Sun Yat-sen University Cancer Center
651 Dongfeng East Road Guangzhou, Guangdong 510000 Phone: +8620 8734 3350 
E-Mail: huanghq@sysucc.org.cn
To: Yuan Qi, PhD
Science Editor, World Journal of Gastroenterology
Date: March 31, 2015
Title: Aggressive Surgical Resection does not Improve Survival in Operable Oesophageal Squamous Cell Carcinoma
with N2-3 status
Author: Zheng Yu-zhen, Zhao Wei , Hu Yi，Ding-Lin Xiao-xiao, Wen Jing, Yang Hong, Liu Qian-wen, Luo Kong-jia,
Huang Qing-yuan, Chen Jun-ying, Fu Jian-hua
Name of journal: World Journal of Gastroenterology
ESPS Manuscript NO: 17299
Columns: ORIGINAL ARTICLE
Retrospective Study
Dear Dr. Qi,:
Thank you very much for yours and the reviewer’s suggestions. They certainly improved the quality of this manuscript.
Specific concerns are addressed below.
1 Format has been updated.
2 Revision has been made according to the suggestions of the reviewer
(1) The concern regarding the manuscripts submitted by non-native speakers of English should provided language
certificate by professional English language editing companies.
Thank you for your suggestion. We had polished our manuscript with American Journal Experts before we
submitted, and the EDITORIAL CERTIFICATE will be attached in the attachment.
(2) A short running title of less than 6 words should be provided.
Thank you for your advice. We added a short running title.
(3) Authorship credit should be given in accordance with the standard proposed by the International Committee of
Medical Journal Editors
We clarified the authorship credit in the manuscript.
(4) The ethic approval document(s)/letter(s) must be provided in a PDF format, and each statement must also be
mentioned as a footnote in the manuscript text.
We added an ethic approval document and PDF format in the attachment.
(5) The informed consent must be provided in a PDF format, and the statement must also be mentioned as a footnote
in the manuscript text.
We added an informed consent document and PDF format in the attachment.
(6)
(7)
The conflict of interest must be provided in a PDF format, and the statement must also be mentioned as a footnote
in the manuscript text.
We added a conflict of interest document and PDF format in the attachment.
The data sharing must be provided in a PDF format, and the statement must also be mentioned as a footnote in
the manuscript text.
(8)
(9)
(10)
(11)
(12)
(13)
(14)
We added a data sharing document signed by the corresponding author and PDF format in the
attachment.
This statistical analysis statement must be mentioned in the text, and a certificate of statistical review signed by a
biostatistician must be provided in PDF format.
We already had a statistical analysis statement in the MATERIALS AND METHODS part, and we
added a certificate of statistical review signed by a biostatistician in PDF format in the attachment.
The concern regarding the informative, structured abstracts.
The format of the abstract has been updated.
Please write a summary of less than 100 words to outline the most innovative and important arguments and core
contents in your paper to attract readers and an audio file describing your final core tip made by the first author
is requested.
We added a core tip document and an audio file describing our final core tip in the attachment.
Please provide all authors abbreviation names and manuscript title here. The abbeviation names should be the
same as the copyright.
We added all authors’ abbreviation names in the manuscript.
Reformat all the reference numbers throughout.
We reformatted all the reference numbers in the manuscript.
Please write the COMMENTS section at here.
We added the comments in the manuscript.
Add PubMed citation numbers and DOI citation to the reference list and list all authors throughout and refer at
least 30 references.
We reformatted the references in the manuscript and added several references.
3. As the suggestion from peer reviewer, we added 3 figures in the manuscript in order to clarify our important aspects.
We hope this revision has reached your satisfaction. Thank you again for allowing us to resubmit this manuscript!
Wei Zhao. M.D., Ph.D.,
Tel：+86-20-87343349
Email：zhaowei@sysucc.org.cn
State Key Laboratory of Oncology in South China
Derpartment of medical Oncology
Sun Yat-sen University Cancer Center
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