Contents Volume 75 Issue 10 | ARD October 2016 The Eular Journal Editorial 1741 Predicting improvement in diffuse scleroderma: lessons learnt 1806 Comparison of lipid and lipid-associated cardiovascular risk marker changes after treatment with tocilizumab OPEN ACCESS or adalimumab in patients with rheumatoid arthritis C Gabay, I B McInnes, A Kavanaugh, K Tuckwell, M Klearman, J Pulley, N Sattar J E Pope Clinical and epidemiological research 1743 Prediction of improvement in skin fibrosis in diffuse cutaneous systemic sclerosis: a EUSTAR analysis OPEN ACCESS Editor Tore K Kvien Associate Editors Francis Berenbaum Johannes Bijlsma Dimitrios Boumpas Gerd Burmester Mary Crow Iain McInnes David Pisetsky Editorial office Annals of the Rheumatic Diseases BMJ Publishing Group Ltd BMA House Tavistock Square London WCIH 9JR,UK T: +44 (0)20 7383 6250 F: +44 (0)20 7383 6668 E: ard@bmj.com Twitter: @ARD_BMJ ISSN: 0003-4967 (print) ISSN: 1468-2060 (online) Impact Factor: 12.384 Disclaimer: ARD is owned and published by BMJ Publishing Group Ltd (a wholly owned subsidiary of the British Medical Association) and the European League Against Rheumatism. 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R Dobrota, B Maurer, N Graf, S Jordan, C Mihai, O Kowal-Bielecka, Y Allanore, O Distler, on behalf of EUSTAR coauthors 1749 Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23 years follow-up of a population-based cohort of middle-aged women S Kluzek, M T Sanchez-Santos, K M Leyland, A Judge, T D Spector, D Hart, C Cooper, J Newton, N K Arden 1757 Increased pretreatment serum IFN-β/α ratio predicts non-response to tumour necrosis factor α inhibition in rheumatoid arthritis T W Muskardin, P Vashisht, J M Dorschner, M A Jensen, B S Chrabot, M Kern, J R Curtis, M I Danila, S S Cofield, N Shadick, P A Nigrovic, E W St Clair, C O Bingham III, R Furie, W Robinson, M Genovese, C C Striebich, J R O’Dell, G M Thiele, L W Moreland, M Levesque, S L Bridges Jr, P K Gregersen, T B Niewold 1813 Comparative effects of biologics on cardiovascular risk among older patients with rheumatoid arthritis J Zhang, F Xie, H Yun, L Chen, P Muntner, E B Levitan, M M Safford, S T Kent, M T Osterman, J D Lewis, K Saag, J A Singh, J R Curtis 1819 Prevalence of ultrasound synovial inflammatory findings in healthy subjects I Padovano, F Costantino, M Breban, M A D’Agostino 1824 Clinical factors, anticitrullinated peptide antibodies and MRI-detected subclinical inflammation in relation to progression from clinically suspect arthralgia to arthritis H W van Steenbergen, L Mangnus, M Reijnierse, T W J Huizinga, A H M van der Helm-van Mil 1831 Parental rheumatoid arthritis and long-term child morbidity: a nationwide cohort study A L Rom, C S Wu, J Olsen, D Jawaheer, M L Hetland, B Ottesen, L S Mørch 1838 Pregnancy outcomes in patients with ankylosing spondylitis: a nationwide register study G L Jakobsson, O Stephansson, J Askling, L T H Jacobsson 1763 Value of ultrasonography as a marker of early response to abatacept in patients with rheumatoid arthritis and OPEN ACCESS an inadequate response to methotrexate: results from the APPRAISE study M-A D’Agostino, R J Wakefield, H Berner-Hammer, O Vittecoq, G Filippou, P Balint, I Möller, A Iagnocco, E Naredo, M Østergaard, M Boers, C Gaillez, K V Holder, M Le Bars, on behalf of the OMERACT-EULAR-Ultrasound Task Force 1770 Elucidating the burden of recurrent and chronic digital ulcers in systemic sclerosis: long-term results from the OPEN ACCESS DUO Registry M Matucci-Cerinic, T Krieg, L Guillevin, B Schwierin, D Rosenberg, P Cornelisse, C P Denton 1843 Real-world comparative risks of herpes virus infections in tofacitinib and biologic-treated patients with rheumatoid arthritis J R Curtis, F Xie, H Yun, S Bernatsky, K L Winthrop 1848 Increased arterial wall inflammation in patients with ankylosing spondylitis is reduced by statin therapy F M van der Valk, S J B Moens, S L Verweij, A C Strang, A J Nederveen, H J Verberne, M T Nurmohamed, D L Baeten, E S G Stroes 1852 Osteoarthritic bone marrow lesions almost exclusively colocate with denuded cartilage: a 3D study using data from the Osteoarthritis Initiative M A Bowes, S WD McLure, C BH Wolstenholme, G R Vincent, S Williams, A Grainger, P G Conaghan 1777 Sofosbuvir plus ribavirin for hepatitis C virus-associated cryoglobulinaemia vasculitis: VASCUVALDIC study D Saadoun, V Thibault, S N Si Ahmed, L Alric, M Mallet, C Guillaud, H Izzedine, A Plaisier, H Fontaine, M Costopoulos, M Le Garff-Tavernier, C Hezode, S Pol, L Musset, T Poynard, P Cacoub 1783 Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study MORE CONTENTS 䉴 This article has been chosen by the Editor to be of special interest or importance and is freely available online. W Han, D Aitken, Z Zhu, A Halliday, X Wang, B Antony, F Cicuttini, G Jones, C Ding 1789 How comparable are rates of malignancies in patients with rheumatoid arthritis across the world? A comparison of cancer rates, and means to optimise their comparability, in five RA registries J Askling, N Berglind, S Franzen, T Frisell, C Garwood, J D Greenberg, M Ho, M Holmqvist, L Horne, E Inoue, K Michaud, F Nyberg, D A Pappas, G Reed, E Tanaka, T N Tran, S M M Verstappen, H Yamanaka, E Wesby-van Swaay, D Symmons OPEN ACCESS This article has been made freely available online under the BMJ Journals Open Access scheme. See http://ard.bmj.com/site/about/guidelines.xhtml#open This journal is a member of and subscribes to the principles of the Committee on Publication Ethics http://publicationethics.org/ 1797 Can rheumatoid arthritis (RA) registries provide contextual safety data for modern RA clinical trials? The case for mortality and cardiovascular disease K Michaud, N Berglind, S Franzén, T Frisell, C Garwood, J D Greenberg, M Ho, M Holmqvist, L Horne, E Inoue, F Nyberg, D A Pappas, G Reed, D Symmons, E Tanaka, T N Tran, S M M Verstappen, E Wesby-van Swaay, H Yamanaka, J Askling The online version of this article contains multiple choice questions hosted on BMJ Learning. Contents Basic and translational research 1858 Nucleosome in patients with systemic sclerosis: possible association with immunological abnormalities via abnormal activation of T and B cells A Yoshizaki, T Taniguchi, R Saigusa, T Fukasawa, S Ebata, H Numajiri, K Nakamura, T Yamashita, T Takahashi, T Toyama, Y Asano, T F Tedder, S Sato 1866 Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal OPEN ACCESS frequent targeting of citrullinated histones of NETs Volume 75 Issue 10 | ARD October 2016 e64 M Scheinberg, V Azevedo e65 A Schwenzer, X Jiang, T R Mikuls, J B Payne, H R Sayles, A-M Quirke, B M Kessler, R Fischer, P J Venables, K Lundberg, K S Midwood e66 e67 e68 e69 e70 e63 Response to: ‘Infliximab and CT-P13 immunogenicity assessment in PLANETAS and PLANETRA main and extension studies: utility of laboratory methods description’ by Francesca Meacci et al J Braun Response to: ‘Let’s stop fooling ourselves. In RA, only ACR/EULAR criteria define remission and equate with absence of disease!’ by Boers P Emery, C O Bingham III, G R Burmester, V P Bykerk, D E Furst, X Mariette, D van der Heijde, R van Vollenhoven, C Arendt, I Mountian, O Purcaru, D Tatla, B VanLunen, M E Weinblatt Electronic pages Correspondence F Meacci, M Manfredi, M Infantino, V Grossi, M Benucci Let’s stop fooling ourselves. In RA, only ACR/EULAR criteria define remission and equate with absence of disease! M Boers J van Heemst, A H Hensvold, X Jiang, H van Steenbergen, L Klareskog, T W J Huizinga, A van der Helm-van Mil, A I Catrina, R E M Toes, K Lundberg, D van der Woude Infliximab and CT-P13 immunogenicity assessment in PLANETAS and PLANETRAS main and extension studies: utility of laboratory methods description Response to: ‘The role of infrapatellar fat pad resection in total knee arthroplasty’ by White et al W Han, F Pan, Z Liu, Z Zhu, X Wang, S Zheng, B Antony, C Ding 1891 Protective effect of HLA-DRB1*13 alleles during specific phases in the development of ACPA-positive RA e62 The role of infrapatellar fat pad resection in total knee arthroplasty L D White, T M Melhuish 1884 T cell subsets: an immunological biomarker to predict progression to clinical arthritis in ACPA-positive OPEN ACCESS individuals L Hunt, E M Hensor, J Nam, A N Burska, R Parmar, P Emery, F Ponchel Difference between SB4 and reference etanercept in the hepatobiliary disorders not considered to be caused by SB4: response to letter by Scheinberg and Azevedo P Emery, J Vencovský, J Ghil, S Y Cheong, Y H Rho E Corsiero, M Bombardieri, E Carlotti, F Pratesi, W Robinson, P Migliorini, C Pitzalis 1876 Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for OPEN ACCESS autoantibodies in rheumatoid arthritis Difference between Enbrel and Benepali treatment groups in ‘hepatobiliary disorders’ Denosumab, cortical bone and bone erosions in rheumatoid arthritis M Rossini, G Adami, O Viapiana, L Idolazzi, D Gatti e71 Response to: ‘Denosumab, cortical bone and bone erosion in rheumatoid arthritis’ by Rossini et al T Takeuchi, Y Tanaka, N Ishiguro, H Yamanaka, T Yoneda, T Ohira, N Okubo, H K Genant, D van der Heijde