Individualized Heparin
Management
RIGHT FOR A COMPLEX ENVIRONMENT
343
HEPARIN
S IGNATURE
443
HEPARIN
S I G N AT U R E
408
HEPARIN
S I G N AT U R E
228
HEPARIN
S I G NATUR E
Sicker, more complex patients. Variable
heparin potency. Increasing urgency
around the need to reduce blood
product use. This complex environment
adds up to the need for more precise,
individualized heparin management.
343
443
408
228
ACT alone is no
longer enough
When ACT alone is used, a complete picture of a patient’s heparin concentration
during surgery is not visible. In fact, with so many variables clouding the view,
one can easily be misled by ACT into over- or under-dosing a patient—potentially
causing significant clinical and financial ramifications.1,2
FINANCIAL
CLINICAL
• Blood products associated with transfusions
• Patient exposure to blood products
• Longer hospital stays
• Factors associated with difficult recoveries
• Return visits to the OR
• Increased morbidity
Greater visibility = better management
Heparin Dose Response (HDR)
Medications, supplements, comorbidities
and other factors can cause significant
differences in the way individual patients
respond to heparin. ACT alone does not
account for these differences. The HMS
Plus System HDR test reveals how two
patients of a similar make-up respond very
differently to the same heparin dose.
AC T (SECONDS)
Normal vs. Resistant
480
P
ie
at
nt
A
Pa
0
tie
3.42
• Initial accurate, individualized heparin dosing
• Precise management of heparin levels
during a case
• Accurate heparin neutralization at the end
5.25
The HMS Plus System helps to:
• Preserve patient clotting factors
• Reduce blood product usage
• Improve outcomes and lower costs
of the case
Individualized Heparin Management with the HMS Plus System delivers significantly
different—and better outcomes—than ACT alone.3
Quantitative Heparin Measurement vs. ACT
PROTAMINE (mg)
% TRANSFUSED
CLOSURE TIME (min)
n = 254 patients
B
HEPARIN (U/ml)
The HMS Plus System allows for improved
precision throughout the care continuum from:
HEPARIN
nt
(Control) ACT
HMS
462 ± 114
612 ± 147
0.94 ± 0.21
0.70 ± 0.64
33%
17%
102 ± 34
92 ± 32
Experience the benefits of Individualized Heparin Management
by scheduling an evaluation of the HMS Plus System for your
facility. Contact your local sales representative.
References:
1. Shander A, et al. “Activity-based Costs of Blood Transfusion in Surgical Patients at Four Hospitals.” Transfusion, 2010, Vol 50 No 4:753-65
2. Koch CG, et al. “Morbidity and Mortality Risk Associated with Red Blood Cell and Blood-component transfusion in isolated coronary artery bypass grafting.” Crit Care Med, 2006, Vol 34, No 6: 1608-1616
3. Despotis GJ, et al. “The Impact of Heparin Concentration and Activated Clotting Time Monitoring on Blood Conservation.” J Thorac Cardiov Sur, 1995,
Vol 1 No 1: 46-54
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