Research
Overview on global research activities
of AOSpine International
AOSpine Research
Our research vision is aligned to the overall vision for research in the AO
Foundation: ‘To produce new findings and to develop them into practice
such that they impact clinical care in accordance with the AO Mission and
Vision in continuous and overlapping cycles in order to produce
at least one successful outcome every 5-10 years.’
Clinical Research
Translational Research
AOSpine Mentorship - Research
The Knowledge Forums are expert surgeondriven working groups focused on five spine
pathologies: tumor, deformity, spinal cord
injury (SCI), trauma, and degenerative disease.
Important evidence-based studies are being
performed and our first results have already
been published. AOSpine members have
exclusive access to the latest advances and
outcomes produced by the Knowledge Forums
that will assist them in clinical decision-making.
Spine Research Network (SRN). The SRN
is AOSpine’s platform for intervertebral
disc research. Represented by Prof. Mauro
Alini, the SRN is composed of 28 AOSpine
investigators worldwide. It is open to any
AOSpine investigator who has previously
received or is currently holding an AO
research grant and is conducting research
pertaining to intervertebral disc degeneration
and regeneration.
After the big success of the first AOSpine
Research mentoring program in 2014, we
are very pleased to announce a new round
for 2016 with slight modifications. This
improved and ambitious program is aimed
to teach a whole team of surgeons in a local
hospital how to perform clinical research.
The team will receive theoretical lessons
and practical support to perform their own
clinical study.
AOSpine Research centers around the globe
2
AOSpine Research Commission
The AOSpine Research
Commission is responsible
for running our global
research initiatives, sharing
expertise, and leveraging
resources across regions.
This body defines,
integrates, and implements
coherent policies beneficial
for the entire organization.
Shanmuganathan
Rajasekaran
K. Daniel Riew
Yoshiharu Kawaguchi
Lorin Benneker
Chairperson
Past Chairperson
Commission member
(representing Asia Pacific)
Commission member
(representing Europe)
Jose Jimenez
Vafa
Rahimi-Movaghar
Thomas Mroz
Mauro Alini
Commission member
(representing
Latin America)
Commission member
(representing
Middle East)
Commission member
(representing
North America)
(Non-voting)
Commission member
(representing ARI
research institute)
The Commission
members are the
facilitators that bring all
AOSpine regions to the
same level of excellence
in spine research.
3
AOSpine Knowledge Forums
What are the Knowledge Forums?
Pathology-focused clinical study groups consisting of a steering committee of up to 10 international spine experts who
meet on a regular basis to drive the research projects forward.
What is the objective?
Foster innovation and evidence-based clinical practice in all spine pathologies.
Currently, there are 5 Knowledge Forums in place, led by the following Chairpersons:
Tumor
Deformity
Spinal
Cord Injury
Trauma
Degenerative
/ Biologics
Charles Fisher
Marinus de Kleuver
Michael Fehlings
Alex Vaccaro
Jeffrey C. Wang
Publish
Educate
How do the Knowledge Forums work?
Identify
Generate
AOSpine members have exclusive access to the latest advances and outcomes produced by the Knowledge Forums which
will assist in clinical decision-making.
4
What is the governance mechanism?
The Knowledge Forums are steered by the Knowledge Forum Review Panel. The Review Panel is comprised
of the Knowledge Forum Chairpersons and the Chairperson of the International Board, and it is chaired by the Research
Commission Chairperson.
What are the main responsibilities?
• Coordination between Knowledge Forums
• Strategic decisions
• Project approval and monitoring
• Approve new Knowledge Forums members
AOSpine Knowledge Forums are managed and supported by the AOSpine Research Team
KNOWLEDGE FORUM
REVIEW PANEL
Eberhard Denk
Research
Manager
Tumor
Deformity
Spinal Cord Injury
Trauma
Degenerative
/Biologics
Niccole Germscheid
Project
Manager
Niccole Germscheid
Project
Manager
María A. Sánchez
Project
Manager
María A. Sánchez
Project
Manager
María A. Sánchez
Project
Manager
Kaija Kurki-Suonio
Research
Project Coordinator
Yvonne Wey
Event
Project Coordinator
5
Knowledge Forum Tumor
Steering Committee
Charles Fisher
Chairperson
Stefano Boriani
Ziya Gokaslan
Peter Pal Varga
Laurence Rhines
Chetan Bettegowda
Norio Kawahara
Arjun Sahgal
University of
British Columbia
Vancouver, BC,
Canada
Rizzoli Institute
Bologna,
Italy
The Warren Alpert
Medical School
of Brown University
Providence, RI,
USA
National Center
for Spinal Disorders
Budapest,
Hungary
The University of Texas
MD Anderson
Cancer Center
Houston, TX,
USA
Johns Hopkins
University
School of Medicine
Baltimore, MD,
USA
Kanazawa
Medical University
Kahoku-gun,
Japan
Sunnybrook Health
Sciences Center
Toronto, ON,
Canada
Projects overview
Status: Planning
Project
Title
MTRON (Module within
Spine ReCORD)
Metastatic Tumor Research and
Outcome Network (MTRON): a
multicenter prospective registry
for the management of metastatic
spine tumors
PTRON (Module within
Spine ReCORD)
Primary Tumor Research and
Outcome Network (PTRON): a
multicenter prospective registry
for the management of primary
tumors of the spine
Investigator(s)
Aim
PI: Charles Fisher
To prospectively investigate the prognostic variables (clinical, diagnostic, and therapeutic)
in patients diagnosed with metastatic spine tumor(s) that are associated with patient
reported outcomes, perioperative morbidity, local control, and survival.
Co-PI: Arjun Sahgal
PI: Charles Fisher
Co-PI: Ziya
Gokaslan, Laurence
Rhines
To prospectively investigate the prognostic variables (clinical, diagnostic, and therapeutic)
within subgroups of patients diagnosed with primary spinal column tumors that are
associated with survival, local recurrence, perioperative morbidity, and patient reported
outcomes.
Status: Executing – data collection
Project
Title
Investigator(s)
Aim
Spine Oncology Focus
Issue
Spine Oncology Focus Issue
PI: Charles Fisher
To product a Spine Oncology Focus Issue which synthesizes the best available evidence
and expert opinion in the management of primary spinal column tumors and metastatic
spine disease.
TERT (an extension
of Primary Tumor
Retrospective)
An analysis of the role of the TERT
promoter mutations in retrospectively collected primary spinal
column tumors
PI: Chetan
Bettegowda
PI: Principle Investigator | Co-PI: Co-Principle Investigator
6
Co-PI: Ziya
Gokaslan
To determine the rates of TERT promoter mutation (mutation of the promoter of the
telomerase gene [23348506,23348503]) and its prognostic significance in primary spinal
column tumors.
Status: Executing – data analysis
Project
Title
Investigator(s)
Aim
PI: Charles Fisher
EPOSO
The Epidemiology, Process and
Outcomes of Spine Oncology
(EPOSO)
To prospectively collect patient, diagnostic and treatment variables along with disease
specific and generic health related quality of life (HRQOL) data on consecutively treated
patients with metastatic spine tumors.
Project
Title
Investigator(s)
Primary Tumor
Retrospective
Predictors of mortality and morbidity in the surgical management
of primary tumors of the spine: a
multi-center retrospective cohort
study with a cross-sectional
survival check
FFPE Chordoma (an
extension of Primary
Tumor Retrospective)
An analysis of the role of the
single nucleotide polymorphism
rs2305089 in retrospectively
collected chordomas
Co-PI: Ziya
Gokaslan
Remark: This project received co-funding from the Orthopaedic Research & Education
Foundation (OREF) through a Spine Prospective Clinical Research Grant.
Status: Disseminating
Systematic Reviews
Systematic reviews about the
outcomes of surgical treatment
of metastases to the spine and
primary tumors of the spine
PI: Charles Fisher
Co-PI: Ziya
Gokaslan
PI: Chetan
Bettegowda
Co-PI: Stephen Yip
PI: Charles Fisher
Co-PI: Michelle
Clarke, Daniel
Sciubba, and Daryl
Fourney
Aim
To determine what variables (clinical, diagnostic, therapeutic, or demographic) are associated with local recurrence and survival within defined groups of primary malignant and
benign bone and soft tissue spine tumors.
1. Overall Analysis - analysis of the complete collection.
2. Histotype Analysis - analysis of each tumor histotype. Each histotype (13 identified)
will undergo a separate analysis by assigned project members.
To determine the role that the SNP rs2305089 has in the prognosis of chordoma patients
by evaluating whether or not there is a relationship between the status of the SNP and
various clinical outcomes/measures (e.g., survival, local recurrence, response to radiation
therapy, response to chemotherapy, link to metastasis, demographics).
To perform a systematic review of the literature for prognostic factors specific to:
1) surgical treatment of prostate metastases to the spine
2) surgical treatment of breast metastases to the spine
3) surgical treatment of renal cell metastases to the spine
4) surgical treatment of lung metastases to the spine
5) symptomatic vertebral hemangioma
To perform a systematic review of the literature for the management of malignant primary
tumors of the spine.
Status: Completion
Project
Title
Investigator(s)
Aim
SINS (Spine Instability
Neoplastic Score)
Interdisciplinary validity and
reliability of the SINS instability
score in radiologists and radiation
oncologists
PI: Charles Fisher
To assess the inter- and intra-observer reliability and validity of SINS in radiologists and
radiation oncologists.
Knowledge Forum Publication Summary can be found on pages 19 to 25
7
Knowledge Forum Deformity
Steering Committee
Marinus
de Kleuver
Chairperson
Lawrence Lenke
Past
Chairperson
VU University
Medical Center
Amsterdam,
the Netherlands
Columbia
University
New York, NY,
USA
Sigurd Berven
Ahmet Alanay
Stephen Lewis
Yong Qiu
Kenneth Cheung
Manabu Ito
David Polly
Christopher
Shaffrey
University of
California San
Francisco
San Francisco,
CA, USA
Acibadem
University School
of Medicine
Istanbul,
Turkey
Toronto Western
Hospital
Toronto, ON,
Canada
Nanjing
University
Nanjing,
China
The University
of Hong Kong
Hong Kong,
China
Hokkaido
University
Sapporo,
Japan
University of
Minnesota
Minneapolis, MN,
USA
University
of Virginia
Charlottesville,
VA, USA
Projects overview
Status: Executing – planning
Project
Title
ASD Complication
Classification
Classification of complications in
adult spinal deformity (ASD)
FLEXIS
FLEXIbility in Scoliosis: Comparison of dynamic radiographs
in determining fusion level in
adolescent idiopathic scoliosis
correction
Investigator(s)
PI: Lawrence Lenke
Co-PI: Christopher
Shaffrey
Aim
To develop and validate a reliable system for categorizing and classifying various complications during and following ASD surgery.
PI: Kenny Kwan
Co-PI: Kenneth
Cheung, Ahmet
Alanay
To identify the dynamic radiograph(s) that can most accurately predict the curve behavior
after surgical correction in patients diagnosed with adolescent idiopathic scoliosis.
Title
Investigator(s)
Aim
PEEDS
Prospective Evaluation of Elderly
Deformity Surgery: a prospective
observational, multicenter study
PI: Stephen Lewis
To show an improvement in SRS-22 total score between baseline and 24 months after
surgery in patients at age 60 or older treated with major spinal reconstruction (spinal
fusion of at least 5 levels) for adult spinal deformity.
COSSCO
Identification of a core outcome
set for spinal deformity surgery
(Core Outcome Set for SCOliosis
– COSSCO)
PI: Marinus de
Kleuver
Status: Executing – data collection
Project
PI: Principle Investigator | Co-PI: Co-Principle Investigator
8
Co-PI: Sigurd
Berven
Co-PI: David Polly
To develop a core outcome set specific to spinal deformity that represents the minimum
that should be measured and reported in all outcome registries of a specific condition.
Status: Disseminating
Project
Title
Investigator(s)
Scoli-Risk 1
Evaluation of neurologic complications associated with surgical
correction of adult spinal deformity (Scoli-RISK-1): a prospective,
observational, multi-center study
PI: Lawrence Lenke
Co-PI: Michael
Fehlings
Aim
To establish the risk of neurologic deficit related to surgical correction of adult spinal
deformity and to identify characteristics associated with increased risk of neurologic
complications related to the surgery.
Remark: This project received co-funding from the Scoliosis Research Society (SRS).
An international consensus on the
appropriate treatment for adults
with spinal deformity
PI: Sigurd Berven
Project
Title
Investigator(s)
Aim
AIS Consensus
An international consensus on the
surgical treatment standards for
adolescent idiopathic scoliosis
PI: Marinus de
Kleuver
To investigate what constitutes optimal operative care for adolescent idiopathic scoliosis
patients between 12 and 20 years of age with curves ranging from 40 to 90 degrees
Cobb angle.
ASD Consensus
Co-PI: Marinus de
Kleuver
To identify goals of care and management strategies that are appropriate for adult spinal
deformity patients based upon worldwide expert opinion.
Status: Completion
Co-PI: Manabu Ito
Knowledge Forum Publication Summary can be found on pages 25 to 30
9
Knowledge Forum Spinal
Cord Injury
Steering Committee
Michael Fehlings
Chairperson
Robert
Grossman
Shekar Kurpad
James Harrop
Bizhan Aarabi
Brian Kwon
University
of Toronto
Toronto, ON,
Canada
The Methodist
Hospital
Houston,TX,
USA
Froedtert & the
Medical College
of Wisconsin
Milwaukee, WI,
USA
Thomas Jefferson
University
Philadelphia, PA,
USA
University of
Maryland
Baltimore, MD,
USA
University of
British Columbia
Vancouver, BC,
Canada
Projects overview
Status: Executing – data collection
Project
RISCIS
Title
A multi-center, randomized,
placebo-controlled, doubleblinded, trial of efficacy and
safety of Riluzole in acute
spinal cord injury
Investigator(s)
Aim
PI: Michael Fehlings
To evaluate efficacy and safety of Riluzole in the treatment of patients with acute
spinal cord injury. The primary objective is to evaluate the superiority of Riluzole as
compared to placebo, in improving motor outcomes as measured by ASIA Motor
Score at 6 months follow-up, in patients with acute
traumatic spinal cord injury, presenting to hospital less than 12 hours after injury.
Remark: Co-sponsered by AOSpine North America, US Department of Defense,
Christopher and Dana Reeve Foundation, Ontario Neurotrauma Foundation, Rick
Hansen Institute.
A set of systematic reviews will serve as the basis of the current state of the field.
Based on this knowledge, a global team of clinical experts in SCI will then go
through the rigorous process of developing evidence-based clinical guidelines for
the treatment of acute spinal cord injury Injury specific to the five selected topics:
SCI Guidelines
Development of an
evidence-based clinical
guideline for the treatment
of acute spinal cord injury
• Use of methylprednisolone
PI: Michael Fehlings
• Timing of decompression
• Role and timing of magnetic resonance imaging
• Type and timing of anticoagulation
• Type and timing of rehabilitation
Remark: Co-sponsored by AOSpine North America
PI: Principle Investigator | Co-PI: Co-Principle Investigator
10
Status: Executing – data analysis
Project
Title
Investigator(s)
Aim
SCI Database Merge
Spinal cord injury database
merge: combining data of two
existing registries (NACTN and
STASCIS)
PI: Michael Fehlings
To combine two existing databases on patients with spinal cord injuries treated
surgically (NACTN and STASCIS) and to assess descriptive data on injury/surgery
details, as well as ASIA score and reported complications.
Knowledge Forum Publication Summary can be found on pages 30 to 32
11
Knowledge Forum Trauma
Steering Committee
Alex Vaccaro
Chairperson
Jens Chapman
Cumhur Öner
Chairperson elect
Frank
Kandziora
S. Rajasekaran
Marcel Dvorak
Klaus Schnake
Thomas
Jefferson
University
Philadelphia, PA,
USA
Swedish
Neurosciene
Institute
Seattle, WA,
USA
University
Medical Center
Utrecht,
the Netherlands
Unfallklinik
Frankfurt
Frankfurt,
Germany
Ganga Hospital
Coimbatore,
India
Vancouver
General Hospital
Vancouver, BC,
Canada
Schön Klinik
Nürnberg Fürth
Fürth,
Germany
Projects overview
Status: Planning – data analysis and reporting
Project
Title
Investigator(s)
Trauma Classification
Development of an AOSpine
trauma injury classification
system
PI: Alex Vaccaro
Co-PI: Cumhur Öner
Aim
To develop and validate a comprehensive classification system of
traumatic spine injuries: phase 1: thoracolumbar system, phase
2: subaxial system, phase 3: sacral system, and phase 4: upper
cervical system.
Status: Executing – data analysis and reporting
Project
Outcome Measurement
Title
Development of an AOSpine
trauma outcome instrument
Investigator(s)
PI: Cumhur Öner
Aim
To develop and validate a multidisciplinary and universal outcome
instrument for spinal trauma patients, which includes both the
patients’ and health professionals’ perspective on health and
functioning:
• Phase 1: define core set
• Phase 2: international consensus conference
• Phase 3: validation
PI: Principle Investigator | Co-PI: Co-Principle Investigator
12
Status: Executing
Project
Title
Investigator(s)
Thoracolumbar Burst
Fractures
Thoracolumbar Burst Fractures
(AOSpine A3, A4) in neurologically intact patients: an
observational, multicenter cohort
study comparing surgical versus
non-surgical treatment
PI: Marcel Dvorak
Co-I: Cumhur Öner
Aim
To establish and quantify the difference in the patients’ clinical
outcome after surgical treatment as compared to non-surgical
treatment of thoracolumbar burst fractures within the first year
after treatment with the Oswestry Disability Index (ODI).
Status: Disseminating
Project
Title
Effect of Riluzole
on Osteogenic
Differentiation
Effect of Riluzole on osteogenetic
differentiation of human mesenchymal stem cells and human
osteoblast
Value of CT and MRI
The additional value of CT and
MRI in determining the fracture
severity and management in
spinal column injuries
Investigator(s)
Aim
PI: Alex Vaccaro
To understand the effects of Riluzole on mesenchymal stem cells'
ability to convert to osteoblasts, on osteogenic and differentiation
and possible toxicity of the drug on these cells.
Co-I: Cumhur Öner
PI: Shanmuganathan Rajasekaran
To define and determine the value of a CT scan and an MRI in
addition to plain radiographs in a cohort of spinal fractures of
various severities.
Knowledge Forum Publication Summary can be found on pages 32 to 35
13
Knowledge Forum
Degenerative/Biologics
Steering Committee
Jeffrey C. Wang
Chairperson
Hans Jörg
Meisel
Tim S. Yoon
Darrel Brodke
Jong-Beom Park
Jim Youssef
USC Spine
Center
Los Angeles, CA,
USA
BG-Clinic
Bergmannstrost
Halle,
Germany
Emory University
Atlanta, GA,
USA
University of Utah
Salt Lake City, UT,
USA
The Catholic
University of
Korea
Uijeongbu-si,
South Korea
Spine Colorado
Durango, CO,
USA
Projects overview
Status: Executing – data collection
Project
Title
DegenPRO
Prospective AOSpine registry
on the use of non-structural
graft material (osteobiologics)
in the surgical treatment of
degenerative spine conditions
Investigator(s)
Aim
PI: Tim Yoon
To better understand what kind of biologics are used in
degenerative cases and to assess their effectiveness in
terms of PRO, complication and fusion rates.
Co-PI: Jeffrey Wang
• Phase 1: Feasibility phase with KF SC members
• Phase 2: Open the registry to other members
Status: Executing – data analysis
Project
Biologics Retrospective
Title
Insurance database
PI: Principle Investigator | Co-PI: Co-Principle Investigator
14
Investigator(s)
Aim
PI: Jeffrey Wang
To mine large databases of HIPAA-compliant orthopedic and
non-orthopedic records that contain charging, reimbursement,
cost, diagnosis, procedure, hospital, patient demographic and
co-morbidity data and other related data that enables us to
evaluate the costs and care patterns for health care services:
Evaluation of trends, complications and costs associated with
the use of biologics in spine surgery.
Status: Disseminating
Project
Title
Investigator(s)
Aim
ACDF Survey
Survey on the current use of
structural and non-structural graft
materials among spine surgeons
worldwide
PI: Tim Yoon
To learn what kind of graft materials spine surgeons around the
world use generally for their ACDF procedures.
PI: All steering committee members
To perform 3 systematic reviews to assess efficacy and safety
of i) ICBG compared with other types of autograft ii) allograft
compared with all other types of graft and iii) DBM compared
with autograft, allograft or other bone graft substitutes in cervical
and thoracolumbar fusion.
Biologics Health
Technology
Assessment
HTA on biologics in spine surgery
Knowledge Forum Publication Summary can be found on pages 36
15
Spine Research Network (SRN)
What is the SRN
The AOSRN is an affiliation of research experts
conducting collaborative applied/translational
research on intervertebral disc regeneration
and degeneration.
Projects overview
Investigator(s)
Center
Duration of
contract / study
Published
manuscripts
Oral
presentations
Poster
presentations
Total
Ari Borthakur
Philadelphia,
PA, USA
01 Oct 07 - 30 Sep 12
6
28
9
44
Thomas Steffen
Montreal, QC,
Canada
01 Sep 07 - 31 Aug 10
3
17
10
30
Danny Chan
Hong Kong,
China
01 Aug 07 - 31 Jul 12
4
15
9
31
Enhancing flow-induced solute transport in
intervertebral disc tissue through electrical
stimulation; applications in the treatment of
disc degeneration
Stephen
Ferguson
Berne,
Switzerland
01 Sep 07 - 31 Aug 10
1
10
0
14
Biomaterials-assisted cell-based therapy for
disc degeneration
Kam Leong
Durham,
NC,USA
01 Feb 08 - 31 Jan 11
14
23
2
39
Identification of endogenous disc-progenitor
cells, its role in homeostasis of disc environment and degeneration, and its use in stem
cell based regeneration
Daisuke Sakai
Japan
01 Sep 07 - 31 Aug 11
13
8
0
24
Morphologic and molecular investigations
of discal inflammatory mechanisms as
sources of painful disc degeneration
Norbert Boos
Zurich,
Switzerland
01 Oct 07 - 30 Sep 11
14
3
13
33
55
104
43
215
Project Title
T1rho-weighted magnetic resonance imaging
as a quantitative biomarker of lumbar disc
degeneration and associated low back pain
Biological repair of the degenerate
intervertebral disc
Genome-wide identification and functional
studies of genetic risk factors for low back pain
and intervertebral disc degeneration
Total
16
Project Title
Quantitative MRI of the intervertebral
disc degeneration
Discovering the genetics, understanding
progenitor cell niche and transcriptional
controls to harness the endogenous
regenerationpotentials of the
intervertebral disc
Notochordal cell technology for
intervertebral disc regeneration​
Biological repair of the degenerate
intervertebral disc
Biomaterial-assisted cell-based therapy
for disc degeneration​
Mesenchymal stem cell chemo-attractive
scaffolds for intervertebral disc regeneration
– in vitro studies using a whole organ culture
system
Investigator(s)
Center
Duration of
contract / study
Published
manuscripts
Oral
presentations
Poster
presentations
Total
Tugan Muftuler
Medical College of
Wisconsin​
Aug 2016 SRN '12 — Single Center​​​
2
2
4
8
Danny Chan
The University of
Hong Kong
Daisuke Sakai
2
2
4
8
Tokai University​
Completed
SRN '12
— Consortium​
Keita Ito
Eindhoven
University of
Technology
Aug 2016 SRN '11
— Consortium
8
6
5
19
Björn Meij
Utrecht University
Lisbet Haglund
McGill University​​
Sept 2016 SRN '11 — Single Center
9
22
28
59
Barbara Chan
The University of
Hong Kong​
Oct 2016 SRN '11
— Consortium
10
12
10
32
Completed
SRN '11
— Consortium
2
3
4
9
33
47
55
135
Mauro Alini
Mario Barbosa
AO Research
Institution
INEB
- Instituto Engenharia Biomédica
Total
SRN Publication Summary can be found on pages 37 to 42
17
AOSpine Research Team
The AOSpine Research Commission, Knowledge
Forums and Spine Research Network activities
are managed by the AOSpine Research Team
located at the AOSpine offices in Duebendorf
and Davos, Switzerland.
Eberhard Denk
Research
Manager​
Duebendorf Office​​
Niccole Germscheid
Project
Manager​
Davos Office
María Alvarez Sánchez
Project
Manager​
Davos Office
Yvonne Wey
Event Project
Coordinator​
Davos Office
Kaija Kurki-Suonio
Research Project
Coordinator​
Davos Office
edenk@aospine.org
ngermscheid@aospine.org
malvarez@aospine.org
ywey@aospine.org
kkurki@aospine.org
AOSpine International
Stettbachstrasse 6
8600 Duebendorf
SWITZERLAND
18
AOSpine International
Clavadelerstrasse 8
7270 Davos Platz
SWITZERLAND
Publication Summary
Knowledge Forum Tumor
Abstracts
Accepted for Presentation
Podium Presentations:
1.
Podium Presentations:
2.
3.
Versteeg AL, Dea N, Boriani S, Varga PP, Luzzati A, Fehlings MG, Bilsky MH, Rhines
LD, Reynolds JJ, Dekutoski MB, Gokaslan ZL, Germscheid NM, Fisher CG. Results
of surgical management and prognostic variables for local recurrence and mortality of spinal osteoblastomas. 16th Annual Scientific Conference of the Canadian
Spine Society (CSS), Whistler, Canada, February 24-27, 2016.
Gokaslan ZL, Zadnik P, Sciubba DM, Germscheid N, Goodwin CR, Wolinsky J-P,
Bettegowda C, Groves M, Luzzati A, Rhines L, Fisher C, Varga PP, Dekutoski MB,
Clarke M, Fehlings MG, Quraishi NA, Chou D, Reynolds JJ, Williams R, Boriani S.
Mobile spine chordoma: results of 166 patients from the AOSpine Knowledge Forum Tumor. North American Spine Society (NASS) 30th Annual Meeting, Chicago,
USA, October 14-17, 2015.
Varga PP, Gokaslan ZL, Fisher C, Boriani S, Wang W-L, Lazary A, Germscheid N,
Bettegowda C, Yip S, Rhines LD. Prognostic significance of T gene SNP rs2305089
in individuals with spinal column chordoma. Scoliosis Research Society (SRS) 50th
Annual Meeting & Course, Minneapolis, MN, USA, September 30-October 3, 2015.
4. Fisher CG, Versteeg AL, Dea N, Boriani S, Varga PP, Dekutoski MB, Luzzati A, Gokaslan ZL, Williams RP, Reynolds JJ, Fehlings MG, Bettegowda C, Rhines LD. Chondrosarcomas of the spine: prognostic variables for local recurrence and mortality
in a multicenter study. 22nd International Meeting on Advanced Spine Techniques
(IMAST), Kuala Lumpur, Malaysia, July 8-11, 2015.
5.
7.
Clarke MJ, Dekutoski MD, Luzzati A, Rhines LD, Varga PP, Rose P, Fisher CG, Chou
D, Fehlings MG, Reynolds JJ, Williams R, Quraishi NA, Germscheid NM, Sciubba D,
Gokaslan ZL, Boriani S. Osteosarcoma of the spine: prognostic variables for local
recurrence and overall survival, a multi-center ambispective study. Global Spine
Congress 2015, Buenos Aires, Argentina, May 20-23, 2015.
8.
G
oldstein CL, Varga PP, Gokaslan ZL, Boriani S, Luzzati A, Rhines L, Fisher CG,
Chou D, Williams RP, Dekutoski MB, Quraishi NA, Bettegowda C, Kawahara N,
Fehlings MG. Outcomes of surgical management and risks of recurrence of symptomatic spinal hemangiomas: a multicenter series of 68 cases. Global Spine Congress 2015, Buenos Aires, Argentina, May 20-23, 2015.
ersteeg AL, Dea N, Boriani S, Varga P, Luzzati A, Fehlings MG, Bilsky MH, Rhines
V
LD, Reynolds JJ, Dekutoski MB, Gokaslan ZL, Germscheid NM, Fisher CG. Surgical
management of spinal osteoblastoma. Global Spine Congress 2016, Dubai, UAE,
April 13-16, 2016.
Presented
1.
6. Rhines LD, Dirks MS, Boriani S, Luzzati A, Fehlings MG, Fisher CG, Dekutoski MB,
Williams R, Quraishi NA, Gokaslan ZL, Bettegowda C, Germscheid N, Varga PP.
Ewing’s sarcoma of the spine: survival and local control in surgically treated patients. 22nd International Meeting on Advanced Spine Techniques (IMAST), Kuala
Lumpur, Malaysia, July 8-11, 2015.
Gokaslan ZL, Zadnik P, Sciubba DM, Germscheid N, Goodwin CR, Wolinsky J-P,
Bettegowda C, Groves M, Luzzati A, Rhines L, Fisher C, Varga PP, Dekutoski MB,
Clarke M, Fehlings MG, Quraishi NA, Chou D, Reynolds JJ, Williams R, Boriani S.
Mobile spine chordoma: results of 166 patients from the AOSpine Knowledge Forum Tumor. 22nd International Meeting on Advanced Spine Techniques (IMAST),
Kuala Lumpur, Malaysia, July 8-11, 2015.
9.
Rhines LD, Dirks MS, Boriani S, Luzzati A, Fehlings MG, Fisher CG, Dekutoski MB,
Williams R, Quraishi NA, Gokaslan ZL, Bettegowda C, Germscheid NM, Varga PP.
Ewing’s sarcoma of the spine: prognostic variables for survival and local control in
surgically treated patients. Global Spine Congress 2015, Buenos Aires, Argentina,
May 20-23, 2015.
10.
Sciubba D, Yurter A, Ju D, Gokaslan Z, Fisher C, Rhines L, Fehlings M, Fourney D,
Mendel E, Laufer I, Bettegowda C, Goodwin CR, Patel S, Rampersaud R, Reynolds J,
Chou D, Weber M, Clarke M. A systematic review of clinical outcomes and prognostic
factors for patients undergoing surgery for spinal metastases secondary to breast
cancer. Global Spine Congress 2015, Buenos Aires, Argentina, May 20-23, 2015.
11.Varga P, Lo S, Puvaneserajah V, Fisher C, Rhines L, Boriani S, Lazary A, Wang W-L,
Gambarotti M, Germscheid NM, Yip S, Gokaslan Z, Bettegowda C. Prognostic significance of T gene SNP rs2305089 in individuals with spinal column chordoma.
Global Spine Congress 2015, Buenos Aires, Argentina, May 20-23, 2015.
12.Varga PP, Szövérfi Z, Lazary A, Gokaslan Z, Fisher C, Boriani S, Dekutoski M, Chou
D, Quraishi N, Fehlings M, Rhines L. Prognostic variables for local recurrence and
overall survival after surgical treatment of sacral chordoma – an analysis from
AOSpine Tumor Knowledge Forum Primary Spinal Tumor Retrospective Database.
Global Spine Congress 2015, Buenos Aires, Argentina, May 20-23, 2015.
13.Versteeg AL, Fisher CG, Boriani S, Varga PP, Dekutoski MB, Luzzati A, Gokaslan
ZL, Williams RP, Reynolds JJ, Fehlings MG, Bettegowda C, Rhines LD. Chondrosarcomas of the spine: prognostic variables for local recurrence and mortality in a
multicenter study. Global Spine Congress 2015, Buenos Aires, Argentina, May 2023, 2015.
19
14.
Zamorano JJ, Fehlings MG, Nater A, Tetreault L, Varga P, Gokaslan ZL, Boriani S,
Fisher CG, Rhines LD, Bettegowda C, Kawahara N, Chou D. Risk factors for local
recurrence after surgical resection of spine schwannomas: retrospective analysis
of 169 patients from a multicenter international database. Global Spine Congress
2015, Buenos Aires, Argentina, May 20-23, 2015.
15.
Lazary A. Local recurrence and overall survival after surgical treatment of sacral
chordoma – an analysis of prognostic variables from AOSpine Knowledge Forum
Primary spinal tumor retrospective database. 11th International Turkish Spine Congress, Cesme, Turkey, April 29-May 3, 2015.
16.
Sewell M. Prognostic factors in the operative management of sacral chordomas.
Spine Society of Australia, 26th Annual Scientific Meeting, Canberra, Australia, April
10-12, 2015.
17.
Sewell M. Systematic review of en bloc resection in the management of Ewing’s
sarcoma of the mobile spine with respect to local control and disease free survival.
Spine Society of Australia, 26th Annual Scientific Meeting, Canberra, Australia, April
10-12, 2015.
18.
Varga P, Szövérfi Z, Gokaslan Z, Fisher C, Boriani S, Dekutoski M, Chou D, Quraishi
N, Fehlings M, Rhines L. Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival. British Association of Spine Surgeons
(BASS) 2015, Bath, UK, March 18-20, 2015.
19.
Williams R, Sewell M, Varga PP, Quraishi N. Systematic review of en bloc resection
in the management of Ewing’s sarcoma of the mobile spine with respect to local
control and disease free survival. British Association of Spine Surgeons (BASS)
2015, Bath, UK, March 18-20, 2015.
20.
Williams R, Sowman B, Boriani S, Varga PP, Luzzati A, Gokaslan ZL, Fehlings MG,
Fisher CG, Dekutoski MB, Rhines LD, Reynolds J, Bettegowda C, Kawahara N, Quraishi NA. Spinal osteoid osteoma: a multicenter retrospective cohort study comparison of results with appendicular osteoid osteoma. British Association of Spine
Surgeons (BASS) 2015, Bath, UK, March 18-20, 2015.
21.Boriani S, Lo SL, Puvanesarajah V, Chou D, Fisher CG, Rhines LD, Williams R, Varga
PP, Szövérfi Z. Aneurysmal bone cysts of the spine: treatment options and considerations. EuroSpine 2014, Lyon, France, October 1-3, 2014.
22.Clarke MJ, Varga PP, Rhines LD, Fisher CG, Chou D, Quraishi NA, Fehlings MG,
Gokaslan ZL, Boriani S. Primary osteosarcomas of the spine: a multicenter review
of 57 surgical cases. EuroSpine 2014, Lyon, France, October 1-3, 2014.
23.Goldstein CL, Varga PP, Gokaslan ZL, Boriani S, Luzzati A, Rhines LD, Fisher CG,
Chou D, Quraishi NA, Fehlings MG. Hemangiomas of the spine: results of surgical management and prognostic variables for local recurrence and mortality in a
multicenter study. EuroSpine 2014, Lyon, France, October 1-3, 2014.
24.
Quraishi NA, Boriani S, Varga PP, Luzzati A, Gokaslan ZL, Fehlings MG, Fisher CG,
Rhines LD, Reynolds JJ, Williams R. A multicenter retrospective cohort study of spinal osteoid osteomas: surgical treatment and local recurrence results. EuroSpine
2014, Lyon, France, October 1-3, 2014.
25.Varga P, Macki M, Bydon M, Sciubba DM, Wolinsky JP, Fisher CG, Reynolds JJ,
Rhines LD, Chou D, Szövérfi Z, Gokaslan ZL. Long-term outcomes in primary,
20
spinal osteochondroma: a multicenter study of 27 patients. EuroSpine 2014, Lyon,
France, October 1-3, 2014.
26.Varga PP, Fisher CG, Rhines LD, Boriani S, Lazary A, Wang W-L, Germscheid N, Yip S,
Bettegowda C. Prognostic significance of T gene SNP rs2305089 in individuals with
spinal column chordoma. EuroSpine 2014, Lyon, France, October 1-3, 2014.
27.Varga PP, Szövérfi Z, Gokaslan Z, Fisher C, Boriani S, Dekutoski M, Chou D, Quraishi N, Fehlings M, Rhines L. Prognostic variables for local recurrence and overall
survival after surgical treatment of sacral chordoma an analysis from AOSpine
Tumor Knowledge Forum primary spinal retrospective database. EuroSpine 2014,
Lyon, France, October 1-3, 2014.
28.Boriani S, Lo SL, Puvanesarajah V, Fisher CG, Rhines LD, Germscheid NM, Chou
D, Williams RP, Bettegowda C, Gokaslan ZL. Aneurysmal bone cysts of the spine:
treatment options and considerations. 27th Annual Meeting of the European Musculo-Skeletal Oncology Society (EMSOS), Vienna, Austria, May 21-23, 2014.
29.
Varga P, Gokaslan ZL, Sciubba DM, Wolinsky J, Bettegowda C, Luzzati A, Rhines L,
Fisher C, Dekutoski M, Boriani S. Mobile spine chordoma. Results of 168 patients
from the AOSpine Primary Tumor Knowledge Forum. 27th Annual Meeting of the
European Musculo-Skeletal Oncology Society (EMSOS), Vienna, Austria, May 2123, 2014.
30.Varga P, Szövérfi Z, Gokaslan Z, Fisher C, Boriani S, Dekutoski M, Chou D, Quraishi
N, Fehlings M, Rhines L. Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival. 27th Annual Meeting of the European
Musculo-Skeletal Oncology Society (EMSOS), Vienna, Austria, May 21-23, 2014.
31.
Varga PP, Dirks MS, Rhines LD, Boriani S, Luzzati A, Fehlings MG, Fisher CG, Dekutoski MB, Williams RP, Gokaslan ZL. Ewing’s sarcoma of the spine: prognostic variables for recurrence and survival in surgically treated patients. 27th Annual Meeting
of the European Musculo-Skeletal Oncology Society (EMSOS), Vienna, Austria, May
21-23, 2014.
32.Varga PP, Fisher CG, Rhines LD, Gokaslan ZL, Boriani S, Lazary A, Wang W, Bozsodi A, Yip S, Bettegowda C. Prognostic significance of T gene SNP rs2305089 in
individuals with spinal column chordoma. 27th Annual Meeting of the European
Musculo-Skeletal Oncology Society (EMSOS), Vienna, Austria, May 21-23, 2014.
33.
Williams R, Sowman B, Boriani S, Varga P, Luzzati A, Gokaslan Z, Fehlings M, Fisher
C, Dekutoski M, Rhines L, Reynolds J, Bettegowda C, Kawahara N, Quraishi NA.
Spinal osteoid osteoma: a multicentre retrospective cohort study comparison of
results with appendicular osteoid osteoma. Spine Society of Australia 25th Annual
Scientific Meeting, Brisbane, Australia, April 10-12, 2014.
34.
Zadnik P, Varga P, Bettegowda C, Fisher C, Fehlings M, Quraishi N, Luzzati A,
Rhines L, Wolinsky JP, Sciubba D, Dekutoski M, Kawahara N, Boriani S, Gokaslan
Z. Survival and recurrence following resection of chordoma in the mobile spine:
results of 171 patients from the AOSpine Primary Tumor Knowledge Forum. 82nd
American Association of Neurological Surgeons (AANS) Annual Scientific Meeting,
San Francisco, CA, USA, April 5-9, 2014.
35.
Zadnik P, Varga P, Bettegowda C, Fisher C, Fehlings M, Quraishi N, Luzzati A,
Rhines L, Wolinsky JP, Sciubba D, Dekutoski M, Kawahara N, Boriani S, Gokaslan
Z. Survival and recurrence following resection of chordoma in the mobile spine:
results of 171 patients from the AOSpine Primary Tumor Knowledge Forum. 30th
Annual Meeting of the AANS/CNS Section on Disorders of the Spine and Peripheral
Nerves, Orlando, FL, USA, March 5-8, 2014.
36.
Goldstein C, Varga P, Gokaslan Z, Boriani S, Luzzati A, Williams R, Rhines L, Fisher
C, Chou D, Dekutoski M, Quraishi N, Bettegowda C, Kawahara N, Fehlings M. Hemangiomas of the spine: results of surgical management and prognostic variables
for local recurrence and mortality in a multicenter study. 30th Annual Meeting of
the AANS/CNS Section on Disorders of the Spine and Peripheral Nerves, Orlando,
USA, March 5-8, 2014.
37.Fehlings M, Zamorano JJ, Nater A, Tetreault L, Varga P, Gokaslan Z, Boriani S, Fisher
C, Rhines L, Bettegowda C, Kawahara N, Chou D. Risk factors for recurrence of
surgically treated spine schwannomas: analysis of 169 patients from a multicenter
international database. Combined meeting with the Canadian Spine Society and
the New Zealand Spine Society 2014, Lake Louise, AB, Canada, February 25-March
1, 2014.
38.
Fisher C, Versteeg A, Boriani S, Varga PP, Dekutoski MB, Gokaslan ZL, Williams RP,
Reynolds JJ, Fehlings MG, Bettegowda C, Kawahara N, Rhines LD. Chondrosarcomas
of the spine: prognostic variables for local recurrence and mortality in a multicenter
study. Combined meeting with the Canadian Spine Society and the New Zealand
Spine Society 2014, Lake Louise, AB, Canada, February 25-March 1, 2014.
39.
Goldstein C, Varga P, Gokaslan Z, Boriani S, Luzzati A, Williams R, Rhines L, Fisher
C, Chou D, Dekutoski M, Quraishi N, Bettegowda C, Kawahara N, Fehlings M. Hemangiomas of the spine: results of surgical management and prognostic variables
for local recurrence and mortality in a multicenter study. Combined meeting with
the Canadian Spine Society and the New Zealand Spine Society 2014, Lake Louise,
AB, Canada, February 25-March 1, 2014.
40.Boriani S, Lo SL, Puvanesarajah V, Fisher CG, Varga PP, Rhines LD, Germscheid NM,
Luzzati A, Chou D, Reynolds JJ, Williams RP, Zadnik P, Groves M, Sciubba DM, Bettegowda C, Gokaslan ZL, Ospine Knowledge Forum Tumor. Aneurysmal bone cysts of
the spine: treatment options and considerations. Association for Collaborative Spine
Research Meeting (ACSR), San Diego, CA, USA, January 30-February 1, 2014.
41.
Clarke M. Systematic review of survival and outcomes in prostate cancer metastases to the spine. Association for Collaborative Spine Research Meeting (ACSR),
San Diego, CA, USA, January 30-February 1, 2014.
42.
Fisher C. Influence of clinical and histopathologic parameters in the management
of metastatic disease of the spine secondary to lung cancer – a systematic review.
Association for Collaborative Spine Research Meeting (ACSR), San Diego, CA, USA,
January 30-February 1, 2014.
43.Fisher CG, Boriani S, Varga PP, Rhines LD, Bilsky MH, Dekutoski MB, Fehlings MG,
Reynolds J, Williams R, Chou D, Quraishi NA, Bettegowda C, Gokaslan ZL, Aospine Knowledge Forum Tumor. The new frontier for research and management of
primary tumors of the spine. Association for Collaborative Spine Research Meeting
(ACSR), San Diego, CA, USA, January 30-February 1, 2014.
44.
Rampersaud R. Determining optimal structural bone graft for reconstruction following en bloc resection of primary spine tumors: a synthesis of best available
evidence and expert opinion. Association for Collaborative Spine Research Meeting,
San Diego, CA, USA, January 30-February 1, 2014.
45.
Rampersaud R. Determining optimal bone graft for reconstruction following
surgery for metastatic spine disease: a synthesis of best available evidence and
expert opinion. Association for Collaborative Spine Research Meeting, San Diego,
CA, USA, January 30-February 1, 2014.
46.
Sciubba D. Systematic review of survival and outcomes in breast cancer metastases to the spine. Association for Collaborative Spine Research Meeting (ACSR), San
Diego, CA, USA, January 30-February 1, 2014.
47.Varga P, Fisher C, Rhines L, Gokaslan Z, Boriani S, Lazary A, Wang WL, Germscheid
N, Yip S, Bettegowda C. Prognostic significance of T gene SNP rs2305089 in individuals with spinal column chordoma. Association for Collaborative Spine Research
Meeting (ACSR), San Diego, CA, USA, January 30-February 1, 2014.
48.Varga P, Macki M, Bydon M, Sciubba D, Wolinsky JP, Boriani S, Bettegowda C, Chou
D, Fisher CG, Luzzati A, Reynolds JJ, Germscheid NM, Zadnik P, Rhines LD, Gokaslan
ZL, Aospine Knowledge Forum Tumor. Long-term outcomes in primary, spinal osteochondroma: a multicenter study of 27 patients. Association for Collaborative
Spine Research Meeting (ACSR), San Diego, CA, USA, January 30-February 1, 2014.
49.
Wu AS, Fourney D. A systematic review of aggressive and symptomatic vertebral
hemangioma. Association for Collaborative Spine Research Meeting (ACSR), San
Diego, CA, USA, January 30-February 1, 2014.
50.
Wu AS, Fourney D. A systematic review of prognosis and treatment outcomes for
metastatic renal cell carcinoma to the spine. Association for Collaborative Spine
Research Meeting (ACSR), San Diego, CA, USA, January 30-February 1, 2014.
51.
Fisher C, Boriani S, Varga PP, Fehlings M, Bilsky MH, Dekutoski MB, Williams RP,
Berven SH, Chou D, Reynolds J, Quraishi NA, Rhines L, Bettegowda C, Gokaslan ZL.
A novel scientific model for rare and often neglected neoplastic conditions: AOSpine International Knowledge Forum Tumor database for primary tumors of the
spine. North American Spine Society (NASS) 28th Annual Meeting, New Orleans,
LA, USA, October 9-12, 2013.
52.
Reynolds J, Fisher C, Boriani S, Varga PP, Fehlings M, Bilsky MH, Dekutoski MB,
Rhines L, Bettegowda C, Gokaslan ZL. A novel scientific model for rare and often neglected neoplastic conditions. EuroSpine 2013, Liverpool, UK, October 2-4,
2013.
53.
Fisher C, Fehlings M, Bilsky M, Dekutoski M, Luzzati A, Williams R, Berven S, Quraishi N, Rhines L, Bettegowda C, Gokaslan Z. A novel scientific model for rare and
often neglected neoplastic conditions: AOSpine knowledge forum tumor international dataset for primary tumors of the spine. 20th International Meeting on Advanced Spine Techniques (IMAST), Vancouver, BC, Canada, July 10-13, 2013.
54.
Fisher C, Rhines L, Kawahara N, Fourney D, Reynolds J, Fehlings M, Schouten
R, Gokaslan ZL. Spinal Instability Neoplastic Score: an analysis of reliability and
validity in radiation oncologists: an AOSpine knowledge forum tumor project. 20th
International Meeting on Advanced Spine Techniques (IMAST), Vancouver, BC, Canada, July 10-13, 2013.
55.Fisher C, Boriani S, Varga PP, Fehlings M, Bilsky MH, Dekutoski M, Luzzati A, Williams RP, Berven SH, Chou D, Reynolds JJ, Quraishi N, Rhines LD, Bettegowda C,
Gokaslan Z. A novel evidence based model for rare and often neglected neoplastic
conditions. 3rd Charité Spine Tumor Days, Berlin, Germany, May 31-June 1, 2013.
21
56.Fisher C, Boriani S, Varga PP, Rhines L, Kawahara N, Fourney D, Reynolds J, Fehlings M, Schouten R, Gokaslan Z. Assessing the reliability of Spinal Instability Neoplastic Score (SINS) among radiation oncologists and radiologists. 3rd Charité
Spine Tumor Days, Berlin Germany, May 31-June 1, 2013.
57.Fisher C, Boriani S, Varga PP, Rhines L, Kawahara N, Fourney D, Reynolds J, Fehlings M, Schouten R, Gokaslan Z. Spinal instability neoplastic score: an analysis
of reliability and validity in radiation oncologists. An AOSpine Knowledge Forum
tumor project. Global Spine Congress 2013, Hong Kong, China, April 4-6, 2013.
58.
Bettegowda C. AOSpine Tumor Knowledge Forum Biobank. Fourth International
Chordoma Research Workshop, Boston, MA, USA, March 21-22, 2013.
59.Fisher C, Goldschlager T, Boriani S, Varga PP, Fehlings MG, Bilsky MH, Dekutoski
M, Luzzati A, Williams RP, Berven SH, Chou D, Quraishi N, Rhines LD, Bettegowda
C, Gokaslan Z. A novel scientific model for rare and often neglected neoplastic
conditions. 11th Annual AOSpine North America Fellows Forum, Banff, AB, Canada,
March 14-16, 2013.
60.
Fisher C, Boriani S, Varga PP, Fehlings M, Bilsky MH, Dekutoski M, Luzzati A, Williams RP, Berven SH, Chou D, Quraishi N, Rhines LD, Bettegowda C, Gokaslan Z.
A novel scientific model for rare and often neglected neoplastic conditions. 13th
Annual Scientific Conference of the Canadian Spine Society (CSS), Mont-Tremblant,
QC, Canada, February 27-March 2, 2013.
61.Fisher C, Nadeau M, Varga P, Boriani S, Rhines L, Kawahara N, Fourney D, Reynolds
J, Fehlings M, Schouten R, Gokaslan Z. Spinal instability neoplastic score: an analysis of reliability and validity in radiologists: An AOSpine Knowledge Forum Tumor
project. 13th Annual Scientific Conference of the Canadian Spine Society (CSS),
Mont-Tremblant, QC, Canada, February 27-March 2, 2013.
62.Fisher C, Boriani S, Varga PP, Rhines LD, Bilsky MH, Dekutoski MB, Fehlings MG, Reynolds JJ, Williams RP, Chou D, Berven S, Quraishi NA, Bettegowda C, Gokaslan ZL. A
novel model for rare and often neglected neoplastic conditions. Association for Collaborative Spine Research Meeting (ACSR), San Diego, CA, USA, February 15-16, 2013.
63.
Fisher C, Boriani S, Varga PP, Rhines LD, Kawahara N, Fourney D, Reynolds JJ,
Fehlings MG, Schouten R, Gokaslan Z. Spinal Instability Neoplastic Score (SINS):
reliability and validity in radiation oncologists. Association for Collaborative Spine
Research Meeting (ACSR), San Diego, CA, USA, February 15-16, 2013.
Poster Presentations
1.
Clarke M, Molina C, Fourney D, Fisher C, Gokaslan Z, Schmidt M, Rhines L, Fehlings M, Laufer I, Patel S, Rampersaud R, Reynolds J, Chou D, Bettegowda C,
Mendel E, Weber M, Sciubba D. Systematic review of surgical treatment outcomes
of prostate metastases to the spine. Global Spine Congress 2015, Buenos Aires,
Argentina, May 20-23, 2015.
2.
Sahgal A, Schouten R, Versteeg A, Boriani S, Varga PP, Rhines L, Kawahara N,
Fourney D, Weir L, Reynolds J, Fehlings M, Gokaslan Z, Fisher C. A multi-institutional study evaluating the reliability of the spinal instability neoplastic score (SINS)
among radiation oncologists for spinal metastases. 56th Annual Meeting of the
American Society for Radiation Oncology (ASTRO), San Francisco, CA, USA, September 14-17, 2014.
22
3.
Dekutoski MB, Boriani S, Rose PS, Clarke MJ, Varga PP, Rhines LD, Fisher CG,
Chou D, Quraishi NA, Fehlings MG, Gokaslan ZL. Enneking appropriate en bloc
surgery of osteogenic sarcoma of the spine results in reduced local recurrence
and enhanced survival over Enneking inappropriate intralesional surgery. Scoliosis
Research Society (SRS) 49th Annual Meeting & Course, Anchorage, AK, USA, September 10-13, 2014.
4.
Varga P, Macki M, Bydon M, Sciubba DM, Wolinsky J, Boriani S, Reynolds JJ, Rhines
LD, Fisher CG, Gokaslan ZL. Long-term outcomes in primary spinal osteochondroma: a multicenter center study of 27 patients. 27th Annual Meeting of the European Musculo-Skeletal Oncology Society (EMSOS), Vienna, Austria, May 21-23, 2014.
5.Fisher CG, Versteeg A, Boriani S, Varga PP, Dekutoski MB, Gokaslan ZL, Williams
RP, Reynolds JJ, Fehlings MG, Bettegowda C, Kawahara N, Rhines LD. Chondrosarcomas of the spine: prognostic variables for local recurrence and mortality in
a multicenter study. 82nd American Association of Neurological Surgeons (AANS)
Annual Scientific Meeting, San Francisco, CA, USA, April 5-9, 2014.
6.Quraishi N, Boriani S, Varga P, Luzzati A, Gokaslan Z, Fehlings M, Dekutoski M,
Rhines L, Reynolds J, Bettegowda C, Kawahara N, Williams R. A multi-center retrospective cohort study of spinal osteoid osteomas: surgical treatment and local
recurrence results. 82nd American Association of Neurological Surgeons (AANS)
Annual Scientific Meeting, San Francisco, CA, USA, April 5-9, 2014.
7.Rhines LD, Dirks MS, Boriani S, Luzzati A, Fehlings MG, Fisher CG, Dekutoski MB,
Williams R, Quraishi NA, Gokaslan ZL, Bettegowda C, Kawahara N, Varga PP. Ewing’s
sarcoma of the spine: prognostic variables for recurrence and survival in surgically
treated patients. 82nd American Association of Neurological Surgeons (AANS) Annual Scientific Meeting, San Francisco, CA, USA, April 5-9, 2014.
8.Varga P, Macki M, Bydon M, Boriani S, Fisher C, Rhines L, Chou D, Luzzati A, Reynolds J, Kawahara N, Bettegowda C, Sciubba D, Wolinsky J, Gokaslan Z. Long-term
outcomes in primary spinal osteochondroma: a multicenter study of 27 patients.
82nd American Association of Neurological Surgeons (AANS) Annual Scientific
Meeting, San Francisco, CA, USA, April 5-9, 2014.
9.
Zamorano JJ, Fehlings M, Nater A, Tetreault L, Varga P, Gokaslan Z, Boriani S, Fisher
C, Rhines L, Bettegowda C, Kawahara N, Chou D. Local recurrence risk factors after
surgical resection of spine schwannomas: analysis of 169 patients from a multicenter international database. 82nd American Association of Neurological Surgeons (AANS) Annual Scientific Meeting, San Francisco, CA, USA, April 5-9, 2014.
10.Varga P, Fisher C, Rhines L, Gokaslan Z, Boriani S, Lazary A, Wang W-L, Germscheid
N, Yip S, Bettegowda C. Prognostic significance of T gene SNP s2305089 in individuals with spinal column chordoma. American Association for Cancer Research
(AACR) 105th Annual Meeting 2014, San Diego, CA, USA, April 5-9, 2014.
11.
Quraishi NA, Boriani S, Varga P, Luzzati A, Gokaslan ZL, Fehlings MG, Fisher C,
Dekutoski M, Rhines L, Reynolds J, Bettegowda C, Kawahara N, Williams R. A multi-center retrospective cohort study of spinal osteoid osteomas: surgical treatment
and local re-currence results. BritSpine 2014, Warwick, UK, April 1-4, 2014.
12.
Lo SL, Puvanesarajah V, Germscheid N, Chou D, Fisher C, Rhines LD, Williams
RP, Boriani S, Gokaslan ZL, Bettegowda C. Aneurysmal bone cysts of the spine:
treatment options and considerations (manuscript-for Mayfield Clinical Science
Award). 30th Annual Meeting of the AANS/CNS Section on Disorders of the Spine
and Peripheral Nerves, Orlando, FL, USA, March 5-8, 2014.
13.
Reynolds J, Fisher C, Boriani S, Varga PP, Rhines L, Kawahara N, Fourney D, Fehlings M, Schouten R, Gokaslan Z. Spinal Instability Neoplastic Score: an analysis of
reliability and validity in radiologists. EuroSpine 2013, Liverpool, UK, October 2-4,
2013.
14.Fisher C, Boriani S, Varga PP, Fehlings MG, Bilsky MH, Dekutoski MB, Luzzati A,
Williams RP, Berven S, Chou D, Quraishi NA, Rhines LD, Bettegowda C, Gokaslan
ZL. A novel scientific model for rare and often neglected neoplastic conditions:
AOSpine Knowledge Forum multicenter, international dataset for primary tumors
of the spine. Global Spine Congress 2013, Hong Kong, China, April 4-6, 2013.
15.Fisher C, Varga PP, Boriani S, Rhines LD, Kawahara N, Fourney D, Reynolds JJ, Fehlings M, Schouten R, Gokaslan Z. Spinal instability neoplastic score: an analysis of
reliability and validity in radiologists, an AOSpine Knowledge Forum Tumor project,
Global Spine Congress 2013, Hong Kong, China, April 4-6, 2013.
Manuscripts
Submitted
1.Batista N, Tee JW, Sciubba DM, Fourney DR, Sahgal A, Laufer I, Weber MH, Gokaslan
ZL, Rhines LD, Fehlings MG, Mendel E, Patel SR, Rampersaud YR, Reynolds JJ, Chou
D, Bettegowda C, Clarke M, Fisher CG. Influence of clinical and histopathologic
parameters on surgical decision making for metastatic disease of the spine secondary to lung cancer - a systematic review. J Clin Neurosci, December, 2015.
2.Chou D, Bilsky MH, Luzzati A, Fisher CG, Gokaslan ZL, Rhines LD, Dekutoski MB, Fehlings MG, Gahg R, Varga P, Boriani S, Germscheid NM, Reynolds JJ, Aospine Knowledge Forum Tumor. Malignant peripheral nerve sheath tumors of the spine: results
of surgical management from a multicenter study. Spine J, December, 2015.
3.Weber MH, Kumar A, Molina CA, Fourney D, Fisher M, Charles G, Gokaslan ZL,
Wolinsky J-P, Schmidt M, Rhines LD, Fehlings MG, Laufer I, Sciubba DM, Clarke
MJ, Sundaresan N, Verlaan J-J, Sahgal A. Metastatic spinal cord compression and
steroid treatment; a systematic review. Global Spine J, November, 2015.
4.Quraishi NA, Boriani S, Kumar A, Varga PP, Luzzati A, Gokaslan ZL, Fehlings MG,
Fisher CG, Dekutoski MB, Rhines LD, Reynolds JJ, Germscheid NM, Bettegowda C,
Williams RP, Aospine Knowledge Forum Tumor. A multicenter cohort study of spinal
osteoid osteomas: results of surgical treatment and analysis of local recurrence.
Spine J, October, 2015.
5.Bettegowda C, Yip S, Lo SL, Fisher CG, Boriani S, Rhines LD, Wang JY, Lazary A,
Gambarotti M, Wang W, Luzzati A, Dekutoski MB, Bilsky MH, Chou D, Fehlings MG,
Mccarthy EF, Quraishi NA, Reynolds JJ, Sciubba DM, Williams RP, Wolinsky JP, Zadnik
PL, Germscheid NM, Kalampoki V, Varga PP, Gokaslan ZL, Aospine Knowledge Forum Tumor. Spinal column chordoma: prognostic significance of clinical variables
and T (brachyury) gene SNP rs2305089 for local recurrence and overall survival:
an ambispective cohort analysis. Neuro Oncol, September, 2015.
Mendel E, Weber MH, Sciubba DM. Systematic review of the outcomes of surgical
treatment of prostate metastases to the spine. Global Spine J, August, 2015.
Accepted
1.Dekutoski MB, Clarke M, Rose P, Luzzati A, Rhines LD, Varga PP, Fisher CG, Chou D,
Fehlings MG, Reynolds JJ, Williams R, Quraishi NA, Germscheid NM, Sciubba DM,
Gokaslan ZL, Boriani S, Aospine Knowledge Forum Tumor. Osteosarcoma of the
spine: prognostic variables for local recurrence and overall survival, a multi-center
ambispective study. J Neurosurg Spine, November, 2015.
2.Sciubba DM, Yurter A, Ju D, Gokaslan ZL, Fisher C, Rhines LD, Fehlings MG, Fourney DR, Mendel E, Laufer I, Bettegowda C, Goodwin CR, Patel SR, Rampersaud
YR, Sahgal A, Reynolds JR, Chou D, Weber MH, Clarke MJ. A systematic review of
clinical outcomes and prognostic factors for patients undergoing surgery for spinal
metastases secondary to breast cancer. Global Spine J, August, 2015.
Published
1.Fisher CG, Versteeg AL, Dea N, Boriani S, Varga PP, Dekutoski MB, Luzzati A, Gokaslan ZL, Williams RP, Reynolds JJ, Fehlings MG, Germscheid NM, Bettegowda
C, Rhines LD. Surgical management of spinal chondrosarcomas. [Epub ahead of
print] Spine (Phila Pa 1976), February 4, 2016.
2.Fehlings MG, Nater A, Zamorano JJ, Tetreault LA, Varga PP, Gokaslan ZL, Boriani S,
Fisher CG, Rhines L, Bettegowda C, Kawahara N, Chou D. Risk factors for recurrence
of surgically treated conventional spinal schwannomas: Analysis of 169 patients
from a multicenter international database. Spine (Phila Pa 1976) 41(5): 390-398,
2016.
3.Gokaslan ZL, Zadnik PL, Sciubba DM, Germscheid N, Goodwin CR, Wolinsky JP,
Bettegowda C, Groves ML, Luzzati A, Rhines LD, Fisher CG, Varga PP, Dekutoski MB,
Clarke MJ, Fehlings MG, Quraishi NA, Chou D, Reynolds JJ, Williams RP, Kawahara
N, Boriani S. Mobile spine chordoma: results of 166 patients from the AOSpine
Knowledge Forum Tumor database. [Epub ahead of print] J Neurosurg Spine: 1-8,
December 18, 2015.
4.Goldstein CL, Varga PP, Gokaslan ZL, Boriani S, Luzzati A, Rhines L, Fisher CG, Chou
D, Williams RP, Dekutoski MB, Quraishi NA, Bettegowda C, Kawahara N, Fehlings
MG. Spinal hemangiomas: results of surgical management for local recurrence
and mortality in a multicenter study. Spine (Phila Pa 1976) 40(9): 656-664, 2015.
5.Sciubba DM, Macki M, Bydon M, Germscheid NM, Wolinsky JP, Boriani S, Bettegowda C, Chou D, Luzzati A, Reynolds JJ, Szoverfi Z, Zadnik P, Rhines LD, Gokaslan ZL,
Fisher CG, Varga PP. Long-term outcomes in primary spinal osteochondroma: a
multicenter study of 27 patients. J Neurosurg Spine 22(6): 582-588, 2015.
6.Sewell MD, Tan KA, Quraishi NA, Preda C, Varga PP, Williams R. Systematic review of EN bloc resection in the management of Ewing’s Sarcoma of the mobile
spine with respect to local control and disease-free survival. Medicine (Baltimore)
94(27): e1019, 2015.
6.Clarke MJ, Molina C, Fourney DR, Fisher C, Gokaslan ZL, Schmidt M, Rhines L, Fehlings MG, Laufer I, Patel SR, Rampersaud R, Reynolds JR, Chou D, Bettegowda C,
23
7.Varga PP, Szoverfi Z, Fisher CG, Boriani S, Gokaslan ZL, Dekutoski MB, Chou D,
Quraishi NA, Reynolds JJ, Luzzati A, Williams R, Fehlings MG, Germscheid NM,
Lazary A, Rhines LD. Surgical treatment of sacral chordoma: prognostic variables
for local recurrence and overall survival. Eur Spine J 24(5): 1092-1101, 2015.
8.Boriani S, Lo SF, Puvanesarajah V, Fisher CG, Varga PP, Rhines LD, Germscheid
NM, Luzzati A, Chou D, Reynolds JJ, Williams RP, Zadnik P, Groves M, Sciubba DM,
Bettegowda C, Gokaslan ZL. Aneurysmal bone cysts of the spine: treatment options
and considerations. J Neurooncol 120(1): 171-178, 2014.
9.Fisher CG, Goldschlager T, Boriani S, Varga PP, Rhines LD, Fehlings MG, Luzzati A,
Dekutoski MB, Reynolds JJ, Chou D, Berven SH, Williams RP, Quraishi NA, Bettegowda C, Gokaslan ZL. An evidence-based medicine model for rare and often
neglected neoplastic conditions. J Neurosurg Spine 21(5): 704-710, 2014.
10.Fisher CG, Schouten R, Versteeg AL, Boriani S, Varga PP, Rhines LD, Kawahara N,
Fourney D, Weir L, Reynolds JJ, Sahgal A, Fehlings MG, Gokaslan ZL. Reliability of
the Spinal Instability Neoplastic Score (SINS) among radiation oncologists: an assessment of instability secondary to spinal metastases. Radiat Oncol 9(69), 2014.
11.Fisher CG, Versteeg AL, Schouten R, Boriani S, Varga PP, Rhines LD, Heran MK,
Kawahara N, Fourney D, Reynolds JJ, Fehlings MG, Gokaslan ZL. Reliability of the
spinal instability neoplastic scale among radiologists: an assessment of instability
secondary to spinal metastases. AJR Am J Roentgenol 203(4): 869-874, 2014.
12.Fisher CG, Goldschlager T, Boriani S, Varga PP, Fehlings MG, Bilsky MH, Dekutoski
MB, Luzzati A, Williams RP, Berven S, Chou D, Reynolds JJ, Quraishi NA, Rhines LD,
Bettegowda C, Gokaslan ZL. A novel scientific model for rare and often neglected
neoplastic conditions. Evid Based Spine Care J 4(2): 160-162, 2013.
Book Chapters
1.Li YM, Dirks MS, Tatsui CE, Rhines LD. Evaluation and decision making for metastatic
spinal tumors, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 1: Metastatic Spinal Tumors. Thieme, New York, 2015, pp. 1-13.
2.Fourney DR, Fisher CG. Neoplastic Spinal Instability, in: Vialle LR, Fisher CG, Boriani
S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 1: Metastatic Spinal Tumors. Thieme, New York, 2015, pp. 14-22.
3.Lo SS, Sahgal A, Chang EL. Major complications associated with stereotactic ablative radiotherapy for spinal metastasis, in: Vialle LR, Fisher CG, Boriani S, Gokaslan
ZL, (eds.), AOSpine Masters Series, Volume 1: Metastatic Spinal Tumors. Thieme,
New York, 2015, pp. 23-33.
4.Laufer I, Wolinsky JP, Bilsky MH. En bloc resection in the treatment of spinal metastases: technique and indications, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL,
(eds.), AOSpine Masters Series, Volume 1: Metastatic Spinal Tumors. Thieme, New
York, 2015, pp. 34-44.
5.Lina IA, Zadnik PL, Sciubba DM. Region-specific approaches, in: Vialle LR, Fisher CG,
Boriani S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 1: Metastatic Spinal
Tumors. Thieme, New York, 2015, pp. 45-60.
24
6.Saigal R, Chou D. Spinal reconstruction and fixation/fusion, in: Vialle LR, Fisher CG,
Boriani S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 1: Metastatic Spinal
Tumors. Thieme, New York, 2015, pp. 61-72.
7.Schmidt MH. Minimally invasive surgery for metastatic spine disease, in: Vialle
LR, Fisher CG, Boriani S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 1:
Metastatic Spinal Tumors. Thieme, New York, 2015, pp. 73-83.
8.Mendel E, Bourekas EC, Porensky P. Vertebral augmentation for metastatic disease, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 1: Metastatic Spinal Tumors. Thieme, New York, 2015, pp. 84-93.
9.Clarke MJ. Surgical complications and their avoidance, in: Vialle LR, Fisher CG,
Boriani S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 1: Metastatic Spinal
Tumors. Thieme, New York, 2015, pp. 94-103.
10.Boriani S, Fisher CG. Evaluation and decision making, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 2: Primary Spinal
Tumors. Thieme, New York, 2015, pp. 1-14.
11.Fourney DR, Fisher CG, Boriani S. Safety and efficacy of surgery for primary tumors
of the spine, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL, (eds.), AOSpine Masters
Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp. 15-22.
12.Kathuria S. Interventional options for primary tumors of the spine, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 2: Primary
Spinal Tumors. Thieme, New York, 2015, pp. 23-34.
13.Kimball BY, Yamada Y. Radiation therapy for primary bone tumors, in: Vialle LR,
Fisher CG, Boriani S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp. 35-49.
14.Okuno SH, Robinson SI, Patel S. Medical oncology principles for the spine oncology
surgeon, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL, (eds.), AOSpine Masters
Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp. 50-59.
15.Nadeau M, Dipaola CP. Spinal osteoid osteoma and osteoblastoma, in: Vialle LR,
Fisher CG, Boriani S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp. 60-70.
16.Boriani S, Bandiera S, Ghermandi R, Colangeli S, Amendola L, Gasbarrini A. Aneurysmal bone cyst and giant cell tumor, in: Vialle LR, Fisher CG, Boriani S, Gokaslan
ZL, (eds.), AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New
York, 2015, pp. 71-84.
17.Sui J, Zadnik PL, Groves ML, Gokaslan ZL. Chordoma, in: Vialle LR, Fisher CG, Boriani
S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 2: Primary Spinal Tumors.
Thieme, New York, 2015, pp. 85-96.
18.Boriani S, Bandiera S, Ghermandi R, Colangeli S, Amendola L, Gasbarrini A. Chondrosarcoma, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme New York 2015, pp. 97-109.
19.Ju DG, Zadnik PL, Sciubba DM. Osteogenic sarcoma and Ewing’s sarcoma of the
spine, in: Vialle LR, Fisher CG, Boriani S, Gokaslan ZL, (eds.), AOSpine Masters
Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp. 110-123.
20.Laufer I, Groves ML, Wolinsky JP. Margins in spine tumor resection: how much is
enough? Is planned transgression okay? in: Vialle LR, Fisher CG, Boriani S, Gokaslan
ZL, (eds.), AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New
York, 2015, pp. 124-133.
21.Dea N, Schouten R. Principles behind determining the right approach, in: Vialle
LR, Fisher CG, Boriani S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 2:
Primary Spinal Tumors. Thieme, New York, 2015, pp. 134-146.
22.Varga PP. Spinopelvic reconstruction/fixation and fusion, in: Vialle L, Fisher C, Boriani S, Gokaslan Z, (eds.), AOSpine Masters Series, Volume 2: Primary Spinal Tumors. Thieme, New York, 2015, pp. 147-156.
23.Rampersaud YR. Structural graft selection, in: Vialle LR, Fisher CG, Boriani S,
Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 2: Primary Spinal Tumors.
Thieme, New York, 2015, pp. 157-164.
24.Sacks JM, Broyles JM. Wound closure techniques, in: Vialle LR, Fisher CG, Boriani
S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 2: Primary Spinal Tumors.
Thieme, New York, 2015, pp. 165-174.
25.Oh MC, Deviren V, Ames CP. Complications and their avoidance: how to plan primary tumor resection to minimize complications and maximize outcome, in: Vialle
LR, Fisher CG, Boriani S, Gokaslan ZL, (eds.), AOSpine Masters Series, Volume 2:
Primary Spinal Tumors. Thieme, New York, 2015, pp. 175-189.
Awards & Nominations
Primary Tumor Retrospective:
•
N
ominated for the Whitecloud Award for Best Clinical Paper at the 22nd International Meeting on Advanced Spine Techniques (IMAST) 2015.
•
Invited by the Editor of Neurosurgery to submit a manuscript about mobile chordoma (2014).
•
N
ominated for the EuroSpine Full Paper Award 2014 & presented as “Best of
Show” papers (the highest scoring abstracts session) at EuroSpine 2014.
•
N
ominated for a value added award at the North American Spine Society (NASS)
28th Annual Meeting 2013.
•
A
warded best paper at the 11th Annual AOSpine North America Fellows Forum
2013 where the abstract will be published in the Evidence Based Spine Journal.
EPOSO:
•
T his project is co-funded by the Orthopaedic Research & Education Foundation
(OREF) through a Spine Prospective Clinical Research Grant.
Knowledge Forum Deformity
Abstracts
Submitted (under review)
1.Berven S, Kamper S, Germscheid N, Dahl B, Shaffrey C, Lenke L, Lewis S, Cheung K,
Alanay A, Ito M, Polly D, De Kleuver M. Appropriate treatment for adults with spinal deformity: an international consensus. SpineWeek 2016, Singapore, May 16-20, 2016.
2.Berven S, Saigal R, Lafage V, Kelly M, Kopjar B, Smith J, Dahl B, Cheung K, Carreon L, Schwab F, Rebmann K, Shaffrey C, Fehlings M, Lenke L, Ames C. Defining
normative quality metrics in complex high-risk deformity cases: results from the
Scoli-Risk1 study. SpineWeek 2016, Singapore, May 16-20, 2016.
3.Berven S, Kamper S, Germscheid N, Dahl B, Shaffrey C, Lenke L, Lewis S, Cheung
K, Alanay A, Ito M, Polly D, De Kleuver M, AOSpine Knowledge Forum Deformity.
Appropriate treatment for adults with spinal deformity: an international consensus.
23rd International Meeting on Advanced Spine Techniques (IMAST), Washington,
DC, USA, July 13-16, 2016.
4.Bow C, Kwan K, Samartzis D, Dekutoski M, Schwab F, Boachie-Adjei O, Kebaish
K, Ames C, Qiu Y, Matsuyama Y, Dahl B, Mehdian H, Pellisé-Urquiza F, Carreon L,
Shaffrey C, Fehlings M, Lenke L, Cheung K. Clinical outcome of unplanned return
to operating room on adult spinal deformity patients: 2 year follow-up of the Scoli-Risk 1 prospective, multicenter, international study. 23rd International Meeting on
Advanced Spine Techniques (IMAST), Washington, DC, USA, July 13-16, 2016.
5.Bow C, Kwan K, Samartzis D, Dekutoski M, Schwab F, Boachie-Adjei O, Kebaish K,
Ames C, Qiu Y, Matsuyama Y, Dahl B, Mehdian H, Pellisé-Urquiza F, Carreon L, Shaffrey C, Fehlings M, Lenke L, Cheung K. Prevalence and risk factors for unplanned
return to operating room for complex adult spinal deformity patients: Scoli-Risk
1 prospective multicenter international study. 23rd International Meeting on Advanced Spine Techniques (IMAST), Washington, DC, USA, July 13-16, 2016.
6.Carreon L, Glassman S, Shaffrey C, Fehlings M, Dahl B, Ames C, Matsuyama Y,
Qiu Y, Mehdian H, Cheung K, Schwab F, Pellisé F, Kebaish K, Lenke L. Predictors of
health-related quality-of-life after complex adult spinal deformity surgery: A Scoli-RISK-1 sub-analysis. 23rd International Meeting on Advanced Spine Techniques
(IMAST), Washington, DC, USA, July 13-16, 2016.
7.Faraj S, Haanstra T, Hooff MV, Holewijn R, Germscheid N, De Kleuver M. The development of a core outcome set for adolescent deformity surgery for the Nordic
spine registries: An AOSpine Knowledge Forum Deformity project. 23rd International Meeting on Advanced Spine Techniques (IMAST), Washington, DC, USA, July
13-16, 2016.
8.Faraj S, Van Hooff M, Haanstra T, Holewijn R, Germscheid N, De Kleuver M. Towards
the development of a global core outcome set for adult spinal deformity. 23rd
International Meeting on Advanced Spine Techniques (IMAST), Washington, DC,
USA, July 13-16, 2016.
9.Jain A, Naef F, Lenke L, Qiu Y, Matsuyama Y, Ames C, Fehlings M, Dahl B, Mehdian
H, Cheung K, Schwab F, Pellisé F, Carreon L, Shaffrey C, Kebaish K. Incidence of
proximal junctional kyphosis in patients with adult spinal deformity fused to the
25
pelvis: A ScoliRisk-1 sub-analysis. 23rd International Meeting on Advanced Spine
Techniques (IMAST), Washington, DC, USA, July 13-16, 2016.
10.Jain A, Naef F, Lenke L, Shaffrey C, Fehlings M, Dahl B, Ames C, Matsuyama Y, Qiu
Y, Mehdian H, Cheung K, Schwab F, Pellisé F, Carreon L, Kebaish K. Effect of age
on postoperative complications and patient reported outcomes in severe adult
spinal deformity: patients ≤60 years vs. >60 years. 23rd International Meeting on
Advanced Spine Techniques (IMAST), Washington, DC, USA, July 13-16, 2016.
11.Jain A, Naef F, Lenke L, Fehlings M, Mehdian H, Ames C, Schwab F, Matsuyama Y,
Shaffrey C, Cheung K, Dahl B, Qiu Y, Pellisé F, Carreon L, Kebaish K. Early postoperative surgical site infections in the Scoli-Risk 1 cohort of complex spinal deformity
patients still allowed for improved health related quality of life outcomes at 2
year follow-up. 23rd International Meeting on Advanced Spine Techniques (IMAST),
Washington, DC, USA, July 13-16, 2016.
12.Jain A, Naef F, Lenke L, Dahl B, Cheung K, Pellisé F, Qiu Y, Fehlings M, Ames C,
Matsuyama Y, Mehdian H, Schwab F, Carreon L, Shaffrey C, Kebaish K. Geographical variations in practice patterns and outcomes in surgically treated adult spinal
deformity patients: a ScoliRisk-1 sub-analysis. 23rd International Meeting on Advanced Spine Techniques (IMAST), Washington, DC, USA, July 13-16, 2016.
13.Jain A, Naef F, Lenke L, Carreon L, Ames C, Fehlings M, Dahl B, Matsuyama Y, Qiu
Y, Shaffrey C, Mehdian H, Schwab F, Pellisé F, Cheung K, Kebaish K. Impact of
depression on health related quality of life outcomes in surgically treated adult
spinal deformity patients: a ScoliRisk-1 sub-analysis. 23rd International Meeting on
Advanced Spine Techniques (IMAST), Washington, DC, USA, July 13-16, 2016.
14.Lenke L, Shaffrey C, Carreon L, Cheung K, Kebaish K, Schwab F, Pellisé F, Ames
C, Qiu Y, Dahl B, Fehlings M, Deformity AKF. Neurologic complications following
complex adult spinal deformity surgery: 2 year follow-up of the Scoli-Risk 1 prospective, multicenter, international study. 23rd International Meeting on Advanced
Spine Techniques (IMAST), Washington, DC, USA, July 13-16, 2016.
15. Miller E, Lenke L, Espinoza-Rebmann K, Neuman B, Sciubba D, Smith J, Qiu Y, Dahl
B, Matsuyama Y, Fehlings M, Cheung K, Carreon L, Ames C, AOSpine Knowledge
Forum Deformity, International Spine Study Group. Use of the Adult Spinal Deformity (ASD) Frailty Index (ASD-FI) to predict major complication risk in the Scoli-Risk
1 patient database. 23rd International Meeting on Advanced Spine Techniques
(IMAST), Washington, DC, USA, July 13-16, 2016.
16.Berven S, Kamper S, Germscheid N, Dahl B, Shaffrey C, Lenke L, Lewis S, Cheung
K, Alanay A, Ito M, Polly D, Kleuver MD, AOSpine Knowledge Forum Deformity.
Appropriate treatment for adults with spinal deformity: an international consensus.
Scoliosis Research Society (SRS) 51st Annual Meeting & Course, Prague, Czech
Republic, September 21-24, 2016.
17.Bow C, Kwan K, Samartzis D, Dekutoski M, Schwab F, Boachie-Adjei O, Kebaish
K, Ames C, Qiu Y, Matsuyama Y, Dahl B, Mehdian H, Pellisé-Urquiza F, Carreon L,
Shaffrey C, Fehlings M, Lenke L, Cheung K. Clinical outcome of unplanned return
to operating room on adult spinal deformity patients: 2 year follow-up of the
Scoli-Risk 1 prospective, multicenter, international study. Scoliosis Research Society
(SRS) 51st Annual Meeting & Course, Prague, Czech Republic, September 21-24,
2016.
26
18.Bow C, Kwan K, Samartzis D, Dekutoski M, Schwab F, Boachie-Adjei O, Kebaish K,
Ames C, Qiu Y, Matsuyama Y, Dahl B, Mehdian H, Pellisé-Urquiza F, Carreon L, Shaffrey C, Fehlings M, Lenke L, Cheung K. Prevalence and risk factors for unplanned
return to operating room for complex adult spinal deformity patients: Scoli-Risk 1
prospective multicenter international study. Scoliosis Research Society (SRS) 51st
Annual Meeting & Course, Prague, Czech Republic, September 21-24, 2016.
19.Carreon L, Glassman S, Shaffrey C, Fehlings M, Dahl B, Ames C, Matsuyama Y,
Qiu Y, Mehdian H, Cheung K, Schwab F, Pellisé F, Kebaish K, Lenke L. Predictors
of health-related quality-of-life after complex adult spinal deformity surgery: a
Scoli-Risk-1 sub-analysis. Scoliosis Research Society (SRS) 51st Annual Meeting &
Course, Prague, Czech Republic, September 21-24, 2016, 2016.
20.Faraj S, Van Hooff M, Haanstra T, Holewijn R, Germscheid N, De Kleuver M. Towards
the development of a global core outcome set for adult spinal deformity. Scoliosis
Research Society (SRS) 51st Annual Meeting & Course, Prague, Czech Republic,
September 21-24, 2016.
21.Faraj S, Haanstra T, Hooff MV, Holewijn R, Germscheid N, De Kleuver M. The development of a core outcome set for adolescent deformity surgery for the Nordic spine registries: an AOSpine Knowledge Forum Deformity project. Scoliosis
Research Society (SRS) 51st Annual Meeting & Course, Prague, Czech Republic,
September 21-24, 2016.
22.Jain A, Naef F, Lenke L, Shaffrey C, Fehlings M, Dahl B, Ames C, Matsuyama Y, Qiu
Y, Mehdian H, Cheung K, Schwab F, Pellisé F, Carreon L, Kebaish K. Effect of age on
postoperative complications and patient reported outcomes in severe adult spinal
deformity: patients ≤60 years vs. >60 years. Scoliosis Research Society (SRS) 51st
Annual Meeting & Course, Prague, Czech Republic, September 21-24, 2016.
23.Jain A, Naef F, Lenke L, Shaffrey C, Fehlings M, Dahl B, Ames C, Matsuyama Y, Qiu Y,
Mehdian H, Cheung K, Schwab F, Pellisé F, Carreon L, Kebaish K. Complications and
patient reported outcomes of primary vs. revision surgery for severe adult spinal
deformity: a ScoliRisk-1 sub-analysis. Scoliosis Research Society (SRS) 51st Annual
Meeting & Course, Prague, Czech Republic, September 21-24, 2016.
24.Jain A, Naef F, Lenke L, Qiu Y, Matsuyama Y, Ames C, Fehlings M, Dahl B, Mehdian
H, Cheung K, Schwab F, Pellisé F, Carreon L, Shaffrey C, Kebaish K. Incidence of
proximal junctional kyphosis in patients with adult spinal deformity fused to the
pelvis: a ScoliRisk-1 sub-analysis. Scoliosis Research Society (SRS) 51st Annual
Meeting & Course, Prague, Czech Republic, September 21-24, 2016.
25.Jain A, Naef F, Lenke L, Fehlings M, Mehdian H, Ames C, Schwab F, Matsuyama Y,
Shaffrey C, Cheung K, Dahl B, Qiu Y, Pellisé F, Carreon L, Kebaish K. Early postoperative surgical site infections in the Scoli-Risk 1 cohort of complex spinal deformity
patients still allowed for improved health related quality of life outcomes at 2 year
follow-up. Scoliosis Research Society (SRS) 51st Annual Meeting & Course, Prague,
Czech Republic, September 21-24, 2016.
26.Jain A, Naef F, Lenke L, Dahl B, Cheung K, Pellisé F, Qiu Y, Fehlings M, Ames C, Matsuyama Y, Mehdian H, Schwab F, Carreon L, Shaffrey C, Kebaish K. Geographical
variations in practice patterns and outcomes in surgically treated adult spinal deformity patients: a ScoliRisk-1 sub-analysis. Scoliosis Research Society (SRS) 51st
Annual Meeting & Course, Prague, Czech Republic, September 21-24, 2016.
27.Jain A, Naef F, Lenke L, Carreon L, Ames C, Fehlings M, Dahl B, Matsuyama Y, Qiu
Y, Shaffrey C, Mehdian H, Schwab F, Pellisé F, Cheung K, Kebaish K. impact of
depression on health related quality of life outcomes in surgically treated adult spinal deformity patients: a ScoliRisk-1 sub-analysis. Scoliosis Research Society (SRS)
51st Annual Meeting & Course, Prague, Czech Republic, September 21-24, 2016.
28.Lenke L, Shaffrey C, Carreon L, Cheung K, Kebaish K, Schwab F, Pellisé F, Ames
C, Qiu Y, Dahl B, Fehlings M, Deformity AKF. Neurologic complications following
complex adult spinal deformity surgery: 2 year follow-up of the Scoli-Risk 1 prospective, multicenter, international study. Scoliosis Research Society (SRS) 51st
Annual Meeting & Course, Prague, Czech Republic, September 21-24, 2016.
29.Miller E, Lenke L, Espinoza-Rebmann K, Neuman B, Sciubba D, Smith J, Qiu Y, Dahl
B, Matsuyama Y, Fehlings M, Cheung K, Carreon L, Ames C, AOSpine Knowledge Forum Deformity, International Spine Study Group. Use of the Adult Spinal Deformity
(ASD) Frailty Index (ASD-FI) to predict major complication risk in the Scoli-Risk 1
patient database. Scoliosis Research Society (SRS) 51st Annual Meeting & Course,
Prague, Czech Republic, September 21-24, 2016.
30. Pellisé F, Lenke L, Shaffrey C, Carreon L, Cheung K, Kebaish K, Schwab F, Qiu Y,
Dahl B, Ames C, Fehlings M, AOSpine Knowledge Forum Deformity. Neurologic
complications following complex adult spinal deformity surgery: 2 year follow-up
of the Scoli-Risk 1 prospective, multicenter, international study. EuroSpine 2016,
Berlin, Germany, October 5-7, 2016.
31. Pellisé F, Jain A, Naef A, Lenke L, Shaffrey C, Fehlings M, Dahl B, Ames C, Matsuyama Y, Qiu Y, Mehdian H, Cheung K, Schwab F, Carreon L, Kebaish K. A comparison
of postoperative complications and patient reported outcomes in severe adult spinal deformity patients aged ≤60 years and >60 years: a Scoli-Risk-1 sub-analysis.
EuroSpine 2016, Berlin, Germany, October 5-7, 2016.
32. Pellisé F, Jain A, Naef F, Lenke L, Carreon L, Ames C, Fehlings M, Dahl B, Matsuyama
Y, Qiu Y, Shaffrey C, Mehdian H, Schwab F, Cheung K, Kebaish K. Impact of depression on health related quality of life (HRQOL) outcomes in surgically treated
adult spinal deformity patients: a Scoli-Risk-1 sub-analysis. EuroSpine 2016, Berlin,
Germany, October 5-7, 2016.
33. Pellisé F, Jain A, Naef F, Lenke L, Dahl B, Cheung K, Qiu Y, Fehlings M, Ames C,
Matsuyama Y, Mehdian H, Schwab F, Carreon L, Shaffrey C, Kebaish K. Geographical variations in practice patterns and outcomes in surgically treated adult spinal
deformity patients: a Scoli-Risk-1 sub-analysis. EuroSpine 2016, Berlin, Germany,
October 5-7, 2016.
34. Pellisé F, Jain A, Naef F, Lenke L, Fehlings M, Ames C, Dahl B, Schwab F, Matsuyama
Y, Shaffrey C, Cheung K, Qiu Y, Mehdian H, Carreon L, Kebaish K. The impact of early postoperative surgical site infections on health related quality of life outcomes
at 2-year follow-up: a Scoli-Risk-1 sub-analysis. EuroSpine 2016, Berlin, Germany,
October 5-7, 2016.
35. Pellisé F, Jain A, Naef F, Lenke L, Qiu Y, Matsuyama Y, Ames C, Fehlings M, Dahl B,
Cheung K, Mehdian H, Schwab F, Carreon L, Shaffrey C, Kebaish K. Incidence of proximal junctional kyphosis in patients with adult spinal deformity fused to the pelvis: a
Scoli-Risk-1 sub-analysis. EuroSpine 2016, Berlin, Germany, October 5-7, 2016.
36. Alanay A, Berven S, Kamper S, Germscheid N, Dahl B, Shaffrey C, Lenke L, Lewis S,
Cheung K, Ito M, Polly D, De Kleuver M, AOSpine Knowledge Forum Deformity. An
international consensus on the appropriate treatment for adult spinal deformity.
EuroSpine 2016, Berlin, Germany, October 5-7, 2016.
37. Faraj S, Haanstra T, van Hooff M, Holewijn R, Germscheid N, De Kleuver M. The development of a core outcome set for adolescent deformity surgery for the Nordic
spine registries: an AOSpine Knowledge Forum Deformity project. EuroSpine 2016,
Berlin, Germany, October 5-7, 2016.
38. Faraj S, van Hooff M, Haanstra T, Holewijn R, Germscheid N, De Kleuver M. Towards
the development of a global core outcome set for adult spinal deformity. EuroSpine 2016, Berlin, Germany, October 5-7, 2016.
39.Jain A, Naef F, Lenke L, Fehlings M, Mehdian H, Ames C, Schwab F, Matsuyama Y,
Shaffrey C, Cheung K, Dahl B, Qiu Y, Pellisé F, Carreon L, Kebaish K. Early postoperative surgical site infections in the Scoli-Risk 1 cohort of complex spinal deformity
patients still allowed for improved health related quality of life outcomes at 2 year
follow-up. North American Spine Society (NASS) 31st Annual Meeting, Boston, MA,
USA, October 26-29, 2016.
40.Jain A, Naef F, Lenke L, Shaffrey C, Fehlings M, Dahl B, Ames C, Matsuyama Y, Qiu
Y, Mehdian H, Cheung K, Schwab F, Pellisé F, Carreon L, Kebaish K. Effect of age on
postoperative complications and patient reported outcomes in severe adult spinal
deformity: patients ≤60 years vs. >60 years. North American Spine Society (NASS)
31st Annual Meeting, Boston, MA, USA, October 26-29, 2016.
41. Jain A, Naef F, Lenke L, Shaffrey C, Fehlings M, Dahl B, Ames C, Matsuyama Y, Qiu
Y, Mehdian H, Cheung K, Schwab F, Pellisé F, Carreon L, Kebaish K. Complications
and patient reported outcomes of primary vs. revision surgery for severe adult
spinal deformity: a ScoliRisk-1 sub-analysis. North American Spine Society (NASS)
31st Annual Meeting, Boston, MA, USA, October 26-29, 2016.
42.Jain A, Naef F, Lenke L, Qiu Y, Matsuyama Y, Ames C, Fehlings M, Dahl B, Mehdian
H, Cheung K, Schwab F, Pellisé F, Carreon L, Shaffrey C, Kebaish K. Incidence of
proximal junctional kyphosis in patients with adult spinal deformity fused to the
pelvis: a ScoliRisk-1 sub-analysis. North American Spine Society (NASS) 31st Annual Meeting, Boston, MA, USA, October 26-29, 2016.
43.Jain A, Naef F, Lenke L, Dahl B, Cheung K, Pellisé F, Qiu Y, Fehlings M, Ames C, Matsuyama Y, Mehdian H, Schwab F, Carreon L, Shaffrey C, Kebaish K. Geographical
variations in practice patterns and outcomes in surgically treated adult spinal deformity patients: a ScoliRisk-1 sub-analysis. North American Spine Society (NASS)
31st Annual Meeting, Boston, MA, USA, October 26-29, 2016.
44.Jain A, Naef F, Lenke L, Carreon L, Ames C, Fehlings M, Dahl B, Matsuyama Y, Qiu
Y, Shaffrey C, Mehdian H, Schwab F, Pellisé F, Cheung K, Kebaish K. Impact of
depression on health related quality of life outcomes in surgically treated adult
spinal deformity patients: a ScoliRisk-1 sub-analysis. North American Spine Society
(NASS) 31st Annual Meeting, Boston, MA, USA, October 26-29, 2016.
45.Miller E, Lenke L, Espinoza K, Neuman B, Sciubba D, Smith J, Qiu Y, Dahl B, Matsuyama Y, Fehlings M, Cheung K, Carreon L, Ames C, AOSpine Knowledge Forum Deformity, International Spine Study Group. Use of the Adult Spinal Deformity (ASD)
27
Frailty Index (ASD-FI) to predict major complications in the Scoli-Risk 1 multicenter,
international patient database. North American Spine Society (NASS) 31st Annual
Meeting, Boston, MA, USA, October 26-29, 2016.
Accepted for Presentation
Podium Presentations
1.Berven S, Kamper S, Germscheid N, Dahl B, Shaffrey C, Lenke L, Lewis S, Cheung
K, Alanay A, Ito M, Polly D, De Kleuver M. An international consensus of the appropriate treatment for adults with spinal deformity: an AOSpine Knowledge Forum
Deformity study. Global Spine Congress 2016, Dubai, UAE, April 13-16, 2016.
2.Bow C, Cheung K, Samartzis D, Dekutoski M, Schwab F, Boachie-Adjei O, Kebaish K,
Ames C, Qiu Y, Matsuyama Y, Dahl B, Mehdian H, Pellisé-Urquiza F, Carreon L, Shaffrey C, Fehlings M, Lenke L. The effect of post-operative complications in complex
adult spinal deformity surgery on surgical outcomes: an international, large-scale,
prospective multi-center study. Global Spine Congress 2016, Dubai, UAE, April 1316, 2016.
3.Fehlings M, Lenke L, Nakashima H, Nagoshi N, Shaffrey C, Kopjar B, Cheung K,
Carreon L, Dekutoski M, Schwab F, Boachie-Adjei O, Kebaish K, Ames C, Qiu Y,
Matsuyama Y, Dahl B, Mehdian H, Pellisé-Urquiza F, Lewis S, Berven S. Predictors of
neurological motor decline in complex adult spinal deformity surgery: results of the
prospective, international, multicenter Scoli-RISK-1 study. Global Spine Congress
2016, Dubai, UAE, April 13-16, 2016.
4.Haanstra TM, van Hooff M, Germscheid N, De Kleuver M. The development of a
core outcome set for adolescents undergoing spinal deformity surgery: an AOSpine Knowledge Forum Deformity initiative. Global Spine Congress 2016, Dubai,
UAE, April 13-16, 2016.
5.Saigal R, Berven S, Lafage V, Kelly M, Kopjar B, Smith J, Dahl B, Cheung K, Carreon L,
Schwab F, Rebmann K, Shaffrey C, Fehlings M, Lenke L, Ames C. New motor deficit
after spinal deformity leads to worsened early HRQOL: subanalysis of 273 patients
from Scoli Risk 1 Prospective study. Global Spine Congress 2016, Dubai, UAE, April
13-16, 2016.
Poster Presentations
1.Berven S, Saigal R, Lafage V, Kelly M, Kopjar B, Smith J, Dahl B, Cheung K, Carreon
L, Schwab F, Rebmann K, Shaffrey C, Fehlings M, Lenke L, Ames C. Defining normative quality metrics in complex high-risk deformity cases: results from the Scoli-Risk
1 study. Global Spine Congress 2016, Dubai, UAE, April 13-16, 2016.
Presented
Podium Presentations
1.
Saigal R, Berven SH, Lafage V, Kelly MP, Kopjar B, Smith JS, Dahl BT, Cheung KM,
Carreon LY, Schwab FJ, Rebmann K, Shaffrey CI, Fehlings MG, Lenke LG, Ames CP.
Impact of new motor deficit on early HRQOL after adult spinal deformity surgery:
subanalysis of 273 patients from Scoli Risk 1 prospective study. The Congress of
28
Neurological Surgeons (CNS) Annual Meeting, New Orleans, LA, USA, September
26-30, 2015.
2.
Bow C, Cheung K, Samartzis D, Kwan K, Dekutoski M, Schwab F, Boachie-Adjei
O, Kebaish K, Ames C, Qiu Y, Matsuyama Y, Dahl B, Mehdian H, Pellisé-Urquiza F,
Carreon L, Shaffrey C, Fehlings M, Lenke L. The effect of post-operative complications in complex adult spinal deformity surgery on surgical outcomes: an international, large-scale, prospective multi-center study. 36th SICOT Orthopaedic World
Congress, Guangzhou, China, September 17-19, 2015.
3.
Bow C, Cheung K, Samartzis D, Dekutoski M, Schwab F, Boachie-Adjei O, Kebaish
K, Ames C, Qiu Y, Matsuyama Y, Dahl B, Mehdian H, Pellisé-Urquiza F, Carreon L,
Shaffrey C, Fehlings M, Lenke L. Risk factors for non-neurological complications in
complex adult spinal deformity surgery: an international, large-scale, prospective
multi-center study. 36th SICOT Orthopaedic World Congress, Guangzhou, China,
September 17-19, 2015.
4.
Haanstra TM, Van Hooff M, Germscheid N, De Kleuver M. The development of
a core outcome set for scoliosis surgery in spine registries. Annual Meeting of the
Nordic Spinal Deformities Society (NSDS), Amsterdam, the Netherlands, August
27-29, 2015.
5.
Berven SH, Saigal R, Lafage V, Kelly M, Kopjar B, Smith J, Dahl B, Cheung KM,
Carreon LY, Schwab FJ, Rebmann K, Shaffrey CI, Fehlings MG, Lenke LG, Ames CP.
Defining normative quality metrics in complex high-risk deformity cases: results
from the Scoli-Risk 1 study. 22nd International Meeting on Advanced Spine Techniques (IMAST), Kuala Lumpur, Malaysia, July 8-11, 2015.
6.
Fehlings M, Lenke L, Shaffrey C, Kopjar B, Cheung K, Carreon L, Dekutoski M,
Schwab F, Boachie-Adjei O, Kebaish K, Ames C, Qiu Y, Matsuyama Y, Dahl B, Mehdian H, Pellisé F, Lewis S, Berven S. Pre-operative predictors of neurological motor decline in complex adult spinal deformity surgery: results of the prospective,
international, multicenter Scoli-RISK-1 study in 271 patients. 22nd International
Meeting on Advanced Spine Techniques (IMAST), Kuala Lumpur, Malaysia, July
8-11, 2015.
7.
Jain A, Naef F, Lenke LG, Ames CP, Matsuyama Y, Dahl BT, Shaffrey CI, Qiu Y,
Fehlings MG, Mehdian H, Boachie-Adjei O, Schwab FJ, Cheung KM, Carreon LY,
Kebaish KM. Analysis of ScoliRisk-1 prospective multicenter database comparing
perioperative complications and patient reported outcomes in primary vs. revision
surgery for severe adult spinal deformity. 22nd International Meeting on Advanced
Spine Techniques (IMAST), Kuala Lumpur, Malaysia, July 8-11, 2015.
8.Cheung K, Bow C, Samartzis D, Kwan K, Dekutoski M, Schwab F, Boachie-Adjei
O, Kebaish K, Ames C, Qiu Y, Matsuyama Y, Dahl B, Mehdian H, Pellisé-Urquiza
F, Carreon L, Shaffrey C, Fehlings M, Lenke L. The effect of post-operative complications in complex adult spinal deformity surgery on surgical outcomes: an
international, large-scale, prospective multi-center study. Asia-Pacific Orthopaedic
Association (APOA) Annual Meeting - Hong Kong 2015 - the Combined Congress
of APSS, APPOS & HKIOF, Hong Kong, China, June 5-7, 2015.
9.
Pellisé F, Domingo M, Moncho D, Rahnama K, Fehling MG, Lenke LG, Shaffrey CI,
Kopjar B, Cheung KM, Carreon LY, Schwab FJ, Boachie-Adjei O, Kebaish KM, Ames
CP, Qiu Y, Matsuyama Y, Dahl BT, Mehdian H, Lewis SJ, Berven SH. Intraoperative
NeuroMonitoring (IONM) may not predict all postoperative neurological adverse
events in adult deformity surgery. A Scoli-RISK-1 Trial subanalysis. Spanish Spine
Society – XXIX Congreso Nacional GEER, Malaga, Spain, June 4-6, 2015.
10.Cheung K, Bow C, Samartzis D, Dekutoski M, Schwab F, Boachie-Adjei O, Kebaish
K, Ames C, Qiu Y, Matsuyama Y, Dahl B, Mehdian H, Pellisé-Urquiza F, Carreon L,
Shaffrey C, Fehlings MG, Lenke LG. Risk factors for non-neurological complications
in adult spinal deformity surgery: an international, large-scale, prospective multi-center study. Global Spine Congress 2015, Buenos Aires, Argentina, May 20-23,
2015.
11.Cheung K, Bow C, Samartzis D, Dekutoski M, Schwab F, Boachie-Adjei O, Kebaish
K, Ames C, Qiu Y, Matsuyama Y, Dahl B, Mehdian H, Pellisé-Urquiza F, Carreon L,
Shaffrey C, Fehlings MG, Lenke L. Risk factors for non-neurological complications
in adult spinal deformity surgery: an international, prospective, multi-center study
of 269 cases. Hong Kong Orthopaedic Association 34th Annual Congress (HKOA
2014), Hong Kong, China, November 15-16, 2014.
12.Fehlings MG, Lenke LG, Shaffrey CI, Kopjar B, Cheung KM, Carreon LY, Dekutoski
MB, Schwab FJ, Boachie-Adjei O, Kebaish K, Ames CP, Qiu Y, Matsuyama Y, Dahl B,
Mehdian H, Pellisé F, Lewis SJ, Berven SH. Risk factors for neurological complications in patients undergoing corrective surgery for spinal deformity: results of the
Scoli-Risk 1 study international, prospective, multicenter study. Scoliosis Research
Society (SRS) 49th Annual Meetings & Courses, Anchorage, AK, USA, September
10-13, 2014.
13.De Kleuver M, Lewis SJ, Germscheid NM, Kamper SJ, Alanay A, Berven SH, Cheung
KM, Ito M, Lenke LG, Polly DW, Qiu Y, Van Tulder M, Shaffrey C. Optimal surgical
care for adolescent idiopathic scoliosis in 2013: an international consensus. 87th
Annual Meeting of the Japanese Orthopaedic Association (JOA), Kobe, Japan, May
22-25, 2014.
14.Lenke L, Fehlings MG, Shaffrey CI, Cheung KMC, Carreon L, Dekutoski MB,
Schwab FJ, Boachie-Adjei O, Kebaish KM, Ames CP, Qiu Y, Matsuyama Y, Dahl B,
Mehdian H, Pellisé-Urquiza F, Lewis SJ, Berven SH. Prospective, multicenter assessment of acute neurologic complications following complex adult spinal deformity
surgery: the Scoli-RISK-1 study. 82nd American Association of Neurological Surgeons (AANS) Annual Scientific Meeting, San Francisco, CA, USA, April 5-9, 2014.
18.
De Kleuver M, Lewis SJ, Alanay A, Berven SH, Cheung KM, Germscheid NM,
Kamper SJ, Lenke LG, Polly DW, Qiu Y, Shaffrey C, Van Tulder M, Ito M. Is there an
international consensus on optimal surgical care for adolescent idiopathic scoliosis? A Delphi study. EuroSpine 2013, Liverpool, UK, October 2-4, 2013.
19.
Lenke L, Fehlings M, Shaffrey C, Cheung K, Carreon L. Prospective, multicenter
assessment of acute neurologic complications following complex adult spinal deformity surgery: The Scoli-Risk-1 trial. Scoliosis Research Society (SRS) 48th Annual
Meetings & Courses, Lyon, France, September 18-21, 2013.
20.
Lenke L, Fehlings M, Shaffrey C, Cheung K, Carreon L. Prospective, multicenter
assessment of acute neurologic complications following complex adult spinal
deformity surgery: The Scoli-Risk-1 trial. 20th International Meeting on Advanced
Spine Techniques (IMAST), Vancouver, BC, Canada, July 10-13, 2013.
Poster Presentations
1.
Pellisé F, Domingo M, Moncho D, Rahnama K, Fehling MG, Lenke LG, Shaffrey CI,
Kopjar B, Cheung KMC, Carreon LY, Schwab FJ, Boachie-Adjei O, Kebaish KM, Ames
CP, Qiu Y, Matsuyama Y, Dahl BT, Mehdian H, Lewis SJ, Berven SH. Intraoperative
NeuroMonitoring (IONM) may not predict all postoperative neurological adverse
events in adult deformity surgery. A Scoli-RISK-1 Trial subanalysis. EuroSpine 2015,
Copenhagen, Denmark, September 2-4, 2015.
2.Cheung KM, Bow C, Samartzis D, Dekutoski M, Schwab F, Boachie-Adjei O, Kebaish
K, Ames C, Qiu Y, Matsuyama Y, Dahl B, Mehdian H, Pellisé-Urquiza F, Carreon L,
Shaffrey C, Fehlings M, Lenke L. Risk factors for non-neurological complications in
complex adult spinal deformity surgery: an international, large-scale, prospective
multi-center study. Asia-Pacific Orthopaedic Association (APOA) Annual Meeting –
Hong Kong 2015 - the Combined Congress of APSS, APPOS & HKIOF, Hong Kong,
China, June 5-7, 2015.
Manuscripts
Published
15.
De Kleuver M, Lewis SJ, Germscheid NM, Kamper SJ, Alanay A, Berven SH, Cheung KM, Ito M, Lenke LG, Polly DW, Qiu Y, Van Tulder M, Shaffrey C. Optimal surgical
care for adolescent idiopathic scoliosis in 2013: an international consensus. Dutch
Orthopedic Association Annual Meeting 2014, Rotterdam, the Netherlands, February 6-7, 2014.
1.Lenke LG, Fehlings MG, Shaffrey CI, Cheung KM, Carreon L, Dekutoski MB, Schwab
FJ, Boachie-Adjei O, Kebaish KM, Ames CP, Qiu Y, Matsuyama Y, Dahl BT, Mehdian H, Pellisé-Urquiza F, Lewis SJ, Berven SH. Neurologic Outcomes of Complex
Adult Spinal Deformity Surgery: Results of the Prospective, Multicenter Scoli-RISK-1
Study. Spine (Phila Pa 1976) 41(3): 204-212, 2016.
16.
De Kleuver M, Lewis SJ, Alanay A, Berven SH, Cheung KM, Germscheid NM,
Kamper SJ, Lenke LG, Polly DW, Qiu Y, Shaffrey C, Van Tulder M, Ito M. Is there
a global consensus on optimal surgical care for adolescent idiopathic scoliosis?
A Delphi study. North American Spine Society (NASS) 28th Annual Meeting, New
Orleans, LA, USA, October 9-12, 2013.
2.De Kleuver M, Lewis SJ, Germscheid NM, Kamper SJ, Alanay A, Berven SH, Cheung
KM, Ito M, Lenke LG, Polly DW, Qiu Y, Van Tulder M, Shaffrey C. Optimal surgical
care for adolescent idiopathic scoliosis: an international consensus. Eur Spine J
23(12): 2603-2618, 2014.
17.
Lenke L, Fehlings M, Shaffrey C, Cheung K, Carreon L. Scoli-Risk 1 Site PIs. Prospective, multicenter assessment of acute neurologic complications following complex adult spinal deformity surgery: The Scoli-Risk-1 trial. North American Spine
Society (NASS) 28th Annual Meeting, New Orleans, LA, USA, October 9-12, 2013.
Book Chapters
1.Wagner S, Kang D, Lehman Jr R, Lenke L. Preoperative evaluation and optimization
for surgery, in: Vialle L, Lenke L, Cheung K, (eds.), AOSpine Masters Series, Volume
4: Adult Spinal Deformities. Thieme, New York, 2015, pp. 1-11.
29
2.Cheung K, Cheung J. Decision making in adult deformity surgery: decompression
versus short or long fusion, in: Vialle L, Lenke L, Cheung K, (eds.), AOSpine Masters
Series, Volume 4: Adult Spinal Deformities. Thieme, New York, 2015, pp. 12-27.
3.Lewis S, Harris S. The use of osteotomies for rigid spinal deformities, in: Vialle L,
Lenke L, Cheung K, (eds.), AOSpine Masters Series, Volume 4: Adult Spinal Deformities Thieme, New York, 2015, pp. 28-44.
4.Jones K, Morgan R, Polly Jr D. Indications and techniques for sacral-pelvic fixation
in adult spinal deformity, in: Vialle L, Lenke L, Cheung K, (eds.), AOSpine Masters
Series, Volume 4: Adult Spinal Deformities. Thieme, New York, 2015, pp. 45-55.
5.Alanay A, Yilgor C. Instrumentation strategies in osteoporotic spine: how to prevent
failure? in: Vialle L, Lenke L, Cheung K, (eds.), AOSpine Masters Series, Volume 4:
Adult Spinal Deformities. Thieme, New York, 2015, pp. 56-67.
6.Butler J, Lenke L. The incidence and management of acute neurologic complications following complex adult spinal deformity surgery, in: Vialle L, Lenke L, Cheung
K, (eds.), AOSpine Masters Series, Volume 4: Adult Spinal Deformities. Thieme,
New York, 2015, pp. 68-77.
7.Qiu Y. Postoperative coronal decompensation in adult deformity surgery, in: Vialle
L, Lenke L, Cheung K, (eds.), AOSpine Masters Series, Volume 4: Adult Spinal Deformities. Thieme, New York, 2015, pp. 78-94.
8.Waldrop R, Berven S. Measure outcome and value in adult deformity surgery, in:
Vialle L, Lenke L, Cheung K, (eds.), AOSpine Masters Series, Volume 4: Adult Spinal
Deformities. Thieme, New York, 2015, pp. 95-105.
9.Kim H, Iyer S, Shaffrey Sr C. Junctional issues following adult deformity surgery, in:
Vialle L, Lenke L, Cheung K, (eds.), AOSpine Masters Series, Volume 4: Adult Spinal
Deformities. Thieme, New York, 2015, pp. 106-119.
10.Ito M, Abe Y, Salmingo R. Biomechanics and material science for deformity correction, in: Vialle L, Lenke L, Cheung K, (eds.), AOSpine Masters Series, Volume 4:
Adult Spinal Deformities Thieme, New York, 2015, pp. 120-129.
11.Kelly M, Berven S. Pseudarthrosis and infection, in: Vialle L, Lenke L, Cheung K,
(eds.), AOSpine Masters Series, Volume 4: Adult Spinal Deformities. Thieme, New
York, 2015, pp. 130-139.
Awards & Nominations
Scoli-Risk 1:
•
S
elected for the Best Paper Session (Deformity) at the Global Spine Congress
2016.
•
W
inner of the Whitecloud Award for Best Clinical Paper at the 22nd International
Meeting on Advanced Spine Techniques (IMAST 2015).
•
W
inner of the Best Paper Award at the Global Spine Congress 2015.
•
N
ominated for Best Paper at the Spanish Spine Society – XXIX Congreso Nacional
GEER 2015.
•
S
hortlisted for the award paper session at the Hong Kong Orthopaedic Association
34th Annual Congress 2014.
•
N
ominated for the Russel A. Hibbs Award for best Clinical paper at the SRS 49th
Annual Meeting & Courses 2014.
•
W
inner of the Russel A. Hibbs Award at the SRS 48th Annual Meetings & Courses
2013.
AIS Consensus:
•
N
ominated for a value added award at the NASS 28th Annual Meeting 2013.
•
N
ominated for the EuroSpine Full Paper Award 2013 & presented as “Best of
Show” papers (the highest scoring abstracts session).
Knowledge Forum
Spinal Cord Injury
Abstracts
Accepted for Presentation
Podium Presentations
1.Fehlings M, Nakashima H, Nagoshi N, Diana S, Chow L, Grossman R, Kopjar B.
Efficacy and Safety of Riluzole in Acute Spinal Cord Injury (SCI). Rationale and
Design of AOSpine Phase III multi-center double blinded randomized controlled
trial. (RISCIS). Global Spine Conference 2016, Dubai, UAE, April 13-16 2016.
2.Wilson J, Tetreault L, Kwon B, Arnold P, Mroz T, Shaffrey C, Chapman J, Casha S,
Skelly A, Holmer H, Brodt E, Fehlings M. Timing of decompression in patients with
acute spinal cord injury: a systematic review. Global Spine Conference 2016, Dubai,
UAE, April 13-16 2016.
Presented
Podium Presentations
1. Fehlings M, Wilson J, Kwon B, Kurpad S, Harrop J, Shamji M, Middleton J. A clinical
guideline for the use of high-dose methylprednisolone in the treatment of acute
traumatic spinal cord injury. International Neurotrauma Society (INTS) meeting,
Cape Town, South Africa, February 1-4, 2016.
2.
Fehlings M, Wilson J, Arnold P, Skelly A, Chapman J, Tetreault L, Aarabi B, Harrop
J. A clinical guideline for the timing of surgical decompression in the treatment
of acute traumatic spinal cord injury. International Neurotrauma Society (INTS)
meeting, Cape Town, South Africa, February 1-4, 2016.
3.
Fehlings MF, Kopjar B, Grossman R, Wilson J. Efficacy and safety of Riluzole in
acute spinal cord injury (SCI). Rationale and design of AOSpine phase III mul-
30
ti-center double blind randomized controlled trial (RISCIS). 22nd International
Meeting on Advanced Spine Techniques (IMAST), Kuala Lumpur, Malaysia, July
8-11, 2015.
4.
Fehlings MF, Kopjar B, Grossman R, Wilson J. Efficacy and safety of Riluzole in
acute spinal cord injury (SCI). Rationale and design of AOSpine phase III multi-center double blind randomized controlled trial. (RISCIS). ASIA/ISCoS Joint Scientific Meeting, Montreal, QC, Canada, May 14-16, 2015.
5.
Fehlings MF, Kopjar B, Grossman R, Wilson J. Efficacy and safety of Riluzole in
acute spinal cord injury (SCI). Rationale and design of AOSpine phase III multi-center double blind randomized controlled trial. (RISCIS). AO ONE Conference,
Las Vegas, NV, USA, February 5-7, 2015.
6.
Fehlings MF, Kopjar B, Grossman R, Wilson J. Efficacy and safety of Riluzole in
acute spinal cord injury (SCI). Rationale and design of AOSpine phase III multi-center double blind randomized controlled trial. (RISCIS). North American Spine
Society (NASS) Meeting, San Francisco, CA, USA, November 12-15, 2014.
7.
Fehlings MF, Kopjar B, Grossman R, Wilson J. Efficacy and safety of Riluzole in
acute spinal cord injury (SCI). Rationale and design of AOSpine phase III multi-center double blind randomized controlled trial. (RISCIS). Congress of Neurological Surgeons (CNS) Meeting, Boston, MA, USA, October 18-22, 2014.
8.
Fehlings MF, Kopjar B, Grossman R, Wilson J. Efficacy and safety of Riluzole in
acute spinal cord injury (SCI). Rationale and design of AOSpine phase III multi-center double blind randomized controlled trial. (RISCIS). International Meeting
on Advanced Spine Techniques (IMAST), Valencia, Spain, July 16-19, 2014.
9.
Fehlings MF, Kopjar B, Grossman R, Wilson J. Efficacy and safety of Riluzole in
acute spinal cord injury (SCI). Rationale and design of AOSpine phase III multi-center double blind randomized controlled trial. (RISCIS). 20th Annual International Meeting on Advanced Spine Techniques (IMAST), Vancouver, BQ, Canada,
July 10-13, 2013.
Poster Presentations
1.
Fehlings MF, Kopjar B, Grossman R, Wilson J. Efficacy and Safety of Riluzole in
Acute Spinal Cord Injury (SCI). Rationale and Design of AOSpine Phase III Multi-center Double Blind Randomized Controlled Trial. (RISCIS). North American
Spine Society Annual Meeting, Chicago, IL, USA, October 14-17, 2015.
2.
Fehlings MF, Kopjar B, Grossman R, Wilson J. Efficacy and Safety of Riluzole in
Acute Spinal Cord Injury (SCI). Rationale and Design of AOSpine Phase III Multi-center Double Blind Randomized Controlled Trial. (RISCIS). Congress of Neurological Surgeons (CNS) Annual Meeting, New Orleans, LA, USA, September 27-30,
2015.
3.
Fehlings MF, Kopjar B, Grossman R, Wilson J. Efficacy and Safety of Riluzole in
Acute Spinal Cord Injury (SCI). Rationale and Design of AOSpine Phase III Multi-center Double Blind Randomized Controlled Trial. (RISCIS). Global Spine Congress (GSC) Buenos Aires, Argentina, May 20-23, 2015.
4.
Fehlings MF, Kopjar B, Grossman R, Wilson J. Efficacy and Safety of Riluzole in
Acute Spinal Cord Injury (SCI). Rationale and Design of AOSpine Phase III Multi-center Double Blind Randomized Controlled Trial. (RISCIS). American Association
of Neurological Surgeons (AANS) Annual Meeting, Washington DC, USA, May 2-6,
2015.
5.
Fehlings MF, Kopjar B, Grossman R, Wilson J. Efficacy and Safety of Riluzole in
Acute Spinal Cord Injury (SCI). Rationale and Design of AOSpine Phase III Multi-center Double Blind Randomized Controlled Trial. (RISCIS). AANS/CNS Joint Section on Disorders of the Spine and Peripheral Nerves, Phoenix, AZ, USA, March 4-7,
2015.
6.
Fehlings MF, Kopjar B, Grossman R. Efficacy and Safety of Riluzole in Acute Spinal
Cord Injury (SCI). Rationale and Design of AOSpine Phase III Multi-center Double
Blind Randomized Controlled Trial. (RISCIS). American Association of Neurological
Surgeons (AANS) Annual Meeting, San Francisco, CA, USA, April 5-9, 2014.
7.
Fehlings MF, Grossman R, Wilson J, Frankowski R, Kopjar B, Burau K, Chow D,
Tator C, Teng A, Toups E, Harrop J, Aarabi B, Shaffrey C, Johns M. The clinical translation of Riluzole for the treatment of traumatic spinal cord injury: design of a phase
II/III trial. 63rd Annual Meeting of the Congress of Neurological Surgeons (CNS),
San Francisco, CA, USA, October 19-23, 2013.
Manuscripts
Published
1.Fehlings MG, Nakashima H, Nagoshi N, Chow DS, Grossman RG, Kopjar B. Rationale, design and critical end points for the Riluzole in Acute Spinal Cord Injury Study
(RISCIS): a randomized, double-blinded, placebo-controlled parallel multi-center
trial. Spinal Cord 54(1): 8-15, 2016.
2.Nagoshi N, Nakashima H, Fehlings MG. Riluzole as a neuroprotective drug for
spinal cord injury: from bench to bedside. Molecules 20(5): 7775-7789, 2015.
3.Fehlings MG, Wilson JR, Frankowski RF, Toups EG, Aarabi B, Harrop JS, Shaffrey CI,
Harkema SJ, Guest JD, Tator CH, Burau KD, Johnson MW, Grossman RG. Riluzole
for the treatment of acute traumatic spinal cord injury: rationale for and design of
the NACTN Phase I clinical trial. J Neurosurg Spine 17(1 Suppl): 151-156, 2012.
4.Tator CH, Hashimoto R, Raich A, Norvell D, Fehlings MG, Harrop JS, Guest J, Aarabi B, Grossman RG. Translational potential of preclinical trials of neuroprotection
through pharmacotherapy for spinal cord injury. J Neurosurg Spine 17(1 Suppl):
157-229, 2012.
Book Chapters
In Press
1.Cohen-Adad J, Martin A, Fehlings M. Magnetic resonance imaging of the injured
spinal cord: the present and the future, in: Vialle L, Riew K, Ito M, AOSpine Masters
Series Volume 7: Thieme, New York.
2.Hawryluk G, Fehlings M. Acute non-operative management of traumatic spinal
cord injury – state of the art, in: Vialle L, Riew K, Ito M, AOSpine Masters Series
Volume 7: Thieme, New York.
31
3.Fehlings M, Witiw C. Role and timing of surgery for traumatic spinal cord injury –
What do we know? What should we do? in: Vialle L, Riew K, Ito M, AOSpine Masters
Series Volume 7: Thieme, New York.
4.Fehlings M, Nagoshi N, Nakashima H. Pathobiology of spinal cord injury, in: Vialle L,
Riew K, Ito M, AOSpine Masters Series, Volume 7: Thieme, New York.
5.Fehlings M, Ahuja C. Neuroprotection of the injured spinal cord – What does the future
hold? in: Vialle L, Riew K, Ito M, AOSpine Masters Series Volume 7: Thieme, New York.
6.Kwon B. Serum and CSF Biomarkers to Predict Functional Recovery after Spinal Cord
Injury, in: Vialle L, Riew K, Ito M, AOSpine Masters Series Volume 7: Thieme, New
York.
7.Wilson J, Fehlings M. Methylprednisolone for acute spinal cord injury: a re-assessment of the literature. Is this drug an option? in: Vialle L, Riew K, Ito M, AOSpine
Masters Series Volume 7: Thieme, New York.
Awards & Nominations
RISCIS
•Nominated for the White Cloud Award at the 21st International Meeting on Advanced Spine Techniques (IMAST) 2014.
•
Accepted for Presentation
Podium Presentations
1.Sadiqi S, Verlaan JJ, Lehr AM, Oner FC. Development of a universal disease-specific
outcome instrument for spine trauma patients – the AOSpine clinician reported
outcome spine trauma (AOSpine CRSOT). Global Spine Congress 2016, Dubai,
UAE, 13-16 April, 2016.
2.Schroeder GD, Kepler CK, Grad S, Alini M, Markova DZ, Koerner JD, Rajasekaran S,
Chapman JR, Kandziora F, Schnake K, Dvorak MF, Oner C, Vaccaro AR. Effect of Riluzole on human bone marrow stromal cells and osteoblasts. Global Spine Congress
2016, Dubai, UAE, 13-16 April, 2016.
3.Schroeder GD, Vaccaro AR, Kepler CK, Kurd MF, Krieg JC, Kleweno CP, Firoozabadi
R, Kandziora F, Schnake K, Rajasekaran S, Holstein JH, Sagi HC, Dvorak MF, Vialle
LR, Oner C, Bellabarba C, Chapman JR. The development of a universally accepted
sacral fracture classification: a survey of AOSpine and AOTrauma members. Global
Spine Congress 2016, Dubai, UAE, 13-16 April, 2016.
4.Sadiqi S, Verlaan JJ, Lehr AM, Oner FC, Aospine Knowledge Forum Trauma. Development of a universal disease-specific outcome instrument for spine trauma – the
AOSpine clinician reported outcome spine trauma (AOSpine CROST). 17th EFORT
Annual Congress, Geneva, Switzerland, June 1-3, 2016.
Awarded with the Trauma and Critical Care Third Place E-poster Award.
Poster Presentations
Knowledge Forum Trauma
Abstracts
Submitted (under review)
1.Sadiqi S, Lehr A, Post M, Oner F, Aospine Knowledge Forum Trauma. AOSpine
Patient Reported Outcome Spine Trauma (AOSpine PROST) – a universal disease-specific outcome instrument for traumatic spinal column injury. EuroSpine
2016, Berlin, Germany, October 5-7, 2016.
2.Sadiqi S, Verlaan JJ, Lehr AM, Oner FC, Aospine Knowledge Forum Trauma. A new
concept of a universal disease-specific outcome instrument for spine trauma – The
AOSpine Clinician Reported Outcome Spine Trauma (AOSpine CROST). EuroSpine
2016, Berlin, Germany, October 5-7, 2016.
3.Schroeder GD, Kepler CK, Grad S, Alini M, Markova DZ, Koerner JD, Rajasekaran S,
Chapman J, Kandziora F, Schnake KJ, Dvorak MF, Oner C, Vaccaro AR. Influence of
Riluzole on osteogenic differentiation of human bone marrow stromal cells and
osteoblasts. North American Spine Society (NASS) 31st Annual Meeting, Boston,
MA, USA, October 26-29, 2016.
1.Bellabarba C, Schroeder GD, Kepler CK, Kurd MF, Krieg JC, Kleweno CP, Firoozabadi R, Chapman JR, Kandziora F, Schnake K, Rajasekaran S, Holstein JH, Sagi HC,
Dvorak MF, Vialle LR, Oner C, Vaccaro AR. The AOSpine sacral fracture classification.
Global Spine Congress 2016, Dubai, UAE, April 13-16 2016.
2.Rajasekaran S, Vaccaro AR, Kanna RM, Schroeder GD, Oner FC, Vialle L, Chapman
J, Dvorak M, Fehlings MG, Shetty AP, Schnake K, Maheshwaran A, Kandziora F. The
role of CT and MRI in the classification and assessment of thoracolumbar fractures. Global Spine Congress 2016, Dubai, UAE, April 13-16 2016.
3.Sadiqi S, Lehr AM, Post MW, Oner FC, Aospine Knowledge Forum Trauma. Universal disease-specific outcome instrument for traumatic spinal column injury – the
AOSpine patient reported outcome spine trauma (AOSpine PROST). 17th EFORT
Annual Congress, Geneva, Switzerland, June 1-3, 2016.
Presented
Podium Presentations
1.
Sadiqi S, Lehr AM, Oner FC. Towards the development of an international disease
specific outcome instrument for spine trauma – surgeon reported outcome. EuroSpine 2015, Copenhagen, Denmark, September 2-4, 2015.
2.Kepler CK, Vaccaro AR, Koerner JD, Chapman J, Dvorak M, Kandziora F, Rajasekaran
S, Aarabi B, Vialle L, Fehlings MG, Schroeder GD, Reinhold M, Audige L, Schnake
KJ, Bellabarbra C, Oner FC. Reliability analysis of the AOSpine thoracolumbar spine
injury classification system by a worldwide group of naïve spinal surgeons. 43rd
32
Annual Meeting of the International Society for the Study of the Lumbar Spine
(ISSLS), San Francisco, CA, USA, June 8-12, 2015.
3.
Schroeder GD, Vaccaro AR, Kepler CK, Koerner JD, Oner FC, Dvorak M, Vialle L,
Aarabi B, Bellabarbra C, Fehlings MG, Kandziora F. Establishing the injury severity of
thoracolumbar trauma: confirmation of the hierarchical structure of the AOSpine
thoracolumbar spine injury classification system. 43rd Annual Meeting of the International Society for the Study of the Lumbar Spine (ISSLS) , San Francisco, CA, USA,
June 8-12, 2015.
4.Kepler CK, Vaccaro AR, Koerner JD, Chapman J, Dvorak M, Kandziora F, Rajasekaran
S, Aarabi B, Vialle L, Fehlings MG, Schroeder GD, Reinhold M, Audige L, Schnake
KJ, Bellabarbra C, Oner FC. Reliability analysis of the AOSpine thoracolumbar spine
injury classification system by a worldwide group of naïve spinal surgeons. Global
Spine Congress 2015, Buenos Aires, Argentina, May 20-23, 2015.
5.Sadiqi S, Lehr AM, Oner FC. Towards the development of an international disease
specific outcome instrument for spine trauma. Global Spine Congress 2015, Buenos Aires, Argentina, May 20-23, 2015.
6.
Schroeder GD, Kepler CK, Chapman J, Oner FC, Dvorak M, Vialle L, Aarabi B, Bellabarbra C, Fehlings MG, Rajasekaran S, Schnake KJ, Reinhold M, Kandziora F, Vaccaro
AR. Is there a regional difference in morphology interpretation of A3 / A4 fractures
among different cultures? Global Spine Congress, Buenos Aires, Argentina, May
20-23, 2015.
7.
Schroeder GD, Vaccaro AR, Kepler CK, Koerner JD, Oner FC, Dvorak M, Vialle L,
Aarabi B, Bellabarbra C, Fehlings MG, Kandziora F. Establishing the injury severity of
thoracolumbar trauma: confirmation of the hierarchical structure of the AOSpine
thoracolumbar spine injury classification system. Global Spine Congress 2015,
Buenos Aires, Argentina, May 20-23, 2015.
8.Vaccaro AR, Kepler CK, Koerner JD, Chapman J, Dvorak M, Vialle L, Aarabi B, Bellabarbra C, Fehlings MG, Rajasekaran S, Schroeder GD, Schnake KJ, Reinhold M,
Kandziora F, Oner FC. AOSpine subaxial cervical spine injury classification system.
Global Spine Congress 2015, Buenos Aires, Argentina May 20-23, 2015.
9.
Kepler CK, Koerner JD, Oner C, Fehlings MG, Aarabi B, Dvorak M, Reinhold M,
Kandziora F, Bellabarba C, Chapman J, Vialle L, Vaccaro AR. A worldwide analysis of
the reliability and perceived importance of an injury to the posterior ligamentous
complex in AO type A fractures. 8th Annual Lumbar Spine Research Society (LSRS),
Chicago, IL, USA, May 9-10, 2015.
10.
Schroeder GD, Vaccaro AR, Kepler CK, Koerner JD, Oner FC, Dvorak M, Vialle L,
Aarabi B, Bellabarbra C, Fehlings MG, Kandziora F. Establishing the injury severity of
thoracolumbar trauma: confirmation of the hierarchical structure of the AOSpine
thoracolumbar spine injury classification system. 8th Annual Lumbar Spine Research Society (LSRS), Chicago, IL, USA, May 9-10, 2015.
11.Vaccaro AR, Schroeder GD, Kepler CK, Oner FC, Vialle L, Kandziora F, Koerner JD,
Kurd MF, Reinhold M, Schnake KJ, Chapman J, Aarabi B, Fehling MG, Dvorak M.
The surgical algorithm for the AOSpine thoracolumbar spine injury classification
system. 8th Annual Lumbar Spine Research Society (LSRS), Chicago, IL, USA, May
9-10, 2015.
12.
Oner FC, Jacobs WC, Lehr AM, Sadiqi S. Towards the development of a universal
outcome instrument for spine trauma – A systematic review and content comparison of outcome measures used in spine trauma research. 11th International
Turkish Spine Congress, Izmir, Turkey, April 29-May 3, 2015.
13.
Sadiqi S, Lehr AM, Oner FC. Towards developing a specific outcome instrument
for spine trauma - An empirical cross-sectional multicenter ICF-based study by the
AOSpine Knowledge Forum Trauma. 11th International Turkish Spine Congress,
Izmir, Turkey, April 29-May 3, 2015.
14.
Sadiqi S, Lehr AM, Oner FC. Towards the development of an international disease
specific outcome instrument for spine trauma – results of an international consensus meeting. 11th International Turkish Spine Congress, Izmir, Turkey, April 29-May
3, 2015.
15.
Sadiqi S, Lehr AM, Oner FC. Towards the development of an outcome instrument
for spine trauma – an international survey of spinal surgeons. 11th International
Turkish Spine Congress, Izmir, Turkey, April 29-May 3, 2015.
16.Vaccaro A, Radcliff K, Koerner J, Kepler C, Kandziora F, Schnake K, Vialle L, Oner
C, Dvorak M, Aarabi B, Fehlings M, Rajasekaran S, Reinhold M. Pre-validation process of the AO subaxial cervical spine classification system. EuroSpine 2014, Lyon,
France, October 1-3, 2014.
Poster Presentations
1.
Schroeder GD, Kepler CK, Grad S, Alini M, Markova DZ, Koerner JD, Rajasekaran S,
Chapman JR, Kandziora F, Schnake K, Dvorak MF, Oner C. Effect of Riluzole on human
bone marrow stromal cells and osteoblasts. ORS/PSRS 3rd International Philadelphia Spine Research Symposium, Philadelphia, PA, USA, November 9-12, 2015.
Manuscripts
Submitted
1.Kepler CK, Vaccaro AR, Schroeder GD, Koerner JD, Vialle L, Aarabi B, Rajasekaran S,
Bellabarba C, Chapman J, Kandziora F, Dvorak M, Reinhold M, Oner C. The thoracolumbar AOSpine injury score (TL AOSIS). Global Spine J, 2016.
2.Rajasekaran S, Vaccaro AR, Kanna RM, Schroeder GR, Oner FC, Vialle L, Chapman
J, Dvorak M, Fehlings M, Shetty AP, Schnake K, Maheshwaran A, Kwon BK, Harrop
JS, Kandziora F. Does the spine surgeon’s experience affect fracture classification,
assessment of stability and treatment plan in thoracolumbar injuries? Eur Spine J
2016.
3.Schnake KJ, Schleicher P, Kandziora F, Reinhold M, Aarabi B, Bellabarba C, Chapman
J, Dvorak MF, Fehlings MG, Kepler CK, Koerner JD, Oner FC, Radcliff KE, Rajasekaran
S, Schroeder GD, Vaccaro AR, Vialle LR, Aospine Spinal Cord Injury & Trauma Knowledge Forum. Die AOSpine Klassifikation für Verletzungen der subaxialen HWS.
Zeitschrift für Orthopädie und Unfallchirurgie, 2016.
33
4.
Critical factors for the adoption of a new thoracolumbar injury classification system. Global Spine J, 2015.
5.Rajasekaran S, Vaccaro AR, Kanna RM, Schroeder GD, Oner FC, Vialle L, Chapman
J, Dvorak M, Fehlings M, Shetty AP, Schnake K, Maheshwaran A, Kandziora F. The
Value of CT and MRI in the evaluation and management of patients with thoracolumbar spinal injuries. Spine (Phila Pa 1976), 2015.
6.Sadiqi S, Lehr AM, Post MW, Jacobs WCH, Aarabi B, Chapman J, Dunn RN, Dvorak
M, Fehlings M, Rajasekaran S, Vialle L, Vaccaro AR, Oner C. The selection of core
international classification of functioning, disability and health (ICF) categories for
patient reported outcome measurement in spine trauma patients - results of an
international consensus process. Spine J, 2015.
7.Sadiqi S, Verlaan JJ, Lehr AM, Dvorak M, Kandziora F, Rajasekaran S, Schnake K, Vaccaro AR, Oner C. Universal disease specific outcome instruments for spine trauma
- A global perspective on relevant parameters to evaluate clinical and functional
outcomes of thoracic and lumbar spine trauma patients. Eur Spine J, 2015.
8.Sadiqi S, Verlaan J-J, Lehr AM, Dvorak MF, Kandziora F, Rajasekaran S, Schnake KJ,
Vaccaro AR, Oner FC. Surgeon reported outcome measure for spine trauma - An
international survey identifying parameters relevant to evaluate outcomes of subaxial cervical spine trauma patients. Eur Spine J, 2015.
Accepted
1.Kandziora F, Schleicher P, Schnake K, Reinhold M, Aarabi B, Bellabarba C, Chapman
J, Dvorak M, Fehlings M, Grossmann R, Kepler CK, Oner C, Shanmuganathan R,
Vialle L, Vaccaro AR, Aospine Spinal Cord Injury & Trauma Knowledge Forum. Die
AOSpine Klassifikation thorakolumbaler Wirbelsäulenverletzungen. Zeitschrift für
Orthopädie und Unfallchirurgie, 2016.
2.Schroeder GD, Vaccaro AR. Variations in the treatment of thoracolumbar burst
fractures. Contemporary Spine Surgery, 2015.
Published
1.Oner FC, Jacobs WCH, Lehr AM, Sadiqi S, Post MW, Aarabi B, Chapman J, Dvorak M,
Fehlings M, Kandziora F, Rajasekaran S, Vaccaro AR. Towards the development of a
universal outcome instrument for spine trauma - A systematic review and content
comparison of outcome measures used in spine trauma research using the ICF as
reference. [Epub ahead of print] Spine (Phila Pa 1976) Oct 17, 2015.
2.Kepler CK, Vaccaro AR, Koerner JD, Dvorak MF, Kandziora F, Rajasekaran S, Aarabi
B, Vialle LR, Fehlings MG, Schroeder GD, Reinhold M, Schnake KJ, Bellabarba C,
Cumhur Oner F. Reliability analysis of the AOSpine thoracolumbar spine injury
classification system by a worldwide group of naive spinal surgeons. [Epub ahead
of print] Eur Spine J, January 20, 2015.
3.Oner FC, Sadiqi S, Lehr AM, Aarabi B, Dunn RN, Dvorak MF, Fehlings MG, Kandziora F, Post MW, Rajasekaran S, Vialle L, Vaccaro AR. Toward developing a specific
outcome instrument for spine trauma: an empirical cross-sectional multicenter
ICF-based study by AOSpine Knowledge Forum Trauma. Spine (Phila Pa 1976)
40(17): 1371-1379, 2015.
34
4.Oner FC, Sadiqi S, Lehr AM, Dvorak MF, Aarabi B, Chapman JR, Fehlings MG, Kandziora F, Rajasekaran S, Vaccaro AR. Towards the development of an outcome instrument for spinal trauma: an international survey of spinal surgeons. Spine (Phila Pa
1976) 40(2): E91-96, 2015.
5.Rubenstein R, Koerner JD, Oh D, Kepler CK, Kandziora F, Shanmuganathan R,
Dvorak M, Aarabi B, Vialle L, Oner C, Vaccaro AR. Thoracolumbar injury severity
scoring systems: a review and rationale for a new system based on the AOSpine
thoracolumbar injury classification system. Int J Phys Med Rehabil 3(2), 2015.
6.Sadiqi S, Lehr AM, Post MW, Vaccaro AR, Dvorak MF, Oner FC. Toward a specific
outcome instrument for spinal trauma: how to measure function and health. Spine
(Phila Pa 1976) 40(10): E578-586, 2015.
7.Sadiqi S, Mechteld Lehr A, Jacobs WC, Post MW, Cumhur Oner F. Reply to the Letter
to the Editor regarding “Towards the development of a universal outcome instrument for spine trauma - a systematic review and content comparison of outcome
measures used in spine trauma research using the ICF as reference.” Spine (Phila
Pa 1976). 2015 Oct 17. [Epub ahead of print]. Spine (Phila Pa 1976), 2015.
8.Sadiqi S, Oner FC, Dvorak MF, Aarabi B, Schroeder GD, Vaccaro AR. The influence of
spine surgeons’ experience on the classification and intraobserver reliability of the
novel AOSpine thoracolumbar spine injury classification system - an international
study. Spine (Phila Pa 1976) 40(23): E1250-1256, 2015.
9.Schroeder GD, Kepler CK, Koerner JD, Chapman J, Bellabarba C, Oner C, Reinhold
M, Dvorak M, Aarabi B, Vialle L, Fehlings M, Rajasekaran S, Kandziora F, Schnake K,
Vaccaro AR. Is there a regional difference in morphology interpretation of A3 / A4
fractures among different cultures. J Neurosurg Spine: 1-8, 2015.
10.Schroeder GD, Kepler CK, Koerner JD, Oner C, Fehlings M, Aarabi B, Kandziora F, Vialle L, Vaccaro AR. Can a thoracolumbar injury severity score be uniformly applied
from T1 to L5 or are modifications necessary? Global Spine J (5): 339-345, 2015.
11.Schroeder GD, Kepler CK, Koerner JD, Oner FC, Fehlings MG, Aarabi B, Dvorak
MF, Reinhold M, Kandziora F, Bellabarba C, Chapman JR, Vialle LR, Vaccaro AR. A
worldwide analysis of the reliability and perceived importance of an injury to the
posterior ligamentous complex in AO type A fractures. Global Spine J 5(5): 378382, 2015.
12.Schroeder GD, Vaccaro AR, Kepler CK, Koerner JD, Oner FC, Dvorak MF, Vialle LR,
Aarabi B, Bellabarba C, Fehlings MG, Schnake KJ, Kandziora F. Establishing the injury
severity of thoracolumbar trauma: confirmation of the hierarchical structure of the
AOSpine thoracolumbar spine injury classification system. Spine (Phila Pa 1976)
40(8): E498-503, 2015.
13.Vaccaro AR, Koerner JD, Radcliff KE, Oner FC, Reinhold M, Schnake KJ, Kandziora F,
Fehlings MG, Dvorak MF, Aarabi B, Rajasekaran S, Schroeder GD, Kepler CK, Vialle
LR. AOSpine subaxial cervical spine injury classification system. Eur Spine J, 2015.
14.Vaccaro AR, Schroeder GD, Kepler CK, Cumhur Oner F, Vialle LR, Kandziora F, Koerner JD, Kurd MF, Reinhold M, Schnake KJ, Chapman J, Aarabi B, Fehlings MG,
Dvorak MF. The surgical algorithm for the AOSpine thoracolumbar spine injury
classification system. Eur Spine J, 2015.
15.Vaccaro AR, Oner C, Kepler CK, Dvorak M, Schnake K, Bellabarba C, Reinhold M,
Aarabi B, Kandziora F, Chapman J, Shanmuganathan R, Fehlings M, Vialle L, Aospine
Spinal Cord Injury Trauma Knowledge Forum. AOSpine thoracolumbar spine injury
classification system: fracture description, neurological status, and key modifiers.
Spine (Phila Pa 1976) 38(23): 2028-2037, 2013.
11.Schroeder GD, Millhouse PW, Vaccaro AR, Oner FC, Vialle LR. The New AOSpine
Subaxial Cervical Spine Injury Classification System, in: Vialle LR, Riew KD, Ito M,
(eds.), AOSpine Masters Series, Volume 5: Cervical Spine Trauma. Thieme, New
York, 2015, pp. 169-176.
In Press
Book Chapters
Published
1.Rajasekaran S, Kanna RM, Maheshwaran A, Shetty AP. Radiographic Assessment of
Thoracolumbar Fractures, in: Vialle L, Bellabarba C, Kandziora F, (eds.), AOSpine
Master Series, Volume 6: Thoracolumbar Spine Trauma. Thieme, New York, 2016,
pp. 9-32.
2.Scholz M, Schleicher P, Kandziora F. Posterior Minimally Invasive Surgery in Thoracolumbar Fractures, in: Vialle L, Bellabarba C, Kandziora F, (eds.), AOSpine Master
Series, Volume 6: Thoracolumbar Spine Trauma. Thieme, New York, 2016, pp. 3346.
3.Schleicher P, Scholz M, Kandziora F. Anterior Minimally Invasive Surgery in Thoracolumbar Fractures, in: Vialle L, Bellabarba C, Kandziora F, (eds.), AOSpine Master
Series, Volume 6: Thoracolumbar Spine Trauma. Thieme, New York, 2016, pp. 4756.
1.Woods BI, Schroeder GD, Vaccaro AR. Fractures and dislocations of the cervical
spine from C-3 to C-7, Chapman’s Orthopaedic Surgery, 4th edition. Lippincott
Williams & Wilkins, 2016.
2.Schroeder GD, Vaccaro AR. Cervical Spine Trauma, Handbook of Spine Surgery.
Thieme, New York, 2016.
3.Schroeder GD, Kepler CK, Vaccaro AR. Thoracolumbar trauma classification and
surgical treatment, Vaccaro AR, Baron EM, (eds.), Atlas of Operative Techniques in
Spinal Surgery, 2016.
4.Kumar P, Lau K, Millhouse P, Kepler C, Vaccaro A. New classification and management of thoracolumbar spine injury. Techniques in Spine Surgery, Springer Korea
Limited, Seoul, 2016.
5.
Koerner JD, Vaccaro AR. Evaluation and Classification and Treatment of Cervical (C3-C7) Injuries, in: Winn HR, Volume Youmans Neurological Surgery. Elsevier, Philadelphia, PA, 2016.
4.Oskouian RJ, Chapman JR. Cervicothoracic Spine Fractures, in: Vialle L, Bellabarba
C, Kandziora F, (eds.), AOSpine Master Series, Volume 6: Thoracolumbar Spine
Trauma. Thieme, New York, 2016, pp. 57-75.
5.Oner FC, Verlaan JJ. Burst Fracture Treatment, in: Vialle LR, Bellabarba C, Kandziora
F, (eds.), AOSpine Master Series, Volume 6: Thoracolumbar Spine Trauma. Thieme,
New York, 2016, pp. 97-108.
6.Schnake KJ, Morrison R. Correction of Posttraumatic Deformity, in: Vialle L, Bellabarba C, Kandziora F, (eds.), AOSpine Master Series, Volume 6: Thoracolumbar Spine
Trauma. Thieme, New York, 2016, pp. 127-140.
7.Schleicher P, Scholz M, Kandziora F. Occipital Condyle Fracture and Occipitocervical
Dissociation, in: Vialle LR, Oner FC, Vaccaro AR, (eds.), AOSpine Master Series,
Volume 5: Cervical Spine Trauma. Thieme, New York, 2015, pp. 49-60.
8.Scholz M, Schleicher P, Kandziora F. Atlas Injuries, in: Vialle LR, Oner FC, Vaccaro
AR, (eds.), AOSpine Master Series, Volume 5: Cervical Spine Trauma. Thieme, New
York, 2015, pp. 61-72.
9.Robinson WA, Mccarthy KP, Vaccaro AR, Harrod CC. Subaxial Cervical Spine Injuries:
Distraction (AO Type-B Injuries), in: Vialle LR, Oner FC, Vaccaro AR, (eds.), AOSpine
Master Series, Volume 5: Cervical Spine Trauma. Thieme, New York, 2015, pp. 94-104.
10.Verlaan J-J, Oner FC. Cervical Trauma in Combination with Ankylosing Spondylitis or
Diffuse Idiopathic Skeletal Hyperostosis, in: Vialle LR, Oner FC, Vaccaro AR, (eds.),
AOSpine Master Series, Volume 5: Cervical Spine Trauma. Thieme, New York, 2015,
pp. 139-146.
35
Knowledge Forum
Degenerative / Biologics
Abstracts
Accepted
Podium Presentations
1.Buser Z, Brodke D, Esmail N, Meisel H, Park J, Myhre S, Youssed J, Wang J, Yoon
T. Postoperative complications associated with rhBMP2 use in posterior lumbar
fusion. Global Spine Congress 2016, Dubai, UAE, April 13-16, 2016.
Presented
Podium Presentations
1.
Yoon ST, Konopka J, Wang J, Youssef J, Meisel HJ, Brodke D, Park J-B. ACDF grafts
selection by surgeons: survey of AOSpine members. Global Spine Congress 2015,
Buenos Aires, Argentina, May 20-23, 2015.
Manuscripts
Accepted
1.Tuchman A, Brodke DS, Youssef JA, Meisel HJ, Dettori J, Park JB, Yoon T, Wang JW.
Iliac crest bone graft versus local autograft or allograft for lumbar spinal fusion: a
systematic review. Global Spine J, 2016.
2.Tuchman A, Brodke DS, Youssef JA, Meisel HJ, Dettori J, Park JB, Yoon T, Wang JW. Autograft versus allograft for cervical spinal fusion: a systematic review. Global Spine J, 2016.
3.Yao Q, Cohen JR, Buser Z, Park JB, Brodke DS, Meisel HJ, Youssef JA, Wang JW.
Analysis of rhBMP-2 use in the treatment of lumbar degenerative spondylolisthesis. Global Spine J, 2016.
4.Buser Z, Brodke DS, Youssef JA, Meisel HJ, Lynn Myhre S, Hashimoto R, Park JB,
Yoon TS, Wang JC. Synthetic bone graft versus autograft or allograft for spinal
fusion: a systematic review. J Neurosurg Spine, 2015.
5.Ruofeng Y, Cohen J, Buser Z, Yoon S, Meisel H-J, Youssef J, Park J-B, Wang J, Brodke
D. Trends of posterior long segment fusion with and without recombinant human
bone morphogenetic protein 2 in patients with scoliosis. Global Spine J, 2015.
Published
1.Lao L, Cohen JR, Lord EL, Buser Z, Wang JC. Trends analysis of rhBMP utilization in
single-level posterior lumbar fusion (PLF) in the United States. Eur Spine J 25(3):
783-788, 2016.
Submitted
1.Takahashi S, Buser Z, Cohen JR, Roe A, Lynn Myhre S, Meisel HJ, Brodke DS, Park
JB, Wang JW, Youssef JA. Complications related to the recombinant human bone
morphogenetic protein 2 use in posterior cervical fusion. Clin Spine Surg, 2016.
2.Tilan J, Buser Z, Cohen JR, Brodke DS, Youssef JA, Park JB, Yoon TS, Meisel HJ, Wang
JC. A retrospective analysis of complications associated with bone morphogenic
protein 2 in anterior lumbar interbody fusion. Int Orthop, 2016.
3.Guibin Z, Cohen JR, Ashana AO, Lord EL, Meisel HJ, Lao L, Youssef JA, Park JB, Wang
JC, Brodke DS. Cost analysis of the surgical treatment of scoliosis with and without
BMP in the United States. J Orthop Sci, 2015.
4.Lao L, Cohen JR, Buser Z, Brodke DS, Youssef JA, Park J-B, Yoon ST, Wang JC, Meise
H-J. Trends analysis of rhBMP utilization in single-level posterior lumbar interbody
fusion (PLIF) in the United States. Int Orthop, 2015.
5.Lao L, Cohen JR, Lord EL, Brodke DS, Youssef JA, Park JB, Meisel HJ, Wang JW.
Trends analysis of rhBMP utilization in single-level anterior lumbar interbody fusion
(ALIF) in the United States. Eur Spine J, 2015.
6.Ruofeng Y, Cohen JR, Buser Z, Meisel H-J, Yoon TS, Youssef JA, Park J-B, Wang JC,
Brodke DS. Trends of surgical treatment in elder scoliosis patients with and without
rhBMP2. Spine J, 2015.
7.Zhong G, Cohen JR, Ashana AO, Lord EL, Meisel HJ, Lao L, Youssef JA, Park JB, Wang
JW, Brodke DS. Cost analysis of the surgical treatment of scoliosis with and without
BMP in the United States. Global Spine J, 2015.
36
Book Chapters
1.Khamsi B, Gidvani S, Wang J. Adjacent segment pathology of the cervical spine, in:
Vialle L, Riew K, Ito M, (eds.), AOSpine Masters Series Volume 3: Cervical Degenerative Conditions. Thieme, New York, 2015, pp. 104-113.
Spine Research
Network (SRN)
Abstracts
Presented
Podium Presentations
1.Bach FC, De Vries SaH, Krouwels A, Creemers LB, Ito K, Meij BP, Tryfonidou MA. The
species-specific regenerative effects of notochordal cell-conditioned medium on
degenerated human nucleus pulposus cells. The Dutch Society of Matrix Biology,
Lunteren, the Netherlands, 28-29 May, 2015.
2.Bach FC, Zhang Y, Verdonschot LC, Miranda BA, Bergknut N, Creemers LB, Ito K,
Sakai D, Chan D, Meij BP, Tryfonidou MA. The role of caveolin-1 in intervertebral
disc degeneration and regeneration. The Dutch Society of Matrix Biology, Lunteren,
the Netherlands 28-29 May, 2015.
3.Chan D. Genetics of intervertebral disc degeneration: Of human and mice. International Musculoskeletal Research Conference, Changsha, China, April 9-11, 2015.
4.De Vries SaH, Van Doeselaar M, Meij BP, Tryfonidoum MA, Ito K. The stimulatory effect of notochordal cell-conditioned medium in a nucleus pulposus explant culture.
Global Spine Conference 2015, Buenos Aires, Argentina, May 20-23, 2015.
5.Haglund L. A Feasibility Study of Cell Injection Therapy in Human Intervertebral
Discs Cultured Under Dynamic Load. Global Spine Congress 2015, Buenos Aires,
Argentina, May 20-23, 2015.
6.Haglund L. Tissue Engineering for Intervertebral Disc Repair and Regeneration.
Global Spine Congress 2015, Buenos Aires, Argentina, May 20-23, 2015.
7.Haglund L. Mechanical Injury to Human Intervertebral Discs and Isolated Cells
Initates Events Implicated in Degeneration and Pain. Global Spine Congress 2015,
Buenos Aires, Argentina, May 20-23, 2015.
8.Li HY, Chooi WH, Chan D, Cheah KSE, Chan BP. Development of 3D culture system
for bovine nucleus pulposus cells. 4th Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress – Past, Present, Future, the
evolution of Regenerative Medicine, Boston, MA, USA, September 8-11, 2015.
12.Muftuler LT, Jarman JP, Maiman DJ, Yu HJ, Gardner VO. Intervertebral disc degeneration and changes in solute transport mechanisms in disc endplates studied by
DCE-MRI. Annual meeting of the International Society of Magnetic Resonance in
Medicine, Milan, Italy, May 10-16, 2014.
13.Potier E, De Vries S, Tryfonidou M, Ito K. Notochordal cells for intervertebral disc
regeneration: what is their most effective application? World Forum for Spine Research 2014, Xi’an, China, May 15-17, 2014.
14.Zhang J, Xiong S, Chan W, Tam V, Sakai D, Chan D. Are there protective genes for
disc degeneration? World Forum for Spine Research 2014, Xi’an, China, May 15-17,
2014.
15.Arkesteijn I, Potier E, Ito K. Maintaining notochordal phenotype. Global Spine Congress 2013, Hong Kong, China, April, 2013.
16.Chik T, Chooi W, Choy T, Sze K, Luk K, Cheung K, Chan B. Fabrication of multi-component spinal motion segment-like construct using mesenchymal stem cells and
collagen. TERMIS-AP 2013 Annual Conference, Shanghai-Wuzhen, China, 2013.
17.Chik TK, Choy ATH, Deng WK, Ma XY, Li YY, Leung V, Cheung KMC, Chan BP. Photochemically crosslinked collagen plug reduces cell leakage during intradiscal injection of mesenchymal stem cells (MSCs). Global Spine Congress 2013, Hong Kong,
China, April, 2013.
18.Gawri R, Antoniou J, Alkhatib B, Ouellet J, Steffen T, Roughley P, Haglund L, Mwale F.
Sustained stimulation of aggrecan synthesis in degenerated human intervertebral
discs by Link N. 47th Annual Meeting of Canadian Orthopaedic Association (COA) and
Canadian Orthopaedics Research Society (CORS), Winnipeg, Canada, June, 2013.
19.Gawri R, Antoniou J, Alkhatib B, Ouellet J, Steffen T, Roughley P, Haglund L, Mwale F.
Sustained stimulation of aggrecan synthesis in degenerated human intervertebral
discs by Link N. Global Spine Congress 2013, Hong Kong, China, April, 2013.
20.Gawri R, Antoniou J, Alkhatib B, Ouellet J, Steffen T, Roughley P, Haglund L, Mwale F.
Sustained stimulation of aggrecan synthesis in degenerated human intervertebral
discs by Link N. Annual Experimental Surgery Graduate Research Day, Montreal,
QC, Canada, 2013.
21.Gawri R, Antoniou J, Alkhatib B, Ouellet J, Steffen T, Roughley P, Haglund L, Mwale F.
Evaluation of the regenerative potential of Link-N in degenerated human intervertebral discs. Orthopaedic Research Society (ORS) Meeting, San Antonio, TX, USA,
January, 2013.
9.Yuan MT, Yeung CW, Au TYK, Chan D, Cheah KSE, Chan BP. Development of 3D
system for culturing notochordal cells. 4th Tissue Engineering and Regenerative
Medicine International Society (TERMIS) World Congress – Past, Present, Future,
the evolution of Regenerative Medicine, Boston, MA, USA, September 8-11, 2015.
22.Gawri R, Antoniou J, Ouellet J, Roughley P, Steffen T, Haglund L, Mwale F. Link-N
peptide: can degenerated human intervertebral discs be repaired? 19th Canadian
Connective Tissue Conference (CCTC), Montreal, QC, Canada, May, 2013.
10.Chooi W, Chan S, Gantenbein B, Chan B. Cellular stress response of intervertebral
cells under mechanical loading. Molecular Chaperones & Stress Responses, Cold
Spring Harbor Laboratory, NY, USA, 2014.
23.Gawri R, Antoniou J, Ouellet J, Roughley P, Steffen T, Mwale F, Haglund L. Link-N stimulates extracellular matrix production by human intervertebral disc cells in the presence
of IL-1. 47th Annual Meeting of Canadian Orthopaedic Association (COA) and Canadian
Orthopaedics Research Society (CORS), Winnipeg, MB, Canada, June, 2013.
11.De Vries SaH, Van Doeselaar M, Meij BP, Tryfonidou MA, Ito K. The stimulatory effect
of notochordal cell-conditioned medium in a nucleus pulposus explant culture.
The Dutch Biomaterials and Tissue Engineering Society conference, Lunteren, the
Netherlands, 4-5 December, 2014.
24.Gawri R, Antoniou J, Ouellet J, Roughley P, Steffen T, Mwale F, Haglund L. Link-N
Stimulates Extracellular Matrix Production by Human Intervertebral Disc Cells in the
Presence of IL-1. 19th Canadian Connective Tissue Conference (CCTC), Montreal,
QC, Canada, May, 2013.
37
25.Gawri R, Antoniou J, Ouellet J, Roughley P, Steffen T, Mwale F, Haglund L. Link-N
stimulates extracellular matrix production by human intervertebral disc cells in the
presence of IL-1. Global Spine Congress 2013, Hong Kong, China, April, 2013.
39.Yuan M, Yeung C, Au T, Gao Y, Chan D, Cheah K, Chan B. Development of three-dimensional system for culturing notochordal cells. TERMIS-AP 2013 Annual Conference, Shanghai-Wuzhen, China, 2013.
26.Gawri R, Moir J, Althukair R, Roughley P, Ouellet J, Steffen T, Haglund L. Culturing
of human intervertebral discs in a customized bioreactor under various cyclical
dynamic load. 47th Annual Meeting of Canadian Orthopaedic Association (COA)
and Canadian Orthopaedic Research Society (CORS), Winnipeg, MB, Canada, June,
2013.
40.Yuan M, Yeung C, Li Y, Diao H, Cheung K, Chan D, Cheah K, Chan B. Reconstitution of nucleus pulposus cell matrix niche in 3D collagen microsphere for mesenchymal stem cell discogenic differentiation. TERMIS-AP 2013 Annual Conference,
Shanghai-Wuzhen, China, 2013.
27.Gawri R, Moir J, Althukair R, Roughley P, Ouellet J, Steffen T, Haglund L. Validation
and optimization of a bioreactor for loading human intervertebral discs. Annual
Experimental Surgery Graduate Research Day, Montreal, QC, Canada, 2013.
28.Goncalves R, Pereira A, Pereira I, Molinos M, Oliveira M, Barbosa M. Chitosan/Poly-g-Glutamic acid nanoparticles as an anti-inflammatory drug delivery system. 25th
Meeting of the European Society of Biomaterials, Madrid, Spain, September, 2013.
29.Grad S. Role of chemokines in stem cell homing into the intervertebral disc. Philadelphia Spine Research Symposium, Philadelphia, PA, USA, November, 2013.
30.Haglund L. Biological repair of the degenerate intervertebral disc. Combined meeting of Orthopaedic Research Societies (CORS), Venice, Italy, October, 2013.
31.Haglund L. Biological repair of the degenerate intervertebral disc. Sigma XI Mc Gill,
Montreal, QC, Canada, September, 2013.
32.Haglund L. Biological repair of the degenerate intervertebral disc. Advances in
Orthopaedic Research Symposium, Shenzhen, China, April, 2013.
33.Haglund L, Mulligan K, Gawri R, Shao Y, Awwad W, Kumar A, Steffen T, Borthakur A,
Ouellet J. Normative values of T1p MRI for intervertebral disc at different ages &
different severity of degenerative disc disease: validation of T1p MRI as a tool to
quantify early degenerative disc disease. Global Spine Congress 2013, Hong Kong,
China, April, 2013.
34.Li H, Chooi W, Chan D, Cheah K, Chan B. Three-dimensional culture of bovine nucleus pulposus cells in protein matrices. 9th Pan Pacific Connective Tissue Societies
Symposium - The Extracellular Matrix Niche, Hong Kong, China, November, 2013.
38
41.Chik TK, Choy ATH, Deng WK, Ma XY, Li YY, Leung V, Cheung KMC, Chan BP. Developing a photochemically crosslinked collagen plug to solve the cell leakage
problem for intradiscal injection of mesenchymal stem cells (MSCs). BME2012
- Biomedical Engineering International Conference, Hong Kong, China, 2012.
42.Chik TK, Luk KDK, Cheung KMC, Sze KL, Chan BP. Fabrication of multi-component
tissue-like constructs towards spinal motion segment and intervertebral disc tissue
engineering. BME2012 - Biomedical Engineering International Conference, Hong
Kong, China, 2012.
43.Diao HJ, Li YY, Chan BP. Delivering mesenchymal stem cell in collagen microsphere carriers to rabbit degenerative disc - Improved functional outcomes and
reduced osteophyte formation. BME2012 - Biomedical Engineering International
Conference, Hong Kong, China, 2012.
44.Gawri R, Antoniou J, Ouellet J, Roughley P, Steffen T, Haglund L, Mwale F. Link-N
peptide: A stepping stone towards biological repair of intervertebral disc degeneration. WFSR - World Forum for Spine Research, Helsinki, Finland, June 18-21, 2012.
45.Gawri R, Mwale F, Ouellet J, Steffen T, Roughley P, Haglund L, Antoniou J. Link-N
peptide: Biological repair of intervertebral disc made possible. 46th Annual Meeting of the Canadian Orthopaedic Research Society, Ottawa, ON, Canada, June,
2012.
46.Gawri R, Mwale F, Ouellet J, Steffen T, Roughley P, Haglund L, Antoniou J. Link-N peptide: A potential agent for biological repair of human intervertebral disc. 58th Annual
Meeting of the Orthopaedic Research Society, San Francisco, CA, USA, 2012.
47.Haglund L. Organ culture if intact human discs. WFSR - World Forum for Spine
Research, Helsinki, Finland, June 18-21, 2012.
35.Li YY, Diao HJ, Chik TK, Chow ST, An XM, Leung V, Cheung KMC, Chan BP. Intradiscal delivery of mesenchymal stem cells in collagen microspheres in a rabbit disc
degeneration model. Global Spine Congress 2013, Hong Kong, China, April, 2013.
Poster Presentations
36.Moir J, Gawri R, Roughley P, Steffen T, Haglund L. Bovine intervertebral discs degenerated by controlled enzyme treatment responds to physiological load by replacing proteoglycans. Canadian Connective Tissue Conference (CCTC), Montreal, QC,
Canada, May, 2013.
1.Bach FC, De Vries SaH, Krouwels A, Creemers LB, Ito K, Meij BP, Tryfonidou MA.
The species-specific regenerative effects of notochordal cell-conditioned medium
on degenerated human nucleus pulposus cells. The International Society for the
Study of the Lumbar Spine conference, San Francisco, CA, USA, June 9-12, 2015.
37.Muftuler LT, Yu HJ, Gardner VO, Maiman DJ. DCEMRI shows slower wash-out in
lumbar disc endplates to sustain diffusion of nutrients into the discs. Proceedings
of the ISMRM (International Society of Magnetic Resonance in Medicine) 21st Scientific Meeting, Salt Lake City, UT, USA, 2013.
2.Bach FC, Zhang Y, Verdonschot LC, Miranda BA, Bergknut N, Creemers LB, Ito K,
Sakai D, Chan D, Meij BP, Tryfonidou MA. The role of caveolin-1 in intervertebral
disc degeneration and regeneration. The International Society for the Study of the
Lumbar Spine conference, San Francisco, CA, USA, June 9-12, 2015.
38.Pereira A, Peroglio M, Pattappa G, Deste M, Eglin D, Goncalves R, Grad S, Barbosa
M, Alini M. Development of chemoattractant delivery system for mesenchymal
cells recruitment to intervertebral disc. 25th Meeting of the European Society of
Biomaterials, Madrid, Spain, September, 2013.
3.Kazezian Z, Gawri R, Haglund L, Ouellet J, Mwale F, Ogaora P, Pandit A, Alini M,
Grad S. Gene expression profiling identifies interferon signaling and IGFBP3 as
mediators in human intervertebral disc degeneration. ORS Orthopeadic Research
Society, Las Vegas, NV, USA, March 28-31, 2015.
4.Rosenzweig DH, Moir J, Gawri R, Eglin D, Weber M, Ouellet J, Steffen T, Haglund
L. Dynamic loading, matrix maintenance and cell injection therapy of human intervertebral discs cultured in a bioreactor. ORS Orthopeadic Research Society, Las
Vegas, NV, USA, March 28-31, 2015.
5.Rosenzweig DH, Moir J, Steffen T, Haglund L. Dynamic loading improves intervertebral disc metabolic activity and nutrient exchange under low glucose conditions.
ORS Orthopeadic Research Society, Las Vegas, NV, USA, March 28-31, 2015.
6.Arpinar VE, Maiman DJ, Muftuler LT. Pharmacokinetic analysis of DCE-MRI data
from lumbar spine reveals pathologic changes in intervertebral disc endplates
and subchondral bone. Annual meeting of the International Society of Magnetic
Resonance in Medicine, Milan, Italy, May 10-16, 2014.
7.Bach F, Verdonschot L, Ito K, Meij B, Tryfonidou M. The role of caveolin-1 in IVD
degeneration and regeneration. 1st Matrix Biology Europe Conference, Rotterdam,
the Netherlands, 2014.
8.Chan WCW, Tam V, Cheah K, Cheung K, Chan D. A systematic and simple scoring
system for histological analysis of the mouse intervertebral disc during natural
ageing, degeneration, and regeneration. WFSR - World Forum for Spine Research,
Xi’an, China, May 15–17, 2014.
9.Chik T, Chooi W, Cheng H, Choy T, Sze K, Luk K, Cheung K, Chan B. Engineering a
multi-component spinal motion segment-like construct from mesenchymal stem
cells. WFSR - World Forum for Spine Research, Xi’an, China, May 15–17, 2014.
10.Chooi W, Chan S, Gantenbein B, Chan B. Loading induced stress response in the intervertebral disc. WFSR - World Forum for Spine Research, Xi’an, China, May 15-17, 2014.
11.De Vries S, Potier E, Van Doeselar M, Meij B, Tryfonidou M, Ito K. Stimulation of
canine nucleus pulposus cells and bone marrow derived stromal cells with notochordal cell-secreted factors. WFSR 2014 - World Forum for Spine Research, Xi’an,
China, May 15–17, 2014.
12.De Vries S, Potier E, Van Doeselar M, Meij B, Tryfonidou M, Ito K. Notochordal
cell-secreted factors stimulate matrix production by canine nucleus pulposus cells
and bone marrow deribed stromal stem cells. ISSLS International Society for the
Study of the Lumbar Spine, Seoul, Korea, June 3-7, 2014.
13.Jarman JP, Maiman DJ, Muftuler LT. Accurate measurement of intervertebral disc
height loss demonstrates the threshold of major pathological changes during the
course of degeneration. Annual meeting of the International Society of Magnetic
Resonance in Medicine, Milan, Italy, May 10-16, 2014.
14.Lee KS, Lam K, Song YQ, Cheah K, Cheung K, Chan D. In-vivo study of asporin in cartilage tissues. WFSR - World Forum for Spine Research, Xi’an, China, May 15–17, 2014.
15.Muftuler LT, Baruah D, Klein AP. T1rho imaging demonstrates inflammatory changes in disc endplates that were not visible in T1 or T2 weighted images. Annual
meeting of the International Society of Magnetic Resonance in Medicine, Milan,
Italy, May 10-16, 2014.
16.Muftuler LT, Jarman JP, Yu HJ, Maiman DJ, Gardner VO. Intervertebral disc degeneration and changes in solute transport mechanisms in disc endplates studied by
DCE-MRI. Annual meeting of the International Society of Magnetic Resonance in
Medicine, Milan, Italy, May 10-16, 2014.
17.Yee A, Tam V, Cheah K, Cheung K, Chan D. Analysis of the static protein profile of
degenerated IVD indicate increased fibrosis-related proteins. WFSR - World Forum
for Spine Research, Xi’an, China, May 15–17, 2014.
18.Zhang Y, Xiong C, Chan C, Sakai D, Chan D. Roles of progenitor cells for intervertebral disc regeneration in “healer” mice. WFSR - World Forum for Spine Research,
Xi’an, China, May 15–17, 2014.
19.Chooi WH, Cheng HW, Chik TK, Luk KDK, Cheung KMC, Chan BP. In vitro nutrient
transport functional test in an engineered osteochondral construct. Global Spine
Congress 2013, Hong Kong, China, April, 2013.
20.Gao C, Lee H, Gawri R, Henderson JE, Ouellet J, Haglund L. Skeletal phenotyping
of vertebral endplate of degenerative spine disease. Annual Experimental Surgery
Graduate Research Day, Montreal, QC, Canada, 2013.
21.Gawri R, Al Thukair R, Moir J, Roughley P, Ouellet J, Steffen T, Haglund L. Validation
and optimization of a bioreactor for loading of human intervertebral discs. ORS Orthopaedic Research Society meeting, San Antonio, TX, USA, January, 2013.
22.Gawri R, Antoniou J, Alkhatib B, Ouellet J, Steffen T, Roughley P, Mwale F, Haglund L.
Link-N stimulates extracellular matrix production by human intervetrebral disc cells in
the presence of IL-1. Annual Orthopaedics Visiting Professor Day, Montreal, QC, Canada,
2013.
23.Gawri R, Antoniou J, Alkhatib B, Ouellet J, Steffen T, Roughley P, Mwale F, Haglund L.
Link-N stimulates extracellular matrix production by human intervertebral disc cells
in the presence of IL-1. ORS - Orthopaedic Research Society meeting, San Antonio,
TX, USA, January, 2013.
24.Gawri R, Antoniou J, Ouellet J, Roughley P, Steffen T, Haglund L, Mwale F. Link-N
peptide: Can degenerated human intervetrebral discs be repaired? Annual Orthopaedic Visiting Professor Day, Montreal, QC, Canada, 2013.
25.Gawri R, Moir J, Althukair R, Roughley P, Ouellet J, Steffen T, Haglund L. Validation and optimization of a bioreactor for loading of human intervertebral discs.
19th Canadian Connective Tissue Conference (CCTC), Montreal, QC, Canada, May,
2013.
26.Gawri R, Moir J, Althukair R, Roughley P, Ouellet J, Steffen T, Haglund L. Validation
and optimization of a bioreactor for loading of human intervertebral discs. Annual
Orthopaedics Visiting Professor Day, Montreal, QC, Canada, 2013.
27.Gawri R, Moir J, Althukair R, Roughley P, Ouellet J, Steffen T, Haglund L. Culturing
of human intervertebral discs in a customized bioreactor under various cyclical
dynamic loads. ORS - Orthopeadic Research Society meeting, San Antonio, TX,
USA, March, 2013.
28.Gawri R, Rozenzweig D, Ouellet J, Quinn T, Haglund L. Effect of excessive mechanical strain in intervertebral disc degeneration. Annual Orthopaedics Visiting
Professor Day, Montreal, QC, Canada, 2013.
29.Haglund L, Mulligan K, Gawri R, Shao Y, Awwad W, Kumar A, Steffen T, Borthakur A,
Ouellet J. Normative values of T1p MRI, Validation on T1p MRI as a tool to quantify
early degenerative disc disease. 13th Annual Scientific Conference of the Canadian
Spine Society, Mount Tremblant, QC, Canada, February 27-March 2, 2013.
39
30.Mulligan K, Gawri R, Shao Y, Awwad W, Kumar A, Steffen T, Borthakur A, Haglund
L, Ouellet J. Normative values of T1p MRI or Intervertebral disc at different ages &
different severity of degenerative disc disease: Validation of T1p MRI as a tool to
quantify early degenerative disc disease. 19th Canadian Connective Tissue Conference (CCTC), Montreal, QC, Canada, May, 2013.
31.Mulligan K, Gawri R, Shao Y, Awwad W, Kumar A, Steffen T, Borthakur A, Haglund
L, Ouellet J. Normative values of T1p MRI for Intervertebral disc at different ages
& different severity of degenerative disc disease: Validation of T1p MRI as a tool
to quantify early degenerative disc disease. Annual Orthopaedics Visiting Professor
Day, Montreal, QC, Canada, 2013.
32.Pattappa G, Peroglio M, Sakai D, Mochida J, Benneker L, Alini M, Grad S. Mesenchymal stem cell homing into the intervertebral disc: A chemotactic induced response.
eCMXIV, Davos, Switzerland, June, 2013.
33.Pattappa G, Peroglio M, Sakai D, Mochida J, Benneker L, Alini M, Grad S. CCL5 is
a key chemoattractant in degenerative intervertebral discs. ORS - Orthopaedic
Research Society, New Orleans, LA, USA, March, 2013.
34.Pereira A, Peroglio M, Pattappa G, Eglin D, Barbosa M, Alini M, Goncalves R, Grad S. Chemoattractant delivery system for mesenchymal cells recruitment to intervertebral disc.
Advanced Summer School Inflammation/Repair Interface, Porto, Portugal, June, 2013.
35.Yuan MT, Yeung CW, Li YY, Diao HJ, Chan D, Cheah KSE, Chan BP. Reconstitution of
nucleus pulposus cell matrix niche in 3D collagen microsphere for mesenchymal
stem cell discogenic differentiation. Global Spine Congress 2013, Hong Kong, China, April, 2013.
36.Chik TK, Choy ATH, Teng WK, Ma XY, Li YY, Leung YL, Cheung KMC, Chan BP.
Developing a photochemically crosslinked collagen plug to solve the cell leakage
problem for intra-discal injection of mesenchymal stem cells: A pilot study. WFSR World Forum for Spine Research, Helsinki, Finland, June 18-21, 2012.
37.Choy ATH, Leong JCY, Chan BP. Collagen-glycosaminoglycan co-precipitate and
photochemically crosslinked collagen for disc replacement. WFSR - World Forum
for Spine Research, Helsinki, Finland, June 18-21, 2012.
38.Gawri R, Althukair R, Moir J, Roughley P, Ouellet J, Steffen T, Haglund L. Optimization
of bioreactor design for normal loading of human intervertebral discs. WFSR World Forum for Spine Research, Helsinki, Finland, June 18-21, 2012.
39.Gawri R, Althukair R, Moir J, Roughley P, Ouellet J, Steffen T, Haglund L. Optimization
of bioreactor design for normal loading of human intervertebral discs. 18th Canadian Connective Tissue Conference, Toronto, ON, Canada, June, 2012.
40.Gawri R, Althukair R, Moir J, Roughley P, Ouellet J, Steffen T, Haglund L. Optimization of bioreactor design for normal loading of human intervertebral discs. Annual
Orthopaedics Visiting Professor Day, Montreal, QC, Canada, 2012.
41.Gawri R, Antoniou J, Ouellet J, Roughley P, Steffen T, Haglund L, Mwale F. Link-N
peptide: Can degenerated human intervertebral discs be repaired? 18th Canadian
Connective Tissue Conference, Toronto, ON, Canada, June, 2012.
42.Gawri R, Antoniou J, Ouellet J, Roughley P, Steffen T, Haglund L, Mwale F. Link-N
peptide: Can degenerated human intervertebral discs be repaired? 3rd Annual
Lady Davis Institute Scientific Retreat, Montreal, QC, Canada, 2012.
40
43.Gawri R, Antoniou J, Ouellet J, Roughley P, Steffen T, Haglund L, Mwale F. Link-N
peptide: Can degenerated human intervertebral discs be repaired? Annual Orthopaedics Visiting Professor Day, Montreal, QC, Canada, 2012.
44.Gawri R, Mwale F, Ouellet J, Steffen T, Roughley P, Haglund L, Antoniou J. Link-N
peptide: Biological repair of intervertebral disc made possible. 46th Annual Meeting of Canadian Orthopaedic Association (COA) and Canadian Orthopaedics Research Society (CORS), Ottawa, ON, Canada, June, 2012.
45.Gawri R, Mwale F, Ouellet J, Steffen T, Roughley P, Haglund L, Antoniou J. Link-N
peptide: A potential candidate for biological repair of the human intervertebral
disc. Canadian Arthritis Network Annual Scientific Conference, Canada, 2012.
46.Gawri R, Ouellet J, Steffen T, Roughley P, Haglund L, Antoniou J. Link-N peptide: Biological repair of intervertebral disc made possible. 12th Annual McGill Biomedical
Graduate Conference, Montreal, Canada, 2012.
47.Haglund L, Moir J, Beckman L, Mulligan K, Jim B, Ouellet J, Roughley P, Steffen T.
The effect of dynamic loading on intervertebral disc matrix integrity and cell viability. Orthopaedic Research Society meeting, San Francisco, CA, USA, February, 2012.
48.Leite Pereira C, Pattappa G, D’este M, Eglin D, Goncalves R, Grad S, Barbosa M, Alini
M. Development of a chemoattractant-delivery system for MSCs recruitment in the
degenerated intervertebral disc. EORS, Amsterdam, the Netherlands, September,
2012.
49.Li YY, Diao HJ, Chow ST, Leung YL, Cheung KMC, Chan BP. Intradiscal delivery of
mesenchymal stem cells in collagen microspheres in a rabbit disc degeneration
model: A preliminary study. WFSR - World Forum for Spine Research, Helsinki,
Finland, June 18-21, 2012.
50.Luk KDK, Chik TK, Cheung KMC, Sze KL, Chan BP. Fabrication of multicomponent
tissue-like constructs - Towards spinal motion segment tissue engineering. WFSR World Forum for Spine Research, Helsinki, Finland, June 18-21, 2012.
51.Moir J, Beckman L, Gawri R, Mulligan K, Wismer N, Roughley P, Ouellet J, Steffen T,
Haglund L. Dynamic loading of intact human intervertebral discs and disc viability.
18th Canadian Connective Tissue Conference, Toronto, ON, Canada, June, 2012.
52.Rossel F, Gawri R, Althukair R, Moir J, Roughley P, Steffen T, Haglund L, Ouellet J.
Bioreactor design for loading of human intervertebral discs: importance of the
stress profilometry. 10th Annual AOSpine North America Fellows Forum, Banff, AB,
Canada, April, 2012.
53.Yeung CW, Au T, Gao Y, Chan D, Cheah KSE, Chan BP. Developing three dimensional culture system for Notochordal cells. WFSR - World Forum for Spine Research,
Helsinki, Finland, June 18-21, 2012.
54.Yuan MT, Yeung CW, Chan BP. Reconstitution of nucleus pulposus cell matrix niche
in 3D configuration for mesenchymal stem cell differentiation. WFSR - World Forum for Spine Research, Helsinki, Finland, June 18-21, 2012.
55.Haglund L, Moir J, Beckman L, Mulligan K, Jim B, Ouellet J, Roughley P, Steffen T.
The effect of dynamic load on intervertebral disc matrix integrity and cell viability.
Philadelphia Spine Research Society Symposium, Philadelphia, PA, USA, November,
2011.
Manuscripts
Submitted
1.Bach FC, Miranda BA, Van Heel FWM, Creemers LB, Ito K, Meij BP, Tryfonidou MA.
The regenerative effect of TGF-β1 and rhBMP2 on canine and human chondrocyte-like cells derived from degenerated intervertebral discs in a micro-aggregate
and albumin hydrogel culture system. Tissue Eng Part C, 2016.
Published
1.De Vries SA, Van Doeselaar M, Meij BP, Tryfonidou MA, Ito K. The stimulatory effect
of notochordal cell-conditioned medium in a nucleus pulposus explant culture.
Tissue Eng Part A 22(1-2): 103-110, 2016.
2.Rosenzweig DH, Gawri R, Moir J, Beckman L, Eglin D, Steffen T, Roughley PJ, Ouellet
JA, Haglund L. Dynamic loading, matrix maintenance and cell injection therapy of
human intervertebral discs cultured in a bioreactor. Eur Cell Mater 30:26-39, 2016.
3.Arkesteijn IT, Smolders LA, Spillekom S, Riemers FM, Potier E, Meij BP, Ito K, Tryfonidou
MA. Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal
stromal cells for intervertebral disc regeneration. Arthritis Res Ther 17(60), 2015.
4.Bach FC, De Vries SA, Krouwels A, Creemers LB, Ito K, Meij BP, Tryfonidou MA. The
species-specific regenerative effects of notochordal cell-conditioned medium on
chondrocyte-like cells derived from degenerated human intervertebral discs. Eur
Cell Mater 30:132-146; discussion 146-137, 2015.
5.Chik TK, Chooi WH, Li YY, Ho FC, Cheng HW, Choy TH, Sze KY, Luk KK, Cheung KM,
Chan BP. Bioengineering a multicomponent spinal motion segment construct--a
3D model for complex tissue engineering. Adv Healthc Mater 4(1): 99-112, 2015.
6.Choy AT, Chan BP. A structurally and functionally biomimetic biphasic scaffold for
intervertebral disc tissue engineering. PLoS One 10(6): e0131827, 2015.
7.De Vries SA, Potier E, Van Doeselaar M, Meij BP, Tryfonidou MA, Ito K. Conditioned
medium derived from notochordal cell-rich nucleus pulposus tissue stimulates matrix production by canine nucleus pulposus cells and bone marrow-derived stromal
cells. Tissue Eng Part A 21(5-6): 1077-1084, 2015.
8.Jarman JP, Arpinar VE, Baruah D, Klein AP, Maiman DJ, Tugan Muftuler L. Intervertebral disc height loss demonstrates the threshold of major pathological changes
during degeneration. Eur Spine J 24(9): 1944-1950, 2015.
9.Kazezian Z, Gawri R, Haglund L, Ouellet J, Mwale F, Tarrant F, O’gaora P, Pandit A,
Alini M, Grad S. Gene expression profiling identifies interferon signalling molecules
and IGFBP3 in human degenerative annulus fibrosus. Sci Rep 5:156-62, 2015.
10.Krock E, Rosenzweig DH, Haglund L. The inflammatory milieu of the degenerate
disc: Is mesenchymal stem cell-based therapy for intervertebral disc repair a feasible approach? Curr Stem Cell Res Ther 10(4): 317-328, 2015.
11.Li YY, Choy TH, Ho FC, Chan PB. Scaffold composition affects cytoskeleton organization, cell-matrix interaction and the cellular fate of human mesenchymal stem
cells upon chondrogenic differentiation. Biomaterials 52: 208-220, 2015.
12.Muftuler LT, Jarman JP, Yu HJ, Gardner VO, Maiman DJ, Arpinar VE. Association
between intervertebral disc degeneration and endplate perfusion studied by DCEMRI. Eur Spine J 24(4): 679-685, 2015.
13.Mulligan KR, Ferland CE, Gawri R, Borthakur A, Haglund L, Ouellet JA. Axial T1rho
MRI as a diagnostic imaging modality to quantify proteoglycan concentration in
degenerative disc disease. Eur Spine J 24(11): 2395-2401, 2015.
14.Schutgens E, Tryfonidou MA, Smit T, Öner C, Krouwels A, Ito K, Creemers LB. Biomaterials for intervertebral disc regeneration; past performance and possible
future strategies. eCM Journal 30: 210-231, 2015.
15.Zeng Y, Chen C, Liu W, Fu Q, Han Z, Li Y, Feng S, Li X, Qi C, Wu J, Wang D, Corbett C,
Chan BP, Ruan D, Du Y. Injectable microcryogels reinforced alginate encapsulation
of mesenchymal stromal cells for leak-proof delivery and alleviation of canine disc
degeneration. Biomaterials (59): 53-65, 2015.
16.Alkhatib B, Rosenzweig DH, Krock E, Roughley PJ, Beckman L, Steffen T, Weber MH,
Ouellet JA, Haglund L. Acute mechanical injury of the human intervertebral disc:
link to degeneration and pain. Eur Cell Mater 28: 98-110; discussion 110-111,
2014.
17.Bach FC, Willems N, Penning LC, Ito K, Meij BP, Tryfonidou MA. Potential regenerative treatment strategies for intervertebral disc degeneration in dogs. BMC Vet Res
10(3), 2014.
18.Gawri R, Moir J, Ouellet J, Beckman L, Steffen T, Roughley P, Haglund L. Physiological loading can restore the proteoglycan content in a model of early IVD degeneration. PLoS One 9(7): e101233, 2014.
19.Gawri R, Ouellet J, Onnerfjord P, Alkhatib B, Steffen T, Heinegard D, Roughley P,
Antoniou J, Mwale F, Haglund L. Link N is cleaved by human annulus fibrosus cells
generating a fragment with retained biological activity. J Orthop Res 32(9): 11891197, 2014.
20.Li YY, Diao HJ, Chik TK, Chow CT, An XM, Leung V, Cheung KM, Chan BP. Delivering
mesenchymal stem cells in collagen microsphere carriers to rabbit degenerative
disc: reduced risk of osteophyte formation. Tissue Eng Part A 20(9-10): 13791391, 2014.
21.Mwale F, Wang HT, Roughley P, Antoniou J, Haglund L. Link N and mesenchymal
stem cells can induce regeneration of the early degenerate intervertebral disc.
Tissue Eng Part A 20(21-22): 2942-2949, 2014.
22.Pattappa G, Peroglio M, Sakai D, Mochida J, Benneker LM, Alini M, Grad S. CCL5/
RANTES is a key chemoattractant released by degenerative intervertebral discs in
organ culture. Eur Cell Mater 27: 124-136; discussion 136, 2014.
23.Potier E, De Vries S, Van Doeselaar M, Ito K. Potential application of notochordal
cells for intervertebral disc regeneration: an in vitro assessment. Eur Cell Mater 28:
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24.Spillekom S, Smolders LA, Grinwis GC, Arkesteijn IT, Ito K, Meij BP, Tryfonidou MA.
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41
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27.Chik TK, Ma XY, Choy TH, Li YY, Diao HJ, Teng WK, Han SJ, Cheung KM, Chan BP.
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28.Choy AT, Leong KW, Chan BP. Chemical modification of collagen improves glycosaminoglycan retention of their co-precipitates. Acta Biomater 9(1): 4661-4672,
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42
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