Curriculum Vitae
(Last updated: 2016-08-01)
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NAME
POSITION TITLE
JE, HYUNSOO SHAWN
Assistant Professor
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
Korea Advanced Institutes of Science and
Technology
University of Michigan, Ann Arbor
National Institutes of Health/The George
Washington University
Duke University Medical Center/HHMI
B.S.
07/97
Biological Sciences
M.S.
08/99
Biology
Ph.D.
05/2005
Genetics
Postdoc
09/2010
Neuroscience
A. Positions and Honors
Positions and Employment
2010Assistant Professor, Program in Neuroscience and Behavioral Disorders, Duke-National
University of Singapore Medical School.
2012Adjunct Assistant Professor, Department of Physiology, Yong Loo Lin School of Medicine,
National University of Singapore.
Other Experience and Professional Memberships
2001Member, Society for Neuroscience
Honors
1993-1997
1999-2001
2001-2005
2005
2007-2008
2015
Student Merit Scholarship, Korea Advanced Institutes of Science and Technology
Institute of Biomedical Science Fellowship, The George Washington University
NIH IRTA Doctoral Fellowship, National Institutes of Health
The Fellows Award for Research Excellence, National Institutes of Health
Research Fellowship Award, the fundamental and translational neuroscience training program,
Duke University Medical Center.
Junior Faculty Award, Association of Korean Neuroscientists, Society for Neuroscience Meeting.
B. Selected Peer-reviewed Publications
1. Luo, Z.G., Je, H.S., Wang, Q., Yang, F., Dobbins, G.C., Yang, Z.H., Xiong, W.C., Lu, B., and Mei, L.
(2003). Implication of geranylgeranyltransferase I in synapse formation. Neuron. 13, 703-17.
2. Je, H.S., Zhou, J., Yang, F., and Lu, B. (2005) Distinct mechanisms for neurotrophin-3-induced acute
and long-term synaptic potentiation. J. Neurosci. 14, 11719-29.
3. Je, H.S., Yang, F., Zhou, J., and Lu, B. (2006) Neurotrophin 3 induces structural and functional
modification of synapses through distinct molecular mechanisms. J Cell Biol. 18, 1029-42.
4. Lu, Z., Je, H.S., Young, P., Gross, J., Lu, B., and Feng, G. (2007) Regulation of synaptic growth and
maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction. J. Cell Biol.18,
1077-89.
5. Yang, F.*, Je, H.S.*, Ji, Y., Nagappan, G., Hempstead, B., and Lu, B. (2009) ProBDNF-induced
Synaptic Depression and Retraction at Developing Neuromuscular Synapses. J. Cell Biol. 185, 72741. *: co-first authors.
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6. Je, H.S.*, Lu, Y.*, Yang, F., Nagappan, G., Zhou, J., Jiang, Z., Nakazawa, K., and Lu, B. (2009)
Chemically Inducible Inactivation of Protein Synthesis in Genetically Targeted Neurons. J. Neurosci.
29, 6761-16. *: co-first authors.
7. Jiang, Z., Belforte, J., Lu, Y., Yabe, Y., Pickel, J., Smith, C., Je, H.S., Lu, B., and Nakazawa, K. (2010)
eIF2α phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory
consolidation without affecting general translation. J. Neurosci.30, 2582-94.
8. Je, H.S. *, Ji. Y. *, Wang, Y., Yang, F., Wu, W., and Lu, B. (2011) Presynaptic protein synthesis
required for NT-3-induced long-term synaptic modulation. Molecular Brain, 4:1. *: co-first authors.
9. Wang, X., McCoy, P.A., Rodriguiz, R.M., Pan, Y., Je, H.S., Roberts, A.C., Kim, C., Berrios, J., Colvin,
J.S., Bousquet-Moore, D., Lorenzo, I., Wu, G., Weinberg, R.J., Ehlers, M.D., Philpot, B.D., Beaudet, A.L.,
Wetsel, W.C., and Jiang, Y. (2011) Synaptic dysfunction and abnormal behaviors in mice lacking the
major isoforms of Shank3. Human Molecular Genetics, 20, 3093-108.
10. Rossi, M.A., Maimon, B., Mak, K., Je, H.S., Yin, H.H. (2012) Prefrontal Cortical Mechanisms Underlying
Delayed Alternation in Mice. J. Neurophysiology. 108, 1211-22
11. Je, H.S., Yang, F., Potluri, S., Ji, Y., Nagappan, G., Hempstead, B., Son, Y.J., and Lu, B. (2012) Role
of proBDNF to Mature BDNF Conversion in Activity-dependent Competition at Developing
Neuromuscular Synapses. PNAS, 109, 15924-9.
12. Lee, K., Kim, Y., Lee, S.J., Qiang, Y., Lee, D., Lee, H.W., Kim, H., Je, H.S., Sudhof, T.C., and Ko, J.
(2013) MDGAs selectively interact with neuroligin-2 but not other neuroligins to regulate inhibitory
synapse development. PNAS, 110, 336-41.
13. Je. H.S.#, Yang, F., Potluri, S., Ji.Y., Nagappan, G., Hempstead, B., Son, Y.J., and Lu, B.# (2013)
proBDNF and Mature BDNF as Punishment and Reward Signals for Synapse Elimination at Mouse
Neuromuscular Junctions. J. Neurosci. 33, 9957-62. #: co-corresponding authors.
14. Zhang, W., Thevapriya, S., Yu, W., Je, H.S., Tan, E.K., and Zeng, L. (2014) mR-574-5p as APP Target
that Mediates Neurogenesis during Brain Development. Nat. Comm. 3; 3330.
15. Mabb, A.M. *, Je, H.S. *, Wall, M.J., Robinson, C.G., Larsen, R.S., Qiang, Y., Correa, S.A., and Ehlers,
M.D. (2014) Triad3A Regulates Synaptic Strength by Ubiquitination of Arc. Neuron, 82, 1299-316. *:
co-first authors.
16. Er, J. C., Leong, C., Teoh, C.L., Yuan, Q., Merchant, P., Dunn, D., Sulzer, D., Sames, D., Bhinge, A.,
Kim, D., Kim, S.M., Yoon, M.H., Stanton, L.W., Je, H.S., Yun, S.W., and Chang, Y.T. (2015) NeuO: a
fluorescent Chemical Probe for Live Neuron Labeling. Angrew Chem. (Epub ahead of print).
17. Yuan, Q., Yang, F., Husain, N., Ng, N., Tan, S., Kim, P., Han, W., Nagata, K., Weinberger, D.R., and
Je, H.S. (2015) Regulation of BDNF exocytosis and GABAergic interneuron synapse function by the
schizophrenia susceptibility gene, dysbindin-1. Biological Psychiatry. (Epub ahead of print).
18. Zhang, W., Kim, P., Chen, Z., Lokman, H., Qiu, L., Zhang, K., Rozen, S.G., Tan, E.K., Je, H.S.#, and
Zeng, L.# (2016) MiRNA-128 Regulates the Proliferation and Neurogenesis of Neural Precursors by
Targeting PCM1 in the Developing Cortex. eLIFE. (in press). #: co-corresponding authors.
19. Montagner, A., Korecka, A., Polizzi, A., Lippi, Y., Blum Y., Canlet, C., Tremblay-Franco, M.,
GautierStein, A., Burcelin, R., Yen, Y., Je, H.S., Al-Asmakh, M., Mithieux, G., Arulampalam, V.,
Lagarrigue, S., Guilus, h., Pettersson, S., Wahli, W. (2016) Hepatic circadian clock oscillators and
nuclear receptors integrate microbiome-derived signals. Scientific Reports. (in press).
20. Yap, K. Xiao, Y., Friedman, B.A., Je, H.S., and Makeyev, E.V. (2016) Polarizing the Neuron through
Sustained Co-expression of Alternatively Spliced isoforms. Cell Reports. 15, 1316-1328.
21. Jo, J., Xiao, Y., Sun, A.X., Cukuroglu, E., Tran, H.D., Goke, J., Tan, Z. Y., Saw, T. Y., Tan, C.P.,
Lokman, H., Lee, Y., Kim, D., Ko, H.S., Kim, S.O., Park, J. H., Cho, N.J., Hyde, T.M., Kleinman, J.E.,
Shin, J.H., Weinberger, D.R., Tan, E.K., Je, H.S.# and Ng, H.H.# (2016) Midbrain-like organoids from
human pluripotent stem cells contain functional dopaminergic and neuromelanin producing neurons.
Cell Stem Cell. (in press). #: co-corresponding authors.
22. Sun, A.X., Yuan, Q., Tan, S., Xiao, Y., Wang, D., Khoo, A.T., Sani L., Tran, H.D., Kim, P., Chiew, Y.S.,
Lee, K.J., Yen, Y.C., Ng, H.H., Lim, B., and Je, H.S. (2016) Direct induction and functional maturation
of forebrain GABAergic neurons from human pluripotent stem cells. Cell Reports. (in press).
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C. Research Support
Ongoing Research Support
MOE2014-T2-071
JE (PI)
05/2015-04/2018
Investigation of Striatal Cholinergic Interneurons Using a Novel Cre Recombinase.
NMRC/CBRG/0075/2014
JE (PI)
02/2015-02/2018
The Role of Cadherin-13 in the Development and Function of the Brain Circuitry and Its Implication for Autism
Spectrum Disorders.
Completed Research Support
NUS CFGFY1132
JE (PI)
01/2012-12/2013
Developing a fiber-optic endoscopic microscope to image neurosecretion in intact mouse brain in vivo.
Role: PI
NMRC/NIG/1054/2011
JE (PI)
08/2011-07/2014
The role of eukaryotic initiation factor 2 alpha phosphorylation in amyloid-beta induced dendritic spine loss.
Role: PI
MOE2012-T2-1-021
JE (PI)
09/2012-08/2015
Regulation of BDNF exocytosis and interneuron synapse by dysbindin-1.
Role: PI
BMRC 13/1/96/688
JE (PI)
04/2013-03/2016
Linking human and experimental genetics to pinpoint causes of autism.
D. Teaching and Mentoring
Teaching Responsibilities
2011- present
Lecturer for the graduate course, Molecules and Cells (GMS6101). Mandatory course for MD students at
Duke-NUS Graduate Medical School.
2011- present
Lecturer for the graduate course, Techniques in Neuroscience (GSN6503). Course for neuroscience PhD
students at National University of Singapore.
2013- present
Lecturer for the graduate course, Neuronal Signaling (GSN6501). Course for neuroscience PhD students at
National University of Singapore.
Mentoring Responsibilities
2012- present
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Thesis advisor to four PhD and one MD/PhD students.
2012- present
Postdoctoral advisor to five postdoctoral fellows.
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