MEDICAL CITY PARTNERS INFORMATION NEMOURS CHILDREN’S HOSPITAL…PAGE 2 ORLANDO VA MEDICAL CENTER…PAGE 8 SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE…PAGE 13 1 UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE…PAGE 10 UNIVERSITY OF FLORIDA RESEARCH & ACADEMIC CENTER...PAGE 15 Updated 2/2016 MEDICAL CITY PARTNERS INFORMATION NEMOURS CHILDREN’S HOSPITAL & THE NEMOURS FOUNDATION VISION, Our Promise: To treat every child as if they were our own. MISSION & Our Commitment: To do everything in our power to help children grow up healthy VALUES Mission: To provide leadership, institutions, and services to restore and improve the health of children PRIMARY CONTACT FUNDING* through care and programs not readily available, with one high standard of quality and distinction, regardless of the recipient's financial status. Values: Excel ~ Respect ~ Serve ~ Honor ~ Learn We believe that our shared values inform and inspire our activities, helping us build and sustain a culture of trust. We are committed to doing whatever it takes to ensure our patients and families, visitors, colleagues, and business partners experience a uniquely satisfying experience each time they interact with Nemours. ABOUT The Nemours Foundation supports one of the largest integrated pediatric health systems in the U.S., NEMOURS including 50 pediatric subspecialty clinics, partner hospitals, and primary and urgent care clinics throughout Delaware, Pennsylvania, New Jersey and Florida, including two free-standing children’s hospital in central Florida and Delaware. Nemours provides clinical care for more than 300,000 unique patients per year. Patient satisfaction scores for Nemours physician practices and hospitals are at or near the top 5 percent nationally. RESEARCH & Your Child – Our Promise. Nemours Research delivers our promise by working every day to create a culture Dr. Terri H. Finkel, $74 million to EDUCATION of inquiry, evidence, scholarship and integration between the bench and the bedside, and to the clinic and the Chair of Pediatrics Nemours, HIGHLIGHTS community. Researchers at Nemours are tackling childhood cancers, medication safety, cardiac surgical and Chief Scientific $4 million to NCH outcomes, diabetes, asthma, genetic conditions, infant mortality and more. We are developing capacity in Officer, NCH from federal, non- Health Care Delivery Science, to shed light on how we can improve the overall patient experience and the federal, and long-term well-being of the children we serve. In 2014, enterprise-wide Nemours had 388 federal, non-federal industry-sponsored and industry-sponsored research grants and contracts with a combined total budget of $74 million; 236 ($40 grants and million) in Florida overall; 67 ($4 million) at Nemours Children’s Hospital in Orlando. Nemours has grown contracts into one of the country’s leading pediatric health networks, ranking 9th in the nation for NIH research funding among free-standing children’s hospitals. In addition, Nemours’ partnerships with the Community are fulfilling the NIH mandate for that highest level of Translational Research, dubbed “T4”, in which investigators study the factors and interventions that influence the health of populations, and ultimately result in improved global health. *2014-2020 2 Updated 2/2016 MEDICAL CITY PARTNERS INFORMATION NEMOURS CHILDREN’S HOSPITAL & THE NEMOURS FOUNDATION PRIMARY CONTACT FUNDING* RESEARCH & The Nemours Center for Endocrinology, Diabetes, and Metabolic Disorders has conducted numerous clinical Dr. Nelly Mauras, Over $12 million EDUCATION trials, Phase II-IV, studying effects of hormones, growth, and metabolism on diabetes in children and young Division Chief, from federal, non- HIGHLIGHTS adults. Sponsors have included the NIH, JDRF, AstraZeneca, the Thrasher Research Fund, Genentech, Endocrinology federal, and (CONT’D) Novartis, Pfizer, Novo Nordisk, Eli Lilly, Medtronic, Merck, and GlaxoSmithKline. In September 2014, the industry-sponsored Center secured a 5-year $10 million multi-site grant from the National Institute of Child Health and Human grants and Development for the project entitled, “Type I diabetes and the brain in children: metabolic interventions.” contracts Included in the research team are collaborators from Nemours, Stanford, Yale, Washington University and University of Iowa. The Nemours Oncology Research Laboratory develops novel treatment paradigms to promote healing and Dr. Tamarah $120,000 tissue regeneration in multiple tissues by modulating the inflammatory response, the composition of the Westmoreland, from FHTCC extracellular matrix, and the progenitor cell content. This effort is supported by a joint Nemours/UCF Surgeon, NCH research agreement with funding from the Florida High Tech Corridor Council. The Oncology lab is also engaged in a collaborative agreement with Sanford Burnham Prebys Medical Discovery Institute to support research on the regulation of the gene MYCN in MYCN-amplified advanced neuroblastomas. The Nemours Center for Pharmacogenomics and Translational Research includes the Asthma Clinical Dr. John Lima, $4,096,159 Research Center; Center for Pharmacogenetics; Core Clinical Research Program; and the Nemours Asthma Associate Director of from ALA, NIH, Research Program (including Comparative Effectiveness and Outcomes Research, Sickle Cell Disease-Related Clinical Research, NHLBI, FLDOH Asthma and Lung Disease, Obesity-Related Asthma and Lung Disease, and the Impact of Nutrition on Nemours Research Asthma. Institute, NCH Dr. Jason Lang, Center Director, NCH The Nemours Center for Cancer and Blood Disorders (NCCBD) focuses on developmental therapeutics Dr. E. Anders Kolb, $16 million targeting the unique genetic events that result in pediatric cancers. The NCCBD recently secured a 5-year Director, Blood and from NIH $10.2 million NIH Center of Biomedical Research Excellence grant to establish a Comprehensive Sickle Cell Bone Marrow Research Center, and our HTS & Drug Discovery Lab was awarded a $1 million RO1 for assay development Transplant Program to discover new inhibitors of NSD1 methyltransferase for pediatric AML. Dr. Eric Sandler, Chief, Division of Hematology/Oncology 3 Updated 2/2016 MEDICAL CITY PARTNERS INFORMATION NEMOURS CHILDREN’S HOSPITAL & THE NEMOURS FOUNDATION PRIMARY CONTACT RESEARCH & The NCCBD strives to maximize our most precious resource: the clinical trial-eligible pediatric cancer Dr. Andrew Napper, EDUCATION patient. Nemours became a new Community Clinical Oncology Program (CCOP) just 18 months ago. The Director, HTS & Drug HIGHLIGHTS mission of the Nemours CCOP is to ensure that each child and young adolescent within our catchment areas Development Lab (CONT’D) FUNDING* has the opportunity to participate in national cancer prevention, control and treatment trials as appropriate to his/her background and need. The Nemours NCORP will continue the Nemours CCOP mission and success with further implementation of systems supportive of Cancer Care Delivery Research and robust quality management. Nemours recently secured a 5-year $4.65 million grant from NIH to support NCORP Dr. Tim Bunnell, $17 million over 5 Nemours is sharing in a $17 million dollar Patient-Centered Outcomes Research Institute (PCORI) grant, Director of years from PCORI partnering with the leading and largest children’s health systems in the nation to transform pediatric health Bioinformatics to PEDSnet care across the United States. Representing more than 5% of the U.S. pediatric population, the PCORI grant Dr. Terri Finkel, Chief partners partners have created a secure electronic network, dubbed PEDSnet, allowing users to tap into a huge patient Scientific Officer, database of existing knowledge for clinical research. PEDSnet offers a platform for the evolution of the NCH learning healthcare system to generate new insights that can be turned quickly to application on behalf of the health of America’s children. PEDSnet was, in fact, born from the IOM Learning Health System Roundtable, when invited participants decided to collaborate. A PEDSnet-wide study on the effects of early childhood antibiotics on obesity is in progress. Dr. David Milov, NemoursOne is a robust, comprehensive, fully integrated and operational electronic health record (EHR) Chief Medical system which has been recognized by Healthcare Information and Management Systems Society (HIMSS) Information Officer, Analytics with its Stage 7 Award. This highest stage represents an advanced patient record environment. NCH Nemours is the first pediatric health institution in the U.S. to achieve HIMSS Stage 7. Both of our Hospitals have been named to the 16th annual Hospital and Health Networks magazine 2014 Most Wired list. “Most Wired” acknowledges excellence in the use of information technology in four key areas: infrastructure; business and administrative management; clinical quality and safety; and clinical integration. 4 Updated 2/2016 MEDICAL CITY PARTNERS INFORMATION NEMOURS CHILDREN’S HOSPITAL & THE NEMOURS FOUNDATION PRIMARY CONTACT FUNDING* RESEARCH & In light of studies indicating that returning military physicians may show a loss of certain clinical skills, the Dr. Tim Wysocki, $3.9 million from EDUCATION Department of Defense awarded Nemours a $3.9 million grant to evaluate how physicians can maintain these Director, CHDS DoD HIGHLIGHTS skills. Using Nemours’ comprehensive electronic medical record system, researchers will compare best Healthcare delivery science (HDS) examines the variables that influence how the right care is delivered to the Dr. Anne Kazak & $1 million right patient at the right time. Embracing this concept for a rapidly changing and value-driven health care Dr. Tim Wysocki, from federal grants economy, Nemours has expanded its Center for Healthcare Delivery Science by bringing aboard a new co- Directors, CHDS (CONT’D) practices to actual care decisions based upon how often a condition is seen. Ultimately, the study will test decision support interventions, such as feedback alerts in the electronic medical records, benefiting military and civilian physicians alike. director, forming a 13-member scientific advisory board, and adding to its research staff. The Center’s vision is to be recognized as one of the nation’s premier models of integration of HDS research, training, clinical application, mentoring and external collaboration. Nemours’ investment in education and training of health professionals makes it one of the largest virtual Dr. Heather Fagan, classrooms in the nation. In 2014, Nemours invested $4.5 million to support education and training for 503 Vice-Chair of medical students, 717 residents, 87 fellows and 1,200 nursing students. Nemours has affiliations with Education, NCH, Jefferson Medical College, Mayo Medical School, and the Colleges of Medicine at the University of Florida, Assistant Dean for Florida State University and the University of Central Florida. UME, UCF COM Nemours offers Continuing Medical Education (CME) for physicians, nurses and health professionals both Dr. Pamela Arn, inside and outside of the Nemours system, including national and regional conferences, regularly scheduled Director of Medical activities and physician outreach. NemoursEducation.org, Nemours’ free online continuing medical education, Education continues to grow. The number of total registered users across the U.S. is more than 76,000. 5 Updated 2/2016 MEDICAL CITY PARTNERS INFORMATION NEMOURS CHILDREN’S HOSPITAL & THE NEMOURS FOUNDATION PRIMARY CONTACT SPACE & Nemours Children’s Hospital (NCH) has access to excellent laboratory space and core resources both within Cyril Doucet FACILITIES NCH and within the outstanding research facilities of its Medical City Partners: Director of Research DEVOTED TO RESEARCH NCH has a fully equipped General Clinical Research Center (GCRC) on the 4th floor of NCH, FUNDING* Operations supported by dedicated clinic rooms and inpatient rooms as required for research studies, and with Nemours Research additional space for equipment, supplies, staff and other resources. (In addition, NCH also Institute, NCH maintains a General Clinical Research Center (GCRC) at NCH’s Clinic at 1717 Orange Avenue in Dr. Kamran Orlando for patients visits at that Clinic.) The research effort is supported by the Pathology Badizadegan, Chair of Department, whose resources include state-of-the-art testing facilities and the recently established Pathology, NCH Nemours-UCF COM Roche Molecular Center of Excellence, designed to accelerate and expand molecular diagnostics testing. NCH leases over 3,000 sq. ft. of laboratory and office space for its biomedical research projects located at the Sanford Burnham Medical Research Institute. Our research efforts are enhanced by Sanford-Burnham’s advanced technology platforms, including ultra-high-throughput small-molecule screening, disease model phenotyping, metabolomics, genomics, medicinal chemistry and pharmacology. NCH also leases over 4,000 sq. ft. of laboratory and office space at the UCF College of Medicine’s Burnett School of Biomedical Sciences. With ample room to expand its activities as necessary, NCH houses its Offices of Clinical Research and Sponsored Projects. Nemours’ efforts are also augmented by UCF’s strengths in nanotechnology, simulation, chemistry, engineering, optics and photonics. The NCH research effort is fully integrated as part of the Nemours Research Institute, with activities at its four locations: Orlando, Jacksonville, Pensacola and Wilmington (Delaware). This provides NCH with direct access to outstanding services, facilities, faculty and staff located throughout the Nemours Children’s Health System. 6 Updated 2/2016 MEDICAL CITY PARTNERS INFORMATION NEMOURS CHILDREN’S HOSPITAL & THE NEMOURS FOUNDATION PRIMARY CONTACT HEALTHY Nemours Health and Prevention Services’ (NHPS) vision is optimal health and development for all Mary Kate Mouser, LIVING children. We take a population-oriented, multi-sector approach in Delaware, and build on community M. Ed., Operational RESOURCES strengths and resources, to make policy, system and environmental changes where children and families live, Vice President, learn, play, worship and seek healthcare. We are committed to working with our partners to transform Nemours Health & communities and health care delivery systems that will improve population health. Prevention Services Nemours Center for Children’s Health Media (KidsHealth) is a national leader in the creation of engaging, Dr. Neil Izenberg, family-friendly health media and tools that educate and motivate families – while helping care-providers to be Operational Vice more efficient and effective. Among its many widely-known products is KidsHealth.org, the #1 most-visited President, NCCHM; site devoted to children’s health and parenting in both English and Spanish. On a typical weekday, about one Madeleine Boyer, million parents, kids, and teens turn to KidsHealth.org for expert advice and answers. KidsHealth’s Chief Marketing physician-led staff consists of clinician-educators, health and science editors, graphic and web designers, video producers, business developers, and technologists. The Center works with, and licenses private-labeled FUNDING* Officer, NCCHM educational products (including online content, patient instructions, educational videos, text and newsletter series, and other communication tools) to 80 of the nation’s children’s hospitals and hundreds of media, governmental, educational, and consumer product companies. KidsHealth also creates KidsHealth in the Classroom, a free website for educators featuring standards-based health curricula, activities, and handouts. The Nemours Florida Prevention Initiative works with the community to share healthy lifestyle messages Dr. Lloyd N. Werk, with children and families. Targeted health promotion and disease prevention programs help child care MPH, Division Chief, providers, educators, health professionals, and community advocates teach children and their families General Pediatrics, positive health habits that can last a lifetime. NCH Established in 2008, Nemours National Office of Policy and Prevention promotes optimal health and well- Debbie I. Chang, being for all children, not only children served within the Nemours health system. To do this, we work with MPH, Vice President stakeholders across Nemours and the country to advocate for federal policy change and identify, promote and of Policy & Prevention grow innovative practice and population-level solutions within and outside Nemours, advancing clinical care and community-based prevention efforts. The Nemours Health System also provides us with a laboratory in which to test new and innovative models, which informs our national policy and practice work. Through this work, we serve as a trusted resource and voice for children nationally. 7 Nemours BrightStart! researches, develops and offers evidence-based tools targeting young children at risk Dr. Laura Bailet, for reading failure, which affects 30 percent or more of our nation’s children. Since BrightStart! began in Operational Vice 2005, tens of thousands of prekindergarteners have been screened on early literacy skills, with thousands of President of Nemours at-risk children receiving Nemours BrightStart! intensive educational instruction. BrightStart! Updated 2/2016 MEDICAL CITY PARTNERS INFORMATION ORLANDO VA MEDICAL CENTER VISION PRIMARY CONTACT We are committed to being a patient-centered integrated health care organization that provides Veterans excellent health care, research, and education. We strive to be an organization where people choose to work and an active community partner. We stand as a back-up in responding to national emergencies. SUMMARY EMERGING CENTER OF INNOVATION The Orlando VA currently employs approximately 3,400 staff at 12 Points of Patient Care across Central Heather Frebe, Orlando Florida, who managed more than 1.3 million visits last year. The organization experienced 3% growth in VA Medical Center Public enrolled patients in the last year. Affairs Officer The Orlando VA Medical Center was designated an Emerging Center of Innovation by the VA Office of Patient Centered Care and Cultural Transformation. Some transformational activities currently underway at the medical center include PACT Team Motivational Interviewing, Complimentary (Alternative) Medicine, Patient Centered Care Hiring, Cooking Demonstrations and Farmers Markets, Patient Interactive System, Patient Centered Care Concierge Concepts, Real Time Customer Service Data Collection and Integrated Data Base Construction, Innovative Complaints Management and Service Recovery Systems, and the Faces of Freedom -- Patient Centered Care Video Project. COMPREHENSIVE MEDICAL SERVICES In addition to services provided through 11 other sites, the new Orlando VA Medical Center in Lake Nona has a large multispecialty outpatient clinic, 134-inpatient beds, 120-community living center beds, a 60 bed Domiciliary and Mental Health Residential Rehabilitation Program, and administrative and support services. The first primary care team began seeing patients at the new facility on Feb. 24. Additional services, including audiology, surgery, interim care, dental care, eye clinic and primary care physicians have been activated and will continue to roll out in 2016. The new Lake Nona medical campus is a stateof-the-art facility, and has increased accessibility to health care for more than 400,000 Central Florida veterans. TELEHEALTH The Orlando VA Medical Center uses communication and information technologies to provide health care delivery to Veterans. The term “Virtual Care” means using modern technology to provide clinical care and patient education when the patient and provider are in separate locations. The Orlando VA Medical Center uses these technologies to improve Veterans’ access to specialty care and services in VA clinics that are located closest to their homes. 55,655 Veterans in the Corporate Orlando system were actively involved in one or more of the five Virtual Care modalities in Fiscal Year 2015. 8 Updated 2/2016 MEDICAL CITY PARTNERS INFORMATION ORLANDO VA MEDICAL CENTER In 2015, the Orlando VA Medical Center’s research program continued to grow with 53 research projects, RESEARCH HIGHLIGHTS PRIMARY CONTACT 18 are ongoing and the remaining are in various preparation stages. We have established collaborations with the DoD, NIH/NIDDK, academic research institutions including several colleges within UCF, University of Florida, Tuft University, Vanderbilt Univ., Duke Univ., MD Anderson Cancer Center, Southwest Oncology Group Consortium, and industry partners. Projects include the VA’s Million Veteran Program, CONFIRM testing, Lithium treatment in depression, hormone replacement, study of Vitamin D and Type 2 diabetes, screening and treatment of anal cancer, treatment of plantar fasciitis and many other disease entities. THE SIMULATION LEARNING, EDUCATION AND RESEARCH NETWORK (SimLEARN) The Veterans Health Administration (VHA) SimLEARN National Simulation Center is currently under construction and will open in Lake Nona in spring 2016. This will be a high-technology, immersive environment for train-the-trainer activities and the operational hub for coordinating national VHA clinical simulation activities to meet the local simulation-based training needs of VA medical centers across the country. The facility will provide a high-fidelity training environment by replicating actual patient treatment areas in outpatient clinic setting, and inpatient/hospital settings including an intensive care unit, an operating room and more. HEALTH CARE FOR HOMELESS VETERANS The Orlando VAMC currently has 316 Grant and Per Diem transitional housing beds in its catchment areas, which includes Brevard, Orange, Volusia, and Osceola counties. Additionally, the OVAMC has more than 1,000 Veterans currently housed through the U.S. Housing and Urban Development Veterans’ Affairs Supportive Housing Program (HUD-VASH), a majority of which live in the greater Orlando area and lesser amounts in Titusville, Daytona, and within the Seminole County housing authority. These services provide permanent supported housing to Veterans and their families. There are 1,200 HUDVASH vouchers allocated to the Orlando catchment area. Orlando is participating in the 25 Priority Cities Initiatives. As part of this initiative, Orlando VA Leadership is working closely with community partners to develop a collaborative coordinated assessment. The goal is aimed at better identifying and matching the “best-fit” housing resources to homeless Veterans. RESIDENCY PROGRAMS In 2015 the Orlando VAMC welcomed 16 residents as part of the new internal medical residency training program. The program is in collaboration with the University of Central Florida Medical School and Osceola Regional Medical Center, and can accommodate up to 20 residents per year. 9 Updated 2/2016 MEDICAL CITY PARTNERS INFORMATION UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE VISION The University of Central Florida College of Medicine aspires to be the nation’s premier 21st century college of medicine. PRIMARY CONTACT Deborah C. German, MD, Vice President for Medical Affairs and Dean The UCF College of Medicine will be a national leader in education, research, and patient care, recognized for supporting and empowering its students and faculty to realize their passion for discovery, healing, health, and life, and for its ability to create partnerships to transform medical education, health care, and research. EDUCATION Provides biomedical and M.D. educational programs for UCF, the nation’s second largest university. Over 3,000 undergraduate students studying biomedical sciences, including a new biomedical engineering program. Graduate Program consisting of Ph.D. and M.S. students in biomedical sciences First M.D. class graduated in May 2013. In 2016 - 2017, the M.D. program will be at full enrollment, training 480 medical students per year. Richard Peppler, Ph.D., Associate Dean, Faculty and Academic Affairs Griffith Parks, Ph.D., Director, Burnett School of Biomedical Sciences 97 percent of medical students who graduated in the past three years matched into top residency programs across the state and country. Combined MD-PhD program trains physician scientists in a multidisciplinary setting. ACGME-accredited Internal Medicine residency program developed in collaboration with Orlando VA Diane Davey, M.D., Assistant Dean, Graduate Medical Education Medical Center and Osceola Regional Medical Center which currently has 34 trainees. New partnership with Hospital Corporation of America will add 550-plus residency slots in Florida. Health Explorers and Leaders (HEAL) pipeline program helps prepare underserved middle and high school students for future health careers. More than 2,200 volunteer and affiliated faculty physicians. Global health initiatives include an annual Global Healthcare Forum, and interdisciplinary teams perform medical mission trips to the Dominican Republic annually. The student-run KNIGHTS (Keeping Neighbors in Good Health Through Service) in collaboration with Grace Medical Home provides clinical care to Orlando’s underserved. The Clinical Skills and Simulation Center uses simulation as a clinical education and treatment tool, partnering with the Orlando VA Medical Center and others and leveraging the region’s $3 billion modeling and simulation industry resources. The college’s simulation resources model new approaches to health care Juan Cendan, M.D., Chair, Medical Education, Assistant Dean of Simulation delivery and patient engagement. The state-of-the-art Anatomy Lab includes larger-than-life medical imaging of hearts, livers and kidneys, touch-screen HD monitors and a table that displays a high-definition virtual cadaver that can show every anatomical system from a full body to individual nerves. 10 Updated 2/2016 MEDICAL CITY PARTNERS INFORMATION UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE UCF Health, the College’s multispecialty physician practice began treating patients in November 2011 at a facility PATIENT CARE blocks from the main UCF campus. The practice opened its second location in Medical City in March 2015 and in spring 2016 will open an on-site clinic for employees of the Osceola County Sheriff’s Office and their dependents. All UCF Health physicians are faculty at the medical school. Members of the Departments of Medical Education, Internal Medicine and Clinical Sciences practice medicine in a variety of clinical settings across the community. PRIMARY CONTACT Edward Ross, M.D., Chair, Department of Internal Medicine, and Interim Associate Dean for Clinical Affairs Diane Davey, M.D., Interim Chair, Clinical Sciences Clinical Directions: Be a catalyst for transforming healthcare in collaboration with local and national partners; develop, test and implement new approaches to delivering efficient, effective high quality care and improving population health. Establish innovative, patient-centered, technology-rich clinical education and research programs and facilities at the UCF Health Sciences campus at Lake Nona. Partner with others across Central Florida to address fragmentation and enable coordinated, seamless care. RESEARCH The College’s Burnett School of Biomedical Sciences (BSBS) focuses its research on: Cancer – faculty are creating innovative models for studying tumor growth, metastasis of human cancers, and anticancer therapeutic agents that target DNA and kill tumor cells Cardiovascular Disease – Areas of focus include topics such as elucidation of molecular/cellular signaling events that control heart development and the application of stem cell therapies for treatment of ischemic heart disease Sampath Parthasarathy, Ph.D., Associate Dean for Research Griffith Parks, Ph.D., Director, Burnett School of Biomedical Sciences Neurodegenerative Disease – Research includes biology of demyelination and potential treatment options for Parkinson’s disease and neurological disorders including ALS (Lou Gehrig’s disease) and Alzheimer’s disease. Infectious Disease – Novel therapies are being developed at BSBS to understand, diagnose, and treat diseases such as Lyme disease, malaria, and tuberculosis, as well as the immune response to microbial infections. 11 Updated 2/2016 MEDICAL CITY PARTNERS INFORMATION UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE Medical school has more than 200 research partnerships across the globe. RESEARCH (CONT’D) PRIMARY CONTACT Medical education research programs focus on medical simulation, assessment, professionalism, humanism and interprofessional education. 100 percent of M.D. students conduct research as part of the curriculum’s two-year FIRE (Focused Inquiry and Research Experience) module. FIRE mentors include many community physicians and scientists. An NIH-sponsored team across three research institutions develops and studies interactive avatars that simulate physician-patient interactions and present pathology to the learner. The Office of the Associate Dean for Research spearheads new research programs, initiatives, and avenues for the college and fosters interdisciplinary collaboration within the College of Medicine, other UCF colleges, and external partners. UCF REGIONAL EXTENSION CENTER FOR HEALTH IT (REC) With an $8.6 million federal grant, the College helped more than 2,800 Central Florida physicians implement Jeanette Schreiber, JD, electronic health records to improve patient care quality and support transformational new models of health care. MSW, AVP for Medical The College’s Regional Extension Center has expanded its services to support patient-centered medical homes, Affairs, CLO ICD-10 training, health analytics and data, clinical decision support, advanced meaningful use, and other initiatives to achieve the triple aim of better quality care, greater population health, and more affordable healthcare. 12 Updated 2/2016 MEDICAL CITY PARTNERS INFORMATION SANFORD-BURNHAM-PREBYS MEDICAL DISCOVERY INSTITUTE AT LAKE NONA VISION PRIMARY CONTACT Scientists at Sanford Burnham Prebys are committed to translating basic research discoveries into innovative therapeutics that have a tangible impact on human health. Scientists in the CMOD are studying the metabolic origins of obesity-related diabetes and its cardiovascular CENTER FOR METABOLIC ORIGINS OF DISEASE (CMOD) complications. The Center is supported by extensive shared resources, including the Conrad Prebys Center for Chemical Genomics, cardiometabolic phenotyping, metabolomics, analytical and functional genomics, medicinal chemistry, and pharmacology. Through partnerships with clinical and commercial organizations, Center Daniel Kelly, M.D., scientific director scientists advance laboratory breakthroughs to provide clinical benefit for those suffering from disease. Researchers study how organs and cells work together to respond to biological and environmental challenges that INTEGRATIVE METABOLISM PROGRAM lead to the development of metabolic diseases. The program brings together investigators with complementary expertise in cell and molecular biology, chemistry, and physiology. Since metabolic changes are also fundamental to many other pathological conditions, the basic principles of the research also provide insight and therapeutic Timothy Osborne, Ph.D., program director avenues for combating other human diseases. Scientists conduct research into fundamental and early translational aspects of cardiovascular biology, physiology, and disease. This research focuses on the intersections of metabolic and cardiovascular diseases, CARDIOVASCULAR METABOLISM PROGRAM including the interrelated effects of heart and vasculature disease. For example, hypertension, ischemic injury, and diabetes all lead to pathologic cardiac remodeling that involves myocyte hypertrophy, fibrosis and progressive ventricular dilatation. Similarly, hypertension, smoking, hypercholesterolemia, and diabetes lead to Peter Crawford, M.D., Ph.D., program director atherosclerosis. This is especially true in the obese or diabetic patient, given that hypertension and ischemic heart disease often coexist with inciting metabolic disturbances. The focus of the Genomic Control of Metabolism program is to dissect and understand the genomic and epigenetic regulatory mechanisms responsible for proper metabolic control to maintain homeostasis. Institute scientists GENOMIC CONTROL OF METABOLISM PROGRAM primarily study diseases in adipose tissue, liver, muscle, and immune cells. Particular emphasis is put on Laszlo Nagy, M.D., defining the role of key transcriptional regulatory proteins and nuclear hormone receptors in metabolic processes Ph.D., program director at the cellular level, in animal models, and in human disease. Another theme of the program’s research is the systems-level analysis of metabolic processes using integrated experimental and bioinformatics approaches. 13 Updated 2/2016 MEDICAL CITY PARTNERS INFORMATION SANFORD-BURNHAM-PREBYS MEDICAL DISCOVERY INSTITUTE AT LAKE NONA CONRAD PREBYS CENTER FOR CHEMICAL GENOMICS FLORIDA TRANSLATIONAL RESEARCH PROGRAM (FTRP) The Conrad Prebys Center for Chemical Genomics is Sanford Burnham Prebys Institute’s robotic ultra-highthroughput and high-content screening center for testing large collections of small chemical structures to find promising drug leads. It is equipped with the most advanced drug discovery technologies in the nonprofit world and staffed with highly trained scientists, many with years of experience in the pharmaceutical industry. PRIMARY CONTACT Layton Smith, Ph.D., director, Drug Discovery Florida The FTRP is a unique research-collaboration program open to Florida-based scientists. Funded by the Florida Layton Smith, Ph.D., Department of Health, the FTRP strives to produce a pipeline of potential new medicines based on laboratory- director, Drug Discovery research discoveries. Florida The business development office manages the commercialization of discoveries that result from Sanford Burnham Prebys research. The business development team is actively engaged in developing relationships with potential BUSINESS DEVELOPMENT partners and funding organizations for the advancement of shared research initiatives. The Intellectual Property team manages the licensing of technology and material transfers. Our multidisciplinary approach provides partners with access to custom-designed teams that include academic investigators, clinical researchers, and in- Leslie Molony, Ph.D., senior director, Business Development house scientists with extensive pharmaceutical and biotechnology industry experience. 14 Updated 2/2016 MEDICAL CITY PARTNERS INFORMATION UNIVERSITY OF FLORIDA RESEARCH AND ACADEMIC CENTER VISION Foster collaboration that stimulates innovative approaches to research and patient care, particularly in the areas of cancer, cardiovascular disease, diabetes and brain disorders The Helen and David Bean Campus of the University of Florida, College of Pharmacy in Orlando is located at ORLANDO COLLEGE OF PHARMACY the UF Research and Academic Center in Lake Nona. The facility houses a four-year Doctor of Pharmacy (Pharm.D.) Program. About 70 new students are accepted each year, with a total of 280 students working to become licensed pharmacists. CENTER FOR PHARMACOMETRICS AND SYSTEMS PHARMACOLOGY PRIMARY CONTACT Erin St.Onge, Pharm.D., Assistant Dean and Campus Director The Center conducts applied research proximal to clinical trials and/or clinical practice oriented toward Larry Lesko, PhD., problem solving through quantitative analysis, drug-disease modeling/simulation, and clinical trial design. Center Director and Research interests include Cancer, Cardiovascular diseases, Diabetes & Obesity, Orphan drugs, and special Clinical Professor patient populations, such as pediatric rare diseases. Housed within the UF College of Pharmacy, the Center is one of the leading educational institutions in Larisa H. Cavallari, CENTER FOR PHARMACOGENOMICS pharmacogenomics research and training of future scientists. Investigations include the study of disease-gene Pharm.D., BCPS, associations and relevance to pharmacogenomics. Director INSTITUTE FOR THERAPEUTIC INNOVATION (ITT) ITT focuses on developing and testing new drugs to treat and cure a variety of infectious diseases caused by George Drusano, MD drug-resistant pathogens such as TB and MRSA commonly linked to hospital-acquired infections. Institute Director Housed within the UF College of Medicine, the Institute on Aging conducts leads the aging and geriatric research department clinical research unit which will allow thousands to participate in clinical and translational research studies aimed at improving the health and independence of older adults. INSTITUTE ON AGING (IOA) Research focuses on mechanisms, etiology, prevention and rehabilitation of cognitive and physical disability. Among several projects, UF is leading the largest NIH funded study of physical activity lifestyle interventions to prevent disability in older adults ($86,000,000 project involving over 1,600 older adults throughout the Marco Pahor, MD, Director; Professor and Chair, Department of Aging and Geriatric Research U.S.). 15 Updated 2/2016 MEDICAL CITY PARTNERS INFORMATION UNIVERSITY OF FLORIDA RESEARCH AND ACADEMIC CENTER PRIMARY CONTACT The mission of the CTSI is to improve human health by accelerating the translation of scientific discoveries CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (CTSI) into practical applications and practices for the diagnosis, treatment, prevention and cure of human diseases. As a catalyst and hub connecting resources, people and ideas, the CTSI expands collaboration and advances science across UF’s 16 colleges, the state of Florida and the national Clinical and Translational Science Award Dr. David Nelson, Director, UF CTSI consortium. MEDICATION THERAPY MANAGEMENT COMMUNICATION AND CARE CENTER (MTMCCC) The center provides an experiential practice site for fourth-year student pharmacists, allowing them to perform comprehensive medication reviews via the telephone, complete patient chart quarterly reviews, and speak to patients regarding adherence issues. Anna Marie Hall, Pharm.D., BCACP, Assistant Director, MTMCCC The Florida Minority Cancer Research and Training Center (MiCaRT) is a partnership between UF and THE FLORIDA MINORITY CANCER RESEARCH AND TRAINING CENTER (MiCaRT) Florida A&M University with funding from the National Cancer Institute. The partnership is the only federally-funded minority partnership focused on cancer research and training for African Americans. The center launched a Minority Health Behavioral Research Core, which has a lab in Lake Nona, including a private waiting room, community resource center, focus group room, computer room for surveys, and for preparing and processing mail surveys. The goal is to train black researchers and support more studies focused on minority health. 16 Updated 2/2016