Research output
Listing of Research output
The complement receptor 3 (CD11b/CD18) agonist Leukadherin-1 suppresses human innate inflammatory signalling
Roberts, A. L., Fürnrohr, B. G., Vyse, T. J. & Rhodes, B. 1 Sep 2016 In : Clinical and Experimental Immunology. 185, 3, p.
361-371 11 p.
Research output: Contribution to journal › Article
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with
systemic lupus erythematosus
Morris, D. L. , Sheng, Y. , Zhang, Y. , Wang, Y. F. , Zhu, Z. , Tombleson, P. , Chen, L. , Cunninghame Graham, D. S. ,
Bentham, J. , Roberts, A. L. , Chen, R. , Zuo, X. , Wang, T. , Wen, L. , Yang, C. , Liu, L. , Yang, L. , Li, F. , Huang, Y. , Yin,
X. & 12 others Yang, S., Rönnblom, L., Fürnrohr, B. G., Voll, R. E., Schett, G., Costedoat–Chalumeau, N., Gaffney, P. M.,
Lau, Y. L., Zhang, X., Yang, W., Cui, Y. & Vyse, T. J. 11 Jul 2016 In : Nature Genetics.
Research output: Contribution to journal › Article
A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic
lupus erythematosus
Márquez, A., Vidal-Bralo, L., Rodríguez-Rodríguez, L., González-Gay, M. A., Balsa, A., González-álvaro, I., Carreira, P.,
Ortego-Centeno, N., Ayala-Gutiérrez, M. M., García-Hernández, F. J., González-Escribano, M. F., Sabio, J. M., Tolosa,
C., Suárez, A., González, A., Padyukov, L., Worthington, J., Vyse, T., Alarcón-Riquelme, M. E. & Martín, J. 18 May 2016
In : Annals of the Rheumatic Diseases.
Research output: Contribution to journal › Article
Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans
Lessard, C. J. , Sajuthi, S. , Zhao, J. , Kim, K. , Ice, J. A. , Li, H. , Ainsworth, H. , Rasmussen, A. , Kelly, J. A. , Marion, M. ,
Bang, S. Y. , Bin Joo, Y. , Choi, J. , Lee, H. S. , Mo Kang, Y. , Suh, C. H. , Tae Chung, W. , Lee, S. K. , Choe, J. Y. , Cheol
Shim, S. & 19 others Hee Oh, J., Jin Kim, Y., Han, B. G., Shen, N., Siew Howe, H., Wakeland, E. K., Li, Q. Z., Wook
Song, Y., Gaffney, P. M., Alarcón-Riquelme, M. E., Criswell, L. A., Jacob, C. O., Kimberly, R. P., Vyse, T. J., Harley, J. B.,
Sivils, K. L., Bae, S. C., Langefeld, C. D. & Tsao, B. P. 1 May 2016 In : Arthritis and Rheumatology. 68, 5, p. 1197-1209
13 p.
Research output: Contribution to journal › Article
X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus
Erythematosus and Sjögren's Syndrome
Liu, K. , Kurien, B. T. , Zimmerman, S. L. , Kaufman, K. M. , Taft, D. H. , Kottyan, L. C. , Lazaro, S. , Weaver, C. A. , Ice, J.
A. , Adler, A. J. , Chodosh, J. , Radfar, L. , Rasmussen, A. , Stone, D. U. , Lewis, D. M. , Li, S. , Koelsch, K. A. , Igoe, A. ,
Talsania, M. , Kumar, J. & 58 others Maier-Moore, J. S., Harris, V. M., Gopalakrishnan, R., Jonsson, R., Lessard, J. A., Lu,
X., Gottenberg, J. E., Anaya, J. M., Cunninghame-Graham, D. S., Huang, A. J. W., Brennan, M. T., Hughes, P., Illei, G.
G., Miceli-Richard, C., Keystone, E. C., Bykerk, V. P., Hirschfield, G., Xie, G., Ng, W. F., Nordmark, G., Eriksson, P.,
Omdal, R., Rhodus, N. L., Rischmueller, M., Rohrer, M., Segal, B. M., Vyse, T. J., Wahren-Herlenius, M., Witte, T., PonsEstel, B., Alarcón-Riquelme, M. E., Guthridge, J. M., James, J. A., Lessard, C. J., Kelly, J. A., Thompson, S. D., Gaffney,
P. M., Montgomery, C. G., Edberg, J. C., Kimberly, R. P., Alarcón, G. S., Langefeld, C. L., Gilkeson, G. S., Kamen, D. L.,
Tsao, B. P., Joseph McCune, W., Salmon, J. E., Merrill, J. T., Weisman, M. H., Wallace, D. J., Utset, T. O., Bottinger, E.
P., Amos, C. I., Siminovitch, K. A., Mariette, X., Sivils, K. L., Harley, J. B. & Hal Scofield, R. 1 May 2016 In : Arthritis and
Rheumatology. 68, 5, p. 1290-1300 11 p.
Research output: Contribution to journal › Article
Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus
Risk Loci and the Role of European Admixture
Alarcón-Riquelme, M. E. , Ziegler, J. T. , Molineros, J. , Howard, T. D. , Moreno-Estrada, A. , Sánchez-Rodríguez, E. ,
Ainsworth, H. C. , Ortiz-Tello, P. , Comeau, M. E. , Rasmussen, A. , Kelly, J. A. , Adler, A. , Acevedo-Vázquez, E. M. ,
Mariano Cucho-Venegas, J. , García-De La Torre, I. , Cardiel, M. H. , Miranda, P. , Catoggio, L. J. , Maradiaga-Ceceña,
M. , Gaffney, P. M. & 25 others Vyse, T. J., Criswell, L. A., Tsao, B. P., Sivils, K. L., Bae, S-C., James, J. A., Kimberly, R.
P., Kaufman, K. M., Harley, J. B., Esquivel-Valerio, J. A., Moctezuma, J. F., García, M. A., Berbotto, G. A., Babini, A. M.,
Scherbarth, H., Toloza, S., Baca, V., Nath, S. K., Aguilar Salinas, C., Orozco, L., Tusié-Luna, T., Zidovetzki, R., PonsEstel, B. A., Langefeld, C. D. & Jacob, C. O. 1 Apr 2016 In : Arthritis and Rheumatology. 68, 4, p. 932-943 12 p.
Research output: Contribution to journal › Article
Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production
Deng, Y. , Zhao, J. , Sakurai, D. , Sestak, A. L. , Osadchiy, V. , Langefeld, C. D. , Kaufman, K. M. , Kelly, J. A. , James, J.
A. , Petri, M. A. , Bae, S. C. , Alarcón-Riquelme, M. E. , Alarcón, G. S. , Anaya, J. M. , Criswell, L. A. , Freedman, B. I. ,
Kamen, D. L. , Gilkeson, G. S. , Jacob, C. O. , Merrill, J. T. & 22 others Gaffney, P. M., Sivils, K. M., Niewold, T. B.,
Ramsey-Goldman, R., Reveille, J. D., Scofield, R. H., Stevens, A. M., Boackle, S. A., Vilá, L. M., Woong Sohn, I. I., Lee,
S., Chang, D. M., Song, Y. W., Vyse, T. J., Harley, J. B., Brown, E. E., Edberg, J. C., Kimberly, R. P., Cantor, R. M., Hahn,
B. H., Grossman, J. M. & Tsao, B. P. 18 Jan 2016 In : Annals of the Rheumatic Diseases.
Research output: Contribution to journal › Article
Improved monitoring of clinical response in Systemic Lupus Erythematosus by longitudinal trend in soluble vascular cell
adhesion molecule-1
Lewis, M. J., Vyse, S., Shields, A. M., Zou, L., Khamashta, M., Gordon, P. A., Pitzalis, C., Vyse, T. J. & D'Cruz, D. P. 8 Jan
2016 In : ARTHRITIS RESEARCH AND THERAPY. 18, 1, 5
Research output: Contribution to journal › Article
Identification of a New Susceptibility Locus for Systemic Lupus Erythematosus on Chromosome 12 in Individuals of
European Ancestry
Demirci, F. Y., Wang, X., Kelly, J. A., Morris, D. L., Barmada, M. M., Feingold, E., Kao, A. H., Sivils, K. L., Bernatsky, S.,
Pineau, C., Clarke, A. E., Ramsey-Goldman, R., Vyse, T. J., Gaffney, P. M., Manzi, S. & Kamboh, M. I. 1 Jan 2016 In :
Arthritis and Rheumatology. 68, 1, p. 174-183 10 p.
Research output: Contribution to journal › Article
Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA
Zhao, J. , Giles, B. M. , Taylor, R. L. , Yette, G. A. , Lough, K. M. , Ng, H. L. , Abraham, L. J. , Wu, H. , Kelly, J. A. , Glenn,
S. B. , Adler, A. J. , Williams, A. H. , Comeau, M. E. , Ziegler, J. T. , Marion, M. , Alarcón-Riquelme, M. E. , Alarcón, G. S. ,
Anaya, J. M. , Bae, S. C. , Kim, D. & 28 others Lee, H. S., Criswell, L. A., Freedman, B. I., Gilkeson, G. S., Guthridge, J.
M., Jacob, C. O., James, J. A., Kamen, D. L., Merrill, J. T., Sivils, K. M., Niewold, T. B., Petri, M. A., Ramsey-Goldman, R.,
Reveille, J. D., Scofield, R. H., Stevens, A. M., Vilá, L. M., Vyse, T. J., Kaufman, K. M., Harley, J. B., Langefeld, C. D.,
Gaffney, P. M., Brown, E. E., Edberg, J. C., Kimberly, R. P., Ulgiati, D., Tsao, B. P. & Boackle, S. A. Jan 2016 In : Annals
of the Rheumatic Diseases. 75, 1, 11 p.
Research output: Contribution to journal › Article
Super-resolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated adhesion with autoimmunity
Burn, G. L., Cornish, G. H., Potrzebowska, K., Samuelsson, M., Griffie, J., Minoughan, S., Yates, M., Ashdown, G.,
Pernodet, N., L. Morrison, V., Sanchez-Blanco, C., Purvis, H. A., Clarke, F. M., Brownlie, R. J., Vyse, T. J., Zamoyska, R.,
Owen, D. M., M. Svensson, L. & Cope, A. P. 2016 In : Science Signaling.
Research output: Contribution to journal › Article
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of
systemic lupus erythematosus
Bentham, J., Morris, D. L., Cunninghame Graham, D. S., Pinder, C. L., Tombleson, P., Behrens, T. W., Martín, J., Fairfax,
B. P., Knight, J. C., Chen, L., Replogle, J., Syvänen, A. C., Rönnblom, L., Graham, R. R., Wither, J. E., Rioux, J. D.,
Alarcón-Riquelme, M. E. & Vyse, T. J. 1 Dec 2015 In : Nature Genetics. 47, 12, p. 1457-1464 8 p.
Research output: Contribution to journal › Article
Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus
Zhao, J. , Wu, H. , Langefeld, C. D. , Kaufman, K. M. , Kelly, J. A. , Bae, S. C. , Alarcón-Riquelme, M. E. , Alarcón, G. S. ,
Anaya, J. M. , Criswell, L. A. , Freedman, B. I. , Kamen, D. L. , Gilkeson, G. S. , Jacob, C. O. , James, J. A. , Merrill, J. T. ,
Gaffney, P. M. , Sivils, K. M. , Niewold, T. B. , Petri, M. A. & 84 others Song, S. T., Jeong, H. J., Ramsey-Goldman, R.,
Reveille, J. D., Hal Scofield, R., Stevens, A. M., Boackle, S. A., Vilá, L. M., Chang, D. M., Song, Y. W., Vyse, T. J., Harley,
J. B., Brown, E. E., Edberg, J. C., Kimberly, R. P., Hahn, B. H., Grossman, J. M., Tsao, B. P., La Cava, A., Frostegård, J.,
Truedsson, L., de Ramón, E., Sabio, J. M., González-Escribano, M. F., Martin, J., Ortego-Centeno, N., Callejas, J. L.,
Sánchez-Román, J., D'Alfonso, S., Migliarese, S., Sebastiani, G. D., Galeazzi, M., Witte, T., Lauwerys, B. R., Endreffy, E.,
Kovács, L., Vasconcelos, C., da Silva, B. M., Scherbarth, H. R., Marino, P. C., Motta, E. L., Gamron, S., Drenkard, C.,
Menso, E., Allievi, A., Tate, G. A., Presas, J. L., Palatnik, S. A., Abdala, M., Bearzotti, M., Alvarellos, A., Caeiro, F., Bertoli,
A., Paira, S., Roverano, S., Graf, C. E., Bertero, E., Caprarulo, C., Buchanan, G., Guillerón, C., Grimaudo, S., Manni, J.,
Catoggio, L. J., Soriano, E. R., Santos, C. D., Prigione, C., Ramos, F. A., Navarro, S. M., Berbotto, G. A., Jorfen, M.,
Romero, E. J., Garcia, M. A., Marcos, J. C., Marcos, A. I., Perandones, C. E., Eimon, A., Parque, S., Battagliotti, C. G.,
Acevedo, E., Cucho, M., de la Torre, I. G., Ríos, M. C., Moctezuma, F. & Maradiaga Ceceña, M. 1 Dec 2015 In :
CLINICAL IMMUNOLOGY. 161, 2, p. 157-162 6 p.
Research output: Contribution to journal › Article
Defective removal of ribonucleotides from DNA promotes systemic lupus erythematosus
Günther, C. , Kind, B. , Reijns, M. A. M. , Berndt, N. , Martinez-Bueno, M. , Wolf, C. , Tüngler, V. , Chara, O. , Lee, Y. A. ,
Hübner, N. , Lee, Y. A. , Bicknell, L. , Blum, S. , Krug, C. , Schmidt, F. , Krug, C. , Kretschmer, S. , Koss, S. , Astell, K. R. ,
Ramantani, G. & 27 others Bauerfeind, A., Morris, D. L., Graham, D. S. C., Bubeck, D., Leitch, A., Ralston, S. H.,
Blackburn, E. A., Gahr, M., Witte, T., Vyse, T. J., Melchers, I., Mangold, E., Nöthen, M. M., Aringer, M., Kuhn, A., Lüthke,
K., Unger, L., Bley, A., Lorenzi, A., Isaacs, J. D., Alexopoulou, D., Conrad, K., Dahl, A., Roers, A., Alarcon-Riquelme, M.
E., Jackson, A. P. & Lee-Kirsch, M. A. 28 Sep 2015 In : Pediatric Rheumatology. 13, 1, O86
Research output: Contribution to journal › Article
Lupus risk variant increases pSTAT1 binding and decreases ETS1 expression
Lu, X. , Zoller, E. E. , Weirauch, M. T. , Wu, Z. , Namjou, B. , Williams, A. H. , Ziegler, J. T. , Comeau, M. E. , Marion, M. C.
, Glenn, S. B. , Adler, A. , Shen, N. , Nath, S. K. , Stevens, A. M. , Freedman, B. I. , Tsao, B. P. , Jacob, C. O. , Kamen, D.
L. , Brown, E. E. , Gilkeson, G. S. & 26 others Alarcón, G. S., Reveille, J. D., Anaya, J. M., James, J. A., Sivils, K. L.,
Criswell, L. A., Vilá, L. M., Alarcón-Riquelme, M. E., Petri, M., Scofield, R. H., Kimberly, R. P., Ramsey-Goldman, R., Joo,
Y. B., Choi, J., Bae, S. C., Boackle, S. A., Graham, D. C., Vyse, T. J., Guthridge, J. M., Gaffney, P. M., Langefeld, C. D.,
Kelly, J. A., Greis, K. D., Kaufman, K. M., Harley, J. B. & Kottyan, L. C. 7 May 2015 In : American Journal of Human
Genetics. 96, 5, p. 731-739 9 p.
Research output: Contribution to journal › Article
Identification of susceptibility loci in IL6, RPS9/LILRB3, and an intergenic locus on chromosome 21q22 in takayasu
arteritis in a genome-wide association study
Renauer, P. A. , Saruhan-Direskeneli, G. , Coit, P. , Adler, A. , Aksu, K. , Keser, G. , Alibaz-Oner, F. , Aydin, S. Z. ,
Kamali, S. , Inanc, M. , Carette, S. , Cuthbertson, D. , Hoffman, G. S. , Akar, S. , Onen, F. , Akkoc, N. , Khalidi, N. A. ,
Koening, C. , Karadag, O. , Kiraz, S. & 35 others Langford, C. A., Maksimowicz-Mckinnon, K., McAlear, C. A., Ozbalkan,
Z., Ates, A., Karaaslan, Y., Duzgun, N., Monach, P. A., Ozer, H. T. E., Erken, E., Ozturk, M. A., Yazici, A., Cefle, A., Onat,
A. M., Kisacik, B., Pagnoux, C., Kasifoglu, T., Seyahi, E., Fresko, I., Seo, P., Sreih, A. G., Warrington, K. J., Ytterberg, S.
R., Cobankara, V., Cunninghame-Graham, D. S., Vyse, T. J., Pamuk, O. N., Ercan Tunc, S., Dalkilic, E., Bicakcigil, M.,
Yentur, S. P., Wren, J. D., Merkel, P. A., Direskeneli, H. & Sawalha, A. H. 1 May 2015 In : Arthritis and Rheumatology. 67,
5, p. 1361-1368 8 p.
Research output: Contribution to journal › Article
UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to
multiple autoimmune diseases
Lewis, M. J., Vyse, S., Shields, A. M., Boeltz, S., Gordon, P., Spector, T. D., Lehner, P. J., Walczak, H. & Vyse, T. J. 5 Feb
2015 In : American Journal of Human Genetics. 96, 2, p. 221-234 14 p.
Research output: Contribution to journal › Article
Defective removal of ribonucleotides from DNA promotes systemic autoimmunity
Günther, C. , Kind, B. , Reijns, M. A. M. , Berndt, N. , Martinez-Bueno, M. , Wolf, C. , Tüngler, V. , Chara, O. , Lee, Y. A. ,
Hübner, N. , Bicknell, L. , Blum, S. , Krug, C. , Schmidt, F. , Kretschmer, S. , Koss, S. , Astell, K. R. , Ramantani, G. ,
Bauerfeind, A. , Morris, D. L. & 25 others Graham, D. S. C., Bubeck, D., Leitch, A., Ralston, S. H., Blackburn, E. A., Gahr,
M., Witte, T., Vyse, T. J., Melchers, I., Mangold, E., Nöthen, M. M., Aringer, M., Kuhn, A., Lüthke, K., Unger, L., Bley, A.,
Lorenzi, A., Isaacs, J. D., Alexopoulou, D., Conrad, K., Dahl, A., Roers, A., Alarcon-Riquelme, M. E., Jackson, A. P. &
Lee-Kirsch, M. A. 2 Jan 2015 In : Journal of Clinical Investigation. 125, 1, p. 413-424 12 p.
Research output: Contribution to journal › Article
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region
Armstrong, D. L., Zidovetzki, R., Alarcon-Riquelme, M. E., Tsaos, B. P., Criswell, L. A., Kimberly, R. P., Harley, J. B.,
Sivils, K. L., Vyse, T. J., Gaffney, P. M., Langefeld, C. D. & Jacob, C. O. Sep 2014 In : Genes and immunity. 15, 6, p. 347354 8 p.
Research output: Contribution to journal › Article
MHC associations with clinical and autoantibody manifestations in European SLE
Morris, D. L. , Fernando, M. M. A. , Taylor, K. E. , Chung, S. A. , Nititham, J. , Alarcon-Riquelme, M. E. , Barcellos, L. F. ,
Behrens, T. W. , Cotsapas, C. , Gaffney, P. M. , Graham, R. R. , Pons-Estel, B. A. , Gregersen, P. K. , Harley, J. B. ,
Hauser, S. L. , Hom, G. , Langefeld, C. D. , Noble, J. A. , Rioux, J. D. , Seldin, M. F. & 3 others Systemic Lupus
Erythematosus Genetics Consortium, Vyse, T. J. & Criswell, L. A. Jun 2014 In : GENES AND IMMUNITY. 15, 4, p. 210217 8 p.
Research output: Contribution to journal › Article
Resequencing the susceptibility gene, ITGAM, identifies two functionally deleterious rare variants in systemic lupus
erythematosus cases
Roberts, A. L., Thomas, E., Bhosle, S., Game, L., Obraztsova, O., Aitman, T. J., Vyse, T. J. & Rhodes, B. 21 May 2014 In
: ARTHRITIS RESEARCH AND THERAPY. 16, 3, 11 p., R114
Research output: Contribution to journal › Article
Lupus risk variants in the PXK locus alter B-cell receptor internalization
Vaughn, S. E. , Patel, Z. , Shen, N. , Harley, I. T. W. , Zoller, E. , Magnusen, A. F. , Williams, A. H. , Ziegler, J. T. ,
Comeau, M. E. , Marion, M. C. , Glenn, S. B. , Adler, A. , Shen, N. , Nath, S. , Stevens, A. M. , Freedman, B. I. , Tsao, B.
P. , Jacob, C. O. , Kamen, D. L. , Brown, E. E. & 27 others Gilkeson, G. S., Alarcón, G. S., Reveille, J. D., Anaya, J. M.,
James, J. A., Moser, K. L., Criswell, L. A., Vilá, L. M., Alarcón-Riquelme, M. E., Petri, M., Scofield, R. H., Kimberly, R. P.,
Ramsey-Goldman, R., Joo, Y. B., Choi, J., Bae, S. C., Boackle, S. A., Vyse, T. J., Guthridge, J. M., Namjou, B., Gaffney,
P. M., Langefeld, C. D., Kaufman, K. M., Kelly, J. A., Harley, I. T. W., Harley, J. B. & Kottyan, L. C. 8 Jan 2014 In :
Frontiers in Genetics. 5, JAN, 12 p., 450
Research output: Contribution to journal › Article
ABIN1 dysfunction as a genetic basis for lupus nephritis
Caster, D. J. , Korte, E. A. , Nanda, S. K. , McLeish, K. R. , Oliver, R. K. , G'Sell, R. T. , Sheehan, R. M. , Freeman, D. W. ,
Coventry, S. C. , Kelly, J. A. , Guthridge, J. M. , James, J. A. , Sivils, K. L. , Alarcon-Riquelme, M. E. , Scofield, R. H. ,
Adrianto, I. , Gaffney, P. M. , Stevens, A. M. , Freedman, B. I. , Langefeld, C. D. & 25 others Tsao, B. P., Pons-Estel, B.
A., Jacob, C. O., Kamen, D. L., Gilkeson, G. S., Brown, E. E., Alarcon, G. S., Edberg, J. C., Kimberly, R. P., Martin, J.,
Merrill, J. T., Harley, J. B., Kaufman, K. M., Reveille, J. D., Anaya, J. M., Criswell, L. A., Vila, L. M., Petri, M., RamseyGoldman, R., Bae, S. C., Boackle, S. A., Vyse, T. J., Niewold, T. B., Cohen, P. & Powell, D. W. 1 Nov 2013 In : Journal of
the American Society of Nephrology : JASN. 24, 11, p. 1743-1754 12 p.
Research output: Contribution to journal › Article
Preferential Binding to Elk-1 by SLE-Associated IL10 Risk Allele Upregulates IL10 Expression
Sakurai, D. , Zhao, J. , Deng, Y. , Kelly, J. A. , Brown, E. E. , Harley, J. B. , Bae, S. C. , Alarcn-Riquelme, M. E. , Edberg,
J. C. , Kimberly, R. P. , Ramsey-Goldman, R. , Petri, M. A. , Reveille, J. D. , Vilá, L. M. , Alarcón, G. S. , Kaufman, K. M. ,
Vyse, T. J. , Jacob, C. O. , Gaffney, P. M. , Sivils, K. M. & 128 others James, J. A., Kamen, D. L., Gilkeson, G. S.,
Niewold, T. B., Merrill, J. T., Scofield, R. H., Criswell, L. A., Stevens, A. M., Boackle, S. A., Kim, J. H., Choi, J., Pons-Estel,
B. A., Freedman, B. I., Anaya, J. M., Martin, J., Yu, C. Y., Chang, D. M., Song, Y. W., Langefeld, C. D., Chen, W.,
Grossman, J. M., Cantor, R. M., Hahn, B. H., Tsao, B. P., Frostegård, J., Truedsson, L., de Ramón, E., Sabio, J. M.,
Martin, J., Ortego-Centeno, N., CAllejas, J. L., González-Escribano, M. F., Sánchez-Román, J., D'Alfonso, S., Migliarese,
S., Sebastiani, G. D., Galeazzi, M., Witte, T., Lauwerys, B. R., Endreffy, E., Kovács, L., Vasconcelos, C., da Silva, B. M.,
Scherbarth, H. R., Marino, P. C., Motta, E. L., Gamron, S., Drenkard, C., Menso, E., Allievi, A., Tate, G. A., Presas, J. L.,
Palatnik, S. A., Abdala, M., Bearzotti, M., Alvarellos, A., Caeiro, F., Bertoli, A., Paira, S., Roverano, S., Graf, C. E.,
Bertero, E., Caprarulo, C., Buchanan, G., Guillerón, C., Grimaudo, S., Manni, J., Catoggio, L. J., Soriano, E. R., Santos, C.
D., Prigione, C., Ramos, F. A., Navarro, S. M., Berbotto, G. A., Jorfen, M., Romero, E. J., Garcia, M. A., Marcos, J. C.,
Marcos, A. I., Perandones, C. E., Eimon, A., Parque, S., Battagliotti, C. G., Acevedo, E., Cucho, M., de la Torre, I. G.,
Ríos, M. C., Moctezuma, J. F., Ceceña, M. M., Scherbarth, H. R., Marino, P. C., Motta, E. L., Gamron, S., Drenkard, C.,
Menso, E., Allievi, A., Tate, G. A., Presas, J. L., Palatnik, S. A., Abdala, M., Bearzotti, M., Alvarellos, A., Caeiro, F., Bertoli,
A., Paira, S., Roverano, S., Graf, C. E., Bertero, E., Caprarulo, C., Buchanan, G., Guillerón, C., Grimaudo, S., Manni, J.,
Catoggio, L. J., Soriano, E. R., Santos, C. D., Prigione, C., Ramos, F. A., Navarro, S. M., Berbotto, G. A., Jorfen, M.,
Romero, E. J., Garcia, M. A., Marcos, J. C., Marcos, A. I., Perandones, C. E., Eimon, A. & Battagliotti, C. G. 10 Oct 2013
In : PL o S Genetics. 9, 10, 12 p., e1003870
Research output: Contribution to journal › Article
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome
Lessard, C. J. , Li, H. , Adrianto, I. , Ice, J. A. , Rasmussen, A. , Grundahl, K. M. , Kelly, J. A. , Dozmorov, M. G. , MiceliRichard, C. , Bowman, S. , Lester, S. , Eriksson, P. , Eloranta, M. L. , Brun, J. G. , Gøransson, L. G. , Harboe, E. ,
Guthridge, J. M. , Kaufman, K. M. , Kvarnström, M. , Jazebi, H. & 40 others Graham, D. S. C., Grandits, M. E., NazmulHossain, A. N. M., Patel, K., Adler, A. J., Maier-Moore, J. S., Farris, A. D., Brennan, M. T., Lessard, J. A., Chodosh, J.,
Gopalakrishnan, R., Hefner, K. S., Houston, G. D., Huang, A. J. W., Hughes, P. J., Lewis, D. M., Radfar, L., Rohrer, M. D.,
Stone, D. U., Wren, J. D., Vyse, T. J., Gaffney, P. M., James, J. A., Omdal, R., Wahren-Herlenius, M., Illei, G. G., Witte, T.,
Jonsson, R., Rischmueller, M., Rönnblom, L., Nordmark, G., Ng, W. F., Mariette, X., Anaya, J. M., Rhodus, N. L., Segal,
B. M., Scofield, R. H., Montgomery, C. G., Harley, J. B. & Sivils, K. L. 6 Oct 2013 In : Nature Genetics. 45, 11, p. 12841294 11 p.
Research output: Contribution to journal › Article
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci
Martin, J-E. , Assassi, S. , Diaz-Gallo, L-M. , Broen, J. C. , Simeon, C. P. , Castellvi, I. , Vicente-Rabaneda, E. , Fonollosa,
V. , Ortego-Centeno, N. , Gonzalez-Gay, M. A. , Espinosa, G. , Carreira, P. , Camps, M. , Sabio, J. M. , D'alfonso, S. ,
Vonk, M. C. , Voskuyl, A. E. , Schuerwegh, A. J. , Kreuter, A. , Witte, T. & 27 others Riemekasten, G., Hunzelmann, N.,
Airo, P., Beretta, L., Scorza, R., Lunardi, C., Van Laar, J., Chee, M. M., Worthington, J., Herrick, A., Denton, C., Fonseca,
C., Tan, F. K., Arnett, F., Zhou, X., Reveille, J. D., Gorlova, O., Koeleman, B. P. C., Radstake, T. R. D. J., Vyse, T.,
Mayes, M. D., Alarcon-Riquelme, M. E., Martin, J., Spanish Scleroderma Grp, SLEGEN Consortium, US Scleroderma
GWAS Grp & BIOLUPUS 1 Oct 2013 In : Human Molecular Genetics. 22, 19, p. 4021-4029 9 p., N/A
Research output: Contribution to journal › Article
The development of genome-wide association studies and their application to complex diseases, including lupus
Bentham, J. & Vyse, T. J. Oct 2013 In : Lupus. 22, 12, p. 1205-1213 9 p.
Research output: Contribution to journal › Article
Systemic Lupus Erythematosus
Rhodes, B. & Vyse, T. J. 29 Aug 2013 Genomic and Personalized Medicine. Ginsburg, G. S. & Willard, H. F. (eds.). 2 ed.
Amsterdam: ELSEVIER ACADEMIC PRESS INC, Vol. 1-2, p. 970-982 13 p.
Research output: Chapter in Book/Report/Conference proceeding › Chapter
PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical SubPhenotypes
Namjou, B. , Kim-Howard, X. , Sun, C. , Adler, A. , Chung, S. A. , Kaufman, K. M. , Kelly, J. A. , Glenn, S. B. , Guthridge,
J. M. , Scofield, R. H. , Kimberly, R. P. , Brown, E. E. , Alarcon, G. S. , Edberg, J. C. , Kim, J-H. , Choi, J. , RamseyGoldman, R. , Petri, M. A. , Reveille, J. D. , Vila, L. M. & 21 others Boackle, S. A., Freedman, B. I., Tsao, B. P., Langefeld,
C. D., Vyse, T. J., Jacob, C. O., Pons-Estel, B., Niewold, T. B., Sivils, K. L. M., Merrill, J. T., Anaya, J-M., Gilkeson, G. S.,
Gaffney, P. M., Bae, S-C., Alarcon-Riquelme, M. E., Harley, J. B., Criswell, L. A., James, J. A., Nath, S. K., Argentine
Collaborative Grp & BIOLUPUS GENLES Networks 7 Aug 2013 In : PL o S One . 8, 8, p. N/A 9 p., e69404
Research output: Contribution to journal › Article
Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4
Manku, H. , Langefeld, C. D. , Guerra, S. G. , Malik, T. H. , Alarcon-Riquelme, M. , Anaya, J-M. , Bae, S-C. , Boackle, S.
A. , Brown, E. E. , Criswell, L. A. , Freedman, B. I. , Gaffney, P. M. , Gregersen, P. A. , Guthridge, J. M. , Han, S-H. ,
Harley, J. B. , Jacob, C. O. , James, J. A. , Kamen, D. L. , Kaufman, K. M. & 18 others Kelly, J. A., Martin, J., Merrill, J. T.,
Moser, K. L., Niewold, T. B., Park, S-Y., Pons-Estel, B. A., Sawalha, A. H., Scofield, R. H., Shen, N., Stevens, A. M., Sun,
C., Gilkeson, G. S., Edberg, J. C., Kimberly, R. P., Nath, S. K., Tsao, B. P. & Vyse, T. 18 Jul 2013 In : PL o S Genetics. 9,
7, e1003554
Research output: Contribution to journal › Article
Three Sgp loci act independently as well as synergistically to elevate the expression of specific endogenous retroviruses
implicated in murine lupus
Ito, K., Baudino, L., Kihara, M., Leroy, V., Vyse, T. J., Evans, L. H. & Izui, S. Jun 2013 In : Journal of Autoimmunity. 43,
N/A, p. 10-17 8 p., N/A
Research output: Contribution to journal › Article
Variable Association of Reactive Intermediate Genes with Systemic Lupus Erythematosus in Populations with Different
African Ancestry
Ramos, P. S. , Oates, J. C. , Kamen, D. L. , Williams, A. H. , Gaffney, P. M. , Kelly, J. A. , Kaufman, K. M. , Kimberly, R. P.
, Niewold, T. B. , Jacob, C. O. , Tsao, B. P. , Alarcon, G. S. , Brown, E. E. , Edberg, J. C. , Petri, M. A. , Ramsey-Goldman,
R. , Reveille, J. D. , Vila, L. M. , James, J. A. , Guthridge, J. M. & 12 others Merrill, J. T., Boackle, S. A., Freedman, B. I.,
Scofield, R. H., Stevens, A. M., Vyse, T. J., Criswell, L. A., Moser, K. L., Alarcon-Riquelme, M. E., Langefeld, C. D.,
Harley, J. B. & Gilkeson, G. S. Jun 2013 In : Journal of Rheumatology. 40, 6, p. 842-849 8 p., N/A
Research output: Contribution to journal › Article
Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral
groups
Kaufman, K. M. , Zhao, J. , Kelly, J. A. , Hughes, T. , Adler, A. , Sanchez, E. , Ojwang, J. O. , Langefeld, C. D. , Ziegler, J.
T. , Williams, A. H. , Comeau, M. E. , Marion, M. C. , Glenn, S. B. , Cantor, R. M. , Grossman, J. M. , Hahn, B. H. , Song,
Y. W. , Yu, C-Y. , James, J. A. , Guthridge, J. M. & 32 others Brown, E. E., Alarcon, G. S., Kimberly, R. P., Edberg, J. C.,
Ramsey-Goldman, R., Petri, M. A., Reveille, J. D., Vila, L. M., Anaya, J-M., Boackle, S. A., Stevens, A. M., Freedman, B.
I., Criswell, L. A., Pons-Estel, B. A., Lee, J-H., Lee, J-S., Chang, D-M., Scofield, R. H. A., Gilkeson, G. S., Merrill, J. T.,
Niewold, T. B., Vyse, T. J., Bae, S-C., Alarcon-Riquelme, M. E., Jacob, C. O., Sivils, K. M., Gaffney, P. M., Harley, J. B.,
Sawalha, A. H., Tsao, B. P., Argentine Collaborat Grp & Biolupus Network Mar 2013 In : Annals of the Rheumatic
Diseases. 72, 3, p. 437-444 8 p.
Research output: Contribution to journal › Article
MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus
Erythematosus
Deng, Y. , Zhao, J. , Sakurai, D. , Kaufman, K. M. , Edberg, J. C. , Kimberly, R. P. , Kamen, D. L. , Gilkeson, G. S. , Jacob,
C. O. , Scofield, H. , Langefeld, C. D. , Kelly, J. A. , Ramsey-Goldman, R. , Petri, M. A. , Reveille, J. D. , Vila, L. M. ,
Alarcon, G. S. , Vyse, T. J. , Pons-Estel, B. A. , Freedman, B. I. & 21 others Gaffney, P. M., Sivils, K. M., James, J. A.,
Gregersen, P. K., Anaya, J-M., Niewold, T. B., Merrill, J. T., Criswell, L. A., Stevens, A. M., Boackle, S. A., Cantor, R. M.,
Chen, W., Grossman, J. M., Hahn, B. H., Harley, J. B., Alarcon-Riquelme, M. E., Brown, E. E., Tsao, B. P., Argentine
Collaborative Grp, BIOLUPUS Network & GENLES Network 28 Feb 2013 In : PL o S Genetics. 9, 2, p. N/A 11 p.,
e1003336
Research output: Contribution to journal › Article
Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation,
and Autoantibody Production
Molineros, J. E. , Maiti, A. K. , Sun, C. , Looger, L. L. , Han, S. , Kim-Howard, X. , Glenn, S. , Adler, A. , Kelly, J. A. ,
Niewold, T. B. , Gilkeson, G. S. , Brown, E. E. , Alarcon, G. S. , Edberg, J. C. , Petri, M. , Ramsey-Goldman, R. , Reveille,
J. D. , Vila, L. M. , Freedman, B. I. , Tsao, B. P. & 18 others Criswell, L. A., Jacob, C. O., Moore, J. H., Vyse, T. J.,
Langefeld, C. L., Guthridge, J. M., Gaffney, P. M., Moser, K. L., Scofield, R. H., Alarcon-Riquelme, M. E., Williams, S. M.,
Merrill, J. T., James, J. A., Kaufman, K. M., Kimberly, R. P., Harley, J. B., Nath, S. K. & BIOLUPUS Network 18 Feb 2013
In : PL o S Genetics. 9, 2, p. N/A 19 p., e1003222
Research output: Contribution to journal › Article
Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus
Mueller, M., Barros, P., Witherden, A. S., Roberts, A., Zhang, Z., Schaschl, H., Yu, C-Y., Hurles, M. E., Schaffner, C.,
Floto, R. A., Game, L., Steinberg, K. M., Wilson, R. K., Graves, T. A., Eichler, E. E., Cook, H. T., Vyse, T. J. & Aitman, T.
J. 10 Jan 2013 In : American Journal of Human Genetics. 92, 1, p. 28-40 13 p.
Research output: Contribution to journal › Article
The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in
human monocytes
Rhodes, B., Fürnrohr, B. G., Roberts, A. L., Tzircotis, G., Schett, G., Spector, T. D. & Vyse, T. J. Dec 2012 In : Annals of
the Rheumatic Diseases. 71, 12, p. 2028-2034 7 p.
Research output: Contribution to journal › Article
Unraveling Multiple MHC Gene Associations with Systemic Lupus Erythematosus: Model Choice Indicates a Role for HLA
Alleles and Non-HLA Genes in Europeans
Morris, D. L. , Taylor, K. E. , Fernando, M. M. A. , Nititham, J. , Alarcon-Riquelme, M. E. , Barcellos, L. F. , Behrens, T. W.
, Cotsapas, C. , Gaffney, P. M. , Graham, R. R. , Pons-Estel, B. A. , Gregersen, P. K. , Harley, J. B. , Hauser, S. L. , Hom,
G. , Langefeld, C. D. , Noble, J. A. , Rioux, J. D. , Seldin, M. F. , Criswel, L. A. & 2 others Vyse, T. J. & Systemic Lupus
Erythematosus Genet, Int MHC Autoimmunity Genetics Netw 2 Nov 2012 In : American Journal of Human Genetics. 91, 5
, p. 778-793 16 p.
Research output: Contribution to journal › Article
Association of Two Independent Functional Risk Haplotypes in TNIP1 With Systemic Lupus Erythematosus
Adrianto, I. , Wang, S. , Wiley, G. B. , Lessard, C. J. , Kelly, J. A. , Adler, A. J. , Glenn, S. B. , Williams, A. H. , Ziegler, J. T.
, Comeau, M. E. , Marion, M. C. , Wakeland, B. E. , Liang, C. , Kaufman, K. M. , Guthridge, J. M. , Alarcon-Riquelme, M.
E. , Alarcon, G. S. , Anaya, J-M. , Bae, S-C. , Kim, J-H. & 30 others Joo, Y. B., Boackle, S. A., Brown, E. E., Petri, M. A.,
Ramsey-Goldman, R., Reveille, J. D., Vila, L. M., Criswell, L. A., Edberg, J. C., Freedman, B. I., Gilkeson, G. S., Jacob, C.
O., James, J. A., Kamen, D. L., Kimberly, R. P., Martin, J., Merrill, J. T., Niewold, T. B., Pons-Estel, B. A., Scofield, R. H.,
Stevens, A. M., Tsao, B. P., Vyse, T. J., Langefeld, C. D., Harley, J. B., Wakeland, E. K., Moser, K. L., Montgomery, C. G.,
Gaffney, P. M. & GENLES Network, BIOLUPUS Network Nov 2012 In : Arthritis & Rheumatism. 64, 11, p. 3695-3705 11
p.
Research output: Contribution to journal › Article
CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and
activation
Manjarrez-Orduno, N. , Marasco, E. , Chung, S. A. , Katz, M. S. , Kiridly, J. F. , Simpfendorfer, K. R. , Freudenberg, J. ,
Ballard, D. H. , Nashi, E. , Hopkins, T. J. , Graham, D. S. C. , Lee, A. T. , Coenen, M. J. H. , Franke, B. , Swinkels, D. W. ,
Graham, R. R. , Kimberly, R. P. , Gaffney, P. M. , Vyse, T. J. , Behrens, T. W. & 3 others Criswell, L. A., Diamond, B. &
Gregersen, P. K. Nov 2012 In : Nature Genetics. 44, 11, p. 1227-1230 4 p.
Research output: Contribution to journal › Article
Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in
American Indian-European populations
Sanchez, E. , Rasmussen, A. , Riba, L. , Acevedo-Vasquez, E. , Kelly, J. A. , Langefeld, C. D. , Williams, A. H. , Ziegler, J.
T. , Comeau, M. E. , Marion, M. C. , Garcia-De La Torre, I. , Maradiaga-Cecena, M. A. , Cardiel, M. H. , Esquivel-Valerio,
J. A. , Rodriguez-Amado, J. , Francisco Moctezuma, J. , Miranda, P. , Perandones, C. E. , Castel, C. , Laborde, H. A. & 34
others Alba, P., Musuruana, J. L., Goecke, I. A., Anaya, J-M., Kaufman, K. M., Adler, A., Glenn, S. B., Brown, E. E.,
Alarcon, G. S., Kimberly, R. P., Edberg, J. C., Vila, L. M., Criswell, L. A., Gilkeson, G. S., Niewold, T. B., Martin, J., Vyse,
T. J., Boackle, S. A., Ramsey-Goldman, R., Scofield, R. H., Petri, M., Merrill, J. T., Reveille, J. D., Tsao, B. P., Orozco, L.,
Baca, V., Moser, K. L., Gaffney, P. M., James, J. A., Harley, J. B., Tusie-Luna, T., Pons-Estel, B. A., Jacob, C. O. &
Alarcon-Riquelme, M. E. Nov 2012 In : Arthritis & Rheumatism. 64, 11, p. 3687-3694 8 p.
Research output: Contribution to journal › Article
Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple
ancestries
Kim, K. , Brown, E. E. , Choi, C-B. , Alarc, M. E. , Kelly, J. A. , Glenn, S. B. , Ojwang, J. O. , Adler, A. , Lee, H-S. , Boackle,
S. A. , Criswell, L. A. , Alarc, G. S. , Edberg, J. C. , Stevens, A. M. , Jacob, C. O. , Gilkeson, G. S. , Kamen, D. L. , Tsao,
B. P. , Anaya, J-M. , Guthridge, J. M. & 32 others Nath, S. K., Richardson, B., Sawalha, A. H., Kang, Y. M., Shim, S. C.,
Suh, C-H., Lee, S-K., Kim, C., Merrill, J. T., Petri, M., Ramsey-Goldman, R., Vil, L. M., Niewold, T. B., Martin, J., PonsEstel, B. A., Vyse, T. J., Freedman, B. I., Moser, K. L., Gaffney, P. M., Williams, A., Comeau, M., Reveille, J. D., James, J.
A., Eld, R. H. S., Langefeld, C. D., Kaufman, K. M., Harley, J. B., Kang, C., Kimberly, R. P., Bae, S-C., BIOLUPUS &
GENLES Nov 2012 In : Annals of the Rheumatic Diseases. 71, 11, p. 1809-1814 6 p., N/A
Research output: Contribution to journal › Article
Analysis of systemic lupus erythematosus sub-phenotype data for genetic association
Morris, D. & Vyse, T. Sep 2012 In : Current Opinion in Rheumatology. 24, 5, p. 482-488 7 p.
Research output: Contribution to journal › Scientific review
A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus
Wang, S. , Adrianto, I. , Wiley, G. B. , Lessard, C. J. , Kelly, J. A. , Adler, A. J. , Glenn, S. B. , Williams, A. H. , Ziegler, J. T.
, Comeau, M. E. , Marion, M. C. , Wakeland, B. E. , Liang, C. , Kaufman, K. M. , Guthridge, J. M. , Alarcon-Riquelme, M.
E. , Alarcon, G. S. , Anaya, J-M. , Bae, S-C. , Kim, J-H. & 31 others Joo, Y. B., Boackle, S. A., Brown, E. E., Petri, M. A.,
Ramsey-Goldman, R., Reveille, J. D., Vila, L. M., Criswell, L. A., Edberg, J. C., Freedman, B. I., Gilkeson, G. S., Jacob, C.
O., James, J. A., Kamen, D. L., Kimberly, R. P., Martin, J., Merrill, J. T., Niewold, T. B., Pons-Estel, B. A., Scofield, R. H.,
Stevens, A. M., Tsao, B. P., Vyse, T. J., Langefeld, C. D., Harley, J. B., Wakeland, E. K., Moser, K. L., Montgomery, C. G.,
Gaffney, P. M., BIOLUPUS Network & GENLES Network Jul 2012 In : GENES AND IMMUNITY. 13, 5, p. 380-387 8 p.
Research output: Contribution to journal › Article
The Wolf at the Door
Uttenthal, B. J., Layton, D. M., Vyse, T. J. & Schreiber, B. E. 7 Jun 2012 In : New England Journal of Medicine. 366, 23,
p. 2216-2221 6 p.
Research output: Contribution to journal › Article
Evaluation of TRAF6 in a large multiancestral lupus cohort
Namjou, B. , Choi, C-B. , Harley, I. T. W. , Alarcon-Riquelme, M. E. , Kelly, J. A. , Glenn, S. B. , Ojwang, J. O. , Adler, A. ,
Kim, K. , Gallant, C. J. , Boackle, S. A. , Criswell, L. A. , Kimberly, R. P. , Brown, E. E. , Edberg, J. , Alarcon, G. S. ,
Stevens, A. M. , Jacob, C. O. , Gilkeson, G. S. , Kamen, D. L. & 29 others Tsao, B. P., Anaya, J-M., Kim, E-M., Park, S-Y.,
Sung, Y-K., Guthridge, J. M., Merrill, J. T., Petri, M., Ramsey-Goldman, R., Vila, L. M., Niewold, T. B., Martin, J., PonsEstel, B. A., Vyse, T. J., Freedman, B. I., Moser, K. L., Gaffney, P. M., Williams, A. H., Comeau, M. E., Reveille, J. D.,
Kang, C., James, J. A., Scofield, R. H., Langefeld, C. D., Kaufman, K. M., Harley, J. B., Bae, S-C., BIOLUPUS Network &
Genoma Lupus Network Jun 2012 In : Arthritis & Rheumatism. 64, 6, p. 1960-1969 10 p., N/A
Research output: Contribution to journal › Article
The genetics of lupus: a functional perspective
Guerra, S. G., Vyse, T. J. & Cunninghame Graham, D. S. 29 May 2012 In : ARTHRITIS RESEARCH AND THERAPY. 14,
3, 211
Research output: Contribution to journal › Article
Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus
erythematosus
Hughes, T. , Adler, A. , Merrill, J. T. , Kelly, J. A. , Kaufman, K. M. , Williams, A. , Langefeld, C. D. , Gilkeson, G. S. ,
Sanchez, E. , Martin, J. , Boackle, S. A. , Stevens, A. M. , Alarcon, G. S. , Niewold, T. B. , Brown, E. E. , Kimberly, R. P. ,
Edberg, J. C. , Ramsey-Goldman, R. , Petri, M. , Reveille, J. D. & 13 others Criswell, L. A., Vila, L. M., Jacob, C. O.,
Gaffney, P. M., Moser, K. L., Vyse, T. J., Alarcon-Riquelme, M. E., James, J. A., Tsao, B. P., Scofield, R. H., Harley, J. B.,
Richardson, B. C. & Sawalha, A. H. May 2012 In : Annals of the Rheumatic Diseases. 71, 5, p. 694 - 699 6 p.
Research output: Contribution to journal › Article
Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting
loci at MSH5, HLA-DPB1 and HLA-G
Fernando, M. M. A., Freudenberg, J., Lee, A., Morris, D. L., Boteva, L., Rhodes, B., Francisca Gonzalez-Escribano, M.,
Angel Lopez-Nevot, M., Navarra, S. V., Gregersen, P. K., Martin, J. & Vyse, T. J. May 2012 In : Annals of the Rheumatic
Diseases. 71, 5, p. 777 - 784 8 p.
Research output: Contribution to journal › Article
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a LargeScale Multiracial Replication Study
Lessard, C. J. , Adrianto, I. , Ice, J. A. , Wiley, G. B. , Kelly, J. A. , Glenn, S. B. , Adler, A. J. , Li, H. , Rasmussen, A. ,
Williams, A. H. , Ziegler, J. , Comeau, M. E. , Marion, M. , Wakeland, B. E. , Liang, C. , Ramos, P. S. , Grundahl, K. M. ,
Gallant, C. J. , Alarcon-Riquelme, M. E. , Alarcon, G. S. & 40 others Anaya, J-M., Bae, S-C., Boackle, S. A., Brown, E. E.,
Chang, D-M., Cho, S-K., Criswell, L. A., Edberg, J. C., Freedman, B. I., Gilkeson, G. S., Jacob, C. O., James, J. A.,
Kamen, D. L., Kimberly, R. P., Kim, J-H., Martin, J., Merrill, J. T., Niewold, T. B., Park, S-Y., Petri, M. A., Pons-Estel, B. A.,
Ramsey-Goldman, R., Reveille, J. D., Scofield, R. H., Song, Y. W., Stevens, A. M., Tsao, B. P., Vila, L. M., Vyse, T. J., Yu,
C-Y., Guthridge, J. M., Kaufman, K. M., Harley, J. B., Wakeland, E. K., Langefeld, C. D., Gaffney, P. M., Montgomery, C.
G., Moser, K. L., BIOLUPUS Network & GENLES Network 6 Apr 2012 In : American Journal of Human Genetics. 90, 4, p.
648-660 13 p., N/A
Research output: Contribution to journal › Article
Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis
Lin, C. P. , Adrianto, I. , Lessard, C. J. , Kelly, J. A. , Kaufman, K. M. , Guthridge, J. M. , Freedman, B. I. , Anaya, J-M. ,
Alarcon-Riquelme, M. E. , Pons-Estel, B. A. , Martin, J. , Glenn, S. , Adler, A. , Bae, S-C. , Park, S-Y. , Bang, S-Y. , Song,
Y-W. , Boackle, S. A. , Brown, E. E. , Edberg, J. C. & 25 others Alarcon, G. S., Petri, M. A., Criswell, L. A., RamseyGoldman, R., Reveille, J. D., Vila, L. M., Gilkeson, G. S., Kamen, D. L., Ziegler, J., Jacob, C. O., Rasmussen, A., James,
J. A., Kimberly, R. P., Merrill, J. T., Niewold, T. B., Scofield, R. H., Stevens, A. M., Tsao, B. P., Vyse, T. J., Langefeld, C.
D., Moser, K. L., Harley, J. B., Gaffney, P. M., Montgomery, C. G. & BIOLUPUS GENLES Networks Apr 2012 In : GENES
AND IMMUNITY. 13, 3, p. 232-238 7 p., N/A
Research output: Contribution to journal › Article
Genetically Determined Partial Complement C4 Deficiency States Are Not Independent Risk Factors for SLE in UK and
Spanish Populations
Boteva, L., Morris, D. L., Cortes-Hernandez, J., Martin, J., Vyse, T. J. & Fernando, M. M. 9 Mar 2012 In : American Journal
of Human Genetics. 90, 3, p. 445 - 456 12 p.
Research output: Contribution to journal › Article
IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain
the majority of the genetic association with systemic lupus erythematosus
Niewold, T. B. , Kelly, J. A. , Kariuki, S. N. , Franek, B. S. , Kumar, A. A. , Kaufman, K. M. , Thomas, K. , Walker, D. ,
Kamp, S. , Frost, J. M. , Wong, A. K. , Merrill, J. T. , Alarcon-Riquelme, M. E. , Tikly, M. , Ramsey-Goldman, R. , Reveille,
J. D. , Petri, M. A. , Edberg, J. C. , Kimberly, R. P. , Alarcon, G. S. & 8 others Kamen, D. L., Gilkeson, G. S., Vyse, T. J.,
James, J. A., Gaffney, P. M., Moser, K. L., Crow, M. K. & Harley, J. B. Mar 2012 In : Annals of the Rheumatic Diseases.
71, 3, p. 463 - 468 6 p.
Research output: Contribution to journal › Article
Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus
Hughes, T. , Adler, A. , Kelly, J. A. , Kaufman, K. M. , Williams, A. H. , Langefeld, C. D. , Brown, E. E. , Alarcon, G. S. ,
Kimberly, R. P. , Edberg, J. C. , Ramsey-Goldman, R. , Petri, M. , Boackle, S. A. , Stevens, A. M. , Reveille, J. D. ,
Sanchez, E. , Martin, J. , Niewold, T. B. , Vila, L. M. , Scofield, R. H. & 13 others Gilkeson, G. S., Gaffney, P. M., Criswell,
L. A., Moser, K. L., Merrill, J. T., Jacob, C. O., Tsao, B. P., James, J. A., Vyse, T. J., Alarcon-Riquelme, M. E., Harley, J.
B., Richardson, B. C. & Sawalha, A. H. Feb 2012 In : Arthritis & Rheumatism. 64, 2, p. 485 - 492 8 p.
Research output: Contribution to journal › Article
Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of
European ancestry
Hunt, K. A. , Smyth, D. J. , Balschun, T. , Ban, M. , Mistry, V. , Ahmad, T. , Anand, V. , Barrett, J. C. , Bhaw-Rosun, L. ,
Bockett, N. A. , Brand, O. J. , Brouwer, E. , Concannon, P. , Cooper, J. D. , Dias, K-R. M. , van Diemen, C. C. , Dubois, P.
C. , Edkins, S. , Foelster-Holst, R. , Fransen, K. & 45 others Glass, D. N., Heap, G. A. R., Hofmann, S., Huizinga, T. W. J.,
Hunt, S., Langford, C., Lee, J., Mansfield, J., Marrosu, M. G., Mathew, C. G., Mein, C. A., Mueller-Quernheim, J., Nutland,
S., Onengut-Gumuscu, S., Ouwehand, W., Pearce, K., Prescott, N. J., Posthumus, M. D., Potter, S., Rosati, G.,
Sambrook, J., Satsangi, J., Schreiber, S., Shtir, C., Simmonds, M. J., Sudman, M., Thompson, S. D., Toes, R., Trynka, G.,
Vyse, T. J., Walker, N. M., Weidinger, S., Zhernakova, A., Zoledziewska, M., Weersma, R. K., Gough, S. C. L., Sawcer,
S., Wijmenga, C., Parkes, M., Cucca, F., Franke, A., Deloukas, P., Rich, S. S., Todd, J. A. & van Heel, D. A. Jan 2012 In :
Nature Genetics. 44, 1, p. 3 - 5 3 p.
Research output: Contribution to journal › Letter
A Comprehensive Analysis of Shared Loci between Systemic Lupus Erythematosus (SLE) and Sixteen Autoimmune
Diseases Reveals Limited Genetic Overlap
Ramos, P. S., Criswell, L. A., Moser, K. L., Comeau, M. E., Williams, A. H., Pajewski, N. M., Chung, S. A., Graham, R. R.,
Zidovetzki, R., Kelly, J. A., Kaufman, K. M., Jacob, C. O., Vyse, T. J., Tsao, B. P., Kimberly, R. P., Gaffney, P. M., AlarconRiquelme, M. E., Harley, J. B. & Langefeld, C. D. Dec 2011 In : PL o S Genetics. 7, 12, e1002406
Research output: Contribution to journal › Article
Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus
Cunninghame Graham, D. S., Morris, D. L., Bhangale, T. R., Criswell, L. A., Syvänen, A-C., Rönnblom, L., Behrens, T. W.,
Graham, R. R. & Vyse, T. J. Oct 2011 In : PL o S Genetics. 7, 10, e1002341
Research output: Contribution to journal › Article
Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus
Sanchez, E. , Nadig, A. , Richardson, B. C. , Freedman, B. I. , Kaufman, K. M. , Kelly, J. A. , Niewold, T. B. , Kamen, D. L.
, Gilkeson, G. S. , Ziegler, J. T. , Langefeld, C. D. , Alarcon, G. S. , Edberg, J. C. , Ramsey-Goldman, R. , Petri, M. ,
Brown, E. E. , Kimberly, R. P. , Reveille, J. D. , Vila, L. M. , Merrill, J. T. & 16 others Anaya, J-M., James, J. A., Pons-Estel,
B. A., Martin, J., Park, S-Y., Bang, S-Y., Bae, S-C., Moser, K. L., Vyse, T. J., Criswell, L. A., Gaffney, P. M., Tsao, B. P.,
Jacob, C. O., Harley, J. B., Alarcon-Riquelme, M. E. & Sawalha, A. H. Oct 2011 In : Annals of the Rheumatic Diseases. 70
, 10, p. 1752 - 1757 6 p.
Research output: Contribution to journal › Article
Large Scale Replication Study of the Association between HLA Class II/BTNL2 Variants and Osteoarthritis of the Knee in
European-Descent Populations
Valdes, A. M. , Styrkarsdottir, U. , Doherty, M. , Morris, D. L. , Mangino, M. , Tamm, A. , Doherty, S. A. , Kisand, K. ,
Kerna, I. , Tamm, A. , Wheeler, M. , Maciewicz, R. A. , Zhang, W. , Muir, K. R. , Dennison, E. M. , Hart, D. J. , Metrustry,
S. , Jonsdottir, I. , Jonsson, G. F. , Jonsson, H. & 6 others Ingvarsson, T., Cooper, C., Vyse, T. J., Spector, T. D.,
Stefansson, K. & Arden, N. K. 11 Aug 2011 In : PL o S One . 6, 8, p. N/A 7 p., e23371
Research output: Contribution to journal › Article
Genetic Analyses of Interferon Pathway-Related Genes Reveal Multiple New Loci Associated With Systemic Lupus
Erythematosus
Ramos, P. S. , Williams, A. H. , Ziegler, J. T. , Comeau, M. E. , Guy, R. T. , Lessard, C. J. , Li, H. , Edberg, J. C. ,
Zidovetzki, R. , Criswell, L. A. , Gaffney, P. M. , Graham, D. C. , Graham, R. R. , Kelly, J. A. , Kaufman, K. M. , Brown, E.
E. , Alarcon, G. S. , Petri, M. A. , Reveille, J. D. , McGwin, G. & 10 others Vila, L. M., Ramsey-Goldman, R., Jacob, C. O.,
Vyse, T. J., Tsao, B. P., Harley, J. B., Kimberly, R. P., Alarcon-Riquelme, M. E., Langefeld, C. D. & Moser, K. L. Jul 2011
In : Arthritis & Rheumatism. 63, 7, p. 2049 - 2057 9 p.
Research output: Contribution to journal › Article
A 4.6 kb genomic duplication on 20p12.2-12.3 is associated with brachydactyly type A2 in a Chinese family
Su, P., Ding, H., Huang, D., Zhou, Y., Huang, W., Zhong, L., Vyse, T. J. & Wang, Y. May 2011 In : Journal of Medical
Genetics. 48, 5, p. 312 - 316 5 p.
Research output: Contribution to journal › Article
Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus
Erythematosus Susceptibility
Zhao, J. , Wu, H. , Khosravi, M. , Cui, H. , Qian, X. , Kelly, J. A. , Kaufman, K. M. , Langefeld, C. D. , Williams, A. H. ,
Comeau, M. E. , Ziegler, J. T. , Marion, M. C. , Adler, A. , Glenn, S. B. , Alarcon-Riquelme, M. E. , Pons-Estel, B. A. ,
Harley, J. B. , Bae, S-C. , Bang, S-Y. , Cho, S-K. & 35 others Jacob, C. O., Vyse, T. J., Niewold, T. B., Gaffney, P. M.,
Moser, K. L., Kimberly, R. P., Edberg, J. C., Brown, E. E., Alarcon, G. S., Petri, M. A., Ramsey-Goldman, R., Vila, L. M.,
Reveille, J. D., James, J. A., Gilkeson, G. S., Kamen, D. L., Freedman, B. I., Anaya, J-M., Merrill, J. T., Criswell, L. A.,
Scofield, R. H., Stevens, A. M., Guthridge, J. M., Chang, D-M., Song, Y. W., Park, J. A., Lee, E. Y., Boackle, S. A.,
Grossman, J. M., Hahn, B. H., Goodship, T. H. J., Cantor, R. M., Yu, C-Y., Shen, N. & Tsao, B. P. May 2011 In : PL o S
Genetics. 7, 5, e1002079
Research output: Contribution to journal › Article
C-reactive protein in rheumatology: biology and genetics
Rhodes, B., Fuernrohr, B. G. & Vyse, T. J. May 2011 In : Nature Reviews Rheumatology. 7, 5, p. 283 - 290 8 p.
Research output: Contribution to journal › Scientific review
Investigation of the HIN200 Locus in UK SLE Families Identifies Novel Copy Number Variants
Fernando, M. M., de Smith, A. J., Coin, L., Morris, D. L., Froguel, P., Mangion, J., Blakemore, A. I. F., Graham, R. R.,
Behrens, T. W. & Vyse, T. J. May 2011 In : Annals of Human Genetics. 75, 3, p. 383 - 397 15 p.
Research output: Contribution to journal › Article
Dense mapping of IL18 shows no association in SLE
Guerra, S. G., Morris, D. L., Gateva, V., Graham, R. R., Vyse, T. & Cunninghame Graham, D. 1 Mar 2011 In : Human
Molecular Genetics. 20, 5, p. 1026-1033 8 p.
Research output: Contribution to journal › Article
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
Adrianto, I. , Wen, F. , Templeton, A. , Wiley, G. , King, J. B. , Lessard, C. J. , Bates, J. S. , Hu, Y. , Kelly, J. A. , Kaufman,
K. M. , Guthridge, J. M. , Alarcon-Riquelme, M. E. , Anaya, J-M. , Bae, S-C. , Bang, S-Y. , Boackle, S. A. , Brown, E. E. ,
Petri, M. A. , Gallant, C. , Ramsey-Goldman, R. & 27 others Reveille, J. D., Vila, L. M., Criswell, L. A., Edberg, J. C.,
Freedman, B. I., Gregersen, P. K., Gilkeson, G. S., Jacob, C. O., James, J. A., Kamen, D. L., Kimberly, R. P., Martin, J.,
Merrill, J. T., Niewold, T. B., Park, S-Y., Pons-Estel, B. A., Scofield, R. H., Stevens, A. M., Tsao, B. P., Vyse, T. J.,
Langefeld, C. D., Harley, J. B., Moser, K. L., Webb, C. F., Humphrey, M. B., Montgomery, C. G. & Gaffney, P. M. Mar
2011 In : Nature Genetics. 43, 3, p. 253 - U102 6 p.
Research output: Contribution to journal › Article
Determination of the Loss of Function Complement C4 Exon 29 CT Insertion Using a Novel Paralog-Specific Assay in
Healthy UK and Spanish Populations
Boteva, L., Wu, Y. L., Cortes-Hernandez, J., Martin, J., Vyse, T. J. & Fernando, M. M. 2011 In : PL o S One . 6, 8, e22128
Research output: Contribution to journal › Article
Risk Alleles in Idiopathic Membranous Nephropathy
Fernando, M. M. & Vyse, T. J. 2011 In : New England Journal of Medicine. 364, 21, p. 2072 - 2072 1 p.
Research output: Contribution to journal › Letter
Chapter 1: Major Histocompatibility Comples Class II
Fernando, M. M. & Vyse, T. Dec 2010 Systemic Lupus Erythematosus. Fifth ed. Academic Press, p. 3-19 17 p.
Research output: Chapter in Book/Report/Conference proceeding › Chapter
HLA Has Strongest Association with IgA Nephropathy in Genome-Wide Analysis
Feehally, J., Farrall, M., Boland, A., Gale, D. P., Gut, I., Heath, S., Kumar, A., Peden, J. F., Maxwell, P. H., Morris, D.,
Padmanabhan, S., Vyse, T., Zawadzka, A., Rees, A. J., Lathrop, M. & Ratcliffe, P. J. Oct 2010 In : Journal of the American
Society of Nephrology. 21, 10, p. 1791-1797 7 p.
Research output: Contribution to journal › Article
A Genetic Association Study of Serum Acute-Phase C-Reactive Protein Levels in Rheumatoid Arthritis: Implications for
Clinical Interpretation
Rhodes, B., Merriman, M. E., Harrison, A., Nissen, M. J., Smith, M., Stamp, L., Steer, S., Merriman, T. R. & Vyse, T. 21
Sep 2010 In : PL o S Medicine. 7, 9, 9 p., e1000341
Research output: Contribution to journal › Article
Evidence for both copy number and allelic (NA1/NA2) risk at the FCGR3B locus in systemic lupus erythematosus
Morris, D. L., Roberts, A. L., Witherden, A. S., Tarzi, R., Barros, P., Whittaker, J. C., Cook, T. H., Aitman, T. J. & Vyse, T.
J. 10 Sep 2010 In : European Journal of Human Genetics. 18, 9, p. 1027-1031 5 p.
Research output: Contribution to journal › Article
Assessing association of common variation in the C1Q gene cluster with systemic lupus erythematosus
Rafiq, S., Frayling, T. M., Vyse, T. J., Cunninghame Graham, D. S. & Eggleton, P. Aug 2010 In : Clinical and Experimental
Immunology. 161, 2, p. 284-289 6 p.
Research output: Contribution to journal › Article
Assessment of Complement C4 Gene Copy Number Using the Paralog Ratio Test
Fernando, M. M. A., Boteva, L., Morris, D., Zhou, B., Wu, Y. L., Lokki, M-L., Yu, C. Y., Rioux, J. D., Hollox, E. J. & Vyse, T.
Jul 2010 In : Human Mutation. 31, 7, p. 866-874 9 p.
Research output: Contribution to journal › Article
Using genetics to deliver personalized SLE therapy-a realistic prospect?
Rhodes, B. & Vyse, T. 10 Jun 2010 In : Nature Reviews Rheumatology. 6, 6, p. 373-377 5 p.
Research output: Contribution to journal › Article
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
Rioux, J. D. , Goyette, P. , Vyse, T. , Hammarstroem, L. , Fernando, M. M. , Green, T. , De Jager, P. L. , Foisy, S. , Wang,
J. , de Bakker, P. I. W. , Leslie, S. , McVean, G. , Padyukov, L. , Alfredsson, L. , Annese, V. , Hafler, D. A. , PanHammarstroem, Q. , Matell, R. , Sawcer, S. J. , Compston, A. D. & 9 others Cree, B. A. C., Mirel, D. B., Daly, M. J.,
Behrens, T. W., Klareskog, L., Gregersen, P. K., Oksenberg, J. R., Hauser, S. L. & Int MHC Autoimmunity Genetics Netw
3 Nov 2009 In : Proceedings of the National Academy of Sciences of the United States of America. 106, 44, p. 1868018685 6 p.
Research output: Contribution to journal › Article
Variation in the upstream region of P-Selectin (SELP) is a risk factor for SLE
Morris, D. L., Graham, R. R., Erwig, L-P., Gaffney, P. M., Moser, K. L., Behrens, T. W., Vyse, T. J. & Graham, D. S. C.
2009 In : GENES AND IMMUNITY. 10, 5, p. 404-13 10 p.
Research output: Contribution to journal › Article
The genetics of SLE: an update in the light of genome-wide association studies
Rhodes, B. & Vyse, T. Nov 2008 In : Rheumatology. 47, 11, p. 1603-1611 9 p.
Research output: Contribution to journal › Scientific review
Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach
Rhodes, B., Morris, D., Subrahmanyan, L., Aubin, C., de Leon, C. F. M., Kelly, J. F., Evans, D. A., Whittaker, J. C.,
Oksenberg, J. R., De Jager, P. L. & Vyse, T. Jul 2008 In : Human Genetics. 123, 6, p. 633-642 10 p.
Research output: Contribution to journal › Article
Defining the role of the MHC in autoimmunity: A review and pooled analysis
Fernando, M. M., Stevens, C. R., Walsh, E. C., De Jager, P. L., Goyette, P., Plenge, R. M., Vyse, T. & Rioux, J. D. Apr
2008 In : PL o S Genetics. 4, 4, 9 p., e1000024
Research output: Contribution to journal › Systematic review
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM,
PXK, KIAA1542 and other loci
Harley, J. B. , Alarcón-Riquelme, M. E. , Criswell, L. A. , Jacob, C. O. , Kimberly, R. P. , Moser, K. L. , Tsao, B. P. , Vyse,
T. J. , Langefeld, C. D. , Nath, S. K. , Guthridge, J. M. , Cobb, B. L. , Mirel, D. B. , Marion, M. C. , Williams, A. H. , Divers,
J. , Wang, W. , Frank, S. G. , Namjou, B. , Gabriel, S. B. & 22 others Lee, A. T., Gregersen, P. K., Behrens, T. W., Taylor,
K. E., Fernando, M. M., Zidovetzki, R., Gaffney, P. M., Edberg, J. C., Rioux, J. D., Ojwang, J. O., James, J. A., Merrill, J.
T., Gilkeson, G. S., Seldin, M. F., Yin, H., Baechler, E. C., Li, Q-Z., Wakeland, E. K., Bruner, G. R., Kaufman, K. M., Kelly,
J. A. & International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN) Feb 2008 In : Nature Genetics.
40, 2, p. 204-210 7 p.
Research output: Contribution to journal › Article
Polymorphisms in the CD3Z Gene Influence TCRζ Expression in Systemic Lupus Erythematosus Patients and Healthy
Controls
Gorman, C. L., Russell, A. I., Zhang, Z., Cunninghame Graham, D., Cope, A. P. & Vyse, T. J. 15 Jan 2008 In : Journal of
Immunology. 180, 2, p. 1060-1070 11 p.
Research output: Contribution to journal › Article
Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus
Cunninghame Graham, D. S., Graham, R. R., Manku, H., Wong, A. K., Whittaker, J. C., Gaffney, P. M., Moser, K. L.,
Rioux, J. D., Altshuler, D., Behrens, T. W. & Vyse, T. J. Jan 2008 In : Nature Genetics. 40, 1, p. 83-89 7 p.
Research output: Contribution to journal › Article
General aspects of the genetics of SLE
Rhodes, B. & Vyse, T. Dec 2007 In : Autoimmunity. 40, 8, p. 550-559 10 p.
Research output: Contribution to journal › Scientific review
Identification of two independent risk factors for lupus within the MHC in United Kingdom families
Fernando, M. M. A., Stevens, C. R., Sabeti, P. C., Walsh, E. C., McWhinnie, A. J. M., Shah, A., Green, T., Rioux, J. D. &
Vyse, T. J. Nov 2007 In : PL o S Genetics. 3, 11, p. 2109-2121 13 p., e192
Research output: Contribution to journal › Article
Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE families
Cunninghame Graham, D. S., Akil, M. & Vyse, T. J. Jun 2007 In : Rheumatology. 46, 6, p. 927-930 4 p.
Research output: Contribution to journal › Article
The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus
Hellquist, A., Zucchelli, M., Kivinen, K., Saarialho-Kere, U., Koskenmies, S., Widen, E., Julkunen, H., Wong, A.,
Karjalainen-Lindsberg, M-L., Skoog, T., Vendelin, J., Cunninghame-Graham, D. S., Vyse, T. J., Kere, J., Lindgren, C. M. &
Cunninghame Graham, D. May 2007 In : Journal of Medical Genetics. 44, 5, p. 314-321 8 p.
Research output: Contribution to journal › Article
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus
Graham, R. R. , Kyogoku, C. , Sigurdsson, S. , Vlasova, I. A. , Davies, L. R. L. , Baechler, E. C. , Plenge, R. M. , Koeuth,
T. , Ortmann, W. A. , Hom, G. , Bauer, J. W. , Gillett, C. , Burtt, N. , Cunninghame Graham, D. S. , Onofrio, R. , Petri, M. ,
Gunnarsson, I. , Svenungsson, E. , Rönnblom, L. , Nordmark, G. & 10 others Gregersen, P. K., Moser, K., Gaffney, P. M.,
Criswell, L. A., Vyse, T. J., Syvänen, A-C., Bohjanen, P. R., Daly, M. J., Behrens, T. W. & Altshuler, D. 17 Apr 2007 In :
Proceedings of the National Academy of Sciences of the United States of America. 104, 16, p. 6758-63 6 p.
Research output: Contribution to journal › Article
Evidence for unique association signals in SLE at the CD28-CTLA4-ICOS locus in a family-based study
Cunninghame Graham, D. S., Wong, A. K., McHugh, N. J., Whittaker, J. C. & Vyse, T. J. 1 Nov 2006 In : Human
Molecular Genetics. 15, 21, p. 3195-3205 11 p.
Research output: Contribution to journal › Article
Mice, humans and haplotypes - the hunt for disease genes in SLE
Rigby, R. J., Fernando, M. M. A. & Vyse, T. J. Sep 2006 In : Rheumatology. 45, 9, p. 1062-1067 6 p.
Research output: Contribution to journal › Scientific review
No association between E- and L-selectin genes and SLE: soluble L-selectin levels do correlate with genotype and a
subset in SLE
Russell, A., Cunninghame Graham, D. S., Chadha, S., Roberton, C., Fernandez-Hart, T., Griffiths, B., D'Cruz, D., Nitsch,
D., Whittaker, J. C. & Vyse, T. J. Aug 2005 In : GENES AND IMMUNITY. 6, 5, p. 422-429 8 p.
Research output: Contribution to journal › Article
The candidate gene approach: have murine models informed the study of human SLE?
Cunninghame Graham, D. S. & Vyse, T. J. Jul 2004 In : Clinical and Experimental Immunology. 137, 1, p. 1-7 7 p.
Research output: Contribution to journal › Article
Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus
erythematosus
Russell, A. I., Cunninghame Graham, D. S., Shepherd, C., Roberton, C. A., Whittaker, J., Meeks, J., Powell, R. J.,
Isenberg, D. A., Walport, M. J. & Vyse, T. J. 1 Jan 2004 In : Human Molecular Genetics. 13, 1, p. 137-147 11 p.
Research output: Contribution to journal › Article
The above report is produced using the following setup
Ordered by: null