March 2016 Volume 39, Number 3 In This Issue 321 392 In This Issue of Diabetes Care L. Fedorko, J.M. Bowen, W. Jones, G. Oreopoulos, R. Goeree, R.B. Hopkins, and D.J. O’Reilly Perspectives in Care 323 Expanding Treatment Options for Youth With Type 2 Diabetes: Current Problems and Proposed Solutions: A White Paper From the NICHD Diabetes Working Group 400 W.V. Tamborlane, M.W. Haymond, D. Dunger, R. Shankar, R. Gubitosi-Klug, K. Bethin, J. Karres, P. Tomasi, I. Libman, P.H. Hale, R. Portman, G. Klingensmith, M. Reed, J. Blumer, and G. Giacoia, for the NICHD Diabetes Working Group Commentary J.C. Florez 333 Abbas E. Kitabchi, PhD, MD: An Exemplary Mentor and Clinical Researcher Pathophysiology/Complications 418 G.E. Umpierrez A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults 426 R.A. Oram, K. Patel, A. Hill, B. Shields, T.J. McDonald, A. Jones, A.T. Hattersley, and M.N. Weedon 345 No Effect of High-Dose Vitamin D Treatment on b-Cell Function, Insulin Sensitivity, or Glucose Homeostasis in Subjects With Abnormal Glucose Tolerance: A Randomized Clinical Trial H. Wagner, M. Alvarsson, B. Mannheimer, M. Degerblad, and C.-G. Östenson 353 Epidemiology/Health Services Research 363 371 434 441 385 Reduced Lower-Limb Muscle Strength and Volume in Patients With Type 2 Diabetes in Relation to Neuropathy, Intramuscular Fat, and Vitamin D Levels M.M. Almurdhi, N.D. Reeves, F.L. Bowling, A.J.M. Boulton, M. Jeziorska, and R.A. Malik Cardiovascular and Metabolic Risk 448 A Link Between Hypoglycemia and Progression of Atherosclerosis in the Veterans Affairs Diabetes Trial (VADT) A. Saremi, G.D. Bahn, and P.D. Reaven, on behalf of the Veterans Affairs Diabetes Trial (VADT) 455 Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): A Randomized Controlled Trial T. Mita, N. Katakami, T. Shiraiwa, H. Yoshii, T. Onuma, N. Kuribayashi, T. Osonoi, H. Kaneto, K. Kosugi, Y. Umayahara, T. Yamamoto, K. Matsumoto, H. Yokoyama, M. Tsugawa, M. Gosho, I. Shimomura, and H. Watada, on behalf of the Collaborators on the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE) Trial Celiac Disease Increases Risk of Thyroid Disease in Patients With Type 1 Diabetes: A Nationwide Cohort Study M. Kurien, K. Mollazadegan, D.S. Sanders, and J.F. Ludvigsson 376 Altered Peripheral B-Lymphocyte Subsets in Type 1 Diabetes and Latent Autoimmune Diabetes in Adults C. Deng, Y. Xiang, T. Tan, Z. Ren, C. Cao, G. Huang, L. Wen, and Z. Zhou Severe Hypoglycemia Requiring Medical Intervention in a Large Cohort of Adults With Diabetes Receiving Care in U.S. Integrated Health Care Delivery Systems: 2005–2011 R.D. Pathak, E.B. Schroeder, E.R. Seaquist, C. Zeng, J.E. Lafata, A. Thomas, J. Desai, B. Waitzfelder, G.A. Nichols, J.M. Lawrence, A.J. Karter, J.F. Steiner, J. Segal, and P.J. O’Connor, for the SUPREME-DM Study Group Impaired Awareness of Hypoglycemia in Adults With Type 1 Diabetes Is Not Associated With Autonomic Dysfunction or Peripheral Neuropathy S.E. Olsen, M.R. Bjørgaas, B.O. Åsvold, T. Sand, M. Stjern, B.M. Frier, and K.B. Nilsen Initial Combination Therapy With Canagliflozin Plus Metformin Versus Each Component as Monotherapy for Drug-Naïve Type 2 Diabetes J. Rosenstock, L. Chuck, M. Gonz alez-Ortiz, K. Merton, J. Craig, G. Capuano, and R. Qiu Predictors of Increased Carotid Intima-Media Thickness in Youth With Type 1 Diabetes: The SEARCH CVD Study A.S. Shah, D. Dabelea, N.F. Fino, L.M. Dolan, R.P. Wadwa, R. D’Agostino Jr., R. Hamman, S. Marcovina, S.R. Daniels, and E.M. Urbina Clinical Care/Education/Nutrition/Psychosocial Research 337 Diabetes and the Association of Postoperative Hyperglycemia With Clinical and Economic Outcomes in Cardiac Surgery G. Greco, B.S. Ferket, D.A. D’Alessandro, W. Shi, K.A. Horvath, A. Rosen, S. Welsh, E. Bagiella, A.E. Neill, D.L. Williams, A. Greenberg, J.N. Browndyke, A.M. Gillinov, M.L. Mayer, J. Keim-Malpass, L.S. Gupta, S.F. Hohmann, A.C. Gelijns, P.T. O’Gara, and A.J. Moskowitz Found in Translation: A Type 1 Diabetes Genetic Risk Score Applied to Clinical Diagnosis Profiles in Progress Association of Gestational Diabetes Mellitus With Left Ventricular Structure and Function: The CARDIA Study D. Appiah, P.J. Schreiner, E.P. Gunderson, S.H. Konety, D.R. Jacobs Jr., C.C. Nwabuo, I.A. Ebong, H.K. Whitham, D.C. Goff Jr., J.A. Lima, I.A. Ku, and S.S. Gidding 408 330 Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb: A Prospective, Double-Blind, Randomized Controlled Clinical Trial Potato Consumption and Risk of Type 2 Diabetes: Results From Three Prospective Cohort Studies I. Muraki, E.B. Rimm, W.C. Willett, J.E. Manson, F.B. Hu, and Q. Sun Novel Communications in Diabetes Association of Lipopolysaccharide-Binding Protein With Aging-Related Adiposity Change and Prediabetes Among African Ancestry Men 465 C.M. Tilves, J.M. Zmuda, A.L. Kuipers, C.S. Nestlerode, R.W. Evans, C.H. Bunker, A.L. Patrick, and I. Miljkovic Nonaqueous, Mini-Dose Glucagon for Treatment of Mild Hypoglycemia in Adults With Type 1 Diabetes: A Dose-Seeking Study M.W. Haymond, M.J. Redondo, S. McKay, M.J. Cummins, B. Newswanger, J. Kinzell, and S. Prestrelski Keep up with the latest information for Diabetes Care and other ADA titles via Facebook (/ADAJournals) and Twitter (@ADA_Journals). Icons shown below appear on the first page of an article if more information is available online. All articles in Diabetes Care are available online at diabetes.org/diabetescare. Cover articles ( ) and ADA Statements are available free of charge. Each cover article is accompanied by a free online slide set that includes a summary of the article’s key points and conclusions as well as associated tables and figures. Other articles are available free to print subscribers or can be purchased as e-prints or reprints. ADA’s Diabetes Core Update podcast is available at diabetesjournals.org and through iTunes. 469 Age at Menarche and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study Among 27,482 Women e36 L. Chen, S. Li, C. He, Y. Zhu, G.M. Buck Louis, E. Yeung, F.B. Hu, and C. Zhang Folic Acid Supplement Intake in Early Pregnancy Increases Risk of Gestational Diabetes Mellitus: Evidence From a Prospective Cohort Study B. Zhu, X. Ge, K. Huang, L. Mao, S. Yan, Y. Xu, S. Huang, J. Hao, P. Zhu, Y. Niu, S. Tong, and F. Tao Review 472 Diabetes in Asia and the Pacific: Implications for the Global Epidemic e38 A. Nanditha, R.C.W. Ma, A. Ramachandran, C. Snehalatha, J.C.N. Chan, K.S. Chia, J.E. Shaw, and P.Z. Zimmet Systematic Review 486 Effects of Palatinose and Sucrose Intake on Glucose Metabolism and Incretin Secretion in Subjects With Type 2 Diabetes F. Keyhani-Nejad, M. Kemper, R. Schueler, O. Pivovarova, N. Rudovich, and A.F.H. Pfeiffer e40 Effect of Long-Acting Insulin Analogs on the Risk of Cancer: A Systematic Review of Observational Studies Two Nights of Recovery Sleep Reverses the Effects of Short-term Sleep Restriction on Diabetes Risk J.L. Broussard, K. Wroblewski, J.M. Kilkus, and E. Tasali J.W. Wu, K.B. Filion, L. Azoulay, M.K. Doll, and S. Suissa e42 Errata 495 Erratum. Risks of Psychiatric Disorders and Suicide Attempts in Children and Adolescents With Type 1 Diabetes: A Population-Based Cohort Study. Diabetes Care 2015;38:453–459 A. Butwicka, L. Frisén, C. Almqvist, B. Zethelius, and P. Lichtenstein 495 Erratum. Consequences of Comorbidity of Elevated Stress and/or Depressive Symptoms and Incident Cardiovascular Outcomes in Diabetes: Results From the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study. Diabetes Care 2016;39:101–109 D.M. Cummings, K. Kirian, G. Howard, V. Howard, Y. Yuan, P. Muntner, B. Kissela, N. Redmond, S.E. Judd, and M.M. Safford M.M. Smits, M.C. Bunck, M. Diamant, A. Corner, B. Eliasson, R.J. Heine, U. Smith, H. Yki-J€ arvinen, and D.H. van Raalte e44 Issues and Events e-Letters – Comments and Responses e46 Little Change in Diet After Onset of Type 2 Diabetes, Metabolic Syndrome, and Obesity in Middle-Aged Adults: 11-Year Follow-up Study T.N. Akbaraly, A.G. Tabak, M.J. Shipley, T. Mura, A. Singh-Manoux, J.E. Ferrie, G.D. Batty, and M. Kivimaki e31 Disparities in Diabetic Retinopathy Screening Rates Within Minority Populations: Differences in Reported Screening Rates Among African American and Hispanic Patients Y. Lu, L. Serpas, P. Genter, C. Mehranbod, D. Campa, and E. Ipp e33 Trends in Insulin Use and Diabetes Control in the U.S.: 1988–1994 and 1999–2012 E. Selvin, C.M. Parrinello, N. Daya, and R.M. Bergenstal Comment on Bonnet et al. Association Between Handedness and Type 2 Diabetes: The E3N Study. Diabetes Care 2015;38: e199 E. Selvin e47 e-Letters – Observations e29 Anti-inflammatory Effect of Mediterranean Diet in Type 2 Diabetes Is Durable: 8-Year Follow-up of a Controlled Trial M.I. Maiorino, G. Bellastella, M. Petrizzo, L. Scappaticcio, D. Giugliano, and K. Esposito Issues and Events 496 Effect of 3 Years of Treatment With Exenatide on Postprandial Glucagon Levels Response to Comment on Bonnet et al. Association Between Handedness and Type 2 Diabetes: The E3N Study. Diabetes Care 2015;38:e199 F. Bonnet, A. Affret, M.-C. Boutron-Ruault, B. Balkau, F. Clavel-Chapelon, and G. Fagherazzi e48 Comment on Haroon et al. Risk of Dementia in Seniors With Newly Diagnosed Diabetes: A Population-Based Study. Diabetes Care 2015;38:1868–1875 T. Kawada e49 Response to Comment on Haroon et al. Risk of Dementia in Seniors With Newly Diagnosed Diabetes: A Population-Based Study. Diabetes Care 2015;38: 1868–1875 N.N. Haroon, P.C. Austin, B.R. Shah, J. Wu, S.S. Gill, and G.L. Booth Cover: Floating Island. By Dina Belenko Photography. For more information, please visit gettyimages.com.