Under the Auspices of: FIT FOR FUTURE - HELP HEALING THE WORLD Asian and Pacific Federation of Clinical Biochemistry 21 International Congress of Clinical Chemistry and Laboratory Medicine st 19 IFCC-EFCC European Congress of Clinical Chemistry and Laboratory Medicine th Clinical and Laboratory Standards Institute 8 Annual Meeting of the German Society of Clinical Chemistry and Laboratory Medicine th Berlin, Germany ICC Berlin - Internationales Congress Centrum 15 - 19 May 2011 FINAL PROGRAM World Association of Societies of Pathology and Laboratory Medicine Bundesministerium für Bildung und Forschung SUNDAY 15 MAY 17.30 - 19.30 OPENING CEREMONY HALL 1 MONDAY 16 MAY 9:00-11:00 SYMPOSIUM 1 HALL 1 BIOMARKERS FOR THE DIAGNOSIS OF CARDIOVASCULAR DISEASES 9:00-11:00 SYMPOSIUM 2 HALL 3 DIAGNOSTIC CHALLENGES IN LIVER DISEASE HALL 14.2 16:45-17:45 Workshop HORIBA THE “LEAN” ALTERNATIVE 14:30-16:00 INTERACTIVE 1 HALL 10 CHALLENGES AT THE CLINICAL INTERFACE 16:45-17:45 Workshop OSM HALL 9 ZENTRALLABOR VS. VERBUNDLABOR 9:00-10:30 WORKSHOP 1 HALL 10 REPORTING HbA1c FOR MONITORING AND DIAGNOSIS: THE DEVIL’S IN THE DETAIL 13:00 - 14:00 Workshop ORTHO HALL 8 CLINICAL DIAGNOSTICS TESTING FOR VITAMIN D DEFICIENCY: DEFINING AT-RISK POPULATIONS 13:00 - 14:00 Workshop BECKMAN HALL 14.2 COULTER CLINICAL AND ECONOMIC ADVANCES IN PROSTATE CANCER DIAGNOSIS 13:00 - 14:00 Workshop ABBOTT HALL 7 IMPORTANCE OF BIOMARKERS IN OPTIMISING THE TREATMENT OF PATIENTS WITH HEART AND KIDNEY DISEASE 13:00 - 14:00 Workshop SYSMEX HALL 4/5 TRUST BY VERIFY: HOW TO EVALUATE HAEMATOLOGY SYSTEMS 9:00-11:00 YEAR IN REVIEW 2 HALL 3 ADVANCES IN CLINICAL CHEMISTRY IN THE FIELD OF NEPHROLOGY AND ENDOCRINOLOGY 13:00 - 14:00 Workshop ZMBD HALL 10 IMPACT OF NEW OMICS-PLATFORMS ON BIOMARKERS DISCOVERY AND APPLICATIONS POSTER AREA 14:15-15:15 Workshop RANDOX HALL 14.2 THE CLINICAL UTILITY OF MULTIPLEX BIOCHIPS FOR THE DETECTION OF MULTIPLE STI’S AND RESPIRATORY PATHOGENS 14:15-15:15 Workshop A.MENARINI HALL 4/5 SEDIMAX: RECENT AND SIGNIFICANT ADVANCES IN AUTOMATED URINE SEDIMENT EXAMINATION 14:30-16:30 SYMPOSIUM 5 HALL 1 FROM BENCH TO BEDSIDE IN AUTOIMMUNITY HALL 4/5 14:30-16:30 DGKL 2 HALL 9 LABORATORY MEDICINE - QUO VADIS? CONDITIONS, STRUCTURES AND DEVELOPMENTAL TRENDS IN EUROPE 14:30-16:00 INTERACTIVE 2 HALL 10 PITFALLS IN THE HEMOSTASIOLOGIC DIAGNOSTICS: CLINICAL CASES 15:30-16:30 Workshop ORTHO HALL 8 CLINICAL DIAGNOSTIC ENHANCING PATIENT CARE IN THE CHALLENGING DIAGNOSTIC ARENA IN EUROPE 15:30-16:30 Workshop SARSTEDT HALL 4/5 WORKFLOW OPTIMISATION BY FRONT AND BACK END AUTOMATION IN THE DIAGNOSTIC LABORATORY 15:30-16:30 Workshop BIOSYSTEMS HALL 4/5 TRACEABILITY AND UNCERTAINTY OF CATALYTIC ACTIVITY MEASUREMENTS 16:45-17:45 Workshop SIEMENS HALL 9 NEW HIGH-PERFORMANCE ASSAYS FOR THE DETERMINATION OF FREE LIGHT CHAIN KAPPA AND LAMBDA - ADDING CONSISTENCY TO MONITORING AND SCREENEING OF MULTIPLE MYELOMA 16:45-17:45 Workshop PERKINELMER HALL 10 CLINICAL MSMS - NEW DEVELOPMENTS IN TODAY’S LABORATORY WEDNESDAY 18 MAY THURSDAY 19 MAY 9:00-11:00 SYMPOSIUM 17 HALL 1 NEW STRATEGIES IN MOLECULAR DIAGNOSTIC 9:00-11:00 SYMPOSIUM 18 HALL 3 STANDARDIZATION AND QUALITY CONTROL ISSUES IN EMERGING AND DEVELOVING COUNTRIES 9:00-10:30 WORKSHOP 10 HALL 8 STANDARDIZATION OF COMPLEX ANALYTE MEASUREMENT: THE CLINBIOTRACE PROJECT 9:00-11:00 SYMPOSIUM 12 HALL 1 BIOMARKERS IN ACUTE AND CHRONIC BRAIN DISEASES 9:00-11:00 SYMPOSIUM 19 HALL 14.2 CURRENT CHALLANGES IN THE PEDIATRIC LABORATORY 9:00-11:00 YEAR IN REVIEW 3 HALL 3 DEVELOPMENTS IN CLINICAL LABORATORY PRACTICE 9:00-11:00 EFCC 4 HALL 7 STANDARDIZATION OF THE PRE-ANALYTICAL PHASE FOR BIOMARKERS 9:00-10:30 WORKSHOP 7 CLINICAL PHARMACOGENETIC 9:00-11:00 SYMPOSIUM 20 VITAMIN D: MYTH OR MAGIC HALL 8 HALL 4/5 9:00-11:00 SYMPOSIUM 13 HALL 14.2 PRENATAL AND NEONATAL SCREENING 9:00-10:30 WASPaLM WS HALL 9 CHRONIC KIDNEY DISEASE - DEVELOPING A NATIONAL TESTING PROGRAM 9:00-10:30 WORKSHOP 4 HALL 10 UPDATE ON CARDIAC TROPONIN - CLINICAL AND LABORATORY ISSUES 9:00-11:00 IFCC 3 HALL 7 STANDARDIZATION IN MOLECULAR DIAGNOSTICS 9:00-10:30 WORKSHOP 11 HALL 10 BIOMARKERS OF ACUTE AND NEURODEGENERATIVE BRAIN DAMAGES 11:30-12:45 PLENARY SESSIONS HALL 1 ADVANCES IN CLINICAL AND DIAGNOSTIC IMMUNOLOGY 9:00-11:00 SYMPOSIUM 14 ALLERGY DIAGNOSTICS 11:30-12:45 PLENARY SESSIONS HALL 1 NEW AVENUES IN LABORATORY DIAGNOSTICS 13:00 - 14:00 Workshop RANDOX HALL 8 INCREMENTAL VALUE OF H-FABP IN AN AREA OF HIGHLY SENSITIVE TROPONINS 9:00-11:00 DGKL 5 HALL 9 DEVELOPMENT OF A TRANSCRIPTOMIC, PROTEOMIC AND METABOLOMIC DATABASE FOR HUMAN BLOOD CELLS 13:00 - 14:00 Workshop LABS ARE HALL 8 VITAL ADDING VALUE TO LABORATORY MEDICINE 9:00-10:30 WORKSHOP 8 HALL 10 MOLECULAR DIAGNOSIS OF INFECTION 13:00 - 14:00 Workshop WATERS HALL 9 LC/MS IN THE CLINICAL LABORATORY TRANSITION FROM A RESEARCH TOOL TO ROUTINE CLINICAL LABORATORY USE 13:00 - 14:00 Workshop ABBOTT HALL 7 LABORATORY DIAGNOSIS OF HEPATITIS C - WHAT ARE LOOKING FOR? HALL 4/5 11:30-12:45 PLENARY SESSIONS HALL 1 THE BRAIN: BIOLOGICAL AND CEREBRAL DISEASES 14:30-16:30 SYMPOSIUM 21 HALL 1 NEW TECHNOLOGIES IN CLINICAL APPLICATION 13:00 - 14:00 Workshop RANDOX HALL 8 THE USE OF MULTIPLEX ASSAYS FOR DETERMINING PREDISPOSITION TO HYPERTENSION 14:30-16:30 SYMPOSIUM 22 HALL 3 INTERWINING EMERGENCY MEDICINE AND LABORATORY MEDICINE 13:00 - 14:00 Workshop BECKMAN HALL 14.2 COULTER NOVEL MARKERS IN REPRODUCTIVE ENDOCRINOLOGY 14:30-16:00 WORKSHOP 12 HALL 8 TRENDS IN THERAPEUTIC DRUG MONITORING: PERSONALIZED IMMUNOSUPPRESSION 13:00 - 14:00 Workshop ORTHO HALL 10 CLINICAL DIAGNOSTIC ENHANCING PATIENT CARE IN THE CHALLENGING DIAGNOSTICS ARENA IN EUROPE 13:00 - 14:00 Workshop ABBOTT HALL 7 VITAMIN D AND B12 - IMMUNOASSAYS IN PREVENTIVE MEDICINE 14:30-16:30 IFCC 4 HALL 7 TRACEABILITY, STANDARDIZATION, HARMONISATION: CONCEPTS AND IMPLEMENTATION 13:30 - 14:30 POSTER WALKS 13:00 - 14:00 Workshop SYSMEX HALL 4/5 WORK AREA MANAGEMENT: THE ULTIMATE PRODUCTIVITY TOOL 13:00 - 14:00 Workshop SYSMEX HALL 4/5 TRUST BY VERIFY: HOW TO EVALUATE HAEMATOLOGY SYSTEMS 13:00 - 14:00 Workshop A.MENARINI HALL 9 FOCUS ON NEW DIAGNOSTIC STRATEGIES IN AUTOIMMUNITY POSTER AREA 14:15-15:15 Workshop SIEMENS HALL 4/5 DIAGNOSTIC AND CLINICAL IMPORTANCE OF MEASURING VITAMIN D TOTAL 14:30-16:30 EFCC 1 HALL 7 HOW TO ASSESS THE CLINICAL EFFECTIVENESS OF LABORATORY TESTS? 16:45-17:45 Workshop ABBOTT HALL 7 AUTOMATION TO ENSURE YOUR LAB’S EFFICIENCY 15:30-16:30 Workshop RANDOX HALL 14.2 CURRENT AND FUTURE PERSPECTIVES IN DRUGS OF ABUSE SCREENING; THE MULTIPLEX APPROACH 9:00-11:00 IFCC 2 HALL 9 BIOBANKING AND LABORATORY MEDICINE: TWO RESOURCES FOR MODERN HEALTH CARE Workshop BECKMAN HALL 14.2 COULTER NEW HORIZONS IN CELLULAR ANALYSIS 14:30-16:00 WORKSHOP 2 HALL 8 EMERGING INFECTIONS AT AFCB COUNTRIES 16:45-17:45 Workshop ROCHE HALL 14.2 PERSONALISED THERAPIES FOR CHRONIC HEPATITIS B AND C: THE LEADING ROLE OF VIROLOGICAL MARKERS 9:00-11:00 DGKL 3 HALL 7 BIOCHEMICAL ANALYSIS PRIZE - AWARD CEREMONY 14:15-15:15 HALL 3 16:45-17:45 Workshop CHROMSYSTEMS HALL 8 THERAPEUTIC DRUG MONITORING IN CLINICAL DIAGNOSTICS FROM RESEARCH TO ROUTINE HALL 14.2 13:00 - 14:00 Workshop BECKMAN HALL 14.2 COULTER FROM CLINICAL CHEMISTRY TO MOLECULAR DIAGNOSTICS: INNOVATIVE SOLUTIONS FOR LABORATORY AUTOMATION AND ORGANISATION 13:00 - 14:00 Workshop SIEMENS HALL 9 THE VALUE OF IMPROVED WORKFLOW SOLUTIONS 16:45-17:45 Workshop ROCHE HALL 14.2 EFFICIENT LAB ORGANIZATION FROM PRE-TO POST ANALYTIC Workshop BECTON HALL 4/5 DICKINSON COUNTING THE COST OF THE PREANALYTICAL PHASE TUESDAY 17 MAY 9:00-11:00 SYMPOSIUM 9 HAEMATOLOGY AND ANEMIA HALL 1 HALL 8 16:45-17:45 9:00-11:00 SYMPOSIUM 8 INFECTIOUS DISEASES 9:00-11:00 DGKL 1 HALL 9 ROLE OF NON-MEDICAL SCIENTISTS 14:30-16:30 SYMPOSIUM 6 DIABETES MELLITUS 16:45-17:45 Workshop SEBIA HALL 4/5 HBA1C: EW BREAKTHROUGH TECHNOLOGY FOR LABORATORIES FACING A CHANGE OF PARADIGM 9:00-10:30 WORKSHOP 3 HALL 8 OXIDATIVE STRESS IN DIABETES MELLITUS 9:00-11:00 SYMPOSIUM 4 HALL 4/5 ACUTE AND CHRONIC KIDNEY DISEASES. AN UPDATE 13:30 - 14:30 POSTER WALKS 14:30-16:30 DGKL 6 HALL 9 RESEARCH FUNDING BY THE FOUNDATION OF PATHOBIOCHEMISTRY AND MOLECULAR DIAGNOSTICS OF THE DGKL 9:00-11:00 SYMPOSIUM 7 HALL 1 PHARMACOGENETIC AND PHARMACOGENOMIC 9:00-11:00 IFCC 1 HALL 7 e-LEARNING AND DISTANCE EDUCATION IN CLINICAL CHEMISTRY AND LABORATORY MEDICINE 11:30-12:45 PLENARY SESSIONS MOLECULAR TUMOR DIAGNOSTICS 15:30-16:30 Workshop IRIS HALL 4/5 THE CLINICAL UTILITY OF REFLEX URINE CULTURES BASED ON URINALYSIS AND AUTOMATED URINE MICROSCOPY USING THE IQ200 WORKSTATION 16:45-17:45 Workshop AXIS SHIELD HALL 10 USING ACTIVE B12 TO DIAGNOSE VITAMIN B12 DEFICIENCY 9:00-11:00 YEAR IN REVIEW 1 HALL CLINICAL CHEMISTRY 2010 AND BEYOND: OPPORTUNITIES AND CHALLENGES FOR THE NEXT DECADE 9:00-11:00 SYMPOSIUM 3 TUMOR MARKERS IN CANCER 16:45-17:45 Workshop ABBOTT HALL 7 OVARIAN CANCER BIOMARKERS IN THE CLINICAL CONTEXT - STRATIFICATION AND MONITORING 14:30-16:30 SYMPOSIUM 10 HALL 1 DIAGNOSTIC USE AND VALUE OF FUCTION TEST IN ENDOCRINOLGY 14:30-16:30 SYMPOSIUM 11 HALL 3 POINT OF CARE TESTING - PRACTICAL ASPECTS 14:30-16:00 WORKSHOP 5 HALL 8 LESSONS FROM ASIAN-PACIFIC MULTICENTER REFERENCE INTERVAL STUDY 14:30-16:30 DGKL 4 HALL 7 QUALITY MANAGEMENT ACCORDING TO THE GERMAN RILIBAEK: AN INTERNATIONAL PERSPECTIVE 14:30-16:30 EFCC 2 HALL 9 ACCREDITATION SHOULD BE FOCUSSED ON MORE THEN WELL ORGANIZED EXAMINATIONS WITHIN THE LABORATORY 14:30-16:00 WORKSHOP 6 HALL 10 THE 2009 INFLUENZA PANDEMIC - LESSONS LEARNED 15:30-16:30 Workshop ROCHE HALL 14.2 NEXT GENERATION IN CARDIAC BIOMARKERS: LABORATORY MEDICINE’S CONTRIBUTION TO INDIVIDUALIZED TREATMENT IN ACS AND HEART FAILURE 13:00 - 14:00 Workshop THE HALL 9 BINDING SITE TM TM Freelite AND Hevylite IN MONOCLONAL GAMMAPATHIES: IMPROVING DIAGNOSIS, MONITORING AND PROGNOSIS ASSESSMENT 13:00 - 14:00 Workshop DIASORIN HALL 10 VITAMIN D DIETARY REFERENCE INTAKES: IMPLICATIONS AND SIGNIFICANCE IN CLINICAL PRACTICE 13:30 - 14:30 POSTER WALKS 14:30-16:00 WORKSHOP 13 HALL 9 VITAMIN DEFICIENCY IN ELDERLY PEOPLE: DIAGNOSIS, PREVENTION AND EFFECT ON AGE-RELATED DISEASES 14:30-16:00 WORKSHOP 14 HALL 10 NOVEL INSIGHTS IN IRON METABOLISM: IMPLICATIONS FOR DIAGNOSTIC MEDICINE 16:30-17:30 CLOSING CEREMONY HALL 1 POSTER AREA 14:15-15:15 Workshop ROCHE HALL 14.2 PERSONALISED HEALTHCARE AS A KEY DRIVER FOR PRESENT AND FUTURE DIAGNOSTIC/THERAPEUTIC STRATEGIES 14:15-15:15 Workshop DIASYS HALL 4/5 A NEW PROSPECTIVE FOR THE AUTOMATION OF CLINICAL CHEMISTRY TESTING 14:30-16:30 SYMPOSIUM 15 HALL 1 NEW DEVELOPMENTS IN HAEMOSTASEOLOGY 14:30-16:30 SYMPOSIUM 16 HALL 3 CONTRIBUTION OF LABORATORY MEDICINE IN LEUKEMIA 14:30-16:00 WORKSHOP 9 HALL 8 WHAT PAPERS WILL BE PREFERRED IN THE FUTURE RELATED TO LABORATORY MEDICINE? SOCIAL EVENTS Sunday 15 May 19:30 Welcome Party Monday 16 May 20:00 Presidents’ Dinner at Adlon Hotel By invitation only Wednesday 18 May 19:30 Congress Party at Museum Island 14:30-16:30 EFCC 3 HALL 7 A SCIENTIFIC APPROACH TO THE POST-ANALYTICAL PHASE - At a glance- Printed as of April 2011 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Welcome to the IFCC-WorldLab-EuroMedLab Berlin 2011 IFCC - International Federation of Clinical Chemistry and Laboratory Medicine EFCC - European Federation of Clinical Chemistry and Laboratory Medicine DGKL - German Society of Clinical Chemistry and Laboratory Medicine Welcome from Local Authorities Committees Executive Boards Travel Grants S CI E NTIF NTI F I C P R O G R A M Sunday 15 May Monday 16 May Tuesday 17 May Wednesday 18 May Thursday 19 May Speakers and Chairs P O S TE R S Information and Map Poster List G E NE RA L I N F O R M AT I O N Information Social Events Tourist Information S P O NS OR RS O R S & E X H I B I TO TORS Conte nts W E LCO M E A D D R E S S E S and CO M M I T T E E S pages 2 - 10 2 3 4 5 6 8 9 10 p a g e s 11 - 9 0 12 15 34 53 68 80 pages 93 - 172 94 97 pages 175 - 188 176 185 187 pages 190 - 257 Platinum Sponsors Gold Sponsors Bronze Sponsors Exhibitors Sponsors Exhibition Area Maps 191 194 195 201 249 250 Program at a glance Front fold out 1 Preside nts ’ We l c ome I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Dear Participants of IFCC-WorldLab-EuroMedLab Berlin 2011, Dear Colleagues and Friends, It is with great pleasure to welcoming you here in Berlin, the capital of reunited Germany! It is a great privilege and honour for us to host this major joint event of Laboratory Medicine and Clinical Chemistry here in our country. The 21st International Congress of Clinical Chemistry and Laboratory Medicine will take place together with the 19th European Congress of Clinical Chemistry and Laboratory Medicine as well as with the 8th Annual Meeting of the German Society of Clinical Chemistry and Laboratory Medicine. We would like to thank the International Scientific Committee (ISC) in bringing together a highly attractive and up-to-date scientific program, consisting of 12 plenary lectures in four sessions, 22 symposia, interactive sessions, 14 workshops and more than 40 industry-sponsored workshops. Altogether we have invited more than one hundred speakers from around the world to deliver to you all facets of our discipline ranging from basic science and translational research to clinical practice. In addition to these classical types of scientific sessions, we will also offer new types of formats such as “The Year in Review”, “Clinical Case Conferences” and other highly interactive formats to discuss cutting-edge science in our field. In addition to science, Berlin is one of the most vibrant cities in Germany and Europe and represents, therefore, an ideal platform to provide not only an international exchange of knowledge and ideas, but also to foster friendship and collegiality among the participants from around the world. In addition to the scientific program, a rich social program providing the frame for relaxation and cultural stimulation has been developed for attendees, families and friends. Particularly, we would like to draw your attention to the Congress Evening on Wednesday with an exclusive visit to the Museum Island, a World Heritage. The motto of our conference, Fit for future - Help healing the World, emphasizes and underscores the importance of laboratory medicine in patient care. However, we all know that this goal is very ambitious and many research efforts are necessary to eventually reach this equation. The realization of this Congress is only possible with the generous support of the Diagnostic Industry. We would like to thank all sponsoring companies for their help and willingness to actively participate in this event. Please use the time slots for visiting the large exhibition area which offers a view on the most recent technological and diagnostic advancement in laboratory medicine! Therefore, a warm welcome to Berlin! Harald Renz President 2 Rudolf Tauber President I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) is proud to host IFCC WorldLab Berlin 2011. IFCC is a global professional organization serving a worldwide partnership of clinical laboratory scientists, laboratory physicians and specialists within the in-vitro diagnostics industry. Founded in 1952 the IFCC membership currently comprises 85 national societies and 42 companies who together represent more than 30,000 laboratory medicine specialists. The IFCC mission statement is: “Through leadership and innovation in science and education: • We strive to enhance the scientific level and the quality of diagnosis and therapy for patients throughout the world • We build on the professionalism of our members to provide quality services to patients • We communicate effectively with our members, other healthcare providers and the public to ensure knowledge of our excellent scientific and educational achievements • We focus on scientific standards, publications, education and communications • We hold outstanding congresses and conferences throughout the world to bring the efforts of IFCC to the global community. The current priorities for IFCC are: • To complement and enhance the activities of its members • To share examples of good practice and to promote the contribution and added value of clinical chemistry and laboratory medicine • To transcend geographical and corporate boundaries by developing global programmes for clinical chemistry and laboratory medicine • Through the Scientific Division (SD) to provide a forum for standardization and traceability, with the establishment of reference systems to improve the quality of health care for individuals and communities • Through the Education and Management Division (EMD) to provide IFCC members and the healthcare community with relevant education directed at clinical, scientific, and management issues, especially in developing countries • Through the Communication and Publications Division (CPD) to communicate and promote the work and image of IFCC to clinical laboratory scientists, physicians and health care policy makers worldwide. The IFCC has extensive co-operation and direct collaboration with a large number of international organizations which are active in clinical, scientific and educational areas of common interest. The Officers of IFCC are always keen to communicate with members, other organizations and with individuals on matters relating to clinical chemistry and laboratory medicine. Please visit the IFCC website (www.ifcc.org) and/or contact the President, Graham Beastall (president@ifcc.org) or the Secretary, Paivi Laitinen (secretary@ifcc.org). Graham Beastall IFCC President 3 I FCC International Federation of Clinical Chemistry and Laboratory Medicine E FCC I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 European Federation of Clinical Chemistry and Laboratory Medicine Dear Colleagues, It is a pleasure to welcome you at the joint IFCC WorldLab and EuroMedLab Congress 2011 in Berlin, the second most populous and one of the most vibrant cities of Europe. Berlin is among the top three convention cities in the world, where research and development have established economic significance, and the Berlin Brandenburg region ranks among the top three innovative regions in the European Union. Thus there is no doubt that Berlin, with its history and resources, provides an infrastructure which enables all attendees to meet their needs and to enjoy the scientific, cultural and social opportunities that this Congress offers. As one would expect there is a wideranging high quality scientific program covering the cutting-edge developments in laboratory medicine. The scientific program of the Congress demonstrates the invaluable role that Laboratory Medicine plays in health care. Main conference topics include the role of prevention, theragnostics, new technologies and biomarkers in the era of "omics", the relevance of automation and IT, and the education and training of our future professionals to cope with these challenges, particularly in a demanding and difficult economic environment. This conference will be an opportunity to meet old friends and make new ones to interact with like-minded colleagues in the pursuit of common goals and interests in the ongoing development of clinical chemistry and laboratory medicine. After the fall of the Berlin Wall in November 1989 the Brandenburg Gate, enhancing the approach into the Boulevard Unter den Linden, became not only a historical landmark but also the symbol of unity. So, let us unite the profession in Europe and all over the world in the exciting city of Berlin! Whether on the congress floor or sampling the attractions of Berlin, I am sure you will enjoy your attendance at a memorable meeting. EFCC welcomes you for an enriching professional conference and friendly exchanges Unter den Linden! Andrea Rita Horvath EFCC President 4 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 DG KL German Society of Clinical Chemistry and Laboratory Medicine Dear Delegates, dear Colleagues, It is my pleasure to welcome you to the 21st International Congress of Clinical Chemistry and Laboratory Medicine in Berlin organized by IFCC, EFCC, and DGKL. As one of the oldest scientific societies devoted primarily to this field of medicine we are proud to host scientists from all over the world on this occasion. The congress presidents Harald Renz and Rudolf Tauber supported by an international congress organizing committee and a scientific advisory board have assembled a program delineating the state of the art of our profession. Looking at the final program it is clear that the hard work of the last three years has led to what can be expected from an outstanding congress. It will underscore the immense impact of laboratory diagnostics on all areas of modern medicine. During the congress there will be ample opportunity for scientific exchange among the delegates and with the invited speakers. Plenary sessions, parallel symposia, industry sponsored workshops, and poster sessions provide the stage for in depth discussions, and I encourage you to take this opportunity. During the meeting the IFCC, EFCC, and DGKL will also award their renowned prizes for scientific and professional achievements among them the Biochemical Analysis Prize of the DGKL with a tradition of more than 40 years. Among the list of prize winners are 5 scientists who were later awarded the Nobel Prize. All this is embedded in the vibrant city of Berlin which offers a wealth of cultural experiences. One of them – the world famous Museum Island – will open its doors exclusively for congress delegates and their company on Wednesday evening. You will have time to visit the unique treasures among them the Pergamon Altar and Nefertiti. I expect this to become an unforgettable congress highlight. I wish that all of you enjoy your stay in Berlin and remember the congress as an exciting and stimulating scientific event that was well worth the travel. Karl J. Lackner President DGKL 5 We l c ome I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Message from the Federal Minister of Education and Research, Annette Schavan Increasingly detailed knowledge about the causes of diseases and new diagnostic technologies are vital prerequisites for medical innovations. Modern laboratory equipment contributes to diagnosing diseases more quickly, more reliably and at an earlier stage. As a result, treatment can be initiated more promptly and in a more targeted way. The aim of individualized medicine is to choose the therapy that is best suited to the patient, avoiding side effects wherever possible. More precise diagnostic tools do not just enable individually tailored treatments - innovative laboratory diagnostics and bioinformatics also change the way in which new drugs are developed. Health research plays an important role in the Federal Government's High-Tech Strategy: since 2007, approximately 800 million euros have been provided for efforts to strengthen basic research and accelerate the transfer of research results to the treatment of patients. During this period, the Federal Ministry of Education and Research has invested 30 million euros in molecular diagnostics alone to ensure that Germany remains a competitive, forward-looking research location in the field of laboratory medicine. After all, the molecular diagnostics market is also important from an economic point of view. It is currently worth 12 billion euros, and experts predict that it will grow to approximately 22.5 billion euros over the next five years. We are facing great challenges in the 21st century - particularly in the field of health research. Demographic change and the rapidly increasing prevalence of certain diseases pose great challenges in the area of health research. To meet them, we need modern health research in all fields of science, and we expect a great deal from the area of laboratory medicine. I would like to thank the organizers of this year's International Congress of Clinical Chemistry and Laboratory Medicine in Berlin for their great commitment. I hope that the event will provide a forum for interesting conversations and discussions, stimulate new ideas for future research activities, and present important information for medical practitioners. Prof. Dr. Annette Schavan Federal Minister of Education and Research 6 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 for the IFCC WorldLab 2011 in Berlin IFCC WorldLab EuroMedLab is one of the world’s largest and most important scientific congresses, and Berlin is greatly honored to be hosting the national and international experts working in this field. You will feel at home in Berlin, which is a city of great scientific capability. Medicine, research, and academics occupy a special position in Berlin. Universities and many non-university research institutes of international renown work together closely here. Networks within disciplines promote cooperation between science and business, and many of our medical products and services are unique in their fields. Berlin is very well prepared to host large national and international congresses and trade fairs. The International Congress Center (ICC); Messe Berlin, our trade fair company; and many other conference facilities offer excellently equipped premises for concentrated professional interaction, and Berlin's hotels and atmospheric restaurants offer inviting opportunities for culinary exploration. Those attending a conference on the banks of the Spree should not forget to take a look at the city's cultural calendar. Whether theater or opera, classical music or jazz, ancient sculpture or contemporary art – Berlin has something for everyone. Berlin is welcoming the IFCC WorldLab-EuroMedLab participants. Klaus Wowereit Governing Mayor of Berlin 7 We l c ome Message from the Governing Mayor of Berlin, Klaus Wowereit, Commit t ees I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 CONGRESS ORGANIZING COMMITTEE T. Brinkmann (Switzerland) J. Klabunde (Germany) K.J. Lackner (Germany) T. Ozben (Turkey) H. Renz (Germany) R. Tauber (Germany) INTERNATIONAL SCIENTIFIC COMMITTEE H. Renz (Germany) - Chairman R. Tauber (Germany) - Vice Chairman V. Blaton (Belgium) K. Brand (Germany) T. Brinkmann (Switzerland) B. Croal (United Kingdom) A. Hedili (Tunisia) J. Hicks (USA) A.R. Horvath (Hungary) K.J. Lackner (Germany) C. Lam (Hong Kong) D. Mazziotta (Argentina) H. Morris (Australia) M. Neumaier (Germany) T. Nobori (Japan) T. Ozben (Turkey) M. Panteghini (Italy) M. Pilonetto (Brazil) K. Pulkki (Finland) R. Sierra Amor (Mexico) C. Wagener (Germany) U. Walter (Germany) J. Wesenberg (Canada) M.A. Zablitt (Lebanon) INTERNATIONAL SCIENTIFIC ADVISORY BOARD H. Renz (Germany) - Chairman A.A. Bulo (Albania) A. Hooper (Australasia) A. Griesmacher (Austria) J.P. Chapelle (Belgium) K. Tzatchev (Bulgaria) P. St. Louis (Canada) E. Aranda (Chile) A. Simundic (Croatia) T. Zima (Czech Republic) K. Tomberg (Estonia) K. Pulkki (Finland) P. Gillery (France) A. Chaliassos (Greece) H.M. Chan (Hong Kong) A.R. Horvath (Hungary) J.J. Jonsson (Iceland) P. Mocarelli (Italy) M. Plebani (Italy) T. Nobori (Japan) Y.Y. Bilto (Jordan) J.Q. Kim (Korea) O.H. Kwon (Korea) G. Gilson (Luxemburg) J.F. Muñoz Valle (Mexico) 8 D. Popovic (Montenegro) D.W. Swinkels (The Netherlands) M.A. Charles-Davies (Nigeria) A.L. Biorke Monsen (Norway) M.M. Blanes Gonzalez (Paraguay) J. Ortellado de Canese (Paraguay) G. Sypniewska (Poland) G. de Sousa (Portugal) G. Benga (Romania) M. Cojocaru (Romania) V.V. Menshikov (Russia) N. Majkic-Singh (Serbia) K. Danova (Slovakia) V. Steenkamp (South Africa) J.M. Queralto (Spain) E. Theodorsson (Sweden) A. von Eckardstein (Switzerland) L. Risch (Switzerland) F. Harb (Syrian Arab Republic) A. Hedili (Tunesia) N. Ozer (Turkey) M. Hallworth (United Kingdom) I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 G. Beastall (United Kingdom) - President C. Lam (Hong Kong) - Vice-President J. M. B. Hicks (USA) - Past President P. Laitinen (Finland) - Secretary G. Shannan (Syria) - Treasurer T. Brinkmann (Switzerland) - Corporate Representative B. Gouget (France) - Member J. B. Lopez (Malaysia) - Member U. Tuma (Brazil) - Member EFCC - European Federation of Clinical Chemistry and Laboratory Medicine A. R. Horváth (Australia) - President I. D. Watson (United Kingdom) - President-Elect V. Blaton (Belgium) - Past President H. J. van Pelt (The Netherlands) - Secretary P. Schuff-Werner (Germany) - Treasurer M. Pazzagli (Italy) - Member-at-large K. Pulkki (Finland) - Member-at-large DGKL - German Society for Clinical Chemistry and Laboratory Medicine K. Lackner (Germany) - President J. Thiery (Germany) - Vice-President K. Kohse (Germany) Secretary H. Patscheke (Germany) - Treasurer R. Lichtinghagen (Germany) - Additional Member J. Aufenanger (Germany) - Additional Member Execu t ive Boards IFCC - International Federation of Clinical Chemistry and Laboratory Medicine ORGANIZING SECRETARIAT M C O N G R E S ila S no I MZ Congressi s.r.l. Member of the MZ International Group (Milano, Torino, Barcelona, London) Individual Company subject to management and coordination by MZ International Group srl Sistema di Gestione certificato secondo la Norma ISO 9001:2008 Via Carlo Farini 81 - 20159 Milano, Italy Phone +39 02 66802323 - Fax +39 02 6686699 e-mail: info@berlin2011.org 9 Travel Gran t s I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 WINNERS ESSIARAB FADWA GUPTA MONIKA NEPAL ASHWINI REVERENDO MARIA AMELIA SHRESTHA ROJEET AJILI FAOUZIA CORT AYSEGUL DUJIC TANJA EL BAZ HATIM JACOBS LEO WAFULA BRAMWEL BARAZA ISFER OLIVEIRA MAUREN SZOKE DOMINIKA BRAGA FEDERICA ARPPE RIIKKA DMYTRUK IRINA OOSTENDORP MARLIES FOROUGHI FOROUGH CULEJ JELENA DZIEGIELEWSKA SYLVIA MOHAN TEENA K I N D LY SU P P O R T E D B Y: 10 MOROCCO INDIA NEPAL ARGENTINA NEPAL TUNISIA TURKEY BOSNIA EGYPT THE NETHERLANDS KENYA BRAZIL ITALY ITALY FINLAND UCRAINA THE NETHERLANDS IRAN CROATIA POLAND INDIA I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Scientific Scientific Program Program Sunda y 1 5 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 17:30 - 19:30 HALL 1 OPENING CEREMONY Musical Introduction A Time to Make Good Friends. Welcome to Germany! Welcome to Berlin! Berlin Symphony Welcome Addresses Congress Presidents, Rudolf Tauber, Harald Renz IFCC President, Graham Beastall EFCC President, Andrea Rita Horvath DGKL President, Karl Lackner Fit For Future Help healing the World “Heal the world” Berliner Rundfunk Kinderchor & Jugendorchester Awards Presentation IFCC Distinguished Clinical Chemist Award - Sponsored by Beckman Coulter IFCC Henry Wishinsky Award for Distinguished International Services Sponsored by Siemens IFCC Award for Distinguished Contributions in Education - Sponsored by Abbott Diagnostics IFCC Award for Significant Contributions in Molecular Diagnostics Sponsored by Abbott Molecular IFCC Distinguished Award for Laboratory Medicine and Patient Care - Sponsored by IFCC IFCC Robert Schaffer Award for Outstanding Achievements in the Development of Standards for Use in Laboratory Medicine - Sponsored by NIST - CLSI IFCC Young Investigator Award - Sponsored by Roche EFCC Scientific Award for Laboratory Medicine - Sponsored by Roche EFCC Labs Are Vital Award for Excellence in Outcomes Research in Laboratory Medicine Sponsored by Abbott DGKL Prize “Biochemical Analysis” - Sponsored by Sarstedt “We are the world” Berliner Rundfunk Kinderchor & Jugendorchester Opening Lecture The Evolution of Medicine to Evolutionary Medicine Detlev Ganten Drumshow Berlin Drum Company After the opening ceremony, you are kindly invited to take part in the Welcome Party. 12 Follow the Presidents of the Congress and the Berlin Drum Company !! I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 The Evolution of Medicine to Evolutionary Medicine Detlev Ganten (Germany) President World Health Summit - Charité - Universitätsmedizin Berlin Professor Ganten was born in Lüneburg in 1941. He studied medicine at the universities of Würzburg, Montpellier (France) and Tübingen. After taking his degree, he spent several years as a research scientist at the Clinical Research Institute in Montreal (Canada), and earned his Ph.D. at McGill University. In 1975 Detlev Ganten was appointed Professor at the Department of Pharmacology at the University of Heidelberg. From 1991 to 2004 Professor Ganten was the Founding Director and President of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch. He also was Director of the Department of Pharmacology at the Benjamin Franklin Medical Center of the Free University of Berlin. From 2004 to 2008 Professor Ganten was Chief Executive Officer at the “Charité –Universitätsmedizin Berlin”, the joint medical faculty of the Free University and Humboldt University of Berlin. Since 2005 Professor Ganten is the Chairman of the Foundation Board of the Charité Foundation. Since 2009 he is also Chairman of the joint Board of Trustees of the Max Planck Institute of Colloids and Interfaces and of the Max Planck Institute of Molecular Plant Physiology (Berlin-Potsdam), and he is President of the World Health Summit. As a research scientist in the field of hypertension, Professor Ganten elucidated fundamental mechanisms of the pathophysiology and molecular biology of high blood pressure. His area of research includes the hormonal regulation of blood pressure, especially the renin-angiotensin system, and the molecular genetics of cardiovascular diseases and evolutionary medicine. S unda y 1 5 May OPENING LECTURE ABSTRACT The human body, its organs, cell function, biochemistry and our genes are the result and a living archive of evolution. Many evolutionary mechanisms are now understood in detail on a molecular and genomic basis. This opens up new vistas to a better understanding of the basis of health and disease. In addition to asking proximate questions how a disease mechanism is best understood, we can start investigating ultimate questions why we get sick. The gap between evolutionary old body functions on the one hand and modern lifestyles in new urban societies on the other hand results in diseases of civilization. Evolutionary Darwinian Medicine makes use of these new insights for research, diagnosis, treatment and prevention of disease. 13 Sunda y 1 5 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 CLOSED MEETINGS 9:00-13:00 Hall 8 IFCC Council 8:30-17:00 Room 47 IFCC C-AQ Co-Chairs: E. Amann, J. Gill 8:30-18:00 Room 50 IFCC SD-EC Chair: I. Young 9:00-13:00 Room 46 IFCC C-CC Chair: T. Ozben 9:00-17:00 Salon 19 IFCC C-RIDL Chair: K. Ichihara 14 13:30-17:00 Hall 8 EFCC General Assembly 13:30-14:30 Salon 20 IFCC TF-HbA1c Chair: G. John 14:30-17:00 Salon 20 HbA1c Network Laboratories Open Meeting Chair: C. Weykamp 15:00-17:00 Room 48 IFCC e-News Chair: E. Delvin I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 PARALLEL SESSIONS Symposium 1 HALL 1 BIOMARKERS FOR THE DIAGNOSIS OF CARDIOVASCULAR DISEASES Chairs: I. Young (United Kingdom), A. von Eckardstein (Switzerland) 9:00 Clinical implication of high sensitive troponin testing S. Blankenberg (Germany) 9:25 Quality specifications for troponin assays R. Christenson (USA) 9:50 Cellular and molecular imaging R. Choudhury (United Kingdom) 10:15 BNP and heart failure C. Müller (Switzerland) 10:40 High sensitive cardiac troponin T in the clinical work-up of patients with stable chest pain A.M.A. Mingels (The Netherlands) 10:50 I-PRESERVE sub-study: Plasma collagen markers in the prediction of death and hospitalisation in patients with heart failure and preserved ejection fraction H.G Schneider (USA) Monda y 1 6 May 9:00 - 11:00 Symposium 2 HALL 3 DIAGNOSTIC CHALLENGES IN LIVER DISEASE Chairs: F. Ceriotti (Italy), B. Gouget (France) 9:00 Non-alcoholic fatty liver disease (NAFLD) V. Ratziu (France) 9:25 Biomarkers of fibrogenesis for the diagnosis and the activity of the fibrosis process in liver diseases M. Vaubourdolle (France) 9:50 Hepatocellular carcinoma: Molecular pathogenesis and clinical aspects H. Blum (Germany) 10:15 Occult hepatitis B infection: Diagnosis and significance W. Gerlich (Germany) 10:40 Plasma levels of soluble CD30 and CD40L in pediatric patients after liver transplantation O. Shevchenko (Russia) 10:50 Serological markers of gastric pathology A. Caleffi (Italy) 15 Monda y 1 6 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 9:00 - 11:00 PARALLEL SESSIONS Year in Review 1 HALL 8 C L I N I C A L C H E M I S T RY 2 0 1 0 A N D B E Y O N D : O P P O R T U N I T I E S AND CHALLANGES FOR THE NEXT DECADE Chairs: V. Blaton (Belgium), N. Rifai (USA) 9: 00 Next-generation sequencing of plasma DNA for molecular diagnosis D. Lo (Hong Kong) 9:30 Drugs of abuse testing, from urine to oral fluid: Scientific and legal ramifications M. Huestis (USA) 10:00 Laboratory and clinical implications of high-sensitivity troponin assays F. Apple (USA) 10:30 The diagnostic proteome: Prospects for biomarker discovery and validation in plasma L. Anderson (USA) Symposium 3 HALL 14/2 TUMOR MARKERS IN CANCER Chairs: M. Neumaier (Germany), T. Zima (Czech Republic) 9:00 Circulating tumor cells and bone marrow micrometastases K. Pantel (Germany) 9:25 Measurement and diagnostic use of Prostate–Specific Antigen (PSA) U.H. Stenman (Finland) 9:50 Biomarkers and personalized models in oncology drug development D. Sidransky (USA) 10:15 Proteomic approaches for novel biomarker discovery V. Kulasingam (Canada) 10:40 KLK3 and steroid 5-alpha reductase type II (SRD5A2) gene polymorphisms might affect clinical reliability of serum PSA measurement C.-F. Zambon (Italy) 10:50 DNA methylation of tumor suppressor and metastasis suppressor genes in circulating tumor cells S. Lianidou (Greece) 16 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Monda y 1 6 May 9:00 - 11:00 PARALLEL SESSIONS Symposium HALL 7 e L E A R N I N G A N D D I S TA N C E E D U C AT I O N I N C L I N I C A L C H E M I S T R Y A N D L A B O R AT O R Y M E D I C I N E Chair: E. Jacobs (USA) 9: 00 Webinairs, steaming media, blogs and other e-communications A. Lyon (Canada) 9:30 Labtestsonline: Transmitting laboratory medicine in the context of national and international guidelines M. Klouche (Germany) 10:00 IFCC experiences with distance learning E. Jacobs (USA) 10:30 e-Learning experiences of National Societies of Clinical Chemistry and Laboratory Medicine P. Kocna (Czech Republic) Symposium 4 HALL 4/5 ACUTE AND CHRONIC KIDNEY DISEASES. AN UPDATE Chairs: N. Greenberg (USA), N. Ozer (Turkey) 9:00 Unmet clinical needs in assessing CKD G. Jones (Australia) 9:25 Cystatin C for estimation of renal function in CKD A. Grubb (Sweden) 9:50 Biomarkers of acute kidney injury C. Ronco (Italy) 10:15 Dyslipidemia of chronic renal disease O. Samuelsson (Sweden) 10:40 Pregnancy associated plasma protein-A (PAPP-A) as a mortality predictor of long-term hemodialysis patients M. Kalousová (Czech Republic) 10:50 An error propagation formula must be used to correctly calculate uncertainty in EGFR D.M. Parry (Canada) 17 Monda y 1 6 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 9:00 - 11:00 PARALLEL SESSIONS Symposium HALL 9 ROLE OF NON-MEDICAL SCIENTISTS Chair: W. Dick (Germany) 9:00 Scientific methods in medicine W. Bauersfeld (Germany) 9:30 The advance of the science in medicine G. Raabe-Meyer (Germany) 10:00 Medical laboratory manager – Non-analytical work R. Lichtinghagen (Germany) 10:30 Requirements for excellence in laboratory medicine – A melting pot of biosciences and medicine N. Gässler (Germany) Simultaneous translation from German to English will be provided Workshop 1 HALL 10 9:00-10:30 REPORTING HBA1C FOR MONITORING AND DIAGNOSIS: T H E D E V I L ' S I N T H E D E TA I L Chair: B. Croal (United Kingdom) 9: 00 Estimated average glucose 2 years on E.S. Kilpatrick (United Kingdom) 9:30 Status of HbA1c measurement and goals for improvement R. Little (USA) 10:00 EQA: HbA1c fit for the diagnosis of diabetes? C.W. Weykamp (The Netherlands) 18 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 PLENARY SESSION MOLECULAR TUMOR DIAGNOSTICS HALL 1 Chairs: G. Beastall (United Kingdom), K. Lackner (Germany) 11:30 The potential impact of individualized therapy approaches on pediatric cancer clinical research: Technology validation and global access G. H. Reaman (USA) Gregory H. Reaman, M.D., is Chair of the Children's Oncology Group (COG) since its inception in 2000. The COG is comprised of over 200 member institutions, dedicated to clinical, translational, and epidemiology research in childhood cancer throughout North America, Australia, and New Zealand. Dr. Reaman is a Professor of Pediatrics at The George Washington University School of Medicine and Health Sciences and a member of the Division of Hematology-Oncology at the Children's National Medical Center in Washington, D.C., which he directed for nearly 18 years. Dr. Reaman serves or has served on the Editorial Boards of Leukemia, Journal of Clinical Oncology, Journal of Pediatric Hematology/Oncology, Pediatric Blood and Cancer, The Oncologist, Cancer, and Physicians Data Query (PDQ), National Cancer Institute as well as the ASCO Cancer Foundation's (www.cancer.net). He has served as an Associate Editor of Cancer and Leukemia and Lymphoma. 11:55 Monda y 1 6 May 11:30-12:45 Cancer gene expression: A systems biology approach to biomarker and drug development W. N. Keith (United Kingdom) Nicol Keith obtained his undergraduate training in genetics at Edinburgh University before undertaking his PhD studies at the CRUK Beatson Institute for Cancer Research in Glasgow. After post-doctoral research in areas related to cancer drug resistance, he established his research program in the Department of Medical Oncology at Glasgow University. In 2004 he became Professor of Molecular Oncology at the Centre for Oncology & Applied Pharmacology of Glasgow University. Nicol's research is focused on the development of novel therapeutics that target cellular senescence and telomerase. The approach is based on integrating within a bioinformatic framework a wide variety of external and in-house data sources with high content screening. Nicol is a founder and Director of Senectus Therapeutics Ltd. a drug discovery company focused on the development of novel therapeutics that target cellular senescence. Nicol is a member of several national and international scientific committees and is particularly active within the International Union Against Cancer (UICC) including chairing the UICC International Cancer Technology Transfer Fellowships (ICRETT) & YY grants committee's which facilitate rapid international transfer of cancer research techniques and technology and clinical management skills across the globe. 12:20 Posttranslational modifications in tumor diagnosis C. Wagener (Germany) Professor Christoph Wagener is director of the Department of Clinical Chemistry in the Center for Diagnostic of the University Medical Center Hamburg-Eppendorf, Germany. The central laboratories of the clinic are part of the institute. C. Wagener was Dean of the Medical Faculty and President of the German Society of Clinical Chemistry and Laboratory Medicine. Molecular tumor diagnostics is the main research focus of his institute. Specifically, posttranslational modifications such as phosphorylation and glycosylation are characterized by the use of human protein domains involved in molecular recognition. 19 Monda y 1 6 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 13:30-14:30 POSTER WALKS Poster Area In order to encourage discussions, poster walks will be held on Monday, Tuesday, and Wednesday from 13:30 to 14:30. The author of the selected posters is asked to be by his/her poster panel from 13:30 to 14:30. Each author will have up to three minutes to present the poster. The chairman selected for each poster walk will guide the walk and chair the discussion. All delegates wishing to attend poster walks must be at the first poster panel (see poster-panel code) at 13:30. A ut oim m une Aut u ne disease Chair: U. Sack (Germany) Posters 0024 0028 0032 0037 0039 0043 0044 0046 0050 0051 0052 0055 0096 0098 0105 0143 0160 0162 0144 0146 0149 0152 0157 0159 0214 0219 0218 0222 0223 0238 0317 0318 0319 0323 0326 0335 C ancer /t umor Cancer u mor ma rkers Chair: C. Wagener (Germany) Posters 0069 0083 0084 0085 0088 0092 C ancer /t umor Cancer u mor ma rkers Chair: M. Kiehntopf (Germany) Posters 0103 0116 0118 0125 0128 0142 C ar diovas c ula r dis ease Car diovascular disease Chair: A. von Eckardstein (Switzerland) Posters 0176 0180 0194 0196 0197 0210 C Crr it ical care /eme rge ncy medici n e Chair: H. van Pelt (The Netherlands) Posters 0309 0310 0311 0313 0314 0315 D iabet es me llitus a nd me taboli Diabet tabo l i c s y n d r o m e Chair: T. Zima (Czech Republic) Posters 0349 0352 0353 20 0355 0358 0361 0375 0376 0377 0380 0386 0398 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Posters 0437 0444 0445 0446 0450 0454 0459 0463 0470 0488 0492 0496 0547 0550 0566 0570 0575 0588 Haem gy H aem at olo ology Chair: R. Sierra Amor (Mexico) Posters 0521 0523 0528 0536 0538 0543 Inf ect ious diseases nd c h r o n i c ) dis e a s e s (acute (a c ute a and Chair: C. Knabbe (Germany) Posters 0648 0651 0655 0656 0660 0667 0668 0672 0673 0675 0676 0692 0778 0779 0786 0787 0795 0796 0914 0915 0918 0921 0922 0923 Liver and gastrointestina l dis e a s e s Chair: F. Ceriotti (Italy) Posters 0761 0762 0765 0771 0773 0776 M o n d ay 16 May Endocr inology ino logy Chair: P. Carayon (France) Pat ient and an d labora tory mana gem e n t Chair: R. Lichtinghagen (Germany) Posters 0895 0897 0901 0902 0909 0911 Toxicology, Toxicolog y, ins trume nta tion an d m e th o d s , m e ta b o l o m i c s Chair: K. Kappert (Germany) Posters 1156 1157 1163 1168 1170 1171 1172 1182 1183 1184 1185 1190 1257 1258 1260 1275 1292 1297 M iscellaneous Chair: P. Sinha (Austria) Posters 1242 1243 1247 1250 1254 1256 21 Monda y 1 6 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 13:00 - 14:00 INDUSTRY-SPONSORED WORKSHOPS HALL 8 TESTING FOR VITAMIN D DEFICIENCY: DEFINING AT-RISK POPULATIONS 13:00 Testing for vitamin D deficiency: Defining at-risk populations To be defined HALL 14.2 CLINICAL AND ECONOMIC ADVANCES IN PROSTATE CANCER DIAGNOSIS Chair: A. Semjonow (Germany) 13:00 Prostate cancer detection: The patient’s view V. Griesser (Switzerland) 13:20 Improving PSA – based prostate cancer detection with the Prostate Health Index (phi) C. Stephan (Germany) 13:40 Quantifying the economic value of phi J. Minken (USA) HALL 7 IMPORTANCE OF BIOMARKERS IN OPTIMISING THE TREATMENT OF PATIENTS WITH HEART AND KIDNEY DISEASE Chair: P. Venge (Sweden) 13:00 Introduction P. Venge (Sweden) 13:10 ARCHITECT sensitive Troponin and clinical outcome in patients with suspected acute coronary syndrome N. Mills (United Kingdom); S. Walker (United Kingdom) 13:34 NGAL for the early identification of renal complications in the Emergency Department K. Schmidt-Ott (Germany) 22 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 INDUSTRY-SPONSORED WORKSHOPS HALL 4/5 TRUST BUT VERIFY: HOW TO EVALUATE HAEMATOLOGY SYSTEMS Chair: O. Hauss (Germany) 13:00 Trust but verify: How to evaluate haematology systems S.J. Machin (United Kingdom) HALL 9 THE VALUE OF IMPROVED WORKFLOW SOLUTIONS Chair: M. Plebani (Italy) 13:00 Impacting Laboratory Workflow with Adaptable Design T. Galloway (USA) 13:30 A User’s Experience J. Bruemmer (Germany) HALL 10 IMPACT OF NEW OMICS-PLATFORMS ON BIOMARKER DISCOVERY AND APPLICATIONS Monda y 1 6 May 13:00 - 14:00 Chair: K. Bindseil (Germany) 13:00 Glycanmicroarrays as Diagnostic Tool P.H. Seeberger (Germany) 13:20 Unbiased and targeted Metabolite Profiling Platforms for Biomarker Discovery and Validation L. Willmitzer (Germany) 13:40 Autonomous Biosensors - Technologies that help to bring Biomarkers to the Patient F.F. Bier (Germany) 23 Monda y 1 6 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 14:15 - 15:15 INDUSTRY-SPONSORED WORKSHOPS HALL 14.2 THE CLINICAL UTILITY OF MULTIPLEX BIOCHIPS FOR THE DETECTION OF MULTIPLE STI’S AND RESPIRATORY PATHOGENS Chair: P.V. Coyle (United Kingdom) 14:15 The clinical and practical implications of 10-plex Sexually Transmitted Infection (STI) biochip array P.V. Coyle (United Kingdom) 14:45 Ability of a multiplex biochip array to simultaneously detect up to 8 bacterial respiratory pathogens in a clinical setting M. Diggle (United Kingdom) HALL 4/5 SEDIMAX: RECENT AND SIGNIFICANT ADVANCES IN AUTOMATED URINE SEDIMENT EXAMINATION Chair: G.B.Fogazzi (Italy) 14:15 New features of sediMAX technology G.Bayer (Hungary) 14:35 Can significant bacteriuria be detected by sediMAX ? R.Falbo (Italy) 14:55 The identification by sediMAX of the clinically relevant urine sediment particles G.B.Fogazzi (Italy) 24 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 PARALLEL SESSIONS Symposium 5 HALL 1 FROM BENCH TO BEDSIDE IN AUTOIMMUNITY Chairs: F. Alvarez Menédez (Spain), U. Sack (Germany) 14:30 Antiphospholipid syndrome: Pathogenesis T. Koike (Japan) 14:55 Novel strategies for the treatment of rheumatoid arthritis S. Gay (Switzerland) 15:20 The many challenges of autoantibody testing J. Sheldon (United Kingdom) 15:45 New clinical aspects in rheumatoid arthritis - Guideline based management J.S. Smolen (Austria) 16:10 Profiling of antiphospholipid antibodies – Association with cerebrovascular events in antiphospholipid syndrome D. Roggenbuck (Germany) 16:20 The Anti-CCP antibodies correlated with rheumatoid factor, erythrocyte sedimentation rate and disease activity index in rheumatoid arthritis IP. Guzmán-Guzmán (Mexico) Monda y 1 6 May 14:30 - 16:30 Symposium 6 HALL 3 DIABETES MELLITUS Chairs: A. Gronowski (USA), E. Schleicher (Germany) 14:30 IFCC standardised HbA1c: Should the world be as one? W. G. John (United Kingdom) 14:55 Genetics of type 2 diabetes - Are we getting any closer? A. Rosengren (Sweden) 15:20 HbA1c in the diagnosis of diabetes: Opportunities and problems D. Sacks USA) 15:45 Molecular and biochemical mechanisms of diabetic complications P. Gillery (France) 16:10 Hemeoxygenase-1 and its metabolic role in the liver E. Einwallner (Austria) 16:20 Urinary 8-hydroxydeoxyguanosine as a biomarker of microangiopathic complications in Type 2 diabetic patients S.H.Atef (Egypt) 25 Monda y 1 6 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 14:30 - 16:30 PARALLEL SESSIONS Workshop 2 HALL 8 14:30-16:00 E M E R G I N G I N F E C T I O N S AT A F C B C O U N T R I E S Chairs: W. ElGarf (Egypt) 14:30 Antimicrobial resistance: An emerging public health problem Z. Hallaj (Egypt) 15:00 Malaria: A global threat E.T. Khalil (Sudan) 15:30 Tuberculosis: Persisting problem in Arab countries G. Shannan (Syria) Symposium HALL 7 HOW TO ASSESS THE CLINICAL EFFECTIVENESS OF LABORATORY TESTS? Chairs: A.R. Horvath (Australia), A. StJohn (Australia) 14:30 Industry and regulatory perspectives: Clinical evidence for IVDs J. Rueda (Belgium) 15:00 Laboratory perspectives: Testing a test - phases of biomarker evaluation A.R. Horvath (Australia) 15:30 Epidemiologic and economic perspectives: Evaluating the effectiveness and costs of monitoring P. Bossuyt (The Netherlands) 16:00 Clinical prespectives: Clinical effectiveness of self-monitoring oral anticoagulant treatment C. Heneghan (United Kingdom) 26 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 PARALLEL SESSIONS Symposium HALL 9 L A B O R AT O R Y M E D I C I N E - Q U O VA D I S ? C O N D I T I O N S , S T R U C T U R E S A N D D E V E L O P M E N TA L T R E N D S I N EUROPE Chair: J. Aufenanger (Germany), M. Müller (Germany) 14:30 Concentration in German laboratory medicine – Where are we headed? M. Müller (Germany) 15:00 Laboratory medicine as a medical discipline – Is the physician in the laboratory (in)dispensable? R. Klakow-Franck (Germany) 15:30 Laboratory medicine in competition – The Swiss experience A.R. Huber (Switzerland) 16:00 France on its way to centralised laboratory diagnostics B. Wiegel (Germany) Simultaneous translation from German to English will be provided Monda y 1 6 May 14:30 - 16:30 Interactive Session 1 HALL 10 14:30-16:00 P I T FA L L S I N T H E H E M O S TA S I O L O G I C D I A G N O S T I C S : CLINICAL CASES Chair: A. Griesmacher (Austria) 14:30 Current aspects and future trends in the analysis of blood coagulation K.T. Preissner (Germany) 14:52 New anticoagulants and routine coagulation tests A. Haushofer (Austria) 15:14 Two puzzling cases B. Lämmle (Switzerland) 15.36 General case report G. Weigel (Austria) A voting system will be provided. This session will allow delegates to interact with the speaker and make the session an active one! 27 Monda y 1 6 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 15:30 - 16:30 INDUSTRY-SPONSORED WORKSHOPS HALL 14.2 ENHANCING PATIENT CARE IN THE CHALLENGING DIAGNOSTIC ARENA IN EUROPE How to face European Healthcare and Diagnostics Challenges with process solutions that maximize clinical laboratory cost efficiencies Chair: M.Naraghi (Germany) 15:30 Introduction and welcome E. Hanna 15:35 Healthcare economics challenges in diagnostics M.Naraghi (Germany) 15:55 Implementation of lean process solutions to improve Clin Lab cost efficiencies A. Lusack (United Kingdom) HALL 4/5 WORKFLOW OPTIMISATION BY FRONT AND BACK END AUTOMATION IN THE DIAGNOSTIC LABORATORY Chair: L. Binder (Germany) 15:30 Company presentation and product portfolio for laboratory automation R. Rest (Germany) 15:40 Front end automation at a university laboratory L. Binder (Germany) 16:05 Automation at a large US reference laboratory C. Hawker (USA) 28 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 INDUSTRY-SPONSORED WORKSHOPS HALL 8 THERAPEUTIC DRUG MONITORING IN CLINICAL DIAGNOSTICSFROM RESEARCH TO ROUTINE Chair: C. Halter (Germany) 16:45 Analytical aspects in therapeutic drug monitoring of immunosuppressant drugs S. Bauer (Germany) 17:15 One TDM-analysis that detects them all: The MassTox® TDM Series C. Halter (Germany) HALL 14.2 PERSONALISED THERAPIES FOR CHRONIC HEPATITIS B AND C: THE LEADING ROLE OF VIROLOGICAL MARKERS Chair: A. Stief (Germany) Monda y 1 6 May 16:45 - 17:45 16:45 Real-time PCR based viral load assay and the increasing complexity of HCV patients management S. Sarrazin (Germany) 17:15 Molecular and serological HBV markers as drivers of individualized patient's care M. Brunetto (Italy) 29 Monda y 1 6 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 16:45 - 17:45 INDUSTRY-SPONSORED WORKSHOPS HALL 7 OVARIAN CANCER BIOMARKERS IN THE CLINICAL CONTEXT – STRATIFICATION AND MONITORING Chair: R. Molina (Spain) 16:45 View of an oncologist – The need to stratify ovarian cancer patients to obtain optimal outcomes J. Sehouli (Germany) 17:05 Diagnostic value of HE4, CA125 and the ROMA Index in ovarian cancer patients from a tertiary center E. Høgdall (Denmark) 17:25 The Role of CA125 in ovarian cancer follow-up C. Marth (Austria) HALL 4/5 HbA1c: NEW BREAKTHROUGH TECHNOLOGY FOR LABORATORIES FACING A CHANGE OF PARADIGM Chair: L. Thomas (Germany) 16:45 HbA1c change of paradigm A. Mosca (Italy) 17:05 Current HbA1c techniques: what is really being measured A. Mosca (Italy) 17:25 Next generation of separation method for HbA1c: First evaluation of the CAPILLARYSTM 2 Flex Piercing HbA1c P. Gillery (France) 30 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 INDUSTRY-SPONSORED WORKSHOPS HALL 9 ZENTRALLABOR VS. VERBUNDLABOR Chairs: J. Kuhn (Germany); K. Richarz (Germany) HALL 10 USING ACTIVE B12 TO DIAGNOSE VITAMIN B12 DEFICIENCY Chair: J. Scott (Ireland) 16:45 The diagnostic accuracy of Active B12 (holotranscobalamin) J. Scott (Ireland) 17:15 Outcomes of a multi-centre study and experience with introducing and running Active B12 in the clinical chemistry lab J. Lindemans (The Netherlands) Monda y 1 6 May 16:45 - 17:45 31 Monda y 1 6 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 CLOSED MEETINGS 8:00-11:00 Room 42 IFCC WG-IANT Chair. M. Blanes Gonzales 12.00-14.00 Room 45 Analytical harmonization EFCC/AACC Chair: S. Sandberg Room 44 8:00-11:00 APFCB Executive Board 14:30-17:30 Room 42 DGKL WG LC-MS/MS in Laboratory Chair: M. Vogeser 8:00-9:00 Room 45 IFCC WG-BMS Chair: S. Vasikaran 14:30-17:30 Room 44 EC4 Register Commission 9:00-11:00 Room 48 EFCC C-P and EC4 Foundation Board Chair: S. Zerah 14:30-17:30 Room 45 IFCC C-CLM Chair: E. Frank 8:00-11:00 Room 49 EFCC WG-BV Chair: B. Bartlet 14:30-17:30 Room 48 EFCC C-S Chair: S. Sandberg 8:00-11:00 Room 13/14 IFCC TF-PG Chair: R. van Schaik 14:30-17:30 Room 49 IFCC C-CMBC Chair: M. Neumaier 8:00-11:00 Salon 20 IFCC C-MD Chair: M. Pazzagli 14:30-17:30 Salon 19 IFCC C-RIDL Networking Chair: K. Ichihara 9:00-11:00 Room 45 DQCLM Chair: M. Thomas 14:30-17:30 Salon 20 IFCC C-TLM Open Meeting Chair: A. Kessler 9:00-11.00 / 14.30-17:30 IFCC C-PR Chair: K. Adeli Salon 19 9:00-11:00 IFCC WG-AETR Open Meeting Chair. R. Bais 11:30-14:00 Room 42 DGKL AG In/Outsourcing 32 Room 47 14:30-17:30 Room 13/14 IFCC WG-SAU and WG-GFRA Open Meeting Chairs: N. Greenberg, G. Miller We Impact Life at Every Stage At Abbott, we deliver products you can count on to provide superior patient care – across the spectrum of health. Discovering new and better ways to manage health has driven our work for more than a century. Today, our comprehensive line of products spans the continuum of care – from pharmaceutical therapies and nutritional products to diagnostics and surgical devices – addressing important health needs from infancy to the golden years, and in more ways than ever. We strive to earn your continued trust by delivering high-quality, reliable products backed by leading-edge science and expertise across a range of health care specialties. AD0061EU2011 We deliver on our promises by focusing on what matters most: innovative care and a desire to make a meaningful difference in all that we do. Anesthesia Cardiovascular Hematology Metabolics Nutrition Point of Care Vascular Animal Health Diabetes Care Immunology Molecular Oncology Renal Care Virology Anti-Infectives Diagnostics Medical Optics Neuroscience Pain Management Respiratory Tu e s da y 1 7 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 9:00 - 11:00 PARALLEL SESSIONS Symposium 7 HALL 1 PHARMACOGENETICS AND PHARMACOGENOMICS Chairs: U. Tuma (Brazil), R. van Schaik (The Netherlands) 9:00 Pharmacogenetics in the treatment of psychiatric diseases C. Hiemke (Germany) 9:25 Pharmacogenetic predictors of drug induced liver injury M. Pirmohamed (United Kingdom) 9:50 The rapidly evolving state of the art in clinical pharmacogenetic applications M. Linder (USA) 10:15 Pharmacogenetics of anti-cancer therapy R. van Schaik (the Netherlands) 10:40 Reduced overall survival of CYP2C19 *2/*2 homozygotes after myeloablative hematopoietic stem cell transplantation P. Jarolim (USA) 10.50 VKORC1, CYP2C9 AND CYP4F2 genetic based algorithm for warfarin dosing. Preliminary results of a prospective Italian study C.-F. Zambon (Italy) Ye a r i n R e v i e w 2 HALL 3 ADVANCES IN CLINICAL CHEMISTRY IN THE FIELD OF NEPHROLOGY AND ENDOCRINOLOGY Chairs: G. Benga (Romania), J. Delanghe (Belgium) 9:00 New markers for acute kidney injury C. Ronco (Italy) 9:30 Beyond creatinine standardisation J. Delanghe (Belgium) 10:00 POCT glucose measurement and its limitations D. Bruns (USA) 10:30 The D-Lightful vitamin D for health M.F. Holick (USA) 34 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Tue s da y 1 7 May 9:00 - 11:00 PARALLEL SESSIONS Workshop 3 HALL 8 9:00-10:30 O X I D AT I V E S T R E S S I N D I A B E T E S M E L L I T U S Chairs: T. Zima (Czech Republic) 9:00 Role of nrf2 and the antistress gene response in countering oxidative stress in diabetes mellitus P.J. Thornalley (United Kingdom) 9:30 Oxidative stress markers in diabetic complications A. Ceriello (United Kingdom) 10:00 Oxidative stress and caloric restriction J. Skrha (Czech Republic) Symposium 8 HALL 14.2 INFECTIOUS DISEASES Chairs: S. Suerbaum (Germany), R. Tauber (Germany) 9:00 Impact of genomics on molecular epidemiology of MRSA W. Witte (Germany) 9:25 Helicobacter pylori – A global carcinogenic pathogen S. Suerbaum (Germany) 9:50 Influenza pandemic, vaccination and pitfalls of communication S. Becker (Germany) 10:15 The fourth dimension: Combining epidemiologic and typing data for the transition from data to knowledge for infectious diseases D. Harmsen (Germany) 10:40 Genotypic prediction of HIV-1 coreceptor tropism from plasma and peripheral blood mononuclear cells in the clinical routine laboratory J. Berg (Austria) 10.50 Leishmania: Probable genetic hybrids between species in Sudanese isolates S.H. Hassabelgawi (Sudan) 35 Tue s da y 1 7 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 9:00 - 11:00 PARALLEL SESSIONS Symposium HALL 7 BIOCHEMICAL ANALYSIS PRIZE – AWARD CEREMONY Chair: K. Lackner (Germany), U. Walter (Germany) 9:00 Laudatory speeches K.J. Lackner – President DGKL J. Thiery – Vice President DGKL 9:20 Award Lectures J.M. Rothberg (USA) S. Pääbo (Germany) 10:40 Closing remarks Simultaneous translation from English to German will be provided Symposium 9 HALL 4/5 HAEMATOLOGY AND ANEMIA Chairs: R. Sierra Amor (Mexico), J. Wesenberg (Canada) 9:00 Diagnostic of thalassemia A. Huber (Switzerland) 9:25 How can hepcidin help us in the diagnosis of iron disorders? D.W. Swinkels (The Netherlands) 9:50 Hepcidin function and regulation M. Muckenthaler (Germany) 10:15 Laboratory diagnosis of hereditary spherocytosis M.J. King (United Kingdom) 10:40 Customizing Sysmex flags for a specific patient population using statistical methods B.A. Stotler (USA) 10:50 JAK2 V617F promotes expression of oncostatin M in myeloproliferative neoplasms: A potential link between abnormal JAK-signaling and bone marrow microenvironment alterations G. Hörmann (Austria) 36 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 PARALLEL SESSIONS E M D C - C M B C Symposium HALL 9 B I O B A N K I N G A N D L A B O R AT O R Y M E D I C I N E : T W O R E S O U R C E S F O R M O D E R N H E A LT H C A R E Chairs: M. Neumaier (Germany) 9:00 Biobanking infrastructures: Networks for future biomedical research and laboratory medicine M. Neumaier (Germany) 9:30 Ethical and bio-legal aspects: Crossborder experiences in Europe M. Kiehntopf (Germany) 10:00 Public health and biobanking – The role of public health genomics A. Brand (The Netherlands) 10:30 The key role of biobanking for the study of complex diseases M. Ferrari (Italy) Workshop 4 HALL 10 U P D AT E O N C A R D I A C T R O P O N I N C L I N I C A L A N D L A B O R AT O R Y I S S U E S Tue s da y 1 7 May 9:00 - 11:00 9:00-10:30 Chair: J. Tate (Australia) 9:00 A roadmap for cardiac troponin I standardization and traceability D. Bunk (USA) 9:30 The round Robin study for cardiac troponin I - Progress report J. Tate (Australia) 10:00 Clinical use of high-sensitivity troponin assays H.A. Katus (Germany) 37 Tue s da y 1 7 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 11:30-12:45 PLENARY SESSION HALL 1 ADVANCES IN CLINICAL AND DIAGNOSTIC IMMUNOLOGY Chairs: A.R. Horvath (Australia), M.M. Müller (Austria) 11:30 Chronic inflammatory bowel disease – From bench to bedside M.F. Neurath (Germany) Markus Neurath is an international leading scientist on the field of immunology and endomicroscopy of the gut who was awarded with well-known research prizes for his work, e.g. the UEGF Research Prize. His research deals with the immunologic and molecular mechanisms in the pathogenesis of inflammatory bowel diseases and GI-cancer. 11:55 Integrative genomic analysis of T cell immunity in humans W.N. Haining (USA) Dr. Haining is a physician-scientist who received his undergraduate and medical degree from Oxford University, UK. He moved to the United States in 1993 to complete medical training in Pediatrics at Children's Hospital, Boston, and subsequently in Pediatric Hematology/Oncology at Dana-Farber Cancer Institute. After post-doctoral research at MIT and Dana-Farber Cancer Institute, he was appointed to the faculty as Assistant Professor of Pediatrics in 2007 in the Department of Pediatric Oncology. Dr. Haining's research focuses on understanding why the immune system fails in cancer and chronic viral disease. His studies have integrated cutting edge genomics and computational biology approaches with cellular immunology to identify the critical molecular mechanisms that impair the T cell response to HIV and tumor cells. His work has provided novel therapeutic targets to revive defective HIV-specific T cell immunity and have laid the groundwork for the broader understanding of the immunologic genome. 12:20 Gene-environment interaction in chronic inflammatory disease H. Renz (Germany) The central research area of Harald Renz is the role of the adaptive immune system in the pathogenesis of allergy and asthma. He is internationally recognized for his work on the role of T-cell effector subsets on initiation, progression and remodelling of chronic inflammatory disease, particularly in bronchial asthma and atopic dermatitis. He was among the first to demonstrate that T-cells play an important role in the development of airway hyperreactivity in asthma and trigger the chronic inflammatory response in this condition. He pioneered the development of disease-related animal models which mimic several important hallmarks of the disease, including initiation, progression and remodelling. In terms of disease-initiation, he provides important contributions to the "hygiene hypothesis". He is serving as immunological study site in several international research consortia and proved the importance of early life events for programming of the immune system. His work offers novel cellular and molecular explanation for the role of microbes in preventing the development of allergic conditions even in a transgenerational manner. 38 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 POSTER WALKS Poster Area In order to encourage discussions, poster walks will be held on Monday, Tuesday, and Wednesday from 13:30 to 14:30. The author of the selected posters is asked to be by his/her poster panel from 13:30 to 14:30. Each author will have up to three minutes to present the poster. The chairman selected for each poster walk will guide the walk and chair the discussion. All delegates wishing to attend poster walks must be at the first poster panel (see poster-panel code) at 13:30. A geing Ageing Chair: M. Walter (Germany) Posters 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0035 0036 0038 0040 0042 0054 0144 0146 0149 0152 0157 0159 0493 0494 0495 0498 0501 0503 0579 0580 0582 0583 0584 0587 0617 0619 0621 0627 0629 0634 A ut oim m une Aut u ne disease Chair: J. Lopez (Malaysia) Posters 0021 0025 0027 0030 0033 0034 Tue s da y 1 7 May 13:30-14:30 Endocr ino logy inology Chair: M. Kiehntopf (Germany) Posters 0103 0116 0118 0125 0128 0142 C ar diovas c ula r dis ease Car diovascular disease Chair: C. Knabbe (Germany) Posters 0449 0451 0452 0453 0464 0491 H aem at ology Haem Chair: L. Thomas (Germany) Posters 0520 0524 0527 0533 0560 0563 H aem ost as Haem a s is Chair: U. Walter (Germany) Posters 0595 0597 0598 0604 0606 0611 39 Tue s da y 1 7 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Kidney K idney dise dis e a s e Chair: F. H. Perschel (Germany) Posters 0696 0700 0703 0705 0713 0718 0724 0730 0739 0741 0745 0755 0815 0817 0821 0825 0831 0834 M olecular dia gnostics diagnos tic s Chair: K. Psarra (Greece) Posters 0798 0802 0805 0806 0809 0814 Neur a l dis e a s e s (acute nd chronic) N eur ologic ological diseases(a c ute a an Chair: G. Sypniewska (Poland) Posters 0836 0839 0841 0844 0845 0846 0847 0850 0855 0858 0859 0900 0906 0907 0910 0917 0920 Pat ient and an d labora tory mana gem e n t Chair: P. Sinha (Austria) Posters 0890 0891 0892 0896 0898 0899 Phar m acogene aco gene tic s /pharmacogen o m i c s Chair: E. Wieland (Germany) Posters 0925 0926 0928 0929 0930 1014 1015 1025 1028 1037 1038 1063 1064 1069 1072 1074 1225 1226 1228 1231 1234 1236 1063 1064 1069 1072 1074 Vit am ins Chair: R. Bais (Australia) Posters 1215 1216 1217 1218 1219 1222 Q ualit y assessme nt, s tandardiz a ti o n Qualit Chair: W. Herrmann (Germany) Posters 1014 1015 1025 40 1028 1037 1038 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 INDUSTRY-SPONSORED WORKSHOPS HALL 8 INCREMENTAL VALUE OF H-FABP IN AN ERA OF HIGHLY SENSITIVE TROPONINS Chair: R. Body (United Kingdom) 13:00 The diagnostic utility of heart-type fatty acid binding protein in patients with acute coronary syndrome J. Barth (United Kingdom) 13:30 Heart-fatty acid binding-protein may enable immediate exclusion of acute myocardial infarction in the emergency department R. Body (United Kingdom) HALL 14.2 FROM CLINICAL CHEMISTRY TO MOLECULAR DIAGNOSTICS: INNOVATIVE SOLUTIONS FOR LABORATORY AUTOMATION AND ORGANISATION Chair: J. Wood (United Kingdom) 13:00 Reaching optimal efficiency in a high volume laboratory D. Münstermann (Germany) 13:20 AU5800: The new ultra high throughput chemistry analyser – First experience T. von Schrenck (Germany) 13:40 UniCel DxN, the next generation in clinical molecular diagnostics automation M. Topham (USA) Tue s da y 1 7 May 13:00 - 14:00 HALL 7 LABORATORY DIAGNOSIS OF HEPATITIS C – WHAT ARE LOOKING FOR? Chair: A. Vockel (Germany) 13:00 Hepatitis C infections – A hidden, but no “occult” disease J. Izopet (France) 13:30 HCV Antigen – An effective marker to improve HCV diagnostics? P. Holder (Ireland) 41 Tue s da y 1 7 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 13:00 - 14:00 INDUSTRY-SPONSORED WORKSHOPS HALL 4/5 TRUST BUT VERIFY: HOW TO EVALUATE HAEMATOLOGY SYSTEMS Chair: O. Hauss (Germany) 13:00 Trust but verify: How to evaluate haematology systems S.J. Machin (United Kingdom) HALL 9 FOCUS ON NEW DIAGNOSTIC STRATEGIES IN AUTOIMMUNITY Chair: I. Abreu (Portugal), N. Bizzaro (Italy) 13:00 A simplified diagnostic algorithm for celiac disease E.Tonutti (Italy) 13:20 Clinical and diagnostic significance of anti-ENA antibodies J.Jimenez Alonso (Spain) 13:40 A new multiparametric chemiluminescent assay for the screening of ENA antibodies N.Bizzaro (Italy) HALL 10 ENHANCING PATIENT CARE IN THE CHALLENGING DIAGNOSTIC ARENA IN EUROPE Innovative technological platforms and high quality services to enhance productivity in increasingly complex Lab structures Chair: A.Lusack (United Kingdom) 13:00 Introduction and Welcome A.Lusack (United Kingdom) 13:05 Implementation of innovative technological platforms in increasingly complex laboratory structures H.Baum (Germany) 13:30 e-connectivity and remote monitoring center: A user’s perspective P.Howell (United Kingdom) 42 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 INDUSTRY-SPONSORED WORKSHOPS HALL 14.2 NEW HORIZONS IN CELLULAR ANALYSIS Chair: R. Simon (Switzerland) 14:15 Volume, conductivity and scatter properties of leukocytes (VCS Technology) is a highly sensitive and specific predictor of blood culture proven neonatal sepsis M. Bhargava (India) 14:35 Is that the microscope WBC differential count has a future in a hematology lab: the benefits of HematoFlowTM concept O. Pradier (Belgium) 14:55 Anemia – New insights R. Simon (Switzerland) HALL 4/5 DIAGNOSTIC AND CLINICAL IMPORTANCE OF MEASURING VITAMIN D TOTAL Tue s da y 1 7 May 14:15 - 15:15 Chair: P. Sibley (United Kongdom) 14:15 Technical and Clinical Aspects M. Vogeser (Germany) 14:40 Multicenter Study of a New Assay on Centaur XP W. Fraser (United Kingdom) 43 Tue s da y 1 7 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 14:30 - 16:30 PARALLEL SESSIONS Symposium 10 HALL 1 D I A G N O S T I C U S E A N D VA L U E O F F U N C T I O N T E S T I N ENDOCRINOLOGY Chairs: P. Carayon (France), L. Thienpont (Belgium) 14:30 Molecular genetic work up for thyroid and parathyroid diseases F. Raue (Germany) 14:55 Diagnostic workup of primary aldosteronism M. Stowasser (Australia) 15:20 Vitamin D: Clinical relevance, analytical issues E. Cavalier (Belgium) 15:45 Hormonal changes after gastric surgery and obesity interventions C. Le Roux (United Kingdom) 16:10 Genetic determinants of serum testosterone concentrations in men R. Haring (Germany) 16:20 Expression of a subset of microRNAs in clinically non-functioning pituitary adenomas correlates with tumor size H. Butz (Hungary) S y m p o s i u m 11 HALL 3 POINT OF CARE TESTING - PRACTICAL ASPECTS Chairs: M. Klouche (Germany), K. Pulkki (Finland) 14:30 Management of POCT testing program in a teaching hospital D. Rogic (Croatia) 14:55 Update on current and developing POC applications with a global and emerging country focus B. Goldsmith (USA) 15:20 The operator is key in delivering quality in POC I. Watson (United Kingdom) 15:45 Designing a Quality POCT Program using CLSI documents L.A. Wyer (USA) 16:10 Effect of marked fluctuations in haematocrit on point of care blood glucose systems G. Creed (United Kingdom) 16:20 Impact of analytical performance of point of care (POCT) blood glucose meters on application of a ´tight glycaemic control´ (TGC) protocol in an intensive care unit setting M. Ryan (United Kingdom) 44 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 PARALLEL SESSIONS Workshop 5 HALL 8 14:30-16:00 L E S S O N S F R O M T H E A S I A N - PA C I F I C M U LT I C E N T E R R E F E R E N C E I N T E R VA L S T U D Y Chairs: K. Ichihara (Japan) 14:30 Study design: Strategy for collaboration in the definition of reference intervals K. Ichihara (Japan) 15:00 Statistical considerations in the generation of reference intervals J. Boyd (USA) 15:30 Obtaining reference intervals traceable to reference measurement systems M. Panteghini (Italy) Symposium HALL 7 QUALITY MANAGEMENT ACCORDING TO THE GERMAN R I L I B A E K : A N I N T E R N AT I O N A L P E R S P E C T I V E Tue s da y 1 7 May 14:30 - 16:30 Chair: W. Vogt (Germany), B. Wiegel (Germany) 14:30 German Medical Associations Directive for Quality Assurance for Medical Laboratory tests, history and last issues W. Vogt (Germany) 15:00 Quality management and quality assurance in Italian medical laboratories M. Ogriseg (Italy) 15:30 Quality management and quality assurance in Austrian medical laboratories M. Hubmann (Austria) 16:00 Root mean square of measurement deviation: a new approach in German Medical Associations Directive for Quality Assurance for Medical Laboratory tests R. Macdonald (Germany) Simultaneous translation from German to English will be provided 45 Tue s da y 1 7 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 14:30 - 16:30 PARALLEL SESSIONS Symposium HALL 9 ACCREDITATION SHOULD BE FOCUSSED ON MORE THAN WELL ORGANIZED EXAMINATIONS WITH THE LABORATORY Chairs: C. Giroud (France), R. Jansen (the Netherlands) 14:30 IVD Directive 98/79/CE in relation to ISO 15189 J.C. Libeer (Belgium) 15:00 Influence of pre-examination aspects on result´s validity – Are ISO 15189 requirements sufficient and clear? L. Sprongl (Czech Republic) 15:30 ISO 15189: Coverage of validation of results and post-examination aspects: Is this sufficient? S. Zerah (France) 16:00 The specific roles of assessors during accreditation and beyond W. Huisman (The Netherlands) Workshop 6 HALL 10 14:30-16:00 T H E 2 0 0 9 I N F L U E N Z A PA N D E M I C - L E S S O N S L E A R N E D Chair: M. Pilonetto (Brazil) 14:30 The 2009 influenza pandemic - The experience in the southern hemisphere A. Kelso (Australia) 15:00 Impact of pandemic A/H1N1 virus mutations on drug resistance and virulence G. Boivin (Canada) 15:30 The role of pathogenic immune complexes in severe disease caused by pandemic influenza F.P. Polack (Argentina) 46 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 INDUSTRY-SPONSORED WORKSHOPS HALL 14.2 NEXT GENERATION IN CARDIAC BIOMARKERS: LABORATORY MEDICINE'S CONTRIBUTION TO INDIVIDUALIZED TREATMENT IN ACS AND HEART FAILURE Chair: S. Rougale (France) 15:30 Troponin T high sensitive : Applying the guidelines to hospital's daily life H. Katus (Germany) 15:50 Future calls : Can GDF 15 be added value to ACS treatment? K.C. Wollert (Germany) 16:10 NT-pro BNP guided heart failure therapy J. Januzzi (USA) HALL 4/5 THE CLINICAL UTILITY OF REFLEX URINE CULTURES BASED ON URINALYSIS AND AUTOMATED URINE MICROSCOPY USING THE IQ200 WORKSTATION Tue s da y 1 7 May 15:30 - 16:30 15:30 The clinical utility of reflex urine cultures based on urinalysis and automated urine microscopy using the IQ200 workstation S. Riedel (USA) 47 Tue s da y 1 7 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 16:45 - 17:45 INDUSTRY-SPONSORED WORKSHOPS HALL 8 THE “LEAN” ALTERNATIVE Chair: S. Rougale (France) 16:45 Lean principles and applications to healthcare M. Chomyn (Germany) 17:15 Practical applications of lean in UK hospital laboratory M. Fottles (Germany) HALL 14.2 EFFICIENT LAB ORGANIZATION FROM PRE- TO POST ANALYTIC Chair: A. Steif (Germany) 16:45 Overview of Roche Cobas Solutions C. Brown (Switzerland) 17:05 Optimizing a University Lab U. Steigerwald (Germany) 17:25 The evolution of a hands-on towards a hands-free laboratory F. Winnock (Belgium) HALL 7 AUTOMATION TO ENSURE YOUR LAB’S EFFICIENCY Chair: G.I. McCurdy (Germany) 16:45 An overwiew of the benefits of an automated inventory system (RMS) M. Orth (Germany) 17:15 The implementation and adoption of a Total Laboratory Automation System (APS) M. Nybo (Denmark) 48 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 INDUSTRY-SPONSORED WORKSHOPS HALL 4/5 COUNTING THE COST OF THE PREANALYTICAL PHASE Chair: V. Palicka (Czech Republic), M. Plebani (Italy) 16:45 The impact of preanalytical errors on patients’ treatment G. Lippi (Italy) 17:05 Understanding the cost of the preanalytical phase in an outpatient setting G. Soffiati (Italy) 17:25 Discovering the opportunity cost of preanalytical errors M. Nauck (Germany) HALL 9 NEW HIGH-PERFORMANCE ASSAYS FOR THE DETERMINATION OF FREE LIGHT CHAINS KAPPA AND LAMBDA – ADDING CONSISTENCY TO MONITORING AND SCREENING OF MULTIPLE MYELOMA Chair: C. Pruemper (Germany) Tue s da y 1 7 May 16:45 - 17:45 16:45 Improving determination of FLC Kappa and Lambda by use of Monoclonal Antibodies H. te Velthuis (The Netherlands) 17:15 High sensitivity and specificity of New Nephelometric Assays for FLC Kappa and Lambda in Clinical Practice R. Hoedemakers (The Netherlands) HALL 10 CLINICAL MSMS – NEW DEVELOPMENTS IN TODAY’S LABORATORY Chair: A. Cohen (Denmark) 16:45 Mass spectrometry for routine analysis of steroids in clinical samples A. Cohen (Denmark) 17:05 Vitamin D: There is a world beyond the bone, and how to gain a reliable insight H.J. Roth (Germany) 17:25 Standardization and quality of in vitro diagnostic medical devices L. Thienpont (Belgium) 49 Tue s da y 1 7 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 CLOSED MEETINGS 8:00-11:00 Room 47 IFCC WG-HbA2 Chair: R. Paleari 11:30-14:00 Room 44 ISC Worldlab Istanbul 2014 Chair. N. Ozer Room 48 8:00-11:00 EFCC WG-TE Chair: AR. Horvath 13:00-15:00 Room Schönefeld DGKL Executive Committee 8:00-9:30 Salon 11/12 EFCC WG-DE Chair: D. Gruson Salon 11/12 9:30-11:00 EFCC C-ET and WG-CPE Chair: E. Topic 14:00-17:00 Salon 11/12 IFCC TF-YS - Open Meeting Chair: D. Gruson 14:30-16:00 Room 43 IFCC Corporate Members Chair: T. Brinkmann 8:00-11:00 Room 49 IFCC C-MD Chair: M. Pazzagli 14:30-17:00 Room 44 IFCC National Societies Editors & Publishers Chair: E. Delvin, E. Jacobs 9:00-10:00 Room 45 EFCC WG-TFG PA Chair: A. Simundic 14:30-17:30 Room 45 IFCC C-RSE Chair: F. Ceriotti 9:00-11:00 Room 44 ISAB Euromedlab Milano 2013 Chair: M. Panteghini 14:30-17:30 Room 47 IFCC C-EBLM Chair: R. Christenson 10:00-13:00 Room 45 EFCC C-PPR Chair: A. Wootton 14:30-17:30 Room 48 IFCC WG-SCC Chair: A. Grubb 10:30-11:30 Room 43 Bergmeyer Conference Steering Committee Meeting Chair: I. Young 14:30-17:30 Room 49 EFCC WG-G Chair: W. Oosterhuis 11:00-16:30 Room 42 DGKL Division Molecular Diagnostics Chair: M. Neumaier 50 17:00-18:30 Room 43 DGKL Meeting Members Incomparable performance in Autoimmunity The chemiluminescence-based Zenit RA analyzer meets laboratory needs and provides the operator with: • Extreme flexibility (up to 15 immunoassays on board; continuous access to samples, reagents consumables and parts) • Rapid analysis (first result within 25 minutes; throughput: 70 tests/hour) • Full traceability (barcode reading for all reagents and samples; continuous control of reagent levels; quality control based on Levey-Jenning & Westgard charts) ô-OREôWAYSôTOôTRANSFORMô LABORATORYôWORKFLOW ô XCEEDINGôEXPECTATIONSôFORôCAPACITYô % PERFORMANCEôANDôQUALITYôATô%Lô0ONIENTEô(OSPITAL “With a workload that has doubled in five years, we needed to improve sample management and laboratory procedures to keep pace with demand. By partnering with Beckman Coulter, we automated 90 percent of our manual test processes, improving our ability to provide physicians with timely and consistent results. El Poniente Hospital is well positioned to support the region’s healthcare structure – helping to advance the quality of medical treatment and patient care to all who live in the area we serve.”– Dr. Cristóbal Avivar, Director of the Integrated Biotechnology Management Area, El Poniente Hospital, El Ejido, Almeria, Spain. Find out more about how Beckman Coulter can help you improve performance in your laboratory at IFCC-WorldLab and EuroMedLab 2011. ô"LOODô"ANKINGôôôô#ENTRIFUGATIONôôôô#HEMISTRYôôôô&LOWô#YTOMETRYôôôô(EMATOLOGYôôôô(EMOSTASIS )MMUNOASSAYôôôô)NFORMATIONô3YSTEMSôôôô,ABô!UTOMATIONôôôô-OLECULARô$IAGNOSTICSôôôô2APIDô$IAGNOSTICS © 2011 Beckman Coulter, Inc. Beckman Coulter and the stylized logo are registered trademarks of Beckman Coulter, Inc. 6ISITôUSôATô )&##7ORLD,ABôANDô %URO-ED,ABôô "OOTHô.Oôô(ALLôô BECKMANCOULTERCOM)&## I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 PARALLEL SESSIONS Symposium 12 HALL 1 BIOMARKERS IN ACUTE AND CHRONIC BRAIN DISEASES Chairs: R.N. Martins (Australia), G. Sypniewska (Poland) 9:00 Dissecting Alzheimer's disease: Is AD pathology as a cause or a consequence? G. Casadesus (USA) 9:25 Multiple sclerosis A.H. Cross (USA) 9:50 Identifying blood biomarkers to improve the management of stroke W. Whiteley (United Kingdom) 10:15 S100B protein: A screening tool for the diagnosis of minor head injury J.L. Beaudeux (France) 10:40 Evaluation of the new Marburg cerebrospinal fluid (CSF) model with human spondylopathies A. Dorn-Beineke (Germany) 10:50 Prostatic acid phosphatase (PAP) in neurotransmission P.Vihko (Finland) Ye a r i n R e v i e w 3 HALL 3 DEVELOPMENTS IN CLINICAL LABORATORY PRACTICE We dne s da y 1 8 May 9:00 - 11:00 Chairs: M. Plebani (Italy), I. Rydén (Sweden) 9:00 Translational medicine: The case of laboratory medicine M. Plebani (Italy) 9:30 Risk management in the pre-analytical phase G. Lippi (Italy) 10:00 Risk analysis of the analytical testing process J. Westgard (USA) 10:30 Reference values and beyond F. Ceriotti (Italy) 53 Wedn e s da y 1 8 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 9:00 - 11:00 PARALLEL SESSIONS Workshop 7 HALL 8 CLINICAL PHARMACOGENETICS 9:00-10:30 Chairs: M. Pirmohamed (United Kingdom) 9:00 CYP2D6 Genotyping to guide use of tamoxifen in breast cancer K. Weck (USA) 9:30 Pharmacogenetics of coumarin J. Oldenburg (USA) 10:00 Can drug induced liver injury be predicted by pharmacogenetics? T. Szekeres (Austria) Symposium 13 HALL 14.2 PRENATAL AND NEONATAL SCREENING Chairs: J.J.M. Hicks (USA), K. Kohse (Germany) 9:00 Pre-eclampsia: Genetic and epigenetic aspects C.B.M. Oudejans (The Netherlands) 9:25 An update on antenatal screening for Down's syndrome N. Wald (United Kingdom) 9:50 Circulating cell-free fetal DNA in maternal plasma: Prospects for non-invasive prenatal assessment of fetal aneuploidies D. van den Boom (USA) 10:15 Recommendations in prenatal screening in the world and connections to other diseases like thyropathy T. Zima (Czech Republic) 10:40 Automated assays for sVEGF-R1, PlGF, Inhibin-A and PAPP-A as an aid in early prediction of preeclampsia : preliminary results from a prospective clinical study in a general population V. Tsatsaris (France) 10:50 First-trimester risk calculation for trisomy 13, 18, and 21: Comparison of the screening efficiency between two self-developed programs and astraia software S. Sørensen (Denmark) 54 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 PARALLEL SESSIONS Symposium HALL 7 S TA N D A R D I Z AT I O N I N M O L E C U L A R D I A G N O S T I C S Chairs: I. Young (United Kingdom) 9:00 The need for standardization in molecular diagnostics M. Pazzagli (Italy) 9:30 Standardization in molecular diagnostics: Definitions and uses of nucleic acid reference materials D. Payne (USA) 10:00 The IFCC network of molecular diagnostic centres F. Rousseau (Canada) 10:30 The pharmacogenetics reference laboratory: An IFCC molecular diagnostic center in action R. van Schaik (The Netherlands) Symposium 14 HALL 4/5 ALLERGY DIAGNOSTICS Chairs: C.W.K. Lam (Hong Kong), J. Lopez (Malaysia) 9:00 Emerging concepts in individualized therapy of atopic dermatitis T. Bieber (Germany) 9:25 Component-based diagnostics - recombinant allergens as diagnostic tools R. Valenta (Austria) 9:50 Carbohydrate allergens T.A.E. Platts-Mills (USA) 10:15 The role of in vitro tests in the diagnosis of food allergy T. Werfel (Germany) 10:40 Components-array technology diagnostic, a step forward in the study of the sensitization profile of allergic patients J.M. Acedo (Spain) 10:50 RecoveryELISA - A newly developed immunoassay for measurement of therapeutic antibodies (MAb) and the target antigen during antibody therapy G. Becher (Germany) We dne s da y 1 8 May 9:00 - 11:00 55 Wedn e s da y 1 8 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 9:00 - 11:00 PARALLEL SESSIONS Symposium HALL 9 DEVELOPMENT OF A TRANSCRIPTOMIC, PROTEOMIC AND M E TA B O L O M I C D ATA B A S E F O R H U M A N B L O O D C E L L S Chair: G. Schmitz (Germany), C. Wagener (Germany) 9:00 Problems and solutions for consolidated blood cell proteome analysis H. E. Meyer (Germany) 9:30 A data storage and retrieval system for across-Omics data integration in eukaryotic systems K. Helsen (Belgium) 10:00 The proteome of resting and activated platelets R. Zahedi (Germany) 10:30 Transcriptomics, proteomics and lipidomics from megakaryopoesis to platelet senescence G. Schmitz (Germany) Simultaneous translation from German to English will be provided Workshop 8 HALL 10 9:00-10:30 MOLECULAR DIAGNOSIS OF INFECTION Chair: M. Tavora Mira (Brazil) 9:00 Molecular diagnosis of tuberculosis E. Domann (Germany) 9:30 Challenges of molecular diagnosis - The leprosy model V. Vissa (USA) 10:00 Molecular diagnosis of viral infections: Arboviruses and rodent-borne viruses L. Moraes Figueiredo (Brazil) 56 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 PLENARY SESSION HALL 1 THE BRAIN: BIOLOGICAL AND CEREBRAL DISEASES Chairs: R. Tauber (Germany), I. Young (United Kingdom) 11:30 Alzheimer's disease: From molecular pathology to diagnosis and treatment approaches R.N. Martins (Australia) Professor Ralph Martins' career in Alzheimer's disease has spanned 25 years and resulted in over 200 publications in mid to high impact journals. He established the McCusker Foundation for Alzheimer's Disease Research. He brought together researchers from Western Australian universities, hospitals and aged care providers to establish the Centre of Excellence for Alzheimer's Disease Research of which he is director. With Professors Colin Masters and David Ames, he was successful in obtaining a CSIRO Flagship grant to identify early diagnostic markers of AD. He founded the Western Australian biotech company Alzhyme to develop anti-amyloid drugs for Alzheimer's Disease. This has allowed Alzhyme to take a lead compound from concept to successful animal trials in 4 years. 11:55 Biomarkers in multiple sclerosis M. Comabella (Spain) Education/Training 1990 University of Barcelona - MD Medicine 1995 Hospital Vall d’Hebron - Specialist Neurology Scientific Training and Experience 1992 - 1995 Resident in Neurology. Hospital Vall d'Hebron, Barcelona. Spain 1996 - 1998 Research fellowship in Neuroimmunology. Harvard Medical School, Center for Neurologic Diseases - Brigham and Women´s Hospital, Boston, US 1999 - 2001 Research and Clinical Neurologist. Hospital Vall d'Hebron Present Position Research and Clinical Neurologist. Deputy Director Neuroimmunology lab. Clinical Neuroimmunology Unit. Hospital Vall d'Hebron. Barcelona, Spain 12:20 We dne s da y 1 8 May 11:30-12:45 Mechanisms of neurotoxicity and neurodegeneration in prion diseases A. Aguzzi (Switzerland) A. Aguzzi is professor and director of the Institute of Neuropathology at the University of Zurich. His research career has focused entirely on prions, exploring how they damage brain cells, why they accumulate in lymphoid organs, and how they reach the brain after entering the body from peripheral sites. He is the Founder and Director of the Swiss National Reference Center for Prion Diseases, and is on the Board of Governors of the Swiss Federal School of Technology. He has developed and patented several diagnostic and therapeutic methods in the field of transmissible spongiform encephalopathies. He is an adviser to the British, Italian, and Swiss government on spongiform encephalopathies. Among other honors, Dr. Aguzzi has won 2009 the Antonio-Feltrinelli Prize in Rome, as well as the medal of the European Molecular Biology Organization (EMBO). 57 Wedne s da y 1 8 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 13:30-14:30 POSTER WALKS Poster Area In order to encourage discussions, poster walks will be held on Monday, Tuesday, and Wednesday from 13:30 to 14:30. The author of the selected posters is asked to be by his/her poster panel from 13:30 to 14:30. Each author will have up to three minutes to present the poster. The chairman selected for each poster walk will guide the walk and chair the discussion. All delegates wishing to attend poster walks must be at the first poster panel (see poster-panel code) at 13:30. C ar diovas c ula r dis ease Car diovascular disease Chair: J. Tate (Australia) Posters 0187 0195 0198 0200 0211 0220 0224 0246 0249 0258 0291 0302 D iabet es mellitus and meta bo l i c s y n d r o m e Diabet Chair: F. H. Perschel (Germany) Posters 0336 0338 0340 0345 0388 0399 0403 0413 0415 0417 0424 0426 0513 0514 0515 0516 0517 0519 Genet isease G enet ic d dis ease Chair: B. Hoppe (Germany) Posters 0507 0508 0509 0510 0511 0512 Inf ect ious diseases (acute a nd c h r o n i c ) Chair: M. Walter (Germany) Posters 0636 0638 0640 0641 0642 0643 0646 0647 0653 0654 0677 0687 0710 0711 0714 0719 0754 0760 0775 0777 0780 0783 0785 0788 K idney disease Kidney dis e a s e Chair: N. Ozer (Turkey) Posters 0694 0695 0702 0706 0707 0709 Liver and ga s trointe s tinall disea gastrointestina dis e a s e s Chair: B. Gouget (France) Posters 0766 0768 0769 58 0770 0772 0774 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Posters 0835 0837 0838 0843 0848 0849 0851 0852 0853 0854 0856 0878 0879 0884 0885 0887 0888 0948 0953 0954 0956 0958 0963 0983 0985 0987 0991 1009 1011 1041 1049 1051 1055 1060 1061 Paediat r ic c linic a l c hemistry Chair: K. Kohse (Germany) Posters 0870 0871 0872 0873 0874 0876 Point of care te s ting Chair: K. Pulkki (Finland) Posters 0933 0934 0936 0937 0938 0947 Pr egnancy a nd ne ona tology Chair: K. Tomberg (Estonia) Posters 0974 0977 0978 0980 0981 0982 We dne s da y 1 8 May Neur a l dis e a s e s (a c ute an N eur ologic ological diseases (acute a nd c h r o n i c ) Chair: J.-L. Beaudeux (France) Q ualit y assessme nt, s tandardiz a ti o n Qualit Chair: C.B.M. Oudejans (The Netherlands) Posters 1019 1020 1024 1026 1035 1036 Technolog y, ins trume nta tion an Technology, instrumentation a n d m e th o d s , m e ta b o l o m i c s Chair: O. Wagner (Austria) Posters 1078 1084 1090 1098 1103 1109 1117 1133 1140 1147 1149 1151 Technolog y, ins trume nta tion an Technology, instrumentation a n d m e th o d s , m e ta b o l o m i c s Chair: E. Wieland (Germany) Posters 1080 1085 1100 1118 1119 1122 1127 1128 1143 1145 1146 1150 1200 1201 1203 1204 1207 1208 Tr aceabllity and s tandardizatio n Chair: K. Ichihara (Japan) Posters 1194 1195 1196 1197 1198 1199 59 Wedn e s da y 1 8 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 13:00 - 14:00 INDUSTRY-SPONSORED WORKSHOPS HALL 8 THE USE OF MULTIPLEX ASSAYS FOR DETERMINING PREDISPOSITION TO HYPERTENSION Chair: J. Lamont (United Kingdom) 13:00 The use of multiplex assays for determining predisposition to hypertension S. Visvikis-Siest (France) HALL 14.2 NOVEL MARKERS IN REPRODUCTIVE ENDOCRINOLOGY Chair: J. Barth (United Kingdom) 13:00 Anti-Müllerian hormone: A market of ovarian reserve R. Anderson (United Kingdom) 13:20 Anti-Müllerian hormone: Does it have a role in polycystic ovarian syndrome? J. Barth (United Kingdom) 13:40 New biomarker of pre-eclampsia V. Tsatsaris (Paris) HALL 7 VITAMIN D AND B12 – IMMUNOASSAYS IN PREVENTIVE MEDICINE Chair: S. Lorenz 13:00 Recommendations on Vitamin D testing and an analytical evaluation of the ARCHITECT 25-OH Vitamin D assay E. Cavalier (Belgium) 13:30 Clinical implications and methods to detect early development of Vitamin B 12 deficiency? W. Hermann (Germany) 60 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 INDUSTRY-SPONSORED WORKSHOPS HALL 4/5 WORK AREA MANAGEMENT: THE ULTIMATE PRODUCTIVITY TOOL Chair: O. Hauss (Germany) 13:00 Work Area Management: The ultimate productivity tool A. Henley (United Kingdom), C. Whittington (United Kingdom) HALL 9 F reelite TM AND H evylite TM IN MONOCLONAL GAMMOPATHIES: IMPROVING DIAGNOSIS, MONITORING AND PROGNOSIS ASSESSMENT Chair: M.L. Villar (Spain) 13:00 Free light chain measurement in serum – Clinical use and laboratory handling G. Merlini (Italy) 13:20 Why serum free light chain testing is critical in patients with renal impairment C. Hutchison (United Kingdom) 13:40 Heavy/Light chain antibodies for monitoring and prognostication in patients with myeloma A. Bradwell (United Kingdom) We dne s da y 1 8 May 13:00 - 14:00 HALL 10 VITAMIN D DIETARY REFERENCE INTAKES: IMPLICATIONS AND SIGNIFICANCE IN CLINICAL PRACTICE 13:00 Vitamin D dietary reference intakes: Implications and significance in clinical practice B. Hollis (USA), S. Pilz (Austria), R. Vieth (Canada) 61 Wedn e s da y 1 8 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 14:15 - 15:15 INDUSTRY-SPONSORED WORKSHOPS HALL 14.2 PERSONALISED HEALTHCARE AS A KEY DRIVER FOR PRESENT AND FUTURE DIAGNOSTIC/THERAPEUTIC STRATEGIES Chair: A. Stief (Germany) 14:15 Roche strategy for PHC T. Gutjahr (Switzerland) 14:35 Biomarkers for management of breast cancer and other tumors J. Rüschhoff (Germany) HALL 4/5 A NEW PROSPECTIVE FOR THE AUTOMATION OF CLINICAL CHEMISTRY TESTING Chair: C. Kostner (Germany) 14:15 respons® 910: A multipurpose clinical chemistry system R. Schenk (Germany) 14:35 Hands-on experience with respons® 910 during external evaluation M.M. Stratmann (Germany) 14:55 Photometric determination of electrolytes – The alternative to ISE S.Meyer (Germany) 62 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 PARALLEL SESSIONS Symposium 15 HALL 1 N E W D E V E L O P M E N T S I N H A E M O S TA S E O L O G Y Chairs: N. Majkic-Singh (Serbia), U. Walter (Gerrmany) 14:30 Coagulation factor XIII deficiency L. Muszbek (Hungary) 14:55 Genetics and epidemiology of thrombophilia F.R Rosendaal (The Netherlands) 15:20 Platelets U. Walter (Germany) 15:45 Monitoring of anticoagulant therapy B. Lämmle (Switzerland) 16:10 Detection of an additional, newly detected polymorphism in the factor V gene with a heterozygous factor V Leiden genotype showing a normal APC-resistence test result F. Prüller (Austria) 16.20 Direct thrombin-inhibitors lead to underestimation of thrombotic risk by influencing functional APC-resistance testing L. Loacker (Austria) We dne s da y 1 8 May 14:30 - 16:30 Symposium 16 HALL 3 CONTRIBUTION OF LABORATORY MEDICINE IN LEUKAEMIA Chairs: P. Schuff-Werner (Germany), O. Zinder (Israel) 14:30 Acute myeloid leukemia: Molecular diagnostics and MRD A. Neubauer (Germany) 14:55 Identification of prognostic subgroups in acute leukemia by novel phenotypic patterns and MDR assay J. Kappelmayer (Hungary) 15:20 Diagnosis of AML between morphology and next generation sequencing T. Haferlach (Germany) 15:45 Myeloproliferative neoplasia: Diagnostic tools for classification and therapy guidance J. Westermann (Germany) 16:10 A rapid bacterial-based bioluminescent assay for in vitro testing of chemotherapy sensitivity J.V. Lamont (Ireland) 16:20 Endogenous colony growth predicts for a less pronounced molecular response to Imatinib therapy in patients with chronic myeloid leukemia E. Einwallner (Austria) 63 Wedn e s da y 1 8 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 14:30 - 16:30 PARALLEL SESSIONS Workshop 9 HALL 8 14:30-16:00 W H AT PA P E R S W I L L B E P R E F E R R E D I N T H E F U T U R E R E L AT E D T O L A B O R AT O R Y M E D I C I N E ? EDITORS POINT OF VIEW Chairs: G. Picheth (Brazil) 14:30 Ethical issues involving publications J. Delanghe (Belgium) 15:00 Position in your journal about the peer review? Is there any alternative? M. Plebani (Italy) 15:30 Editors role in improving laboratory science N. Rifai (USA) Symposium HALL 7 A SCIENTIFIC APPROACH TO THE POST-ANALYTICAL PHASE Chairs: E. Ajzner (Hungary), D. Rogic (Croatia) 14:30 Biological variation data: the need for appraisal of the evidence base B. Bartlett (United Kingdom) 15:00 Reflective testing - Is there evidence that it is worthwhile and for which clinical problems? W. Oosterhuis (The Netherlands) 15:30 Post-analytical external quality assessment - A way to assess test requesting and interpretation? S. Sandberg (Norway) 16:00 Postanalytical errors in lipid & lipoprotein testing M. Langlois (Belgium) 64 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 PARALLEL SESSIONS Symposium HALL 9 R E S E A R C H F U N D I N G B Y T H E F O U N D AT I O N O F PAT H O B I O C H E M I S T R Y A N D M O L E C U L A R D I A G N O S T I C S O F THE DGKL – 10 YEARS ON Chair: K. Lackner (Germany), J. Thiery (Germany) 14:30 Immunoprofiling of the new variable immunoreceptor of neutrophils in acute systemic inflammation W. Kaminski (Germany) 15:00 Pathogenesis of the antiphospholipid syndrome N. Prinz (Germany) 15:30 Role of protease signalling in vascular disease B. Isermann (Germany) 16:00 Sphingoid bases – A new class of biomarkers? T. Hornemann (Switzerland) Simultaneous translation from German to English will be provided Interactive Session HALL 10 C H A L L A N G E S AT T H E C L I N I C A L I N T E R FA C E S We dne s da y 1 8 May 14:30 - 16:30 Chair: B. Croal (United Kingdom) 14:30 Interpretative paradigm 1: Endocrinology case D. Freedman (United Kingdom) 15:00 Interpretative paradigm 2: Water and electrolytes case A.R. Horvath (Australia) 15:30 Interpretative paradigm 3: Toxicology case M. Hallworth (United Kingdom) 16:00 Interpretative paradigm 4: Diabetes case E. Kilpatrick (United Kingdom) A voting system will be provided. This session will allow delegates to interact with the speaker and make the session an active one! 65 Wedn e s da y 1 8 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 15:30 - 16:30 INDUSTRY-SPONSORED WORKSHOPS HALL 14.2 CURRENT AND FUTURE PERSPECTIVES IN DRUGS OF ABUSE SCREENING; THE MULTIPLEX APPROACH Chair: C. Johnston (United Kingdom) 15:30 The evaluation of the first meprobamate, zopiclone, zolpidem and zaleplon antibodies using biochip multiplexing technology from Randox in plasma, serum and whole blood J.-C. Alvarez (France) 16:00 Drugs of abuse testing in the routine laboratory; multiplex screening for urine drugs of abuse assays C. Johnston (United Kingdom) HALL 4/5 TRACEABILITY AND UNCERTAINTY OF CATALYTIC ACTIVITY MEASUREMENTS Chair: F.-J. Gella (Spain) 15:30 Uncertainty of the primary reference systems chemistry system F. Canalias (Spain) 15:55 Traceability and uncertainty of the values assigned to commercial calibrators F.-J. Gella (Spain) 16:10 Traceability and uncertainty of the patient measured values X. Fuentes-Arderiu (Spain) 66 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 8:00-9:30 Room 47 EFCC WG-A/ISO Chair. W. Huisman 14:30-17:30 Room 48 EFCC WG-CM Chair. P. Laitinen 8:00-11:00 Room 48 IFCC WG-POCT Chair. R. Tirimacco 14:30-17:30 Room 49 IFCC TF-INTLN Chair: I. Watson 8:00-11:00 Salon 20 IFCC WG-CDT Chair. F. Schellenberg 14:30-17:30 Salon 20 IFCC WG-CDT - Open Meeting Chair. F. Schellenberg 9:00-11:00 Room 49 EFCC WG-CS Chair. J. Delanghe 9:30-11:00 Room 47 EFCC WG-IVD Chair: JC. Libeer 11:30-14:00 Room 48 DGKL - VDGH Executive Boards We dne s da y 1 8 May CLOSED MEETINGS 14:30-17:00 Room 47 IFCC WG-LEPS Chair. M. Plebani 67 Thu rs da y 1 9 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 9:00 - 11:00 PARALLEL SESSIONS Symposium 17 HALL 1 NEW STRATEGIES IN MOLECULAR DIAGNOSTIC Chairs: C. Mannhalter (Austria), K. Psarra (Greece) 9:00 DNA melting analysis: From fundamentals to practical applications C. T. Wittwer (USA) 9:25 Quality assurance and quality control in the routine molecular diagnostic laboratory H. Kessler (Austria) 9:50 Next generation sequencing in leukemia diagnostics A. Kohlmann (Germany) 10:15 High throughput qPCR expression profiling, from tissue samples to single cells M. Kubista (Sweden) 10:40 Centrifugal microfluidic platforms for molecular diagnostics D. Mark (Germany) 10:50 Lanthanide chelate complementation in homogeneous well-based four-plex nucleic acid array U. Karhunen (Finland) Symposium 18 HALL 3 STARDARDIZATION AND QUALITY CONTROL ISSUES IN EMERGING AND DEVELOPING COUNTRIES Chairs: G. Shannan (Syria), V. Steenkamp (South Africa) 9:00 Analytical quality in the Latin America area G. Migliarino (Argentina) 9:25 Quality assurance programs in Arab countries F. Harb (Syria) 9:50 Standardization and quality control issues in emerging and developing countries E. Frank (India) 10:15 Current status of quality management in laboratory medicine in China S. Hong (China) 10:40 Stabilizing leukocytes enables global implementation of an external quality control for HIV-monitoring C. Prante (Germany) 68 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Thurs da y 1 9 May 9:00 - 11:00 PARALLEL SESSIONS Workshop 10 HALL 8 9:00-10:30 S TA N D A R D I Z AT I O N O F C O M P L E X A N A LY T E M E A S U R E M E N T S : THE CLINBIOTRACE PROJECT Chairs: H. Parkes (United Kingdom) 9:00 The case of human growth hormone: measurement limitations and desirable performance for clinical use M. Bidlingmaier (Germany) 9:30 Making laboratory medicine results comparable: Understanding the measurements H. Schimmel (Germany) 10:00 Novel mass spectrometry approaches to detect structural variability in clinically useful proteins: Impact on the implementation of reference systems G. O'Connor (United Kingdom) Symposium 19 HALL 14.2 CURRENT CHALLANGES IN THE PEDIATRIC LABORATORY Chairs: H. Reguengo (Portugal), K. Tomberg (Estonia) 9:00 The immature platelet fraction as a novel dynamic cellular parameter for predicting and monitoring the course of neonatal thrombocytopenia A. Weimann (Germany) 9:25 Laboratory markers for differential diagnosis of bacterial and viral infections in children with fever N. Mayansky (Russia) 9:50 Childhood metabolic syndrome: Pathophysiology and laboratory assessment K. Adeli (Canada) 10:15 Diagnostic, prognostic and therapeutic relevance of assay of B-type natriuretic hormone and related peptides in children with congenital heart diseases M. Cantinotti (Italy) 10:40 Pediatric normative data on Abbott, Roche, and Ortho Clinical chemistry systems: Instrument agreement and equivalence determination utilizing pediatric samples A.A. Venner (Canada) 10:50 The use of procalcitonin in early diagnosis V. Santos (Portugal) 69 Thu rs da y 1 9 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 9:00 - 11:00 PARALLEL SESSIONS Symposium HALL 7 S TA N D A R D I Z AT I O N O F T H E P R E - A N A LY T I C A L P H A S E F O R BIOMARKERS Chairs: G. Lippi (Italy), A.M. Simundic (Croatia) 9:00 Standardization and improvement of generic pre-analytical tools and procedures for in-vitro diagnostics U.Oelmueller (Germany) 9:30 Pre-analytical parameters impacting on tissue-based biomarkers K. Zatloukal (Austria) 10:00 Pre-analytical aspects of the Carmague study. Adherence to the AMI and CHF guidelines P. Laitinen (Finland) 10:30 Evidence-based quality guidelines for the pre-analytical phase of blood samples M. Pazzagli (Italy) Symposium 20 HALL 4/5 VITAMIN D: MYTH OR MAGIC Chairs: R. Bais (Australia), V. Palicka (Czech Republic) 9:00 Vitamin D requirements for health H. Bischoff-Ferrari (Switzerland) 9:25 A new paradigm for vitamin D activity in bone: Autocrine/paracrine actions H. Morris (Australia) 9:50 Biochemistry and metabolism of vitamin D G. Jones (Canada) 10:15 25-Hydroxyvitamin D assays - Are they fit for purpose? G. Carter (United Kingdom) 10:40 Vitamin D in problem oriented request panel “vague complaints” I.C.A. Munnix (The Netherlands) 10:50 Abbott Architect 25-OH vitamin D assay compared against LC-MS/MS J. Bailey (United Kingdom) 70 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 PARALLEL SESSIONS IFCC-WASPaLM Workshop 10 HALL 9 C H R O N I C K I D N E Y D I S E A S E - D E V E L O P I N G A N AT I O N A L TESTING PROGRAM Chairs: M. Oellerich (Germany) 9:00 A global clinical perspective F. Alcantara (Brazil) 9:30 Why a national program for CKD testing? D. Seccombe (Canada) 10:00 Key factors in successful national CKD programs G. Jones (Australia) W o r k s h o p 11 HALL 10 9:00-10:30 BIOMARKERS OF ACUTE AND NEURODEGENERATIVE BRAIN DAMAGES Chairs: J.L. Beaudeaux (France) 9:00 Diagnosis values of biomarkers for Alzheimer’s disease S. Lehmann (France) 9:30 No future for CSF Alzheimer’s disease biomarkers without standardization of preanalytical steps A. Perret-Liaudet (France) 10:00 Cerebrospinal fluid biomarkers for the diagnosis/prognosis of neurological diseases I. Quadrio (France) Thurs da y 1 9 May 9:00 - 11:00 71 Thu rs da y 1 9 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 11:30-12:45 PLENARY SESSION HALL 1 NEW AVENUES IN LABORATORY DIAGNOSTICS Chairs: T. Ozben (Turkey), H. Renz (Germany) 11:30 Development and clinical implementation of next generation sequencing for multi-gene diagnostic panels K.V Voelkerding (USA) K.V Voelkerding received his medical degree from the University of Cincinnati College of Medicine in 1983. He subsequently pursued postgraduate training in molecular biology and clinical pathology. From 1990 to 2000, Dr. Voelkerding was a faculty member in the Department of Pathology and Laboratory Medicine at the University of Wisconsin-Madison. Currently, Dr. Voelkerding is an Associate Professor of Pathology at the University of Utah and Medical Director for Advanced Technology and Bioinformatics at the ARUP Laboratories. Dr. Voelkerding's presentation will cover technical and bioinformatic approaches coupled with clinical examples of multi-gene diagnostics. 11:55 Mass Spectrometry: Its future in several disciplines of laboratory medicine D.F. Hochstrasser (Switzerland) D.F. Hochstrasser is the chairman of the Genetic & Laboratory Medicine Department of the Geneva University Hospital and Vice Dean of the Faculty of Medicine, University Geneva, Switzerland. He is also Head of the Laboratory Medicine Division of the Geneva University Hospital, Switzerland's largest acute hospital. He still practices as a Board certified physician. At the academic level, he is Full Professor both to Geneva's Department of Structure Biology & Bioinformatics, Medicine Faculty and to the School of Pharmacy, Sciences Faculty. His research focus is on the discovery of clinical biomarkers in brain, pancreas and kidney diseases, on human toxicology and the development of proteomic & clinical chemistry related technologies. 12:20 Proteomics strategies looking into cardiovascular disease. Disrupted signalling pathways as biomarkers A. J.R. Heck (The Netherlands) Since 1998 Albert Heck is Full Professor at Utrecht University at the Science Faculty in the Netherlands. He is scientific director of The Netherlands Proteomics Centre (since 2003) and the Bijvoet Centre for Biomolecular Research (since 2006). In 2001 he was recipient of the Golden Medal of the Dutch Royal Chemical Society. In 2004 he received an honoree Utrecht University “ABC”-professorship and in 2010 he was guest-professor at the ETH Zürich. He has published more than 300 papers in internationally reviewed journals. The Heck laboratory has a track record in proteomics and especially in the analysis of protein post-translational modifications and quantitative proteomics. He introduced and developed TiO2 as enrichment material for the targeted analysis of phosphopeptides. For quantitative proteomics, the group introduced metabolic stable isotope labeling in multicellular organisms such as Drosophila and C. elegans, and stable isotope labeling by using chemical approaches. Amongst the broad biomedical interest of the group are embryonic and adult stem cells and chemical proteomics approaches in a cardiovascular context. 72 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 INDUSTRY-SPONSORED WORKSHOPS HALL 8 ADDING VALUE TO LABORATORY MEDICINE Chair: G. Beastall (United Kingdom) 13:00 Introduction of new program mission B. Luna (USA) 13:20 Good Practices: An example of UK National Pathology Week S. Jarvis (United Kingdom) 13:40 Good Practices: Connecting with Key Stakeholders G. Beastall (United Kingdom) HALL 9 LC/MS IN THE CLINICAL LABORATORY - TRANSITION FROM A RESEARCH TOOL TO ROUTINE CLINICAL LABORATORY USE Chair: K. Khan (United Kingdom) 13:00 Implementing LC/MS/MS for therapeutic drug monitoring A 10 year review from a routine clinical laboratory perspective M. Vogeser (Germany) 13:30 Experiences of running a routine clinical service for 25-OH vitamin D using a semiautomated LC/MS/MS L. Perry (United Kingdom) Thurs da y 1 9 May 13:00 - 14:00 73 Thu rs da y 1 9 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 14:30 - 16:30 PARALLEL SESSIONS Symposium 21 HALL 1 N E W T E C H N O L O G I E S I N C L I N I C A L A P P L I C AT I O N Chairs: S. Sandberg (Norway), O. Wagner (Austria) 14:30 NMR-spectroscopy in the diagnosis of metabolic diseases R. Wevers (The Netherlands) 14:55 Strategies for protein quantification by integrated elemental and molecular mass spectrometry Q. Wang (China) 15:20 Screening, identifying and quantifying small molecules by hyphenated mass spectrometry in toxicology & drug monitoring H. Maurer (Germany) 15:45 Recent developments in the biology and applications of plasma nucleic acids D. Lo (China) 16:10 Quantification of blood folate forms using stable-isotope dilution ultra performance liquid chromatography tandem mass spectrometry S.H. Kirsch (Germany) 16:20 Lanthanide chelate complementation for highly sensitive protein detection T. Riuttamäki (Finland) Symposium 22 HALL 3 INTERTWINING EMERGENCY MEDICINE AND LABORATORY MEDICINE Chairs: J. Smith (United Kingdom), H. van Pelt (The Netherlands) 14:30 Medical emergencies: What is the laboratory’s role? D.S. Young (USA) 14:55 What should the clinical laboratory and the toxicologist-pharmacologist offer the poisoned patient? D.R. A. Uges (The Netherlands) 15:20 The clinical laboratory and acts of chemical or biological terrorism… Can we be prepared? M. D. Kellogg (USA) 15:45 Laboratory resources needed to address unanticipated disasters C. Kosack (The Netherlands) 16:10 Diagnostic and prognostic value of soluble CD14 subtype (sCD14-ST) in emergency patients with early sepsis using the new assay PATHFAST Presepsin E. Spanuth (Germany) 16:20 Usefulness of urinary biomarker NGAL in the management of renal replacement therapy (RRT, hemofiltration) O. Stanger (Austria) 74 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 PARALLEL SESSIONS Workshop 12 HALL 8 14:30-16:00 J O I N T S E S S I O N W I T H I AT D M C T - T R E N D S I N T H E R A P E U T I C DRUG MONITORING: PERSONALIZED IMMUNOSUPPRESSION Chairs: E. Wieland (Germany) 14:30 TDM of immunosuppressants: Current practice and guidelines T. van Gelder (The Netherlands) 15:00 Use of endogenous biomarkers to achieve personalized immunosuppression in transplant recipients M. Oellerich (Germany) 15:30 Impact of pharmacogenetics to optimize immunosuppressive therapy I. MacPhee (United Kingdom) Symposium HALL 7 TRACEABILITY, STANDARDIZATION, HARMONIZATION: CONCEPTS AND IMPLEMENTATION Chairs: P. Gillery (France) Thurs da y 1 9 May 14:30 - 16:30 14:30 Traceability in laboratory medicine: A review of the international activities A. Kessler (Germany) 15:00 Standardization versus harmonization L. Siekmann (Germany) 15:30 Traceability, standardization, harmonization: Concepts and implementation for heterogeneous analytes L. Thienpont (Belgium) 16:00 Implementation of standardization in clinical practice: Not always an easy task M. Panteghini (Italy) 75 Thu rs da y 1 9 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 14:30 - 16:30 PARALLEL SESSIONS Workshop 13 HALL 9 14:30-16:00 V I TA M I N D E F I C I E N C Y I N E L D E R LY P E O P L E : D I A G N O S I S , P R E V E N T I O N A N D E F F E C T O N A G E - R E L AT E D D I S E A S E S Chairs: W. Hermann (Germany) 14:30 B-Vitamins and neurodegeneration R. Obeid (Germany) 15:00 Vitamin D and cardiovascular disease: A review of the epidemiological and clinical evidence R. Scragg (New Zealand) 15:30 Vitamin K and bone health M.J. Shearer (United Kingdom) Workshop 14 HALL 10 14:30-16:00 NOVEL INSIGHTS IN IRON METABOLISM: IMPLICATIONS FOR DIAGNOSTIC MEDICINE Chairs: D.W. Swinkels (The Netherlands) 14:30 Newly identified inherited disorders of iron metabolism R. Fleming (USA) 15:00 Anemia of chronic disease: Markers for diagnosis and treatment monitoring G. Weiss (Austria) 15:30 Hepcidin-25, a new biomarker for differentiation of iron-restricted erythropoiesis L. Thomas (Germany) 76 I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 HALL 1 CLOSING CEREMONY 16:30 Congress Presidents Rudolf Tauber, Harald Renz 16:40 Welcome to Milano President of the EuroMedLab Milano 2013 Mauro Panteghini 16:50 Welcome to Istanbul President of the IFCC WorldLab Istanbul 2014 Nazmi Ozer 17:00 Closing remarks IFCC / EFCC / DGKL Presidents Graham Beastall, Rita Horvath, Karl Lackner 17:30 Farewell Istanbul Party Thurs da y 1 9 May 16:30 - 17:30 See you in Istanbul 2014 77 Thu rs da y 1 9 Ma y I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 CLOSED MEETINGS 8:00-11:00 Room 47 IFCC TF-PG Chair. R. van Schaik 14:30-15:30 Room 48 IFCC WG-cMSP Chair: S. Lehman 8:00-11:00 Room 48 EFCC WG-PEQA Chair: S. Sandberg 14:30-17:30 Room 47 IFCC TF-CKD Chair: G. Jones 78 Visit us at IFCC - EuroMedLab Hall 15 / Booth 15-01a $! !& " ! "!"% !# !# We invite you to attend our workshop : TLA - The "Lean" Alternative Tuesday, May, 17 - 16:45 - 17:45 - Hall 8 Presented by Mick CHOMYN & Martin FOTTLES (Path Links Pathology - UK) Speak e rs & Cha i r s I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Adeli Khosrow (page 69) The Hospital for Sick Children, University of Toronto, Canada khosrow.adeli@sickkids.ca Beaudeux Jean-Louis (pages 53; 59; 71) Department of Clinical Biology, Charles Foix Hospital, Paris, France jean-louis.beaudeux@cfx.aphp.fr Aguzzi Adriano (page 57) Institute of Neuropathology, Zurich University, Switzerland adriano.aguzzi@usz.ch Becker Stefan (page 35) Institut fur Virologie, Philipps Universitat Marburg, Germany becker@staff.uni-marburg.de Ajzner Eva (page 64) University of Debrecen, Debrecen, Hungary ajzner@gmail.com Benga Gheorghe (page 34) First Laboratory of Genetic Explorations, ClujCounty Clinical Emergency Hospital, Romania gbenga@umfcluj.ro Alcantara Flavio (page 71) Central Laboratory Division, Hosp das Clinicas, University of Sao Paulo, Brazil alcantara@hcnet.usp.br Bidlingmaier Martin (page 69) Medizinische Klinik Innenstadt, LudwigMaximilians University, Munich, Germany Martin.Bidlingmaier@med.uni-muenchen.de Álvarez Menéndez Francisco (page 25) Hospital Universitario Central de Asturias, Oviedo, Spain falvarezmen@gmail.com Bieber Thomas (page 55) Universitäts-Klinikum Bonn, Germany Thomas.Bieber@ukb.uni-bonn.de Anderson Leigh (page 16) Plasma Proteome Institute, Washington, USA leighanderson@plasmaproteome.org Bischoff-Ferrari Heike (page 70) University of Zurich, Switzerland Heike.Bischoff@usz.ch Apple Fred (page 16) Hennepin County Medical Center and University of Minnesota, Minneapolis, USA apple004@umn.edu Blankenberg Stefan (page 15) University Medical Center Mainz, Dept. of Medicine II, Germany stefan.blankenberg@unimedizin-mainz.de Aufenanger Johannes (page 27) Institut fur Laboratoriumsmedizin, Klinikum Ingolstadt, Germany johannes.aufenanger@klinikum-ingolstadt.de Blaton Victor (page 16) Department of Clinical Chemistry, Brugge, Belgium victor.blaton@skynet.be Bais Renze (page 40; 70) Pacific Laboratory Medicine Services Pathology North, Sydney, Australia rbais@med.usyd.edu.au Blum Hubert (page 15) Universitäts-Klinikum Freiburg, Germany Hubert.blum@uniklinik-freiburg.de Bartlett Bill (page 64) Blood Sciences, Diagnostics Group, Ninewells Hospital and Medical School, NHS Tayside, Dundee, UK b.bartlett@dundee.ac.uk Bauersfeld Walter (page 18) Zentrallabr, KKH Lörrach, Germany bauersfeld.walter@klinloe.de Beastall Graham H. (page 19) Department of Clinical Biochemistry, Macewen Building Royal Infirmary, Glasgow, UK gbeastall@googlemail.com 80 Boivin Guy (page 46) Laval University, Quebec City, Canada guy.boivin@crchul.ulaval.ca Bossuyt Patrick (page 26) University of Amsterdam, The Netherlands p.m.bossuyt@amc.nl Boyd Jim (page 45) Dept. of Pathology, University of Virginia Health System, Charlottesville, USA jboyd@virginia.edu Brand Angela (page 37) Institute for Public Health Genomics CIPHal, Maastricht University, The Netherlands a.brand@phg.unimaas.nl I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Cross Anne H. (page 53) Washington University School of Medicine, Saint Louis, USA crossa@neuro.wustl.edu Bunk David (page 37) Analytical Chemistry Division, NIST, Gaithesburg, USA david.bunk@nist.gov Delanghe Joris (pages 34; 64) Ghent University Hospital, Ghent, Belgium joris.delanghe@ugent.be Cantinotti Massimiliano (page 69) Hearth Hospital Massa, National Institute Research, Massa, Italy massimiliano.cantinotti@ifc.cnr.it Dick Wolfgang (page 18) Staedtische Kliniken Neuss Zentrallabor, Neuss, Germany Wolfgang_Dick@lukasneuss.de Carayon Pierre (page 21; 44) Marseille Medical School and Mediterranean University Hospital, Marseille, France pierre.carayon@univmed.fr Domann Eugen (page 56) Institut für Medizinische Mikrobiologie, Molekulare Diagnostik, Frankfurt, Germany eugen.domann@mikrobio.med.uni-giessen.de Carter Graham (page 70) Charing Cross Hospital, London, UK b.carter1@which.net ElGarf Wael (page 26) National Research Center, Medical Research Division-Reproductive Health Department, DokkiCairo, Egypt elgarfw@gmail.com Casadesus Smith Gemma (page 53) Case Western Reserve University, Cleveland, USA gxc40@case.edu Cavalier Etienne (page 44) University of Liege, Chu Sart-Tilman, Belgium Etienne.cavalier@chu.ulg.ac.be Ceriello Antonio (page 35) Insititut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Antonio.Ceriello@hotmail.it Ceriotti Ferruccio (pages 15; 21; 53) Diagnostica & Ricerca, San Raffaele, Milano, Italy ceriotti.ferruccio@hsr.it Choudhury Robin (page 15) University of Oxford, Oxford, United Kingdom robin.choudhury@cardiov.ox.ac.uk Christenson Robert (page 15) University of Maryland, School of Medicine, Baltimore, USA rchristenson@umm.edu Comabella Manuel (page 57) Centre d’Esclerosi Multiple de Catalunya, Hospital Universitari, Barcelona, Spain mcomabel@vhebron.net Croal Bernie (pages 18; 65) NHS Grampian, Aberdeen, United Kingdom bernie.croal@nhs.net Ferrari Maurizio (page 37) Vita-Salute San Raffaele University, Milan, Italy Ferrari.maurizio@hsr.it S pe a k e rs & Chairs Bruns David (page 34) University of Virginia, Charlottesville, USA dbruns@virginia.edu Fleming Robert (page 76) Saint Louis University, School of Medicine, USA flemingr@slu.edu Frank Elisabeth (page 68) Bio Chem Diagnostics Pvt, Mysore, India anet21frank@yahoo.com Freedman Danielle B. (page 65) Clinical Biochemistry Luton and Dunstable Hospital, Luton, United Kingdom Danielle.Freedman@ldh.nhs.uk Ganten Detlev (page 12) Charité, Universitätsmedizin Berlin, Berlin, Germany detlev.ganten@charite.de Gässler Norbert (page 18) Zentrum für Labordiagnostik, Hildesheim, Germany n.gaessler@bernward-khs.de Gay Steffen (page 25) Dept. Rheum, University Hospital, Zurich, Switzerland steffen.gay@usz.ch Gerlich Wolfram (page 15) Institute for Medical Virology, Justus Liebig University, Giessen, Germany wolfram.gerlich@viro.med.uni-giessen.de 81 Speak e rs & Cha i r s I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Gillery Philippe (pages 25; 75) University Hospital of Reims, France pgillery@chu-reims.fr Harmsen Dag (page 35) University Munster, Germany dag.harmsen@ukmuenster.de Giroud Claude (page 46) Bio-Rad, France Claude.Giroud@bio-rad.com Haushofer Alexander (page 27) Hospital St. Poelten, St. Poelten, Austria Alexander.Haushofer@stpoelten.lknoe.at Goldsmith Barbara (page 44) Clinical and Laboratory Standards Institute (CLSI), Pennsylvania, Wayne, USA bgoldsmith@clsi.org Heck Albert J.R. (page 72) Utrecht University, Biomolecular Mass Spectrometry and Proteomics Group, The Netherlands a.j.r.heck@chem.uu.nl Gouget Bernard (page 15; 58) Fédération Hospitalière de France, Paris, France b.gouget@fhf.fr Greenberg Neil (page 17) Clinical Laboratory Products, Ortho-Clinical Diagnostics, Inc., Rochester, NY, USA ngreenbe@ocdus.jnj.com Griesmacher Andrea (page 27) Centre Institute of Medical and Chemical Laboratory Diagnostics, University Hospital of Innsbruck, Austria andrea.griesmacher@uki.at Gronowski Ann (page 25) Washington University School of Medicine, St. Louis, Missouri, USA gronowski@wustl.edu Grubb Anders (page 17) Department of Clinical Chemistry, University Hospital, Lund, Sweden anders.grubb@med.lu.se Haferlach Torsten (page 63) MLL Munich Leukemia Laboratory, Munich, Germany Torsten.haferlach@mll.com Haining W. Nicholas (page 38) Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA nicholas_haining@dfci.harvard.edu Hallaj Zuhair (page 26) World Health Organization, Cairo, Egypt hallajz@emro.who.int Hallworth Michael (page 65) Dept. Clinical Biochemistry, Royal Shrewsbury Hospital, Shrewsbury, United Kingdom mike.hallworth@sath.nhs.uk Harb Fouad (page 68) Arab Fed. of Clinical Chemistry, Damascus, Syria fouad.harb@scs-net.org 82 Helsens Kenny (page 56) Computational Omics and Systems Biology Group, Department of Medical Protein Research, Universiteit Gent, Belgium kenny.helsens@ugent.be Heneghan Carl (page 26) Dept. of Primary Health Care and Directory Centre for Evidence-Based Medicine, Oxford, United Kingodm carl.heneghan@dphpc.ox.ac.uk Herrmann Wolfgang (page 40; 76) Medical School, Saarland University, Homburg, Germany w-herrmann@gmx.de Hicks Jocelyn J.M. (page 54) George Washington University Medical Center, Washington, USA hicksjmb@gmail.com Hiemke Christoph (page 34) Department of Psychiatry and Psychotherapy, University Medical Center, Mainz, Germany hiemke@mail.uni-mainz.de Hochstrasser Denis F. (page 72) Hopitaux universitaires de Genéve, Switzerland denis.hochstrasser@unige.ch Holick Michael F. (page 34) Boston University Medical Center, Boston, USA mfholick@bu.edu; lorrie@bu.edu Hong Shang (page 66) First Hospital, China Medical University, Shenyang, China hongshang100@hotmail.com Hoppe Berthold (page 58) Institute of Transfusion Medicine, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Germany berthold.hoppe@charite.de I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Horvath Andrea Rita (pages 26; 38; 65) Seals Department Clinical Chemistry, Prince of Wales Hospital, Sydney, Australia rita.horvath@sesiahs.health.nsw.gov.au Huber Andreas R. (pages 27; 36) Kantonsspital, Aarau, Switzerland andreas.huber@ksa.ch Hubmann Michael (page 45) Medizinisches Zentrallaboratorium, Feldkirch, Austria mhubmann@mzl.at Huestis Marilyn (page 16) National Institute on Drug Abuse, Baltimore, USA mhuestis@intra.nida.nih.gov Huisman Wim (page 46) Clinical Chemistry Laboratory, Medical Center Haaglanden, Den Haag, The Netherlands w.huisman@mchaaglanden.nl Ichihara Kiyoshi (page 45; 59) Yamaguchi University Graduate School of Medicine, Faculty of Health Sciences, Ube, Japan ichihara@yamaguchi-u.ac.jp Isermann Berend (page 65) Universitatsklinikum Heidelberg, Heidelberg, Germany Berend.Isermann@med.uni-heidelberg.de Jacobs Ellis (page 17) New York University, School of Medicine, USA Ellis.Jacobs@nyumc.org Jansen Rob (page 46) SKML, Nijmegen, The Netherlands rjansen@skml.nl John W. Garry (page 25) Clinical Biochemistry Norfolic and Norwich University Hospital, Norwich, United Kingdom g.john@nnuh.nhs.uk Jones Graham (pages 17; 71) St Vincents Hospital, Sydney, Australia gjones@stvincents.com.au Jones Glenville (page 70) Department of Biochemistry Queen's University, Kingston, Canada gj1@queensu.ca Kaminski Wolfgang (page 65) Institute for Clinical Chemistry, University of Hedelberg, Mannheim, Germany Wolfgang.Kaminski@umm.de Kappelmayer Janos (page 63) University of Debrecen, Hungary kappelmayer@med.unideb.hu Kappert Kai (page 21) Zentralinstitut für Laboratoriumsmedizin Charité, Berlin, Germany kai.kappert@charite.de Katus Hugo A. (page 37) University Hospital Heidelberg Internal Medicine, Internal III Cardiology, Germany Hugo.Katus@med.uni-heidelberg.de Keith W. Nicol (page 19) Institute of Cancer Sciences, Glasgow University, United Kingdom n.keith@beatson.gla.ac.uk Kellogg Mark D. (page 74) Children's Hospital Boston, USA mark.kellogg@childrens.harvard.edu Kelso Anne (page 46) WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Australia anne.kelso@influenzacentre.org S pe a k e rs & Chairs Hornemann Thorsten (page 65) Inst. fur Klinische Chemie, Zurich, Switzerland thorsten.hornemann@usz.ch Kessler Anja (page 75) Reference Institute of Bioanalytics, Bonn, Germany anja.kessler@uni-bonn.de Kessler Harald (page 68) Medical University of Graz, Graz, Austria harald.kessler@medunigraz.at Khalil El Taher (page 26) Institute of Endemic Diseases, Medical Sciences Campus, Khartoum, Sudan eltahirk@iend.org Kiehntopf Michael (page 20; 37; 39) Institut für Klinische Chemie und Laboratoriumsdiagnostik, Jena, Germany michael.kiehntopf@med.uni-jena.de Kilpatrick Eric S. (pages 18; 65) Dept. of Clinical Biochemistry, Hull Royal Infirmary, United Kingdom Eric.Kilpatrick@hey.nhs.uk 83 Speak e rs & Cha i r s I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 King May-Jean (page 36) International Blood Group Reference Laboratory, NHS Blood & Transplant, Bristol, UK may-jean.king@nhsbt.nhs.uk Lam Christopher W.K (page 55) Macau Institute for Applied Research in Medicine and Health, Taipa, Macau wklam@must.edu.mo Klakow-Franck Regina (page 27) Bundesärztekammer, Berlin, Germany Regina.Klakow-Franck@baek.de Lämmle Bernhard (pages 27; 63) Universitätklinik fur Haematologie, Inselspital, Bern, Switzerland bernhard.laemmle@insel.ch Klouche Mariam (pages 17; 44) Laborzentrum Bremen, Germany mariam.klouche@laborzentrum-bremen.de Knabbe Cornelius (page 21; 39) Institut für Laboratoriums- und Transfusionsmedizin, Universitätsklinik der Ruhr, Bad Oeynhausen, Germany cknabbe@hdz-nrw.de Langlois Michel (page 64) Dept. Laboratory Medicine, Az. St. Jan Hospital, Bruges, Belgium michel.langlois@azsintjan.be Le Roux Carel (page 44) Imperial College London, United Kingdom c.leroux@imperial.ac.uk Kocna Petr (page 17) Charles University, Prague, Czech Republic kocna@lf1.cuni.cz Lehmann Sylvain (page 71) Hopital St. Eloi-Biochimie, Montpellier, France s-lehmann@chu-montpellier.fr Kohlmann Alexander (page 68) MLL Munich Leukemia Laboratory, Munich, Germany alexander.kohlmann@mll.com Libeer Jean-Claude (page 46) EFCC Quality Management Committee, Belgium jclibeer@skynet.be Kohse Klaus (page 54; 59) Klinikum Oldenburg, Germany Kohse.Klaus@klinikum-oldenburg.de Lichtinghagen Ralf (page 18; 21) Hannover Medical School, Institute of Clinical Chemistry, Hannover, Germany lichtinghagen.ralf@mh-hannover.de Koike Takao (page 25) Depart. of Medicine II, Hokkaido University Graduated School of Medicine, Sapporo, Japan tkoike@med.hokudai.ac.jp Kosack Cara (page 74) Medicins sans frontieres, Amsterdam, The Netherlands cara.kosack@amsterdam.msf.org Kubista Mikael (page 68) Tataa Biocenter, Gothenburg, Sweden mikael.kubista@tataa.com Kulasingam Vathany (page 16) University Health Network and University of Toronto, Toronto, Canada vathany.kulasingam@uhn.on.ca Lackner Karl (pages 19; 36; 65) Institute of Clinical Chemistry and Laboratory Medicine, Medical Center of the J.G. University, Mainz, Germany karl.lackner@unimedizin-mainz.de Laitinen Päivi (page 70) Laboratory, Central Ostrobothin Hospital District, Kokkola, Finland paivi.laitinen@oulu.fi 84 Linder Mark (page 34) University of Louisville, School of Medicine, Lousville, USA mwlind01@gwise.louisville.edu Lippi Giuseppe (page 53; 70) U.O. Diagnostica Ematochimica, Azienda Ospedaliero-Universitaria di Parma, Italy giuseppe.lippi@univr.it Little Randie (page 18) University of Missouri, School of Medicine, Columbia, USA littler@health.missouri.edu Lo Dennis (pages 16; 74) The Chinese University of Hong Kong, China loym@cuhk.edu.hk Lopez Joseph (page 39; 55) Mahsa University, Petaling Jaya, Malaysia jblopez@streamyx.com Lyon Andrew (page 17) University of Calgary & Calgary, Lab. Services, Canada andrew.lyon@cls.ab.ca I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Müller Mathias M. (page 38) Austrian Society of Quality Assurance and Standardisation, Wien, Austria mathias.mueller1@chello.at MacPhee Iain (page 75) St. George's, University of London, London, UK imacphee@sghms.ac.uk Müller Michael (page 27) BDL C.V. Oldenburg, Germany m.mueller@medlab-oldenburg.de Majkic-Singh Nada (page 63) Institute of Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia singh@eunet.rs; dmbj@eunet.rs Muszbek László (page 63) University of Debrecen, Medical and Health Science Center, Debrecen, Hungary muszbek@med.unideb.hu Mannhalter Christine (page 68) Medical University Vienna, Dept. Laboratory Medicine, Vienna, Austria christine.mannhalter@meduniwien.ac.at Neubauer Andreas (page 63) Universitatsklinik fur Hematologie, Onkologie, Immunologia, Marburg, Germany neubauer@staff.uni-marburg.de Martins Ralph N. (pages 53; 57) Ageing and Alzheimers, Edith Cowan University, Perth, Australia r.martins@ecu.edu.au Neumaier Michael (pages 16; 37) University Medicine Mannheim, Mannheim, Germany michael.neumaier@medma.uni-heidelberg.de Maurer Hans (page 74) Department of Experimental and Clinical Toxicology, Saarland University, Homburg, Germany hans.maurer@uks.eu Mayansky Nikolay (page 69) Scientific Center for Children's Health, Moscow, Russia mayansky@nczd.ru Meyer Helmut E. (page 56) Ruhr-University of Bochum, Recklinghausen, Germany helmut.e.meyer@rub.de Neurath Markus F. (page 38) Department of Medicine 1, University Hospital Erlangen, Germany markus.neurath@uk-erlangen.de Obeid Rima (page 76) Department of Clinical Chemistry Central Laboratory, University of Saarland, Homburg, Germany rima.obeid@uniklinikum-saarland.de O'Connor Gavin (page 69) Principal Scientist, Mass Spectrometry LGC, United Kingdom GOC@lgc.co.uk Migliarino Gabriel (page 68) GMigliarino Consultores, Buenos Aires, Argentina gmigliarino@gmigliarino.com Oellerich Michael (pages 71; 75) Chemistry, George-August-University, Gottingen, Germany moeller@med.uni-goettingen.de Moraes Figueiredo Luiz Tadeu (page 56) University of Sao Paulo, Ribeirao Preto, Brazil ltmfigue@fmrp.usp.br Oelmueller Uwe (page 70) Qiagen GmbH, Hilden, Germany Uwe.Oelmueller@qiagen.com Morris Howard (page 70) University of South Australia, Adelaide, Australia howard.morris@health.sa.gov.au Ogriseg Martin (page 45) Lab. of Clinical Pathology, Ospital of Brixen, Italy martin.ogriseg@sb-brixen.it Muckenthaler Martina (page 36) Paediatric Oncology, Haematology and Immunology University of Heidelberg, Germany Martina.Muckenthaler@med.uni-heidelberg.de Oldenburg Johannes (page 54) Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Germany johannes.oldenburg@ukb.uni-bonn.de Müller Christian (page 15) Univeritatsspital Basel, Switzerland chmueller@uhbs.ch S pe a k e rs & Chairs Macdonald Rainer (page 45) Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany Rainer.Macdonald@ptb.de Oosterhuis Wytze (page 64) Atrium Medical Center, Heerlen, The Netherlands w.oosterhuis@atriummc.nl 85 Speak e rs & Cha i r s I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Oudejans Cees (page 54; 59) VU University Medical Center, Amsterdam, The Netherlands cbm.oudejans@vumc.nl Platts-Mills Thomas A. E. (page 55) University of Virginia Health system, Charlottesville, USA tap2Z@virginia.edu Ozben Tomris (page 72) Akdeniz University, Medical Faculty, Antalya, Turkey tomris.ozben@unimore.it Plebani Mario (pages 53; 64) University of Padova, Italy mario.plebani@unipd.it Ozer Nazmi (page 17; 58) Hacettepe University, Faculty of Medicine, Department of Biochemistry, Sihhiye-Ankara, Turkey nozertbd@gmail.com Polack Fernando P. (page 46) Vanderbilt University, Hashville, USA Malinez@infant.org.ar Palicka Vladimir (page 70) Charles University, Prague, Czech Republic palicka@lfhk.cuni.cz Panteghini Mauro (pages 45; 75) University of Milan, Milan, Italy mauro.panteghini@unimi.it Pantel Klaus (page 16) Universitatklinikum Hamburg, Hamburg, Germany pantel@uke.uni-hamburg.de Parkes Helen (page 69) LGC LTD, Teddington, United Kingdom helen.parkes@lgc.co.uk Payne Deborah (page 55) American Pathology Partners - Unipath LLC, Denver, USA dpayne@unipathllc.com Pazzagli Mario (pages 55; 70) University of Florence, Italy m.pazzagli@dfc.unifi.it Perret-Liaudet Armand (page 71) Hospices Civils de Lyon, France armand.perret-liaudet@chu-lyon.fr Perschel Frank Holger (pages 40; 58) Charité, Universitatsmedizin, Berlin, Germany frank.perschel@charite.de Picheth Geraldo (page 64) Federal University of Parana, Department of Medical Pathology, Curitiba, Brazil gpicheth@ufpr.br Pilonetto Marcelo (page 46) Brazilian Society of Clinical Analysis, Brazil m.pilonetto@pucpr.br Pirmohamed Munir (pages 34; 54) University of Liverpool, United Kingdom munirp@liverpool.ac.uk 86 Preissner Klaus T. (page 27) Justus Liebig Universitat Medical School, Department Biochemistry, Giessen, Germany Klaus.T.Preissner@biochemie.med.unigiessen.de Prinz Nadine (page 65) Institute of Clinical Chemistry and Laboratory Medicine, University Medical Centre Mainz, Germany Nad.Prinz@web.de Psarra Katherina (page 40; 68) Evangelismis Hospital, Athens, Greece stcps@hol.gr; info@eekx-kb.gr Pulkki Kari (page 44; 59) Clinical Chemistry, University of Eastern Finland, Kuopio, Finland kari.pulkki@islab.fi Quadrio Isabelle (page 71) Service de Neurobiologie, Centre de Biologie Est, Hospice Civils de Lyon, France isabelle.quadrio@chu-lyon.fr Raabe-Meyer Gisela (page 18) Praxis fur Humangenetik, Hannover, Germany grm@humangenetik-hannover.de Ratziu Vlad (page 15) University Pierre et Marie Curie, Paris, France vratziu@teaser.fr Raue Friedhelm (page 44) Endocrine Practice, Heidelberg, Germany friedhelm.raue@raue-endokrinologie.de Reaman Gregory H. (page 19) The George Washington University, USA greaman@cnmc.org Reguengo Henrique (page 69) Centro Hospitalar do Porto, Portugal hlreguengo@gmail.com I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Sandberg Sverre (page 64; 74) Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway sverre.sandberg@isf.uib.no Rifai Nader (pages 16; 64) Children's Hospital, Boston, USA Nader.Rifai@tch.harvard.edu Schimmel Heinz (page 69) European Commission, Joint Research Centre, Geel, Belgium Heinz.Schimmel@ec.europa.eu Rogic Dunja (pages 44; 64) Clinical Institute for Laboratory Diagnsotics, University Hospital Zagreb, Croatia dunjarogic@hotmail.com Schleicher Erwin (page 25) University Clinic Tübinger, Clinical Chemistry, Tübinger, Germany erwin.schleicher@med.uni-tuebingen.de Ronco Claudio (pages 17; 34) Department of Nephrology, Dialysis and renal transplantation, St. Bortolo Hospital, Vicenza, Italy cronco@goldnet.it Schmitz Gerd (page 56) University Hospital Regensburg, Institute for Clinical Chemistry and Laboratory Medicine, Germany gerd.schmitz@klinik.uni-regensburg.de Rosendaal Frits R. (page 63) Leiden University Medical Ctr, Dept. Clinical Epidemiology, The Netherlands f.r.rosendaal@lumc.nl Rosengren Anders (page 25) Lund University Diabetes Centre, Dep. Clinical Sciences Malmö, Sweden Anders.Rosengren@med.lu.se Rousseau Francois (page 55) Faculté de Médicine, Université Laval & Chuq, Québec, Canada Francois.Rousseau@mac.com Rueda Jesus (page 26) European Diagnostic Manufacturers Association (EDMA), Brussels, Belgium j.rueda@edma-ivd.be Rydén Ingvar (page 51) Swedish Society of Clinical Chemistry, Sweden Ingvar.Ryden@ltkalmar.se Sack Ulrich (pages 20; 25) TRM Leipzig, Germany Ulrich.Sack@medizin.uni-leipzig.de Sacks David (page 25) National Institutes of Healt, Bethesda, Maryland, USA sacksdb@mail.nih.gov Samuelsson Ola (page 17) Department of Nephrology, Sahlgrenska University Hospital, Goteborg, Germany ola.samuelsson@vgregion.se S pe a k e rs & Chairs Renz Harald (pages 38; 72) Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics Philipps University Marburg, Germany renzh@med.uni-marburg.de Schuff-Werner Peter (page 63) Institute of Clinical Chemistry and Laboratory Medicine, University of Rostock, Germany pschuffw@med.uni-rostock.de Scragg Robert (page 76) School of Population Health, University S. Auckland, New Zealand r.scragg@auckland.ac.nz Seccombe David (page 71) Canadian External Quality Assessment Laboratory (CEQAL), Vancouver, Canada dseccombe@ceqal.com Shannan Ghassan (pages 26; 68) Syrian Clinical Laboratory Association, Damascus, Syria ghassanshannan@gmail.com Shearer Martin J. (page 76) GSTS Pathology, St. Thomas’ Hospital, Londo, United Kingdom Martin.Shearer@gsts.com Sheldon Joanna (page 25) St. George's Hospital, London, United Kingdom jsheldon@sgul.ac.uk Sidransky David (page 16) Johns Hopkins School of Medicine Director, Otolaryingology-Head and Neck Cancer Research, Baltimore, USA dsidrans@jhmi.edu Siekmann Lothar (page 75) University of Bonn, Germany lothar.siekmann@ukb.uni-bonn.de 87 Speak e rs & Cha i r s I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Sierra Amor Rosa (page 21; 36) Veracruz, Ver, Mexico rsierramor@hotmail.com Simundic Ana-Maria (page 70) Clinical Institute of Chemistry, University Hospital "Sestre Milosrdnice", Zagreb, Croatia am.simundic@gmail.com Sinha Pranav (page 21; 40) IMCL, LKH-Klagenfurt, Austria pksinha@gmx.net Skrha Jan (page 35) 3rd Dept. of Internal Medicine and Laboratory for Endocrinology & Metabolism, 1st Faculty of Medicine, Prague, Czech Republic jan.skrha@lf1.cuni.cz Smith Janet (page 74) Chair IFCC Education and Management Division, Birmingham, United Kingodm janmsmith@Talk21.com Smolen Josef S. (page 25) Medical University of Vienna, Hietzing Hospital Vienna, Austria josef.smolen@wienkav.at Sprongl Ludek (page 46) Central Laboratory, Sumperk Hospital, Czech Republic sprongl@nemspk.cz Steenkamp Vanessa (page 68) University of Pretoria, South Africa vanessa.steenkamp@up.ac.za Stenman Ulf-Hakan (page 16) Dept. of Clinicla Chemistry, Helsinki University, Finland ulf-hakan.stenman@hus.fi StJohn Andrew (page 26) Ortho Clinical Diagnostics, Asia Pacific, Australia ASTJOHN@its.jnj.com Stowasser Michael (page 44) Endocrine Hypertension Research Centre, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia m.stowasser@uq.edu.au Suerbaum Sebastian (page 35) Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Germany suerbaum.sebastian@mh-hannover.de 88 Swinkels Dorine W. (pages 36; 76) Department of Laboratory Medicine, Radboud University Nymegen, The Netherlands D.Swinkels@labgk.umcn.nl Sypniewska Grazyna (page 40; 53) Dept. of Laboratory Medicine, Collegium Medicum Nicolaus Copernicus University, Bydgoszcz, Poland grazynaodes@interia.pl Szekeres Thomas (page 54) Clinical Institute for Laboratory Medicine, Wien, Austria thomas.szekeres@meduniwien.ac.at Tate Jill (page 37; 58) Chemical Pathology Dept., Pathology Queensland, Royal Brisbane and Womens' Hospital, Australia jill_tate@health.qld.gov.au Tauber Rudolf (pages 35; 57) Zentralinstitut für Laboratoriumsmedizin Charité Universitätsmedizin Berlin, Berlin, Germany Rudolf.Tauber@charite.de Tavora Mira Marcelo (page 56) Graduate Program in Health Sciences, PUCPR, Curitiba, Brazil m.mira@pucpr.br Thienpont Linda (pages 44; 75) Laboratory for Analytical Chemistry, Fac. Pharm. Sci, Ghent University, Belgium linda.thienpont@ugent.be Thiery Joachim (pages 36; 65) Institut für Laboratoriumsmedizin, Leipzig, Germany thiery@medizin.uni-leipzig.de Thomas Lothar (page 39; 76) Krankenhaus Nordwest, Frankfurt, Germany th-books@t-online.de Thornalley Paul J. (page 35) University of Warwick, Coventry, United Kingdom P.J.Thornalley@warwick.ac.uk Tomberg Karel (page 59; 69) North Estonia Medical Centre, Tallinn, Estonia karel.tomberg@regionaalhaigla.ee Tuma Ulisses (page 34) Laboratory Moderno Ltda, Goiania, Brazil ultuma@terra.com.br Uges Donald R.A. (page 74) University Medical Center Groningen, The Netherlands d.r.a.uges@apoth.umcg.nl I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 van den Boom Dirk (page 54) Research & Development Sugunam, Inc. 3595 John Hopkins Court, San Diego, USA dvandenboom@sequenom.com van Gelder Teunis (page 75) Erasmus Medical Center Rotterdam, The Netherlands t.vangelder@erasmusmc.nl van Pelt Hans (page 20; 74) U. Diagnsotics, Utrecht, The Netherlands f2hjvpelt@hetnet.nl van Schaik Ron (pages 34; 55) Dept. Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands r.vanschaik@erasmusmc.nl Vaubourdolle Michel (page 15) Pole de Biologie-Imagine, AP HP, Paris, France michel.vaubourdolle@sat.aphp.fr Vissa Varalakshmi (page 56) Colorado State University, Fort Collins, USA Varalakshmi.Vissa@ColoState.edu Voelkerding Karl V. (page 72) ARUP Laboratories, University of Utah, USA voelkek@aruplab.com Vogt Wolfgang (page 45) Munich, Germany wolfgang.vogt148@superkabel.de von Eckardstein Arnold (page 15; 20) UniversitätsSpital Zürich, Switzerland arnold.voneckardstein@usz.ch Wagener Christoph (pages 19; 20; 56) Dept. of Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany wagener@uke.uni-hamburg.de Wagner Oswald (page 59; 74) University of Wien, Austria oswald.wagner@meduniwien.ac.at Wald Nicholas (page 54) Wolfson Institute of Preventive Medicine, London, United Kingdom n.j.wald@qmul.ac.uk Walter Michael (pages 39; 58) Zentralinstitut fur Laboratoriumsmedizin und Pathobiocemie, Charité, Berlin, Germany M.Walter@charite.de Walter Ulrich (pages 36; 39; 63) Zentrum Innere Medizin, Universitatsklinikum Wurzburg, Germany uwalter@klin-biochem.uni-wuerzburg.de Wang Qiuquan (page 74) Department of Chemistry & the Key Lab of Analytical Sciences, College of Chemistry and Chemical Engineering, Xiamen University, China qqwang@xmu.edu.cn Watson Ian (page 44) Aintree University Hospital NHS Foundation Trust, Liverpool, United Kingdom IAN.WATSON@aintree.nhs.uk Weck Karen (page 54) University of North Carolina, Chupel Hill, USA KWeck@unch.unc.edu Weigel Günter (page 27) Innsbruck Medical University, Inst. for Medicine and Chem., Austria guenter.weigel@uki.at S pe a k e rs & Chairs Valenta Rudolf (page 55) Medical University of Vienna, Austria rudolf.valenta@meduniwien.ac.at Weimann Andreas (page 69) Central Institute of Laboratory Medicine, Charité University Medical Center, Berlin, Germany andreas.weimann@charite.de Weiss Gunter (page 76) Dept. of Internal Medicine, Clinical Immunology and Infectious Diseases, Innsbruck, Austria guenter.weiss@i-med.ac.at Werfel Thomas (page 55) Hannover Medical School, Hannover, Germany werfel.thomas@mh-hannover.de Wesenberg James (page 36) Alberta Health Services Red Deer Regional Hospital Centre, Canada jwesenberg@dthr.ab.ca Westermann Jörg (page 63) Charité Universitäts-medizin Berlin, Germany joerg.westermann@charite.de Westgard James (page 53) University of Wisconsin, Madison, USA James@westgard.com 89 Speak e rs & Cha i r s I F C C - W o r l d L a b - E u r o M e d L a b B e r l i n 2 0 11 Wevers Ron (page 74) Laboratory Genetic Endocrine and Metabolic Diseases, Dept. Laboratory Medicine, Univ. Medical Centre Nymegen, The Netherlands r.wevers@labgk.umcn.nl Weykamp Cas W. (page 18) Queen Beatrix Hospital, Winterswijk, The Netherlands C.W.Weykamp@skbwinterswijk.nl Whiteley William (page 53) MRC Clinician Scientist, University of Edinburgh, United Kingdom william.whiteley@ed.ac.uk Wiegel Bernhard (pages 27; 45) German Society for Clinical Chemistry and Laboratory Medicine, Working Group on Laboratory Management, Germany dr.bernhard.wiegel@t-online.de Wieland Eberhard (page 40; 59; 75) Klinikum Stuttgart, Center for Clinical Pathology, Pharmacy and Hygiene, Germany e.wieland@klinikum-stuttgart.de Witte Wolfgang (page 35) Robert Koch Institute, Wernigerode Branch, Germany wittew@rki.de Wittwer Carl T. (page 68) University of Utah, Salt Lake City, USA carl.wittwer@path.utah.edu Wyer Lou Ann (page 44) Sentara Helthcare, Norfolk, USA lawyer@sentara.com Young Ian (pages 15; 55; 57) Centre for Public Health, Queen's University Belfast, United Kingdom i.young@qub.ac.uk Young Donald S. (page 74) University of Pennsylvania, Philadelphia, USA donaldyo@mail.med.upenn.edu Zahedi Rene (page 56) Leibniz, Institut für Analytische, Wissenschaften ISAS - Dortmund, Germany rene.zahedi@isas.de 90 Zatloukal Kurt (page 70) Institute of Pathology, Medical University of Graz, Austria kurt.zatloukal@medunigraz.at Zerah Simone (page 46) Laboratory Zerah-Taar-Pfeffer, Paris, France simone.zerah@wanadoo.fr Zima Tomas (pages 16; 20; 35; 54) First Faculty of Medicine, Prague, Czech Republic zimatom@cesnet.cz Zinder Oren (page 63) Laboratory Medicine, Faculty of Medicine, the Technion, Israel Institute of Technology, Haifa, Israel ozinder@matav.net.il Solutions that drive knowledge Life changing knowledge begins in the laboratory. At Ortho Clinical Diagnostics, we are leading efficiency and productivity through innovative technology and high quality services that help you provide the highest level of care for your patients. 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