir, A., Konrad, C., Slanina, H., Czapek, F., Hebling, S., & Frosch,
M. (2010).PLoS pathogens, 6(4), e1000874. doi:10.1371/journal.ppat.1000874
5. A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time
monitoring of parasite motility. Smout, M. J., Kotze, A. C., McCarthy, J. S., & Loukas, A. (2010).PLoS neglected
tropical diseases, 4(11), e885. doi:10.1371/journal.pntd.0000885
6. Cellular impedance measurement as a new tool for poxvirus titration, antibody neutralization testing and
evaluation of antiviral substances. Witkowski, P. T., Schuenadel, L., Wiethaus, J., Bourquain, D. R., Kurth, A.,
& Nitsche, A. (2010).Biochemical and biophysical research communications, 401(1), 37–41.
doi:10.1016/j.bbrc.2010.09.003
7. Real-time monitoring of flavivirus induced cytopathogenesis using cell electric impedance technology. Fang, Y.,
Ye, P., Wang, X., Xu, X., & Reisen, W. (2011).Journal of virological methods, 173(2), 251–8.
doi:10.1016/j.jviromet.2011.02.013
8. New bis(thiosemicarbazonate) gold(III) complexes inhibit HIV replication at cytostatic concentrations: potential
for incorporation into virostatic cocktails. Fonteh, P. N., Keter, F. K., & Meyer, D. (2011).Journal of inorganic
biochemistry, 105(9), 1173–80. doi:10.1016/j.jinorgbio.2011.05.011
9. Cross-disciplinary approaches for measuring parasitic helminth viability and phenotype. Peak, E., & Hoffmann,
K. F. (2011).Anais da Academia Brasileira de Ciências, 83(2), 649–62. Retrieved from
http://www.ncbi.nlm.nih.gov/pubmed/21670885
10. Fluoroquinolones inhibit human polyomavirus BK (BKV) replication in primary human kidney cells. Sharma, B.
N., Li, R., Bernhoff, E., Gutteberg, T. J., & Rinaldo, C. H. (2011).Antiviral research, 92(1), 115–23.
doi:10.1016/j.antiviral.2011.07.012
49
11. Exploration of novel in vitro assays to study drugs against Trichuris spp. Silbereisen, A., Tritten, L., & Keiser, J.
(2011).Journal of microbiological methods, 87(2), 169–75. doi:10.1016/j.mimet.2011.08.009
12. Real-time impedance analysis of host cell response to meningococcal infection. Slanina, H., König, a, Claus, H.,
Frosch, M., & Schubert-Unkmeir, a. (2011).Journal of microbiological methods, 84(1), 101–8.
doi:10.1016/j.mimet.2010.11.004
13. Impact of human adenovirus type 3 dodecahedron on host cells and its potential role in viral infection.
Fender, P., Hall, K., Schoehn, G., & Blair, G. E. (2012).Journal of virology, 86(9), 5380–5.
doi:10.1128/JVI.07127-11
14. The xCELLigence system for real-time and label-free analysis of neuronal and dermal cell response to equine
herpesvirus type 1 infection. Golke, A., Cymerys, J., Słońska, A., Dzieciatkowski, T., Chmielewska, A.,
Tucholska, A., & Bańbura, M. W. (2012).Polish journal of veterinary sciences, 15(1), 151–3. Retrieved from
http://www.ncbi.nlm.nih.gov/pubmed/22708370
15. Novel, real-time cell analysis for measuring viral cytopathogenesis and the efficacy of neutralizing antibodies
to the 2009 influenza A (H1N1) virus. Tian, D., Zhang, W., He, J., Liu, Y., Song, Z., Zhou, Z., Zheng, M., et al.
(2012).PloS one, 7(2), e31965. doi:10.1371/journal.pone.0031965
16. Nature-inspired antimicrobial polymers - assessment of their potential for biomedical applications. Al-Ahmad,
A., Laird, D., Zou, P., Tomakidi, P., Steinberg, T., & Lienkamp, K. (2013).PloS one, 8(9), e73812.
doi:10.1371/journal.pone.0073812
17. Quantitative Detection of Vibrio cholera Toxin by Real-Time and Dynamic Cell Cytotoxicity Monitoring. Jin, D.,
Luo, Y., Zheng, M., Li, H., Zhang, J., Stampfl, M., Xu, X., et al. (2013).Journal of clinical microbiology.
doi:10.1128/JCM.01959-13
18. A bacterial RTX toxin causes programmed necrotic cell death through calcium-mediated mitochondrial
dysfunction. Kim, Y. R., Lee, S. E., Kang, I.-C., Nam, K. Il, Choy, H. E., & Rhee, J. H. (2013).The Journal of
infectious diseases, 207(9), 1406–15. doi:10.1093/infdis/jis746
19. Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication
complexes of semliki forest virus. Varjak, M., Saul, S., Arike, L., Lulla, A., Peil, L., & Merits, A. (2013).Journal of
virology, 87(18), 10295–312. doi:10.1128/JVI.01105-13
20. Transcriptional responses of in vivo praziquantel exposure in schistosomes identifies a functional role for
calcium signalling pathway member CamKII. You, H., McManus, D. P., Hu, W., Smout, M. J., Brindley, P. J., &
Gobert, G. N. (2013).PLoS pathogens, 9(3), e1003254. doi:10.1371/journal.ppat.1003254
21. Real-time Cell Analysis-A New Method for Dynamic, Quantitative Measurement of Infectious Viruses and
Antiserum Neutralizing Activity. Zheng, T., Xiao-Zhou, K., & Xi, W. J.-Y. Z. (2013).Journal of virological
methods, 1–7. doi:10.1016/j.jviromet.2013.06.034
22. Senescence affects endothelial cells susceptibility to dengue virus infection. Abubakar, S., Shu, M.-H., Johari, J.,
& Wong, P.-F. (2014).International journal of medical sciences, 11(6), 538–44. doi:10.7150/ijms.7896
50
23. An improved method for determining virucidal efficacy of a chemical disinfectant using an electrical
impedance assay. Ebersohn, K., Coetzee, P., & Venter, E. H. (2014).Journal of virological methods, 199C, 25–
28. doi:10.1016/j.jviromet.2013.12.023
24. Real-time cellular analysis coupled with a specimen enrichment accurately detects and quantifies Clostridium
difficile toxins in stool. Huang, B., Jin, D., Zhang, J., Sun, J. Y., Wang, X., Stiles, J., Xu, X., et al. (2014).Journal of
clinical microbiology, 52(January), 1105–11. doi:10.1128/JCM.02601-13
25. Cytotoxicity of diplodiatoxin, dipmatol and diplonine, metabolites synthesized by Stenocarpella maydis.
Masango, M. G., Ferreira, G. C. H., Ellis, C. E., Elgorashi, E. E., & Botha, C. J. (2014).Toxicon : official journal of
the International Society on Toxinology, 82, 26–9. doi:10.1016/j.toxicon.2014.02.002
26. In vitro assessment of marine bacillus for use as livestock probiotics. Prieto, M. L., O’Sullivan, L., Tan, S. P.,
McLoughlin, P., Hughes, H., Gutierrez, M., Lane, J. a, et al. (2014).Marine drugs, 12(5), 2422–45.
doi:10.3390/md12052422
27. Antiviral Effects of Artesunate on Polyomavirus BK Replication in Primary Human Kidney Cells. Sharma, B. N.,
Marschall, M., Henriksen, S., & Rinaldo, C. H. (2014).Antimicrobial agents and chemotherapy, 58(1), 279–89.
doi:10.1128/AAC.01800-13
28. Initiation of multicellular differentiation in Dictyostelium discoideum is regulated by coronin A. Vinet, A. F.,
Fiedler, T., Studer, V., Froquet, R., Dardel, A., Cosson, P., & Pieters, J. (2014).Molecular biology of the cell,
25(5), 688–701. doi:10.1091/mbc.E13-04-0219
29. Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical
and pancreatic carcinomas. Li, J., Bonifati, S., Hristov, G., Marttila, T., Valmary-Degano, S., Stanzel, S.,
Schnölzer, M., et al. (2013).EMBO molecular medicine, 5(10), 1537–55. doi:10.1002/emmm.201302796
30. Generation of an adenovirus-parvovirus chimera with enhanced oncolytic potential. El-Andaloussi, N.,
Bonifati, S., Kaufmann, J. K., Mailly, L., Daeffler, L., Deryckère, F., Nettelbeck, D. M., et al. (2012).Journal of
virology, 86(19), 10418–31. doi:10.1128/JVI.00848-12
31. In vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile toxin A and
toxin B. D’Auria, K. M., Kolling, G. L., Donato, G. M., Warren, C. a, Gray, M. C., Hewlett, E. L., & Papin, J. a.
(2013).Infection and immunity, 81(10), 3814–24. doi:10.1128/IAI.00869-13
32. Chemical Induction of Unfolded Protein Response Enhances Cancer Cell Killing through Lytic Virus Infection.
Prasad, V., Suomalainen, M., Pennauer, M., Yakimovich, A., Andriasyan, V., Hemmi, S., & Greber, U. F.
(2014).Journal of virology, 88(22), 13086–98. doi:10.1128/JVI.02156-14
33. Reversible paralysis of Schistosoma mansoni by forchlorfenuron, a phenylurea cytokinin that affects septins.
Zeraik, A. E., Galkin, V. E., Rinaldi, G., Garratt, R. C., Smout, M. J., Loukas, A., Mann, V. H., et al.
(2014).International journal for parasitology, 44(8), 523–31. doi:10.1016/j.ijpara.2014.03.010
34. Real-Time Cell Analysis for Monitoring Cholera Toxin-Induced Human Intestinal Epithelial Cell Response. Ye, J.,
Luo, Y., Fang, W., Pan, J., Zhang, Z., Zhang, Y., Chen, Z., et al. (2014).Current microbiology.
doi:10.1007/s00284-014-0752-z
51
NEUROBIOLOGY
1. Effects of promyelocytic leukemia zinc finger protein on the proliferation of cultured human corneal
endothelial cells. Joko, T., Nanba, D., Shiba, F., Miyata, K., Shiraishi, A., Ohashi, Y., & Higashiyama, S.
(2007).Molecular vision, 13(December 2006), 649–58. Retrieved from
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2765476&tool=pmcentrez&rendertype=abstract
2. Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early
postnatal lethality. Ke, Y., Zhang, E. E., Hagihara, K., Wu, D., Pang, Y., Klein, R., Curran, T., et al.
(2007).Molecular and cellular biology, 27(19), 6706–17. doi:10.1128/MCB.01225-07
3. Inactivation of glycogen synthase kinase-3beta contributes to brain-derived neutrophic factor/TrkB-induced
resistance to chemotherapy in neuroblastoma cells. Li, Z., Tan, F., & Thiele, C. J. (2007).Molecular cancer
therapeutics, 6(12 Pt 1), 3113–21. doi:10.1158/1535-7163.MCT-07-0133
4. ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma. Hogarty, M. D.,
Norris, M. D., Davis, K., Liu, X., Evageliou, N. F., Hayes, C. S., Pawel, B., et al. (2008).Cancer research, 68(23),
9735–45. doi:10.1158/0008-5472.CAN-07-6866
5. Identification of ALK as a major familial neuroblastoma predisposition gene. Mossé, Y. P., Laudenslager, M.,
Longo, L., Cole, K. a, Wood, A., Attiyeh, E. F., Laquaglia, M. J., et al. (2008).Nature, 455(7215), 930–5.
doi:10.1038/nature07261
6. Prevalence and functional consequence of PHOX2B mutations in neuroblastoma. Raabe, E. H., Laudenslager,
M., Winter, C., Wasserman, N., Cole, K., LaQuaglia, M., Maris, D. J., et al. (2008).Oncogene, 27(4), 469–76.
doi:10.1038/sj.onc.1210659
7. A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling
pathway investigations. Sari, Y., Chiba, T., Yamada, M., Rebec, G. V, & Aiso, S. (2009).Neuroscience, 164(4),
1653–64. doi:10.1016/j.neuroscience.2009.09.049
8. BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family
antagonists. Goldsmith, K. C., Lestini, B. J., Gross, M., Ip, L., Bhumbla, a, Zhang, X., Zhao, H., et al. (2010).Cell
death and differentiation, 17(5), 872–82. doi:10.1038/cdd.2009.171
9. Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a
prerequisite for oxidative neuronal cell death. Grohm, Julia, Plesnila, N., & Culmsee, C. (2010).Brain,
behavior, and immunity, 24(5), 831–8. doi:10.1016/j.bbi.2009.11.015
10. Clinical Outcome in Children With Recurrent Neuroblastoma Treated With ABT-751 and Effect of ABT-751 on
Proliferation of Neuroblastoma Cell Lines and on Tubulin Polymerization In Vitro. Meany, H. J., Sackett, D. L.,
Maris, J. M., Ward, Y., Krivoshik, A., Cohn, S. L., Steinberg, S. M., et al. (2010)., (August 2009), 47–54.
doi:10.1002/pbc
11. The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma.
Mestdagh, P., Boström, A.-K., Impens, F., Fredlund, E., Van Peer, G., De Antonellis, P., von Stedingk, K., et al.
(2010).Molecular cell, 40(5), 762–73. doi:10.1016/j.molcel.2010.11.038
52
12. Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Joyal, J.-S.,
Sitaras, N., Binet, F., Rivera, J. C., Stahl, A., Zaniolo, K., Shao, Z., et al. (2011).Blood, 117(22), 6024–35.
doi:10.1182/blood-2010-10-311589
13. Comparison of long-term retinoic acid-based neural induction methods of bone marrow human mesenchymal
stem cells. Mammadov, B., Karakas, N., & Isik, S. (2011).In vitro cellular & developmental biology. Animal,
47(7), 484–91. doi:10.1007/s11626-011-9425-4
14. Integrative genomics identifies LMO1 as a neuroblastoma oncogene. Wang, K., Diskin, S. J., Zhang, H., Attiyeh,
E. F., Winter, C., Hou, C., Schnepp, R. W., et al. (2011).Nature, 469(7329), 216–20. doi:10.1038/nature09609
15. Impedance measurement for real time detection of neuronal cell death. Diemert, S., Dolga, a M., Tobaben, S.,
Grohm, J., Pfeifer, S., Oexler, E., & Culmsee, C. (2012).Journal of neuroscience methods, 203(1), 69–77.
doi:10.1016/j.jneumeth.2011.09.012
16. Inhibition of Drp1 provides neuroprotection in vitro and in vivo. Grohm, J, Kim, S.-W., Mamrak, U., Tobaben, S.,
Cassidy-Stone, a, Nunnari, J., Plesnila, N., et al. (2012).Cell death and differentiation, 1–13.
doi:10.1038/cdd.2012.18
17. Phosphorylation of serine 774 of the neural cell adhesion molecule is necessary for cyclic adenosine
monophosphate response element binding protein activation and neurite outgrowth. Pollscheit, J., Glaubitz,
N., Haller, H., Horstkorte, R., & Bork, K. (2012).Journal of neuroscience research, 90(8), 1577–82.
doi:10.1002/jnr.23038
18. Evidence suggesting that ghrelin O-acyl transferase inhibitor acts at the hypothalamus to inhibit
hypothalamo-pituitary-adrenocortical axis function in the rat. Rucinski, M., Ziolkowska, A., Szyszka, M.,
Hochol, A., & Malendowicz, L. K. (2012).Peptides, 35(2), 149–59. doi:10.1016/j.peptides.2012.04.007
19. MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells.
Schulte, J. H., Lindner, S., Bohrer, a, Maurer, J., De Preter, K., Lefever, S., Heukamp, L., et al. (2012).Oncogene,
(February), 1–7. doi:10.1038/onc.2012.106
20. Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells.
Vella, S., Conti, M., Tasso, R., Cancedda, R., & Pagano, A. (2012).International journal of cancer. Journal
international du cancer, 130(7), 1484–93. doi:10.1002/ijc.26173
21. Exposure to inflammatory cytokines IL-1β and TNFα induces compromise and death of astrocytes;
implications for chronic neuroinflammation. van Kralingen, C., Kho, D. T., Costa, J., Angel, C. E., & Graham, E.
S. (2013).PloS one, 8(12), e84269. doi:10.1371/journal.pone.0084269
22. Enrichment of differentiated hNT neurons and subsequent analysis using flow-cytometry and xCELLigence
sensing. MacDonald, C., Unsworth, C. P., & Graham, E. S. (2014).Journal of neuroscience methods, 227, 47–56.
doi:10.1016/j.jneumeth.2014.02.004
23. Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced
toxicity. Oppermann, S., Schrader, F. C., Elsässer, K., Dolga, A. M., Kraus, A. L., Doti, N., Wegscheid-Gerlach, C.,
et al. (2014).The Journal of pharmacology and experimental therapeutics, 350(2), 273–89.
doi:10.1124/jpet.114.213777
53
RECEPTOR ACTIVATION
1. Label-free and real-time cell-based kinase assay for screening selective and potent receptor tyrosine kinase
inhibitors using microelectronic sensor array. Atienza, J. M., Yu, N., Wang, X., Xu, X., & Abassi, Y.
(2006).Journal of biomolecular screening, 11(6), 634–43. doi:10.1177/1087057106289334
2. Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure. Olsen, M. W. B., Ley, C. D., Junker,
N., Hansen, A. J., Lund, E. L., & Kristjansen, P. E. G. (2006).Neoplasia (New York, N.Y.), 8(5), 364–72.
doi:10.1593/neo.06127
3. Real-time monitoring of morphological changes in living cells by electronic cell sensor arrays: an approach to
study G protein-coupled receptors. Yu, N., Atienza, J. M., Bernard, J., Blanc, S., Zhu, J., Wang, X., Xu, X., et al.
(2006).Analytical chemistry, 78(1), 35–43. doi:10.1021/ac051695
4. bFGF induces S1P1 receptor expression and functionality in human pulmonary artery smooth muscle cells.
Birker-Robaczewska, M., Studer, R., Haenig, B., Menyhart, K., Hofmann, S., & Nayler, O. (2008).Journal of
cellular biochemistry, 105(4), 1139–45. doi:10.1002/jcb.21918
5. A Human Bone Morphogenetic Protein Antagonist Is Down-Regulated in Renal Cancer. Blish, K. R., Wang, W.,
Willingham, M. C., Du, W., Birse, C. E., Krishnan, S. R., Brown, J. C., et al. (2008)., 19(February), 457–464.
doi:10.1091/mbc.E07
6. CNTO 95, a fully human anti alphav integrin antibody, inhibits cell signaling, migration, invasion, and
spontaneous metastasis of human breast cancer cells. Chen, Q., Manning, C. D., Millar, H., McCabe, F. L.,
Ferrante, C., Sharp, C., Shahied-Arruda, L., et al. (2008).Clinical & experimental metastasis, 25(2), 139–48.
doi:10.1007/s10585-007-9132-4
7. TLR7 agonist 852A inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type I
IFN. Inglefield, J. R., Dumitru, C. D., Alkan, S. S., Gibson, S. J., Lipson, K. E., Tomai, M. a, Larson, C. J., et al.
(2008).Journal of interferon & cytokine research : the official journal of the International Society for Interferon
and Cytokine Research, 28(4), 253–63. doi:10.1089/jir.2007.0097
8. Yeast-derived beta-glucan augments the therapeutic efficacy mediated by anti-vascular endothelial growth
factor monoclonal antibody in human carcinoma xenograft models. Salvador, C., Li, B., Hansen, R., Cramer,
D. E., Kong, M., & Yan, J. (2008).Clinical cancer research : an official journal of the American Association for
Cancer Research, 14(4), 1239–47. doi:10.1158/1078-0432.CCR-07-1669
9. The application of cell-based label-free technology in drug discovery. Xi, B., Yu, N., Wang, X., Xu, X., & Abassi, Y.
a. (2008).Biotechnology journal, 3(4), 484–95. doi:10.1002/biot.200800020
10. Cloning, expression, and functional analysis of rhesus monkey trace amine-associated receptor 6: evidence for
lack of monoaminergic association. Xie, Z., Vallender, E. J., Yu, N., Kirstein, S. L., Yang, H., Bahn, M. E.,
Westmoreland, S. V, et al. (2008).Journal of neuroscience research, 86(15), 3435–46. doi:10.1002/jnr.21783
54
11. Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil
kinase-dependent mechanism. Meshki, J., Douglas, S. D., Lai, J.-P., Schwartz, L., Kilpatrick, L. E., & Tuluc, F.
(2009).The Journal of biological chemistry, 284(14), 9280–9. doi:10.1074/jbc.M808825200
12. Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance.
Sahin, O., Fröhlich, H., Löbke, C., Korf, U., Burmester, S., Majety, M., Mattern, J., et al. (2009).BMC systems
biology, 3, 1. doi:10.1186/1752-0509-3-1
13. Activation of relaxin-related receptors by short, linear peptides derived from a collagen-containing precursor.
Shemesh, R., Hermesh, C., Toporik, A., Levine, Z., Novik, A., Wool, A., Kliger, Y., et al. (2009).Annals of the New
York Academy of Sciences, 1160, 78–86. doi:10.1111/j.1749-6632.2009.03827.x
14. The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Suizu, F., Hiramuki, Y.,
Okumura, F., Matsuda, M., Okumura, A. J., Hirata, N., Narita, M., et al. (2009).Developmental cell, 17(6), 800–
10. doi:10.1016/j.devcel.2009.09.007
15. Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. Yanagida, K.,
Masago, K., Nakanishi, H., Kihara, Y., Hamano, F., Tajima, Y., Taguchi, R., et al. (2009).The Journal of biological
chemistry, 284(26), 17731–41. doi:10.1074/jbc.M808506200
16. Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma. Davis, R. L.,
Kahraman, M., Prins, T. J., Beaver, Y., Cook, T. G., Cramp, J., Cayanan, C. S., et al. (2010).Bioorganic &
medicinal chemistry letters, 20(11), 3361–6. doi:10.1016/j.bmcl.2010.04.020
17. Cellular and Pharmacological Selectivity of the Peroxisome Proliferator-Activated Receptor- ␤ / ␦ Antagonist
GSK3787 □. Palkar, P. S., Borland, M. G., Naruhn, S., Ferry, C. H., Lee, C., Sk, U. H., Sharma, A. K., et al. (2010).,
78(3), 419–430. doi:10.1124/mol.110.065508.
18. Evaluation of cannabinoid receptor 2 and metabotropic glutamate receptor 1 functional responses using a cell
impedance-based technology. Scandroglio, P., Brusa, R., Lozza, G., Mancini, I., Petrò, R., Reggiani, A., &
Beltramo, M. (2010).Journal of biomolecular screening, 15(10), 1238–47. doi:10.1177/1087057110375615
19. β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA
following angiotensin II type 1A receptor stimulation. Anthony, D. F., Sin, Y. Y., Vadrevu, S., Advant, N., Day,
J. P., Byrne, a M., Lynch, M. J., et al. (2011, March).Molecular and cellular biology. doi:10.1128/MCB.00883-10
20. Sensitization of melanoma cells for death ligand-induced apoptosis by an indirubin derivative--Enhancement
of both extrinsic and intrinsic apoptosis pathways. Berger, A., Quast, S.-A., Plötz, M., Hein, M., Kunz, M.,
Langer, P., & Eberle, J. (2011).Biochemical pharmacology, 81(1), 71–81. doi:10.1016/j.bcp.2010.09.010
21. Potent agonists of the protease activated receptor 2 (PAR2). Boitano, S., Flynn, A. N., Schulz, S. M., Hoffman, J.,
Price, T. J., & Vagner, J. (2011).Journal of medicinal chemistry, 54(5), 1308–13. doi:10.1021/jm1013049
22. Real-time cellular impedance measurements detect Ca(2+) channel-dependent oscillations of morphology in
human H295R adrenoma cells. Denelavas, A., Weibel, F., Prummer, M., Imbach, A., Clerc, R. G., Apfel, C. M., &
Hertel, C. (2011).Biochimica et biophysica acta, 1813(5), 754–62. doi:10.1016/j.bbamcr.2011.01.016
23. The protease-activated receptor-2-specific agonists 2-aminothiazol-4-yl-LIGRL-NH2 and 6-aminonicotinylLIGRL-NH2 stimulate multiple signaling pathways to induce physiological responses in vitro and in vivo.
55
Flynn, A. N., Tillu, D. V, Asiedu, M. N., Hoffman, J., Vagner, J., Price, T. J., & Boitano, S. (2011).The Journal of
biological chemistry, 286(21), 19076–88. doi:10.1074/jbc.M110.185264
24. Impedance measurement: a new method to detect ligand-biased receptor signaling. Kammermann, M.,
Denelavas, a, Imbach, a, Grether, U., Dehmlow, H., Apfel, C. M., & Hertel, C. (2011).Biochemical and
biophysical research communications, 412(3), 419–24. doi:10.1016/j.bbrc.2011.07.087
25. A Comparative Study of Impedance versus Optical Label-Free Systems Relative to Labelled Assays in a
Predominantly Gi Coupled GPCR (C5aR) Signalling. Halai, R., Croker, D. E., Suen, J. Y., Fairlie, D. P., & Cooper,
M. a. (2012).Biosensors, 2(4), 273–290. doi:10.3390/bios2030273
26. In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469. Urban, C.,
Hamacher, a, Partke, H. J., Roden, M., Schinner, S., Christiansen, E., Due-Hansen, M. E., et al. (2013).NaunynSchmiedeberg’s archives of pharmacology, 1(2012). doi:10.1007/s00210-013-0899-3
27. Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Kapp, G. T., Liu, S.,
Stein, A., Wong, D. T., Reményi, A., Yeh, B. J., Fraser, J. S., et al. (2012).Proceedings of the National Academy of
Sciences of the United States of America, 109(14), 5277–82. doi:10.1073/pnas.1114487109
28. Impedance responses reveal β₂-adrenergic receptor signaling pluridimensionality and allow classification of
ligands with distinct signaling profiles. Stallaert, W., Dorn, J. F., van der Westhuizen, E., Audet, M., & Bouvier,
M. (2012).PloS one, 7(1), e29420. doi:10.1371/journal.pone.0029420
29. Label-free impedance responses of endogenous and synthetic chemokine receptor CXCR3 agonists correlate
with Gi-protein pathway activation. Watts, A. O., Scholten, D. J., Heitman, L. H., Vischer, H. F., & Leurs, R.
(2012).Biochemical and biophysical research communications, 419(2), 412–8. doi:10.1016/j.bbrc.2012.02.036
30. Endothelin-1 activation of ETB receptors leads to a reduced cellular proliferative rate and an increased cellular
footprint. Wilson, J. L., Taylor, L., & Polgar, P. (2012).Experimental cell research, 318(10), 1125–33.
doi:10.1016/j.yexcr.2012.03.029
31. Possible aryl hydrocarbon receptor-independent pathway of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced
antiproliferative response in human breast cancer cells. Yoshioka, H., Hiromori, Y., Aoki, A., Kimura, T., FujiiKuriyama, Y., Nagase, H., & Nakanishi, T. (2012).Toxicology letters, 211(3), 257–65.
doi:10.1016/j.toxlet.2012.04.005
32. Phosphoproteomic Analysis Implicates the mTORC2-FoxO1 Axis in VEGF Signaling and Feedback Activation of
Receptor Tyrosine Kinases. Zhuang, G., Yu, K., Jiang, Z., Chung, A., Yao, J., Ha, C., Toy, K., et al. (2013).Science
signaling, 6(271), ra25. doi:10.1126/scisignal.2003572
33. Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Brown, K. M., Day, J. P., Huston, E., Zimmermann,
B., Hampel, K., Christian, F., Romano, D., et al. (2013).Proceedings of the National Academy of Sciences of the
United States of America, 110(16), E1533–42. doi:10.1073/pnas.1303004110
34. Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Brown, K. M., Day, J. P., Huston, E., Zimmermann,
B., Hampel, K., Christian, F., Romano, D., et al. (2013).Proceedings of the National Academy of Sciences of the
United States of America, 110(16), E1533–42. doi:10.1073/pnas.1303004110
56
35. Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial
dysfunction. Dolga, A. M., Netter, M. F., Perocchi, F., Doti, N., Meissner, L., Tobaben, S., Grohm, J., et al.
(2013).The Journal of biological chemistry, 288(15), 10792–804. doi:10.1074/jbc.M113.453522
36. Development of highly potent protease-activated receptor 2 agonists via synthetic lipid tethering. Flynn, A. N.,
Hoffman, J., Tillu, D. V, Sherwood, C. L., Zhang, Z., Patek, R., Asiedu, M. N. K., et al. (2013).FASEB journal :
official publication of the Federation of American Societies for Experimental Biology, 1–13. doi:10.1096/fj.12217323
37. Targeted nanoparticle delivery of doxorubicin into placental tissues to treat ectopic pregnancies. Kaitu’u-Lino,
T. J., Pattison, S., Ye, L., Tuohey, L., Sluka, P., MacDiarmid, J., Brahmbhatt, H., et al. (2013).Endocrinology,
154(2), 911–9. doi:10.1210/en.2012-1832
38. 5-HT2A serotonin receptor agonist DOI alleviates cytotoxicity in neuroblastoma cells: Role of the ERK
pathway. Marinova, Z., Walitza, S., & Grünblatt, E. (2013).Progress in neuro-psychopharmacology & biological
psychiatry, 44C, 64–72. doi:10.1016/j.pnpbp.2013.01.017
39. Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung
fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. Sobel, K., Menyhart, K., Killer, N.,
Renault, B., Bauer, Y., Studer, R., Steiner, B., et al. (2013).The Journal of biological chemistry, 288(21), 14839–
51. doi:10.1074/jbc.M112.426726
40. Pigment Epithelium-derived Factor (PEDF) Prevents Retinal Cell Death via Pigment Epithelium-derived FactorR (PEDF-R): Identification of a Functional Ligand Binding Site. Subramanian, P., Locatelli-Hoops, S., Kenealey,
J., Desjardin, J., Notari, L., & Becerra, S. P. (2013).The Journal of biological chemistry, 0–29.
doi:10.1074/jbc.M113.487884
41. Co-expression of VAL- and TMT-opsins uncovers ancient photosensory interneurons and motorneurons in the
vertebrate brain. Fischer, R. M., Fontinha, B. M., Kirchmaier, S., Steger, J., Bloch, S., Inoue, D., Panda, S., et al.
(2013, January).PLoS biology. doi:10.1371/journal.pbio.1001585
42. Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2. Zweemer, A. J. M.,
Nederpelt, I., Vrieling, H., Hafith, S., Doornbos, M. L. J., de Vries, H., Abt, J., et al. (2013).Molecular
pharmacology, 84(4), 551–61. doi:10.1124/mol.113.086850
43. PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction.
Gagliardi, P. A., di Blasio, L., Puliafito, A., Seano, G., Sessa, R., Chianale, F., Leung, T., et al. (2014).The Journal
of cell biology, 206(3), 415–34. doi:10.1083/jcb.201312090
44. Detection and Quantification of Allosteric Modulation of Endogenous M4 Muscarinic Acetylcholine Receptor
Using Impedance-Based Label-Free Technology in a Neuronal Cell Line. Chen, A. N. Y., Malone, D. T., Pabreja,
K., Sexton, P. M., Christopoulos, A., & Canals, M. (2014).Journal of biomolecular screening.
doi:10.1177/1087057114563025
45. Derivation of ligands for the complement C3a receptor from the C-terminus of C5a. Halai, R., BellowsPeterson, M. L., Branchett, W., Smadbeck, J., Kieslich, C. a, Croker, D. E., Cooper, M. a, et al. (2014).European
journal of pharmacology, 745, 176–81. doi:10.1016/j.ejphar.2014.10.041
57
*46. Real-time monitoring of cell protrusion dynamics by impedance responses. Armando Gagliardi, P., Puliafito,
A., di Blasio, L., Chianale, F., Somale, D., Seano, G., Bussolino, F., et al. (2015).Scientific Reports, 5, 10206.
doi:10.1038/srep10206
*47. A new impedance based approach to test the activity of recombinant protein – Semaphorins as a test case.
Birger, A., Besser, E., Reubinoff, B., & Behar, O. (2015).European Journal of Cell Biology.
doi:10.1016/j.ejcb.2015.06.006
SMALL RNA
1. A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. Cole, K. a, Attiyeh,
E. F., Mosse, Y. P., Laquaglia, M. J., Diskin, S. J., Brodeur, G. M., & Maris, J. M. (2008).Molecular cancer
research : MCR, 6(5), 735–42. doi:10.1158/1541-7786.MCR-07-2102
2. Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation in vitro and in vivo.
Heidel, J. D., Liu, J. Y.-C., Yen, Y., Zhou, B., Heale, B. S. E., Rossi, J. J., Bartlett, D. W., et al. (2007).Clinical cancer
research : an official journal of the American Association for Cancer Research, 13(7), 2207–15.
doi:10.1158/1078-0432.CCR-06-2218
3. The BRCA1 alternative splicing variant Δ14-15 with an in-frame deletion of part of the regulatory SCD impairs
the DNA repair capacity in MCF-7 cells.pdf. The BRCA1 alternative splicing variant Δ14-15 with an in-frame
deletion of part of the regulatory SCD impairs the DNA repair capacity in MCF-7 cells.pdf. (n.d.).
4. Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.
Azorsa, D. O., Gonzales, I. M., Basu, G. D., Choudhary, A., Arora, S., Bisanz, K. M., Kiefer, J. a, et al.
(2009).Journal of translational medicine, 7, 43. doi:10.1186/1479-5876-7-43
5. A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. Cole, K. a, Attiyeh,
E. F., Mosse, Y. P., Laquaglia, M. J., Diskin, S. J., Brodeur, G. M., & Maris, J. M. (2008).Molecular cancer
research : MCR, 6(5), 735–42. doi:10.1158/1541-7786.MCR-07-2102
6. RNAi phenotype profiling of kinases identifies potential therapeutic targets in Ewing’s sarcoma. Arora, S.,
Gonzales, I. M., Hagelstrom, R. T., Beaudry, C., Choudhary, A., Sima, C., Tibes, R., et al. (2010).Molecular
cancer, 9, 218. doi:10.1186/1476-4598-9-218
7. c-Src differentially regulates the functions of microtentacles and invadopodia. Balzer, E. M., Whipple, R. a,
Thompson, K., Boggs, a E., Slovic, J., Cho, E. H., Matrone, M. a, et al. (2010).Oncogene, 29(48), 6402–8.
doi:10.1038/onc.2010.360
8. Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and betacell apoptosis. Berchtold, L. A., Størling, Z. M., Ortis, F., Lage, K., Bang-Berthelsen, C., Bergholdt, R., Hald, J., et
al. (2011).Proceedings of the National Academy of Sciences of the United States of America, 108(37), E681–8.
doi:10.1073/pnas.1104384108
9. RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in
neuroblastoma. Cole, K. a, Huggins, J., Laquaglia, M., Hulderman, C. E., Russell, M. R., Bosse, K., Diskin, S. J., et
58
al. (2011).Proceedings of the National Academy of Sciences of the United States of America, 108(8), 3336–41.
doi:10.1073/pnas.1012351108
10. MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports
neural differentiation in medulloblastoma. de Antonellis, P., Medaglia, C., Cusanelli, E., Andolfo, I., Liguori, L.,
De Vita, G., Carotenuto, M., et al. (2011).PloS one, 6(9), e24584. doi:10.1371/journal.pone.0024584
11. Sec62 protein level is crucial for the ER stress tolerance of prostate cancer. Greiner, M., Kreutzer, B., Lang, S.,
Jung, V., Cavalié, A., Unteregger, G., Zimmermann, R., et al. (2011).The Prostate, 71(10), 1074–83.
doi:10.1002/pros.21324
12. Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclindependent kinase 6. Hennessy, E. J., Sheedy, F. J., Santamaria, D., Barbacid, M., & O’Neill, L. a J. (2011).The
Journal of biological chemistry, 286(29), 25531–9. doi:10.1074/jbc.M111.256206
13. Multifunctional quantum-dot-based siRNA delivery for HPV18 E6 gene silence and intracellular imaging. Li, J.M., Zhao, M.-X., Su, H., Wang, Y.-Y., Tan, C.-P., Ji, L.-N., & Mao, Z.-W. (2011).Biomaterials, 32(31), 7978–87.
doi:10.1016/j.biomaterials.2011.07.011
14. Integrative network analysis reveals active microRNAs and their functions in gastric cancer. Tseng, C.-W., Lin,
C.-C., Chen, C.-N., Huang, H.-C., & Juan, H.-F. (2011).BMC systems biology, 5(1), 99. doi:10.1186/1752-0509-599
15. Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators
of cell proliferation. Zhang, J. D., Koerner, C., Bechtel, S., Bender, C., Keklikoglou, I., Schmidt, C., Irsigler, A., et
al. (2011).PloS one, 6(7), e22176. doi:10.1371/journal.pone.0022176
16. MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL. Baraniskin, A., BirkenkampDemtroder, K., Maghnouj, A., Zöllner, H., Munding, J., Klein-Scory, S., Reinacher-Schick, A., et al.
(2012).Carcinogenesis, 33(4), 732–9. doi:10.1093/carcin/bgs020
17. Death inducer-obliterator 1 (Dido1) is a BMP target gene and promotes BMP-induced melanoma progression.
Braig, S., & Bosserhoff, a-K. (2012).Oncogene, 1(February), 1–12. doi:10.1038/onc.2012.115
18. STEAP1 is associated with the invasive and oxidative stress phenotype of Ewing tumors. Grunewald, T. G. P.,
Diebold, I., Esposito, I., Plehm, S., Hauer, K., Thiel, U., da Silva-Buttkus, P., et al. (2012).Molecular cancer
research : MCR, 10(1), 52–65. doi:10.1158/1541-7786.MCR-11-0524
19. Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic
miR-17-92 cluster. Humphreys, K. J., Cobiac, L., Le Leu, R. K., Van der Hoek, M. B., & Michael, M. Z.
(2012).Molecular carcinogenesis, (January). doi:10.1002/mc.21879
20. Dysregulation of microRNA-34a expression in head and neck squamous cell carcinoma promotes tumor
growth and tumor angiogenesis. Kumar, B., Yadav, A., Lang, J., Teknos, T. N., & Kumar, P. (2012).PloS one,
7(5), e37601. doi:10.1371/journal.pone.0037601
21. Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug
resistance and real-time tracking. Li, J.-M., Wang, Y.-Y., Zhao, M.-X., Tan, C.-P., Li, Y.-Q., Le, X.-Y., Ji, L.-N., et
al. (2012).Biomaterials, 33(9), 2780–90. doi:10.1016/j.biomaterials.2011.12.035
59
22. Sec62 bridges the gap from 3q amplification to molecular cell biology in non-small cell lung cancer. Linxweiler,
M., Linxweiler, J., Barth, M., Benedix, J., Jung, V., Kim, Y.-J., Bohle, R. M., et al. (2012).The American journal of
pathology, 180(2), 473–83. doi:10.1016/j.ajpath.2011.10.039
23. Down-regulation of microRNAs controlling tumourigenic factors in follicular thyroid carcinoma. Rossing, M.,
Borup, R., Henao, R., Winther, O., Vikesaa, J., Niazi, O., Godballe, C., et al. (2012).Journal of molecular
endocrinology, 48(1), 11–23. doi:10.1530/JME-11-0039
24. CHC promotes tumor growth and angiogenesis through regulation of HIF-1α and VEGF signaling. Tung, K.-H.,
Lin, C.-W., Kuo, C.-C., Li, L.-T., Kuo, Y.-H., Lin, C.-W., & Wu, H.-C. (2013).Cancer letters, 331(1), 58–67.
doi:10.1016/j.canlet.2012.12.001
25. Growth inhibitory effects of three miR-129 family members on gastric cancer. Yu, X., Song, H., Xia, T., Han, S.,
Xiao, B., Luo, L., Xi, Y., et al. (2013).Gene, 532(1), 87–93. doi:10.1016/j.gene.2013.09.048
26. MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines. de
Antonellis, P., Liguori, L., Falanga, A., Carotenuto, M., Ferrucci, V., Andolfo, I., Marinaro, F., et al.
(2013).Naunyn-Schmiedeberg’s archives of pharmacology, 386(4), 287–302. doi:10.1007/s00210-013-0837-4
27. The Rho Guanine Nucleotide Exchange Factor Syx Regulates the Balance of Dia and ROCK Activities To
Promote Polarized-Cancer-Cell Migration. Dachsel, J. C., Ngok, S. P., Lewis-Tuffin, L. J., Kourtidis, A., Geyer, R.,
Johnston, L., Feathers, R., et al. (2013).Molecular and cellular biology, 33(24), 4909–18.
doi:10.1128/MCB.00565-13
28. AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in
early stage colon cancer. Dunne, P., McArt, D. G., Blayney, J. K., Kalimutho, M., Greer, S., Wang, T., Srivastava,
S., et al. (2013).Clinical cancer research : an official journal of the American Association for Cancer Research.
doi:10.1158/1078-0432.CCR-13-1354
29. The pan-deacetylase inhibitor panobinostat suppresses the expression of oncogenic miRNAs in hepatocellular
carcinoma cell lines. Henrici, A., Montalbano, R., Neureiter, D., Krause, M., Stiewe, T., Slater, E. P., Quint, K.,
et al. (2013).Molecular carcinogenesis, (November). doi:10.1002/mc.22122
30. MiR-124 targets Slug to regulate epithelial-mesenchymal transition and metastasis of breast cancer. Liang, Y.J., Wang, Q.-Y., Zhou, C.-X., Yin, Q.-Q., He, M., Yu, X.-T., Cao, D.-X., et al. (2013).Carcinogenesis, 34(3), 713–22.
doi:10.1093/carcin/bgs383
31. Small interfering RNA transfection against serum response factor mediates growth inhibition of benign
prostatic hyperplasia fibroblasts. Nolte, A., Aufderklamm, S., Scheu, K., Walker, T., König, O., Böttcher, M.,
Niederlaender, J., et al. (2013).Nucleic acid therapeutics, 23(1), 62–70. doi:10.1089/nat.2012.0392
32. Aryl Hydrocarbon Receptor Negatively Regulates Expression of the Plakoglobin Gene (Jup). Procházková, J.,
Kabátková, M., Smerdová, L., Pacherník, J., Sykorová, D., Kohoutek, J., Simecková, P., et al.
(2013).Toxicological sciences : an official journal of the Society of Toxicology. doi:10.1093/toxsci/kft110
33. Anoctamin 1 dysregulation alters bronchial epithelial repair in cystic fibrosis. Ruffin, M., Voland, M., Marie, S.,
Bonora, M., Blanchard, E., Blouquit-Laye, S., Naline, E., et al. (2013).Biochimica et biophysica acta, 1832(12),
2340–51. doi:10.1016/j.bbadis.2013.09.012
60
34. Platinum compounds sensitize ovarian carcinoma cells to ABT-737 by modulation of the Mcl-1/Noxa axis.
Simonin, K., N’Diaye, M., Lheureux, S., Loussouarn, C., Dutoit, S., Briand, M., Giffard, F., et al.
(2013).Apoptosis : an international journal on programmed cell death, 18(4), 492–508. doi:10.1007/s10495012-0799-x
35. Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung
fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. Sobel, K., Menyhart, K., Killer, N.,
Renault, B., Bauer, Y., Studer, R., Steiner, B., et al. (2013).The Journal of biological chemistry, 288(21), 14839–
51. doi:10.1074/jbc.M112.426726
36. Tumor-derived hydrogen sul fi de, produced by cystathionine- β -synthase, stimulates bioenergetics, cell
proliferation, and angiogenesis in colon cancer. Szabo, C., Coletta, C., Chao, C., Módis, K., Szczesny, B., &
Papapetropoulos, A. (2013)., 110(30). doi:10.1073/pnas.1306241110//DCSupplemental.www.pnas.org/cgi/doi/10.1073/pnas.1306241110
37. The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclindependent kinase 4 to transactivate microRNA-141 and microRNA-146b-5p spontaneously and in response
to ultraviolet light-induced DNA damage. Al-Khalaf, H. H., Mohideen, P., Nallar, S. C., Kalvakolanu, D. V, &
Aboussekhra, A. (2013).The Journal of biological chemistry, 288(49), 35511–25. doi:10.1074/jbc.M113.512640
38. Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication
complexes of semliki forest virus. Varjak, M., Saul, S., Arike, L., Lulla, A., Peil, L., & Merits, A. (2013).Journal of
virology, 87(18), 10295–312. doi:10.1128/JVI.01105-13
39. MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype-associated genes in
medulloblastoma. Venkataraman, S., Birks, D. K., Balakrishnan, I., Alimova, I., Harris, P. S., Patel, P. R.,
Handler, M. H., et al. (2013).The Journal of biological chemistry, 288(3), 1918–28.
doi:10.1074/jbc.M112.396762
40. Inhibition of cyclin-dependent kinase 6 suppresses cell proliferation and enhances radiation sensitivity in
medulloblastoma cells. Whiteway, S. L., Harris, P. S., Venkataraman, S., Alimova, I., Birks, D. K., Donson, A. M.,
Foreman, N. K., et al. (2013).Journal of neuro-oncology, 111(2), 113–21. doi:10.1007/s11060-012-1000-7
41. Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice. Barathi, V. a,
Kwan, J. L., Tan, Q. S. W., Weon, S. R., Seet, L. F., Goh, L. K., Vithana, E. N., et al. (2013).Disease models &
mechanisms, 1158, 1146–1158. doi:10.1242/dmm.010967
42. Amplification of FRS2 and Activation of FGFR/FRS2 Signaling Pathway in High-Grade Liposarcoma. Zhang, K.,
Chu, K., Wu, X., Gao, H., Wang, J., Yuan, Y.-C., Loera, S., et al. (2013).Cancer research, 73(4), 1298–307.
doi:10.1158/0008-5472.CAN-12-2086
43. The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells
and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer
cells. Henderson, D. J. P., Byrne, a, Dulla, K., Jenster, G., Hoffmann, R., Baillie, G. S., & Houslay, M. D.
(2014).British journal of cancer, 110(5), 1278–87. doi:10.1038/bjc.2014.22
44. Identification of genomic alterations in oesophageal squamous cell cancer. Song, Y., Li, L., Ou, Y., Gao, Z., Li, E.,
Li, X., Zhang, W., et al. (2014).Nature, 509(7498), 91–5. doi:10.1038/nature13176
61
45. G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate cancer.
Chakraborty, P. K., Zhang, Y., Coomes, A. S., Kim, W.-J., Stupay, R., Lynch, L. D., Atkinson, T., et al.
(2014).Cancer research, 74(13), 3489–500. doi:10.1158/0008-5472.CAN-13-2708
46. Placental expression of aminopeptidase-Q (laeverin) and its role in the pathophysiology of preeclampsia.
Nystad, M., Sitras, V., Larsen, M., & Acharya, G. (2014).American journal of obstetrics and gynecology.
doi:10.1016/j.ajog.2014.06.047
46. Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma
susceptibility and oncogenicity. Bosse, K. R., Diskin, S. J., Cole, K. a, Wood, A. C., Schnepp, R. W., Norris, G.,
Nguyen, L. B., et al. (2012).Cancer research, 72(8), 2068–78. doi:10.1158/0008-5472.CAN-11-3703
47. Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b
expression in liver cancer cell lines. Di Fazio, P., Montalbano, R., Neureiter, D., Alinger, B., Schmidt, A.,
Merkel, A. L., Quint, K., et al. (2012).Experimental cell research, 318(15), 1832–43.
doi:10.1016/j.yexcr.2012.04.018
48. miR-146a functions as a tumor suppressor in prostate cancer by targeting Rac1. Sun, Q., Zhao, X., Liu, X., Wang,
Y., Huang, J., Jiang, B., Chen, Q., et al. (2014).The Prostate, 74(16), 1613–21. doi:10.1002/pros.22878
49. MicroRNA library-based functional screening identified miR-137 as a suppresser of gastric cancer cell
proliferation. Zheng, X., Dong, J., Gong, T., Zhang, Z., Wang, Y., Li, Y., Shang, Y., et al. (2014).Journal of cancer
research and clinical oncology. doi:10.1007/s00432-014-1847-4
50. ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling. Gee, H., Saisawat, P., &
Ashraf, S. (2013).The Journal of Clinical Investigation, 123(8), 3243–3253. doi:10.1172/JCI69134.Research
51. A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs
for broad applications. Chen, Q.-X., Wang, W.-P., Zeng, S., Urayama, S., & Yu, a.-M. (2015).Nucleic Acids
Research, 1–13. doi:10.1093/nar/gkv228
52. Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy
for pancreatic adenocarcinoma. Guillaumond, F., Bidaut, G., Ouaissi, M., Servais, S., Gouirand, V., Olivares, O.,
Lac, S., et al. (2015).Proceedings of the National Academy of Sciences, 201421601.
doi:10.1073/pnas.1421601112
*53. The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis. Lou, G., Liu, Y., Wu, S., Xue,
J., Yang, F., Fu, H., Zheng, M., et al. (2015).Cellular Physiology and Biochemistry, 35, 2192–2202.
doi:10.1159/000374024
*54. ROS-induced nanotherapeutic approach for ovarian cancer treatment based on the combinatorial effect of
photodynamic therapy and DJ-1 gene suppression. Schumann, C., Taratula, O., Khalimonchuk, O., Palmer, A.
L., Cronk, L. M., Jones, C. V., Escalante, C. a., et al. (2015).Nanomedicine: Nanotechnology, Biology and
Medicine. doi:10.1016/j.nano.2015.07.005
62
STEM CELLS AND CELL DIFFERENTIATION
1. Human Pompe disease-induced pluripotent stem cells for pathogenesis modeling, drug testing and disease
marker identification. Huang, H.-P., Chen, P.-H., Hwu, W.-L., Chuang, C.-Y., Chien, Y.-H., Stone, L., Chien, C.-L.,
et al. (2011).Human molecular genetics, 20(24), 4851–64. doi:10.1093/hmg/ddr424
2. Peculiar Characteristics of Human Mesenchymal Stem Cell Clones Suitable as Tissue Engineering Models.
Silvani, G., Galli, D., Benedetti, L., & Ceccarelli, G. (2011).Journal of Tissue Science & Engineering, 02(02).
doi:10.4172/2157-7552.1000106
3. Directed differentiation of skin-derived precursors into functional vascular smooth muscle cells. Steinbach, S.
K., El-Mounayri, O., DaCosta, R. S., Frontini, M. J., Nong, Z., Maeda, A., Pickering, J. G., et al.
(2011).Arteriosclerosis, thrombosis, and vascular biology, 31(12), 2938–48. doi:10.1161/ATVBAHA.111.232975
4. Urine is a highly cytotoxic agent: does it influence stem cell therapies in urology? Adamowicz, J., Kloskowski, T.,
Tworkiewicz, J., Pokrywczyńska, M., & Drewa, T. (2012).Transplantation proceedings, 44(5), 1439–41.
doi:10.1016/j.transproceed.2012.01.128
5. Evaluation of the cell viability of human Wharton’s jelly stem cells for use in cell therapy. Garzón, I. (2012).…
Engineering Part C: …, 18(6). doi:10.1089/ten.tec.2011.0508
6. Optimization and Scale-up Culture of Human Endometrial Multipotent Mesenchymal Stromal Cells: Potential
for Clinical Application. Rajaraman, G., Ph, D., White, J., Sci, B. A., Tan, K. S., Sc, M., Ulrich, D., et al.
(2012).Tissue Engineering: Part C, 00(00). doi:10.1089/ten.tec.2011.0718
7. Factors secreted by mesenchymal stem cells and endothelial progenitor cells have complementary effects on
angiogenesis in vitro. Burlacu, A., Grigorescu, G., Rosca, A.-M., Preda, M. B., & Simionescu, M. (2013).Stem
cells and development, 22(4), 643–53. doi:10.1089/scd.2012.0273
8. A new quantitative experimental approach to investigate single cell adhesion on multifunctional substrates.
Canale, C., Petrelli, A., Salerno, M., Diaspro, A., & Dante, S. (2013).Biosensors & bioelectronics, 48C, 172–179.
doi:10.1016/j.bios.2013.04.015
9. Real-time monitoring of 3T3-L1 preadipocyte differentiation using a commercially available electric cellsubstrate impedance sensor system. Kramer, A. H., Joos-Vandewalle, J., Edkins, A. L., Frost, C. L., & Prinsloo,
E. (2014).Biochemical and biophysical research communications, (January), 1–6.
doi:10.1016/j.bbrc.2013.12.123
10. Pathways commonly dysregulated in mouse and human obese adipose tissue: FAT/CD36 modulates
differentiation and lipogenesis. Berger, E., Héraud, S., Mojallal, a, Lequeux, C., Weiss-Gayet, M., Damour, O.,
& Géloën, a. (2015).Adipocyte, (January), 1–20. doi:10.4161/21623945.2014.987578
63
TECHNOLOGY AND METHODS
1. Real-time monitoring of cellular responses to carbon nanotubes. Mu, Q., Zhai, S., & Yan, B. (2010). (K.
Balasubramanian & M. Burghard, Eds.)Methods in Molecular Biology, 625(5), 85–94. doi:10.1007/978-160761-579-8
2. Label-free whole-cell assays: expanding the scope of GPCR screening. Scott, C. W., & Peters, M. F. (2010).Drug
discovery today, 15(17-18), 704–16. doi:10.1016/j.drudis.2010.06.008
3. Tumors on chips: oncology meets microfluidics. Wlodkowic, D., & Cooper, J. M. (2010).Current opinion in
chemical biology, 14(5), 556–67. doi:10.1016/j.cbpa.2010.08.016
4. The use of real-time cell analyzer technology in drug discovery: defining optimal cell culture conditions and
assay reproducibility with different adherent cellular models. Atienzar, F. a, Tilmant, K., Gerets, H. H.,
Toussaint, G., Speeckaert, S., Hanon, E., Depelchin, O., et al. (2011).Journal of biomolecular screening, 16(6),
575–87. doi:10.1177/1087057111402825
5. The xCELLigence System for Real-Time and Label-Free Monitoring of Cell Viability. Ke, N., Wang, X., Xu, X., &
Abassi, Y. A. (2011). (M. J. Stoddart, Ed.)Methods in Molecular Biology, 740, 33–43. doi:10.1007/978-1-61779108-6
6. Assessment of endothelial permeability and leukocyte transmigration in human endothelial cell monolayers.
Ludwig, A., Sommer, A., & Uhlig, S. (2011).Methods in Molecular Biology, 763, 319–332. doi:10.1007/978-161779-191-8
7. In vitro analyses of endothelial cell permeability. Monaghan-benson, E., & Wittchen, E. S. (2011). (K. Turksen,
Ed.)Methods in Molecular Biology, 763, 281–290. doi:10.1007/978-1-61779-191-8
8. Impedance measurements in the biomedical sciences. Coffman, F. D., & Cohen, S. (2012).Analytical cellular
pathology (Amsterdam), 1–12. doi:10.3233/ACP-2012-0070
9. Medium to high throughput screening - microfabrication and chip-based technology. Wen, Y., Zhang, X., & Yang,
S. (2012).New Technologies for Toxicity testing, 181–209.
10. Electrical Impedance Sensors for Cancer Cell Study. Yang, L. (2013).ECS Transactions, 50(12), 101–108.
doi:10.1149/05012.0101ecst
11. A new quantitative experimental approach to investigate single cell adhesion on multifunctional substrates.
Canale, C., Petrelli, A., Salerno, M., Diaspro, A., & Dante, S. (2013).Biosensors & bioelectronics, 48C, 172–179.
doi:10.1016/j.bios.2013.04.015
12. Synthesis and characterization of a pH-sensitive conjugate of isoniazid with Fe3O4@SiO2 magnetic
nanoparticles. Sedlák, M., Bhosale, D. S., Beneš, L., Palarčík, J., Kalendová, A., Královec, K., & Imramovský, A.
(2013).Bioorganic & medicinal chemistry letters, 4–7. doi:10.1016/j.bmcl.2013.05.103
13. Concise review: microfluidic technology platforms: poised to accelerate development and translation of stem
cell-derived therapies. Titmarsh, D. M., Chen, H., Glass, N. R., & Cooper-White, J. J. (2014).Stem cells
translational medicine, 3(1), 81–90. doi:10.5966/sctm.2013-011
14. Analysis of inter-/intra-E-plate repeatability in the real-time cell analyzer. Chen, J., Pan, T., Devendran, B. D.,
Xi, Z., Khare, S., Huang, B., Zhang, W., et al. (2015).Analytical Biochemistry, 477, 98–104.
doi:10.1016/j.ab.2015.01.026
64
OTHERS
1. Dynamic Monitoring of Cellular Remodeling Induced by the Transforming Growth Factor-β1. Staršíchová, A.,
Kubala, L., Lincová, E., Pernicová, Z., Kozubík, A., & Souček, K. (2009, January).Biological procedures online.
doi:10.1007/s12575-009-9017-9
2. Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target
effects. Abassi, Y. a, Xi, B., Zhang, W., Ye, P., Kirstein, S. L., Gaylord, M. R., Feinstein, S. C., et al.
(2009).Chemistry & biology, 16(7), 712–23. doi:10.1016/j.chembiol.2009.05.011
3. N-glycosylation of the I-like domain of beta1 integrin is essential for beta1 integrin expression and biological
function: identification of the minimal N-glycosylation requirement for alpha5beta1. Isaji, T., Sato, Y.,
Fukuda, T., & Gu, J. (2009).The Journal of biological chemistry, 284(18), 12207–16.
doi:10.1074/jbc.M807920200
4. Antibodies blocking adhesion and matrix binding domains of laminin-332 inhibit tumor growth and metastasis
in vivo. Salo, S., Boutaud, A., Hansen, A. J., He, L., Sun, Y., Morales, S., Venturini, A., et al. (2009).International
journal of cancer. Journal international du cancer, 125(8), 1814–25. doi:10.1002/ijc.24532
5. An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its
function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III. Sato, Y., Isaji, T.,
Tajiri, M., Yoshida-Yamamoto, S., Yoshinaka, T., Somehara, T., Fukuda, T., et al. (2009).The Journal of biological
chemistry, 284(18), 11873–81. doi:10.1074/jbc.M807660200
6. Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and
NFAT pathways to decrease cell adhesion and promote cell migration. Foldynová-Trantírková, S., Sekyrová,
P., Tmejová, K., Brumovská, E., Bernatík, O., Blankenfeldt, W., Krejcí, P., et al. (2010).Breast cancer research :
BCR, 12(3), R30. doi:10.1186/bcr2581
7. Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS
and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells. Kuo, Y.-F., Su, Y.-Z., Tseng, Y.H., Wang, S.-Y., Wang, H.-M., & Chueh, P. J. (2010).Free radical biology & medicine, 49(2), 214–26.
doi:10.1016/j.freeradbiomed.2010.04.005
8. Ganglioside GD3 enhances adhesion signals and augments malignant properties of melanoma cells by
recruiting integrins to glycolipid-enriched microdomains. Ohkawa, Y., Miyazaki, S., Hamamura, K., Kambe,
M., Miyata, M., Tajima, O., Ohmi, Y., et al. (2010).The Journal of biological chemistry, 285(35), 27213–23.
doi:10.1074/jbc.M109.087791
9. Validation of xCELLigence real-time cell analyzer to assess compatibility in xenotransplantation with pig-tobaboon model. Quereda, J. J., Martínez-Alarcón, L., Mendoça, L., Majado, M. J., Herrero-Medrano, J. M.,
Pallarés, F. J., Ríos, a, et al. (2010).Transplantation proceedings, 42(8), 3239–43.
doi:10.1016/j.transproceed.2010.05.059
10. Exon-skipping brain natriuretic peptide variant is overexpressed in failing myocardium and attenuates brain
natriuretic peptide production in vitro. Torrado, M., Iglesias, R., Centeno, A., López, E., & Mikhailov, A. T.
(2010).Experimental biology and medicine (Maywood, N.J.), 235(8), 941–51. doi:10.1258/ebm.2010.010078
11. Fluorescent small molecule probe to modulate and explore α2β1 integrin function. Koivunen, J. T., Nissinen, L.,
Käpylä, J., Jokinen, J., Pihlavisto, M., Marjamäki, A., Heino, J., et al. (2011, September 21).Journal of the
American Chemical Society. doi:10.1021/ja206086c
12. Rapid and quantitative assessment of cell quality, identity, and functionality for cell-based assays using realtime cellular analysis. Irelan, J. T., Wu, M.-J., Morgan, J., Ke, N., Xi, B., Wang, X., Xu, X., et al. (2011).Journal of
biomolecular screening, 16(3), 313–22. doi:10.1177/1087057110397359
65
13. Modelling the porcine oviduct epithelium: a polarized in vitro system suitable for long-term cultivation.
Miessen, K., Sharbati, S., Einspanier, R., & Schoen, J. (2011).Theriogenology, 76(5), 900–10.
doi:10.1016/j.theriogenology.2011.04.021
14. Electrical impedance as a novel biomarker of myotube atrophy and hypertrophy. Rakhilin, S., Turner, G., Katz,
M., Warden, R., Irelan, J., Abassi, Y. a, & Glass, D. J. (2011).Journal of biomolecular screening, 16(6), 565–74.
doi:10.1177/1087057111401392
15. Donor-graft compatibility tests in pig-to-primate xenotransplantation model: serum versus plasma in realtime cell analyzer trials. Ramis, G., Martínez-Alarcón, L., Majado, M. J., Quereda, J. J., Mendonça, L., HerreroMedrano, J. M., Abellaneda, J. M., et al. (2011).Transplantation proceedings, 43(1), 249–53.
doi:10.1016/j.transproceed.2010.11.009
16. Local anesthetics inhibit kinesin motility and microtentacle protrusions in human epithelial and breast tumor
cells. Yoon, J. R., Whipple, R. a, Balzer, E. M., Cho, E. H., Matrone, M. a, Peckham, M., & Martin, S. S.
(2011).Breast cancer research and treatment, 129(3), 691–701. doi:10.1007/s10549-010-1239-7
17. Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy. Zheng, H., Whitman,
S. a, Wu, W., Wondrak, G. T., Wong, P. K., Fang, D., & Zhang, D. D. (2011).Diabetes, 60(11), 3055–66.
doi:10.2337/db11-0807
18. The response of cementoblasts to calcium phosphate resin-based and calcium silicate-based commercial
sealers. Hakki, S. S., Bozkurt, B. S., Ozcopur, B., Gandolfi, M. G., Prati, C., & Belli, S. (2012).International
endodontic journal, 1–11. doi:10.1111/j.1365-2591.2012.02122.x
19. Immortalized gingival fibroblasts as a cytotoxicity test model for dental materials. Illeperuma, R. P., Park, Y. J.,
Kim, J. M., Bae, J. Y., Che, Z. M., Son, H. K., Han, M. R., et al. (2012).Journal of materials science. Materials in
medicine, 23(3), 753–62. doi:10.1007/s10856-011-4473-6
20. Real-time cell analysis of the cytotoxicity of orthodontic mini-implants on human gingival fibroblasts and
mouse osteoblasts. Malkoç, S., Ö ztürk, F., Çörekçi, B., Bozkurt, B. S., & Hakki, S. S. (2012).American journal of
orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its
constituent societies, and the American Board of Orthodontics, 141(4), 419–26.
doi:10.1016/j.ajodo.2011.12.009
21. Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the
endothelial basement membrane. Scheppke, L., Murphy, E. a, Zarpellon, A., Hofmann, J. J., Merkulova, A.,
Shields, D. J., Weis, S. M., et al. (2012).Blood, 119(9), 2149–58. doi:10.1182/blood-2011-04-348706
22. Cells lacking β-actin are genetically reprogrammed and maintain conditional migratory capacity. Tondeleir, D.,
Lambrechts, A., Müller, M., Jonckheere, V., Doll, T., Vandamme, D., Bakkali, K., et al. (2012).The American
Society for Biochemistry and Molecular Biology, Inc.
23. Kinetic tracking of therapy-induced senescence using the real-time cell analyzer single plate system. Weiland,
T., Berger, A., Essmann, F., Lauer, U. M., Bitzer, M., & Venturelli, S. (2012).Assay and drug development
technologies, 10(3), 289–95. doi:10.1089/adt.2011.0402
24. Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as
cholinesterase inhibitors. Imramovský, A., Pejchal, V., Štěpánková, Š., Vorčáková, K., Jampílek, J., Vančo, J.,
Šimůnek, P., et al. (2013).Bioorganic & medicinal chemistry, 21(7), 1735–48. doi:10.1016/j.bmc.2013.01.052
25. BRCA1 Expression Is Epigenetically Repressed in Sporadic Ovarian Cancer Cells by Overexpression of CTerminal Binding Protein 2 1 , 2. May, T., Yang, J., Shoni, M., Ng, S., & Crum, C. (2013)., 15(6), 600–608.
doi:10.1593/neo.121674
66
26. Real-time cellular analysis as a novel approach for in vitro cytotoxicity testing of medical device extracts.
Garcia, S. N., Gutierrez, L., & McNulty, A. (2013).Journal of biomedical materials research. Part A,
2012(October 2012), 1–10. doi:10.1002/jbm.a.34507
27. Using real-time impedance based assay to monitor the effects of fibroblast derived media on the adhesion,
proliferation, migration, and invasion of colon cancer cells. Kiely, P. (2014).Bioscience Reports.
67